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Protein

Kinesin light chain 3

Gene

KLC3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 3
Gene namesi
Name:KLC3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cytoplasmcytoskeleton Curated

  • Note: Elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Kinesin light chain 3PRO_0000244524Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei173 – 1731PhosphoserineBy similarity
Modified residuei467 – 4671PhosphoserineBy similarity
Modified residuei499 – 4991PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2TBQ9.
PRIDEiQ2TBQ9.

Interactioni

Subunit structurei

Oligomer composed of two heavy chains and two light chains. Associates with microtubulin in an ATP-dependent manner. Interacts with KIF5C and ODF1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041235.

Structurei

3D structure databases

ProteinModelPortaliQ2TBQ9.
SMRiQ2TBQ9. Positions 226-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati207 – 24034TPR 1Add
BLAST
Repeati249 – 28234TPR 2Add
BLAST
Repeati291 – 32434TPR 3Add
BLAST
Repeati333 – 36634TPR 4Add
BLAST
Repeati375 – 40834TPR 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili88 – 15063Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 1844Poly-Glu
Compositional biasi193 – 1964Poly-Ala

Domaini

The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity).By similarity

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated
Contains 5 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
HOGENOMiHOG000261663.
HOVERGENiHBG006217.
InParanoidiQ2TBQ9.
KOiK10407.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR002151. Kinesin_light.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TBQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQVAAPGG LGLGLERPSP EELVRQTRQV VKGLEALRAE HRGLAGHLAE
60 70 80 90 100
ALAAQGPAAG LELLEEKQQV VSHSLEAIEL GLGEAQVLLA LSAHVGALEA
110 120 130 140 150
EKQRLRAQAR RLAQENAWLR EELEETQRRL RASEEAVAQL EEEKSHLEFL
160 170 180 190 200
GQLRQYDPPA ESQQPESPPR RDSLASLFPS EEEERRGPEA VGAAAAQQGG
210 220 230 240 250
YEIPARLRTL HNLVIQYAGQ GRYEVAVPLC RQALEDLERS SGHCHPDVAT
260 270 280 290 300
MLNILALVYR DQNKYKEATD LLHDALQIRE QTLGPEHPAV AATLNNLAVL
310 320 330 340 350
YGKRGRYREA EPLCQRALEI REKVLGADHP DVAKQLNNLA LLCQNQGKFE
360 370 380 390 400
EVERHYARAL SIYEALGGPH DPNVAKTKNN LASAYLKQNK YQQAEELYKE
410 420 430 440 450
ILHREALPAP LGAPNTGTTS DTQQQTLSRS SSFSKLRESI RRGSEKLVSR
460 470 480 490 500
LRGEGAAGAA GMKRAMSLSM LNTDGSRAPE NQFPRQHLSE ASRTLSTSTQ

DLGPR
Length:505
Mass (Da):55,583
Last modified:January 24, 2006 - v1
Checksum:iAFDBCC1FF7031651
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109786 mRNA. Translation: AAI09787.1.
RefSeqiNP_001033638.1. NM_001038549.1.
UniGeneiBt.54295.

Genome annotation databases

GeneIDi517633.
KEGGibta:517633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109786 mRNA. Translation: AAI09787.1.
RefSeqiNP_001033638.1. NM_001038549.1.
UniGeneiBt.54295.

3D structure databases

ProteinModelPortaliQ2TBQ9.
SMRiQ2TBQ9. Positions 226-443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041235.

Proteomic databases

PaxDbiQ2TBQ9.
PRIDEiQ2TBQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi517633.
KEGGibta:517633.

Organism-specific databases

CTDi147700.

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
HOGENOMiHOG000261663.
HOVERGENiHBG006217.
InParanoidiQ2TBQ9.
KOiK10407.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR002151. Kinesin_light.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 4 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLC3_BOVIN
AccessioniPrimary (citable) accession number: Q2TBQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 24, 2006
Last modified: June 8, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.