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Protein

Histone H4 transcription factor

Gene

HINFP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 3925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri127 – 15125C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri167 – 19125C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27624C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33526C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36624C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4 transcription factor
Alternative name(s):
Histone nuclear factor P
Short name:
HiNF-P
MBD2-interacting zinc finger protein
Methyl-CpG-binding protein 2-interacting zinc finger protein
Gene namesi
Name:HINFP
Synonyms:MIZF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity

  • Note: Associated with discrete nuclear foci.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Histone H4 transcription factorPRO_0000281105Add
BLAST

Post-translational modificationi

Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ2TBP2.
PRIDEiQ2TBP2.

Interactioni

Subunit structurei

Binds MBD2 and a histone deacetylase complex. Interacts with NPAT (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019990.

Structurei

3D structure databases

ProteinModelPortaliQ2TBP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni371 – 516146Interaction with NPATBy similarityAdd
BLAST
Regioni372 – 40534Required for activation of histone H4 transcription and contributes to DNA-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi49 – 557Poly-Glu
Compositional biasi444 – 4496Poly-Gly

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 3925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri127 – 15125C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri167 – 19125C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27624C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri282 – 30423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri310 – 33526C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri343 – 36624C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3608. Eukaryota.
ENOG410XQF8. LUCA.
HOGENOMiHOG000232129.
InParanoidiQ2TBP2.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TBP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPGKVPRK ENLGLQCEWG SCSFVCSAME EFCEHVTQHL QQHLQGSGEE
60 70 80 90 100
EEEEEDLLEE EFSCLWRECG FCSPDNSADL IRHVYFHCYH TKLKQWGLQA
110 120 130 140 150
LQSQADLSPC ILDFQSRNLI PDIPDHFLCL WEHCENSFDN PEWFYRHVEA
160 170 180 190 200
HSQCCEYQVV GKDNNVVLCG WKGCTCTFKD RFKLREHLRS HTQEKVVACP
210 220 230 240 250
TCGGMFANNT KFLDHIRRQS SLDQQHFQCS HCSKRFATER LLRDHMRNHV
260 270 280 290 300
NHYKCPLCDM TCPLPSSLRN HMRFRHSEAR PFKCDCCDYS CKNLIDLRKH
310 320 330 340 350
LDTHSKEPAY SCDFENCTFS ARSLYSIKSH YRKVHEGDSE PRYRCHVCDK
360 370 380 390 400
CFTRGNNLTV HLRKKHQFKW PSGHPRFRYK EHEDGYMRLQ LVRYESVELT
410 420 430 440 450
QQLLRQPQEG SGLGASLNES SLQDIILETV PGEPGPQEEA EEEGGGGEGI
460 470 480 490 500
ALPASQGTSS PIIHVVNQTN AQGEREVVYY VLFEAPGEPP PASEPPSGGV
510
MGELQGAAEE PEVQMV
Length:516
Mass (Da):59,256
Last modified:January 24, 2006 - v1
Checksum:i19AEA2148217DDC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109865 mRNA. Translation: AAI09866.1.
RefSeqiNP_001033620.1. NM_001038531.2.
UniGeneiBt.43786.

Genome annotation databases

GeneIDi511965.
KEGGibta:511965.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109865 mRNA. Translation: AAI09866.1.
RefSeqiNP_001033620.1. NM_001038531.2.
UniGeneiBt.43786.

3D structure databases

ProteinModelPortaliQ2TBP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019990.

Proteomic databases

PaxDbiQ2TBP2.
PRIDEiQ2TBP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi511965.
KEGGibta:511965.

Organism-specific databases

CTDi25988.

Phylogenomic databases

eggNOGiKOG3608. Eukaryota.
ENOG410XQF8. LUCA.
HOGENOMiHOG000232129.
InParanoidiQ2TBP2.

Miscellaneous databases

NextBioi20870186.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiHINFP_BOVIN
AccessioniPrimary (citable) accession number: Q2TBP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: January 24, 2006
Last modified: December 9, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.