Reviewed, UniProtKB/Swiss-Prot Q2TBL8 (CDK10_BOVIN)

Names and origin

Protein names

Recommended name:
    Cell division protein kinase 10
    EC=2.7.11.22

Gene names

Name:

CDK10

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Cell division protein kinase 10		PRO_0000261032
Regions
	Domain	37 – 321	285	Protein kinase
	Nucleotide binding	43 – 51	9	ATP By similarity
Sites
	Active site	161	1	Proton acceptor By similarity
	Binding site	66	1	ATP By similarity
Amino acid modifications
	Modified residue	194	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2TBL8-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 166CEE224496DEE8	FASTA	361	41,047
	10 20 30 40 50 60 MGEPEPEQIR LKCVRKEGFF TVPPEHRLGR CRSVKEFEKL NRIGEGTYGI VYRARDTHTD 70 80 90 100 110 120 EIVALKKVRM DKEKDGVPIS SLREITLLLR LRHPNIVELK EVVVGNHLES IFLVMGYCEQ 130 140 150 160 170 180 DLASLLENMP TPFSEAQVKC IVLQVLRGLQ YLHRNFIIHR DLKVSNLLMT DKGCVKTADF 190 200 210 220 230 240 GLARAYGIPV KPMTPKVVTL WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT 250 260 270 280 290 300 SEIHQVDLIV QLLGTPSENI WPGFSQLPLA SQYSLRKQPY NNLKHKFPWL SEAGLRLMNL 310 320 330 340 350 360 LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRATPATSL GTESQSRRGR P

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC109954 mRNA. Translation: AAI09955.1.
IPI	IPI00716066.
RefSeq	NP_001033666.1. XP_001251816.1.
UniGene	Bt.7907 Bt.88216
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2TBL8.
Genome annotation databases
Ensembl	ENSBTAT00000016228; ENSBTAP00000016228; ENSBTAG00000012233; Bos taurus. [Genome view] ENSBTAT00000047400; ENSBTAP00000044609; ENSBTAG00000033333; Bos taurus. [Genome view]
GeneID	615171. 785111.
KEGG	bta:615171. bta:785111.
Organism-specific databases
CTD	615171.
Phylogenomic databases
HOVERGEN	Q2TBL8.
Enzyme and pathway databases
BRENDA	2.7.11.22. 251.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDK10_BOVIN

Accession

Primary (citable) accession number: Q2TBL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	January 24, 2006
Last modified:	September 1, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)