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Q2TBL8

- CDK10_BOVIN

UniProt

Q2TBL8 - CDK10_BOVIN

Protein

Cyclin-dependent kinase 10

Gene

CDK10

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells).By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei66 – 661ATPPROSITE-ProRule annotation
    Active sitei161 – 1611Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi43 – 519ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 10 (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 10
    Gene namesi
    Name:CDK10
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Cyclin-dependent kinase 10PRO_0000261032Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei194 – 1941PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ2TBL8.

    Interactioni

    Subunit structurei

    Heterodimer with FAM58A/Cyclin-M, the interaction is required for kinase activity. Interacts with ETS2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000044609.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2TBL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 321285Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00740000114964.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ2TBL8.
    KOiK02449.
    OMAiPYNNLKN.
    OrthoDBiEOG74BJS4.
    TreeFamiTF101026.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2TBL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEPEPEQIR LKCVRKEGFF TVPPEHRLGR CRSVKEFEKL NRIGEGTYGI    50
    VYRARDTHTD EIVALKKVRM DKEKDGVPIS SLREITLLLR LRHPNIVELK 100
    EVVVGNHLES IFLVMGYCEQ DLASLLENMP TPFSEAQVKC IVLQVLRGLQ 150
    YLHRNFIIHR DLKVSNLLMT DKGCVKTADF GLARAYGIPV KPMTPKVVTL 200
    WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT SEIHQVDLIV 250
    QLLGTPSENI WPGFSQLPLA SQYSLRKQPY NNLKHKFPWL SEAGLRLMNL 300
    LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRATPATSL 350
    GTESQSRRGR P 361
    Length:361
    Mass (Da):41,047
    Last modified:January 24, 2006 - v1
    Checksum:i166CEE224496DEE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC109954 mRNA. Translation: AAI09955.1.
    RefSeqiNP_001033666.1. NM_001038577.2.
    XP_001251816.1. XM_001251815.4.
    UniGeneiBt.7907.

    Genome annotation databases

    EnsembliENSBTAT00000047400; ENSBTAP00000044609; ENSBTAG00000033333.
    GeneIDi615171.
    785111.
    KEGGibta:615171.
    bta:785111.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC109954 mRNA. Translation: AAI09955.1 .
    RefSeqi NP_001033666.1. NM_001038577.2.
    XP_001251816.1. XM_001251815.4.
    UniGenei Bt.7907.

    3D structure databases

    ProteinModelPortali Q2TBL8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000044609.

    Proteomic databases

    PRIDEi Q2TBL8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000047400 ; ENSBTAP00000044609 ; ENSBTAG00000033333 .
    GeneIDi 615171.
    785111.
    KEGGi bta:615171.
    bta:785111.

    Organism-specific databases

    CTDi 8558.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00740000114964.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q2TBL8.
    KOi K02449.
    OMAi PYNNLKN.
    OrthoDBi EOG74BJS4.
    TreeFami TF101026.

    Miscellaneous databases

    NextBioi 20899483.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiCDK10_BOVIN
    AccessioniPrimary (citable) accession number: Q2TBL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3