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Protein

Cyclin-dependent kinase 10

Gene

CDK10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66ATPPROSITE-ProRule annotation1
Active sitei161Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 51ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 10 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 10
Gene namesi
Name:CDK10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:27116 CDK10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002610321 – 361Cyclin-dependent kinase 10Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2TBL8
PRIDEiQ2TBL8

Expressioni

Gene expression databases

BgeeiENSBTAG00000033333

Interactioni

Subunit structurei

Heterodimer with CCNQ, the interaction is required for kinase activity. Interacts with ETS2. Interacts with PRK2.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000044609

Structurei

3D structure databases

ProteinModelPortaliQ2TBL8
SMRiQ2TBL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 321Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0663 Eukaryota
ENOG410XQ50 LUCA
GeneTreeiENSGT00910000144030
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ2TBL8
KOiK02449
OMAiMTDKGCI
OrthoDBiEOG091G048P
TreeFamiTF101026

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q2TBL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEPEPEQIR LKCVRKEGFF TVPPEHRLGR CRSVKEFEKL NRIGEGTYGI
60 70 80 90 100
VYRARDTHTD EIVALKKVRM DKEKDGVPIS SLREITLLLR LRHPNIVELK
110 120 130 140 150
EVVVGNHLES IFLVMGYCEQ DLASLLENMP TPFSEAQVKC IVLQVLRGLQ
160 170 180 190 200
YLHRNFIIHR DLKVSNLLMT DKGCVKTADF GLARAYGIPV KPMTPKVVTL
210 220 230 240 250
WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT SEIHQVDLIV
260 270 280 290 300
QLLGTPSENI WPGFSQLPLA SQYSLRKQPY NNLKHKFPWL SEAGLRLMNL
310 320 330 340 350
LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRATPATSL
360
GTESQSRRGR P
Length:361
Mass (Da):41,047
Last modified:January 24, 2006 - v1
Checksum:i166CEE224496DEE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109954 mRNA Translation: AAI09955.1
RefSeqiNP_001033666.1, NM_001038577.2
UniGeneiBt.7907

Genome annotation databases

EnsembliENSBTAT00000047400; ENSBTAP00000044609; ENSBTAG00000033333
GeneIDi615171
KEGGibta:615171

Entry informationi

Entry nameiCDK10_BOVIN
AccessioniPrimary (citable) accession number: Q2TBL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 24, 2006
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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