Q2TBX0 (ZPR1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein ZPR1

Alternative name(s):
Zinc finger protein 259

Gene names

Name:	ZNF259
Synonyms:	ZPR1

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus By similarity.
Subunit structure	Binds to the EGF and PDGF receptors. Binds to the elongation factor 1-alpha EF1A. Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus › nucleolus By similarity. Note: Translocates to the nucleolus after treatment with mitogens By similarity.
Sequence similarities	Belongs to the ZPR1 family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 459	459	Zinc finger protein ZPR1		PRO_0000328434
Regions
	Zinc finger	51 – 83	33	C4-type 1
	Zinc finger	259 – 291	33	C4-type 2

Sequences

	Sequence		Length	Mass (Da)
	Q2TBX0 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: CB03264626E284A7	FASTA	459	51,015
	10 20 30 40 50 60 MSAGGAVEPG LPAAAAAPSA APARDPGPGH LFRPISAEDE EQQPTEIESL CMNCYRNGMT 70 80 90 100 110 120 RLLLTKIPFF REIIVSSFSC EHCGWNNTEI QSAGRIQDQG VRYTLTVRAQ EDMDREVVKT 130 140 150 160 170 180 DSATTRIPEL DFEIPAFSQK GALTTVEGLI SRAISGLEQD QPTRRANEEA VAERIDEFIA 190 200 210 220 230 240 KLKELKQVAS PFTLIIDDPS GNSFVENPHA PRKDDALVIT HYNRTLQQEE MLGLQAEAPE 250 260 270 280 290 300 EKPEEEDIRN EVLQFNTNCP ECNAPAQTNM KLVQIPHFKE VIIMATNCEN CGHRTNEVKS 310 320 330 340 350 360 GGAVEPLGTR ITFHITDPSD MTRDLLKSET CSVEIPELEF ELGMAVLGGK FTTLEGMLKD 370 380 390 400 410 420 IRELVTKNPF TLGDSSSPGQ TEKLQEFSQK LDQILEGILK AHFIMDDPAG NSYLQNVYAP 430 440 450 EDDPEMKVEH YKRTFDQNEE LGLNDMKTEG YETGLPAQR

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC109540 mRNA. Translation: AAI09541.1.
IPI	IPI00711583.
RefSeq	NP_001033593.1. NM_001038504.1.
UniGene	Bt.2531.
3D structure databases
ProteinModelPortal	Q2TBX0.
SMR	Q2TBX0. Positions 47-440.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000003433.
Proteomic databases
PRIDE	Q2TBX0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000003433; ENSBTAP00000003433; ENSBTAG00000002650.
GeneID	504523.
KEGG	bta:504523.
Organism-specific databases
CTD	8882.
Phylogenomic databases
eggNOG	COG1779.
GeneTree	ENSGT00390000005306.
HOGENOM	HOG000216492.
HOVERGEN	HBG002608.
InParanoid	Q2TBX0.
KO	K06874.
OMA	KLQEFSQ.
OrthoDB	EOG4CNQR2.
Enzyme and pathway databases
BioCyc	CATTLE:504523-MONOMER.
Family and domain databases
InterPro	IPR004457. Znf_ZPR1. [Graphical view]
Pfam	PF03367. zf-ZPR1. 2 hits. [Graphical view]
SMART	SM00709. Zpr1. 2 hits. [Graphical view]
TIGRFAMs	TIGR00310. ZPR1_znf. 2 hits.
ProtoNet	Search...
Other
NextBio	20866706.

Entry information

Entry name

ZPR1_BOVIN

Accession

Primary (citable) accession number: Q2TBX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	January 24, 2006
Last modified:	May 29, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program