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Q2TBQ8

- 6PGL_BOVIN

UniProt

Q2TBQ8 - 6PGL_BOVIN

Protein

6-phosphogluconolactonase

Gene

PGLS

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

    Catalytic activityi

    6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.

    Pathwayi

    GO - Molecular functioni

    1. 6-phosphogluconolactonase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    SABIO-RKQ2TBQ8.
    UniPathwayiUPA00115; UER00409.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconolactonase (EC:3.1.1.31)
    Short name:
    6PGL
    Gene namesi
    Name:PGLS
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 2582576-phosphogluconolactonasePRO_0000288666Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei180 – 1801N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ2TBQ8.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000022314.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0363.
    HOGENOMiHOG000256285.
    HOVERGENiHBG000030.
    InParanoidiQ2TBQ8.
    KOiK01057.

    Family and domain databases

    InterProiIPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view]
    PfamiPF01182. Glucosamine_iso. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01198. pgl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2TBQ8-1 [UniParc]FASTAAdd to Basket

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    MAAPAPRLIS VFSSPQELGA SLAQLVVQQA ACCLADAGAR FTLGLSGGSL    50
    VSMLARELPA AAAPAGPASL ARWTLGFCDE RLVPFEHAES TYGLYRTHLL 100
    SKLPIFDSQV ITINPALPVE EAAEDYAKKL RQAFQGDSIP VFDLLILGVG 150
    PDGHTCSLFP DHPLLQEREK IVAPISDSPK PPPQRVTLTL PVLNAARTVI 200
    YVATGEGKAA ILKRILEDKE ENPLPAALVQ PSAGKLCWFL DEAAARLLTV 250
    PFEKHSTL 258
    Length:258
    Mass (Da):27,547
    Last modified:January 24, 2006 - v1
    Checksum:iC6C56548D40C310A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC109789 mRNA. Translation: AAI09790.1.
    RefSeqiNP_001033669.1. NM_001038580.1.
    UniGeneiBt.60804.

    Genome annotation databases

    GeneIDi616120.
    KEGGibta:616120.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC109789 mRNA. Translation: AAI09790.1 .
    RefSeqi NP_001033669.1. NM_001038580.1.
    UniGenei Bt.60804.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000022314.

    Proteomic databases

    PRIDEi Q2TBQ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 616120.
    KEGGi bta:616120.

    Organism-specific databases

    CTDi 25796.

    Phylogenomic databases

    eggNOGi COG0363.
    HOGENOMi HOG000256285.
    HOVERGENi HBG000030.
    InParanoidi Q2TBQ8.
    KOi K01057.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00409 .
    SABIO-RK Q2TBQ8.

    Miscellaneous databases

    NextBioi 20899969.

    Family and domain databases

    InterProi IPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view ]
    Pfami PF01182. Glucosamine_iso. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01198. pgl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry namei6PGL_BOVIN
    AccessioniPrimary (citable) accession number: Q2TBQ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3