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Protein

5-demethoxyubiquinone hydroxylase, mitochondrial

Gene

COQ7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 2 iron ions per subunit.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron 1UniRule annotation
Metal bindingi90 – 901Iron 1UniRule annotation
Metal bindingi90 – 901Iron 2UniRule annotation
Metal bindingi93 – 931Iron 1UniRule annotation
Metal bindingi142 – 1421Iron 2UniRule annotation
Metal bindingi178 – 1781Iron 1UniRule annotation
Metal bindingi178 – 1781Iron 2UniRule annotation
Metal bindingi181 – 1811Iron 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
5-demethoxyubiquinone hydroxylase, mitochondrialUniRule annotation (EC:1.14.13.-UniRule annotation)
Short name:
DMQ hydroxylaseUniRule annotation
Alternative name(s):
Timing protein clk-1 homologUniRule annotation
Ubiquinone biosynthesis monooxygenase COQ7UniRule annotation
Gene namesi
Name:COQ7UniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434MitochondrionSequence analysisAdd
BLAST
Chaini35 – 2171835-demethoxyubiquinone hydroxylase, mitochondrialPRO_0000252363Add
BLAST

Proteomic databases

PaxDbiQ2TBW2.
PRIDEiQ2TBW2.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021242.
ExpressionAtlasiQ2TBW2. baseline and differential.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.UniRule annotation

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043418.

Structurei

3D structure databases

ProteinModelPortaliQ2TBW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati48 – 129821Add
BLAST
Repeati130 – 217882Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni48 – 2171702 X approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the COQ7 family.UniRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG4061. Eukaryota.
COG2941. LUCA.
GeneTreeiENSGT00390000014520.
HOGENOMiHOG000184972.
HOVERGENiHBG002214.
InParanoidiQ2TBW2.
KOiK06134.
OMAiEGHEQVH.
OrthoDBiEOG091G0N8Z.
TreeFamiTF314559.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
HAMAPiMF_01658. COQ7. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR011566. Ubq_synth_Coq7.
[Graphical view]
PANTHERiPTHR11237. PTHR11237. 1 hit.
PfamiPF03232. COQ7. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TBW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCARALAAC CLWRLRTGAL QPLSAYGRRI SVRFCSSGMT LDNINREAVD
60 70 80 90 100
RIIRVDHAGE YGANRIYAGQ MAVLGRTSIG PVIQKMWDQE KDHLKKFNEL
110 120 130 140 150
MVAFRVRPTV LMPFWNVVGF ALGAGTALLG KEGAMACTVA VEESIAHHYN
160 170 180 190 200
NQIRTLMEKE PEKYEELLQV IKKFRDEELE HHDIGLEHDA ELAPAYVVLK
210
SVIQAGCKVA IYLSERL
Length:217
Mass (Da):24,361
Last modified:January 24, 2006 - v1
Checksum:i722E4A141731D1CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109578 mRNA. Translation: AAI09579.1.
RefSeqiNP_001106712.1. NM_001113241.1.
UniGeneiBt.20358.

Genome annotation databases

EnsembliENSBTAT00000046091; ENSBTAP00000043418; ENSBTAG00000021242.
GeneIDi504771.
KEGGibta:504771.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109578 mRNA. Translation: AAI09579.1.
RefSeqiNP_001106712.1. NM_001113241.1.
UniGeneiBt.20358.

3D structure databases

ProteinModelPortaliQ2TBW2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043418.

Proteomic databases

PaxDbiQ2TBW2.
PRIDEiQ2TBW2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000046091; ENSBTAP00000043418; ENSBTAG00000021242.
GeneIDi504771.
KEGGibta:504771.

Organism-specific databases

CTDi10229.

Phylogenomic databases

eggNOGiKOG4061. Eukaryota.
COG2941. LUCA.
GeneTreeiENSGT00390000014520.
HOGENOMiHOG000184972.
HOVERGENiHBG002214.
InParanoidiQ2TBW2.
KOiK06134.
OMAiEGHEQVH.
OrthoDBiEOG091G0N8Z.
TreeFamiTF314559.

Enzyme and pathway databases

UniPathwayiUPA00232.

Gene expression databases

BgeeiENSBTAG00000021242.
ExpressionAtlasiQ2TBW2. baseline and differential.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
HAMAPiMF_01658. COQ7. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR011566. Ubq_synth_Coq7.
[Graphical view]
PANTHERiPTHR11237. PTHR11237. 1 hit.
PfamiPF03232. COQ7. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOQ7_BOVIN
AccessioniPrimary (citable) accession number: Q2TBW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: January 24, 2006
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.