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Protein

Prefoldin subunit 3

Gene

VBP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiR-BTA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.
R-BTA-392029. Prefoldin mediated transfer of substrate to CCT/TriC.

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 3
Alternative name(s):
Von Hippel-Lindau-binding protein 1
Short name:
VBP-1
Short name:
VHL-binding protein 1
Gene namesi
Name:VBP1
Synonyms:PFDN3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: In complex with VHL can translocate to the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002828562 – 197Prefoldin subunit 3Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei59N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ2TBX2.
PRIDEiQ2TBX2.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022946.

Structurei

3D structure databases

ProteinModelPortaliQ2TBX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

eggNOGiKOG3313. Eukaryota.
ENOG410XRZ8. LUCA.
HOGENOMiHOG000184744.
HOVERGENiHBG053576.
InParanoidiQ2TBX2.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR016655. PFD3.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PANTHERiPTHR12409. PTHR12409. 1 hit.
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
PIRSFiPIRSF016396. Prefoldin_subunit_3. 1 hit.
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TBX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASKDGCGV GEVAAGNGRR LHLGIPEAVF VEDVDSFMKQ PGNETADIVL
60 70 80 90 100
KKLDEQYQKY KFMELNLAQK KRRLKGQIPE IKQTLEILKY KQKKKESTSS
110 120 130 140 150
LETRFLLADN LYCKASVPPT DKVCLWLGAN VMLEYDIDEA QALLEKNLLT
160 170 180 190
ATKNLDSLEE DLDFLRDQFT TTEVNMARVY NWDVKRRNKD DSTKNKA
Length:197
Mass (Da):22,483
Last modified:January 24, 2006 - v1
Checksum:iB5B74277D1ECA4BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109526 mRNA. Translation: AAI09527.1.
RefSeqiNP_001033605.1. NM_001038516.2.
UniGeneiBt.20583.

Genome annotation databases

GeneIDi508727.
KEGGibta:508727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109526 mRNA. Translation: AAI09527.1.
RefSeqiNP_001033605.1. NM_001038516.2.
UniGeneiBt.20583.

3D structure databases

ProteinModelPortaliQ2TBX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022946.

Proteomic databases

PaxDbiQ2TBX2.
PRIDEiQ2TBX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi508727.
KEGGibta:508727.

Organism-specific databases

CTDi7411.

Phylogenomic databases

eggNOGiKOG3313. Eukaryota.
ENOG410XRZ8. LUCA.
HOGENOMiHOG000184744.
HOVERGENiHBG053576.
InParanoidiQ2TBX2.

Enzyme and pathway databases

ReactomeiR-BTA-389957. Prefoldin mediated transfer of substrate to CCT/TriC.
R-BTA-392029. Prefoldin mediated transfer of substrate to CCT/TriC.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR016655. PFD3.
IPR009053. Prefoldin.
IPR004127. Prefoldin_subunit_alpha.
[Graphical view]
PANTHERiPTHR12409. PTHR12409. 1 hit.
PfamiPF02996. Prefoldin. 1 hit.
[Graphical view]
PIRSFiPIRSF016396. Prefoldin_subunit_3. 1 hit.
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPFD3_BOVIN
AccessioniPrimary (citable) accession number: Q2TBX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 24, 2006
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.