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Protein

5-demethoxyubiquinone hydroxylase, mitochondrial

Gene

COQ7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 2 iron ions per subunit.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Iron 1UniRule annotation1
Metal bindingi90Iron 1UniRule annotation1
Metal bindingi90Iron 2UniRule annotation1
Metal bindingi93Iron 1UniRule annotation1
Metal bindingi142Iron 2UniRule annotation1
Metal bindingi178Iron 1UniRule annotation1
Metal bindingi178Iron 2UniRule annotation1
Metal bindingi181Iron 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processUbiquinone biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
5-demethoxyubiquinone hydroxylase, mitochondrialUniRule annotation (EC:1.14.13.-UniRule annotation)
Short name:
DMQ hydroxylaseUniRule annotation
Alternative name(s):
Timing protein clk-1 homologUniRule annotation
Ubiquinone biosynthesis monooxygenase COQ7UniRule annotation
Gene namesi
Name:COQ7UniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:27615 COQ7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionUniRule annotationAdd BLAST34
ChainiPRO_000025236335 – 2175-demethoxyubiquinone hydroxylase, mitochondrialAdd BLAST183

Proteomic databases

PaxDbiQ2TBW2
PRIDEiQ2TBW2

Expressioni

Gene expression databases

BgeeiENSBTAG00000021242
ExpressionAtlasiQ2TBW2 baseline and differential

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with COQ8B and COQ6. Interacts with COQ9.UniRule annotation

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043418

Structurei

3D structure databases

ProteinModelPortaliQ2TBW2
SMRiQ2TBW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 1291Add BLAST82
Repeati130 – 2172Add BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 2172 X approximate tandem repeatsAdd BLAST170

Sequence similaritiesi

Belongs to the COQ7 family.UniRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG4061 Eukaryota
COG2941 LUCA
GeneTreeiENSGT00390000014520
HOGENOMiHOG000184972
HOVERGENiHBG002214
InParanoidiQ2TBW2
KOiK06134
OMAiTIGHMWE
OrthoDBiEOG091G0N8Z
TreeFamiTF314559

Family and domain databases

CDDicd01042 DMQH, 1 hit
HAMAPiMF_01658 COQ7, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR011566 Ubq_synth_Coq7
PANTHERiPTHR11237 PTHR11237, 1 hit
PfamiView protein in Pfam
PF03232 COQ7, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TBW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCARALAAC CLWRLRTGAL QPLSAYGRRI SVRFCSSGMT LDNINREAVD
60 70 80 90 100
RIIRVDHAGE YGANRIYAGQ MAVLGRTSIG PVIQKMWDQE KDHLKKFNEL
110 120 130 140 150
MVAFRVRPTV LMPFWNVVGF ALGAGTALLG KEGAMACTVA VEESIAHHYN
160 170 180 190 200
NQIRTLMEKE PEKYEELLQV IKKFRDEELE HHDIGLEHDA ELAPAYVVLK
210
SVIQAGCKVA IYLSERL
Length:217
Mass (Da):24,361
Last modified:January 24, 2006 - v1
Checksum:i722E4A141731D1CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109578 mRNA Translation: AAI09579.1
RefSeqiNP_001106712.1, NM_001113241.1
UniGeneiBt.20358

Genome annotation databases

EnsembliENSBTAT00000046091; ENSBTAP00000043418; ENSBTAG00000021242
GeneIDi504771
KEGGibta:504771

Similar proteinsi

Entry informationi

Entry nameiCOQ7_BOVIN
AccessioniPrimary (citable) accession number: Q2TBW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: January 24, 2006
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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