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Protein

POC1 centriolar protein homolog A

Gene

POC1A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
POC1 centriolar protein homolog A
Alternative name(s):
WD repeat-containing protein 51A
Gene namesi
Name:POC1A
Synonyms:WDR51A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:50094. POC1A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002315211 – 407POC1 centriolar protein homolog AAdd BLAST407

Proteomic databases

PaxDbiQ2TBP4.
PRIDEiQ2TBP4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001471.

Interactioni

Subunit structurei

Interacts with POC1B.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001927.

Structurei

3D structure databases

ProteinModelPortaliQ2TBP4.
SMRiQ2TBP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati17 – 56WD 1Add BLAST40
Repeati59 – 98WD 2Add BLAST40
Repeati101 – 140WD 3Add BLAST40
Repeati143 – 182WD 4Add BLAST40
Repeati185 – 224WD 5Add BLAST40
Repeati227 – 266WD 6Add BLAST40
Repeati269 – 308WD 7Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili369 – 397Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the WD repeat POC1 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IF90. Eukaryota.
ENOG410XR4H. LUCA.
GeneTreeiENSGT00810000125363.
HOVERGENiHBG057502.
InParanoidiQ2TBP4.
KOiK16482.
OMAiCLENQQL.
OrthoDBiEOG091G07ES.
TreeFamiTF324210.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF00400. WD40. 7 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2TBP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAHCPEDPS LERHFKGHRD AVTSVDFSLN TKQLASGSMD SCLMVWHMKP
60 70 80 90 100
QTRAYRFAGH KDAVTCVNFS PSGHLLASGS RDKTVRIWVP NVKGESTVFR
110 120 130 140 150
AHTATVRSVH FCSDGQSFVT ASDDKTVKVW STHRQKFLFS LSQHINWVRC
160 170 180 190 200
AKFSPDGRLI VSASDDKTVK LWDKTSRECV HSYCEHGGFV TYVDFHPSGT
210 220 230 240 250
CIAAAGMDNT VKVWDVRTHR LLQHYQLHSA AVNALSFHPS GNYLVTASSD
260 270 280 290 300
STLKILDLME GRLLYTLHGH QGPATTVAFS RTGEYFASGG SDEQVMVWKS
310 320 330 340 350
NFDIVDYGEV LRVQRPPATR ASSSGTLPEV DPLVPPGRGR SQESMQSHSQ
360 370 380 390 400
EPVSVPQSLT STLEHIVGQL DVLTQTVSIL EQRLTLTEDK LKQCLENQQL

IMQRTTP
Length:407
Mass (Da):45,228
Last modified:January 24, 2006 - v1
Checksum:iA73AA7CAD0F87113
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109862 mRNA. Translation: AAI09863.1.
RefSeqiNP_001033649.1. NM_001038560.2.
UniGeneiBt.4084.

Genome annotation databases

EnsembliENSBTAT00000001927; ENSBTAP00000001927; ENSBTAG00000001471.
GeneIDi534489.
KEGGibta:534489.

Similar proteinsi

Entry informationi

Entry nameiPOC1A_BOVIN
AccessioniPrimary (citable) accession number: Q2TBP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 24, 2006
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome