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Protein

Protein SERAC1

Gene

SERAC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Protein family/group databases

ESTHERibovin-srac1 PGAP1

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SERAC1
Alternative name(s):
Serine active site-containing protein 1
Gene namesi
Name:SERAC1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 9

Organism-specific databases

VGNCiVGNC:34460 SERAC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 54HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002746701 – 654Protein SERAC1Add BLAST654

Proteomic databases

PaxDbiQ2TBM9
PRIDEiQ2TBM9

Expressioni

Gene expression databases

BgeeiENSBTAG00000011509

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000015295

Structurei

3D structure databases

ProteinModelPortaliQ2TBM9
SMRiQ2TBM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SERAC1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2029 Eukaryota
ENOG410YIPC LUCA
GeneTreeiENSGT00390000003560
HOGENOMiHOG000154411
HOVERGENiHBG057428
InParanoidiQ2TBM9
OMAiKTMANLD
OrthoDBiEOG091G061M
TreeFamiTF319689

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit
SSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q2TBM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAAYCVIC CRRMGTSTPP PKSSTYWRDI RNIIKFTGSL ILGGSLFITY
60 70 80 90 100
EVLALKKSLT LDTQVIEREK MKSYIYVHTV SLDKTENHGI TYQARKELHK
110 120 130 140 150
AVRKVLATSA RIFRGPFADT FSTVDIEDHD CAVWLLLRKS RSDDRAARLQ
160 170 180 190 200
AVQEMSEARH WHDYQYRIIA QACDMRTLTG LARSKDSDLR FFLRPPPLPS
210 220 230 240 250
LKEDSSTEEE LRHLLASLPQ TDLDECIQCF TALALSESSQ SLAAQKGGLW
260 270 280 290 300
CFGGNGLPYA ESFGEVPSAT VEMFCLEALV KHSEIPTHCD KIEANGGLQL
310 320 330 340 350
LQRLYQLHKD CPKVQRNIMR ILGNMALNEH LHSTIVRSGW VSILAEAIKS
360 370 380 390 400
QHIMEASHAA RTLANLDRET VPDKYHDGVY VLHPQYRTSQ PIKADVLFIH
410 420 430 440 450
GLMGAAFKTW RQQDNDQDLT EKVSEDETKY TTCWPKSWLA RDCPALRIIS
460 470 480 490 500
VEYDTSLSDW RARCPTERKS IAFRSNELLR KLRAAGVGDR PVVWVSHSMG
510 520 530 540 550
GLLVKKMLLE ASKRPEMNTI INNTRGIIFY SVPHHGSHLA EYSVNIRYLL
560 570 580 590 600
FPSLEVKELS KDSPALKTLQ DDFLEFAKDK NFQVLSFVET LPTYIGSMIK
610 620 630 640 650
LHVVPLDSAD LGLGDLIPVD VNHLNICKPK KKDAFLYQRT LQFIRDALAK

DLEN
Length:654
Mass (Da):74,196
Last modified:January 24, 2006 - v1
Checksum:iE75298FC8A593D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109896 mRNA Translation: AAI09897.1
RefSeqiNP_001033639.1, NM_001038550.2
XP_005211129.1, XM_005211072.3
XP_010807020.1, XM_010808718.2
UniGeneiBt.87758

Genome annotation databases

EnsembliENSBTAT00000015295; ENSBTAP00000015295; ENSBTAG00000011509
GeneIDi519860
KEGGibta:519860

Similar proteinsi

Entry informationi

Entry nameiSRAC1_BOVIN
AccessioniPrimary (citable) accession number: Q2TBM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: January 24, 2006
Last modified: April 25, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health