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Q2TBP0

- PSB7_BOVIN

UniProt

Q2TBP0 - PSB7_BOVIN

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Protein
Proteasome subunit beta type-7
Gene
PSMB7
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Nucleophile

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT01.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-7 (EC:3.4.25.1)
Gene namesi
Name:PSMB7
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cytoplasm. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. proteasome core complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 4343Removed in mature form By similarity
PRO_0000329062Add
BLAST
Chaini44 – 277234Proteasome subunit beta type-7
PRO_0000329063Add
BLAST

Keywords - PTMi

Zymogen

Proteomic databases

PRIDEiQ2TBP0.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit can be displaced by the equivalent immune-specific subunit PSMB10.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003990.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi46 – 516
Beta strandi54 – 596
Beta strandi63 – 7311
Beta strandi77 – 815
Beta strandi84 – 918
Helixi92 – 11322
Helixi119 – 13214
Turni133 – 1353
Beta strandi139 – 1468
Beta strandi151 – 1566
Beta strandi162 – 1643
Beta strandi166 – 1716
Helixi174 – 18310
Helixi191 – 1955
Helixi197 – 20812
Beta strandi216 – 2227
Beta strandi225 – 2273
Beta strandi230 – 2334

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IRUX-ray2.75I/W44-277[»]
ProteinModelPortaliQ2TBP0.
SMRiQ2TBP0. Positions 44-263.

Miscellaneous databases

EvolutionaryTraceiQ2TBP0.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000182856.
HOVERGENiHBG093416.
InParanoidiQ2TBP0.
KOiK02739.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TBP0-1 [UniParc]FASTAAdd to Basket

« Hide

MAAVSVYERP VGGFSFDNCR RNAVLEADFA KKGYKLPTAR KTGTTIAGVV    50
YKDGIVLGAD TRATEGMVVA DKNCSKIHFI SPNIYCCGAG TAADTDMTTQ 100
LISSNLELHS LSTGRLPRVV TANRMLKQML FRYQGYIGAA LVLGGVDVTG 150
PHLYSIYPHG STDKLPYVTM GSGSLAAMAV FEDKFRPDME EEEAKKLVSE 200
AIAAGIFNDL GSGSNIDLCV ISKSKLDFLR PYSVPNKKGT RFGRYRCEKG 250
TNAVLTEKVT TLEIEVLEET VQTMDTS 277
Length:277
Mass (Da):30,009
Last modified:January 24, 2006 - v1
Checksum:iC3DE3CB1782AEBB3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC109868 mRNA. Translation: AAI09869.1.
RefSeqiNP_001033616.1. NM_001038527.2.
UniGeneiBt.56882.

Genome annotation databases

GeneIDi511207.
KEGGibta:511207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC109868 mRNA. Translation: AAI09869.1 .
RefSeqi NP_001033616.1. NM_001038527.2.
UniGenei Bt.56882.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IRU X-ray 2.75 I/W 44-277 [» ]
ProteinModelPortali Q2TBP0.
SMRi Q2TBP0. Positions 44-263.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000003990.

Protein family/group databases

MEROPSi T01.011.

Proteomic databases

PRIDEi Q2TBP0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 511207.
KEGGi bta:511207.

Organism-specific databases

CTDi 5695.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000182856.
HOVERGENi HBG093416.
InParanoidi Q2TBP0.
KOi K02739.

Miscellaneous databases

EvolutionaryTracei Q2TBP0.
NextBioi 20869822.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR024689. Proteasome_bsu_C.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF12465. Pr_beta_C. 1 hit.
PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  2. "The structure of the mammalian 20S proteasome at 2.75 A resolution."
    Unno M., Mizushima T., Morimoto Y., Tomisugi Y., Tanaka K., Yasuoka N., Tsukihara T.
    Structure 10:609-618(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 44-277 OF COMPLEX WITH 20S PROTEASOME.

Entry informationi

Entry nameiPSB7_BOVIN
AccessioniPrimary (citable) accession number: Q2TBP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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