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Protein

Protein SERAC1

Gene

SERAC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Protein family/group databases

ESTHERibovin-srac1. PGAP1.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SERAC1
Alternative name(s):
Serine active site-containing protein 1
Gene namesi
Name:SERAC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 54HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002746701 – 654Protein SERAC1Add BLAST654

Proteomic databases

PaxDbiQ2TBM9.
PRIDEiQ2TBM9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000011509.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015295.

Structurei

3D structure databases

ProteinModelPortaliQ2TBM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SERAC1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2029. Eukaryota.
ENOG410YIPC. LUCA.
GeneTreeiENSGT00390000003560.
HOGENOMiHOG000154411.
HOVERGENiHBG057428.
InParanoidiQ2TBM9.
OMAiALVQHSK.
OrthoDBiEOG091G061M.
TreeFamiTF319689.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2TBM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAAYCVIC CRRMGTSTPP PKSSTYWRDI RNIIKFTGSL ILGGSLFITY
60 70 80 90 100
EVLALKKSLT LDTQVIEREK MKSYIYVHTV SLDKTENHGI TYQARKELHK
110 120 130 140 150
AVRKVLATSA RIFRGPFADT FSTVDIEDHD CAVWLLLRKS RSDDRAARLQ
160 170 180 190 200
AVQEMSEARH WHDYQYRIIA QACDMRTLTG LARSKDSDLR FFLRPPPLPS
210 220 230 240 250
LKEDSSTEEE LRHLLASLPQ TDLDECIQCF TALALSESSQ SLAAQKGGLW
260 270 280 290 300
CFGGNGLPYA ESFGEVPSAT VEMFCLEALV KHSEIPTHCD KIEANGGLQL
310 320 330 340 350
LQRLYQLHKD CPKVQRNIMR ILGNMALNEH LHSTIVRSGW VSILAEAIKS
360 370 380 390 400
QHIMEASHAA RTLANLDRET VPDKYHDGVY VLHPQYRTSQ PIKADVLFIH
410 420 430 440 450
GLMGAAFKTW RQQDNDQDLT EKVSEDETKY TTCWPKSWLA RDCPALRIIS
460 470 480 490 500
VEYDTSLSDW RARCPTERKS IAFRSNELLR KLRAAGVGDR PVVWVSHSMG
510 520 530 540 550
GLLVKKMLLE ASKRPEMNTI INNTRGIIFY SVPHHGSHLA EYSVNIRYLL
560 570 580 590 600
FPSLEVKELS KDSPALKTLQ DDFLEFAKDK NFQVLSFVET LPTYIGSMIK
610 620 630 640 650
LHVVPLDSAD LGLGDLIPVD VNHLNICKPK KKDAFLYQRT LQFIRDALAK

DLEN
Length:654
Mass (Da):74,196
Last modified:January 24, 2006 - v1
Checksum:iE75298FC8A593D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109896 mRNA. Translation: AAI09897.1.
RefSeqiNP_001033639.1. NM_001038550.2.
XP_005211129.1. XM_005211072.3.
XP_010807020.1. XM_010808718.2.
UniGeneiBt.87758.

Genome annotation databases

EnsembliENSBTAT00000015295; ENSBTAP00000015295; ENSBTAG00000011509.
GeneIDi519860.
KEGGibta:519860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109896 mRNA. Translation: AAI09897.1.
RefSeqiNP_001033639.1. NM_001038550.2.
XP_005211129.1. XM_005211072.3.
XP_010807020.1. XM_010808718.2.
UniGeneiBt.87758.

3D structure databases

ProteinModelPortaliQ2TBM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015295.

Protein family/group databases

ESTHERibovin-srac1. PGAP1.

Proteomic databases

PaxDbiQ2TBM9.
PRIDEiQ2TBM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000015295; ENSBTAP00000015295; ENSBTAG00000011509.
GeneIDi519860.
KEGGibta:519860.

Organism-specific databases

CTDi84947.

Phylogenomic databases

eggNOGiKOG2029. Eukaryota.
ENOG410YIPC. LUCA.
GeneTreeiENSGT00390000003560.
HOGENOMiHOG000154411.
HOVERGENiHBG057428.
InParanoidiQ2TBM9.
OMAiALVQHSK.
OrthoDBiEOG091G061M.
TreeFamiTF319689.

Gene expression databases

BgeeiENSBTAG00000011509.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSRAC1_BOVIN
AccessioniPrimary (citable) accession number: Q2TBM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: January 24, 2006
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.