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Q2TBL8 (CDK10_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 10

EC=2.7.11.22
Alternative name(s):
Cell division protein kinase 10
Gene names
Name:CDK10
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Cyclin-dependent kinase 10
PRO_0000261032

Regions

Domain37 – 321285Protein kinase
Nucleotide binding43 – 519ATP By similarity

Sites

Active site1611Proton acceptor By similarity
Binding site661ATP By similarity

Amino acid modifications

Modified residue1941Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2TBL8 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 166CEE224496DEE8

FASTA36141,047
        10         20         30         40         50         60 
MGEPEPEQIR LKCVRKEGFF TVPPEHRLGR CRSVKEFEKL NRIGEGTYGI VYRARDTHTD 

        70         80         90        100        110        120 
EIVALKKVRM DKEKDGVPIS SLREITLLLR LRHPNIVELK EVVVGNHLES IFLVMGYCEQ 

       130        140        150        160        170        180 
DLASLLENMP TPFSEAQVKC IVLQVLRGLQ YLHRNFIIHR DLKVSNLLMT DKGCVKTADF 

       190        200        210        220        230        240 
GLARAYGIPV KPMTPKVVTL WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT 

       250        260        270        280        290        300 
SEIHQVDLIV QLLGTPSENI WPGFSQLPLA SQYSLRKQPY NNLKHKFPWL SEAGLRLMNL 

       310        320        330        340        350        360 
LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRATPATSL GTESQSRRGR 


P 

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC109954 mRNA. Translation: AAI09955.1.
RefSeqNP_001033666.1. NM_001038577.2.
XP_001251816.1. XM_001251815.4.
UniGeneBt.7907.

3D structure databases

ProteinModelPortalQ2TBL8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000044609.

Proteomic databases

PRIDEQ2TBL8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000047400; ENSBTAP00000044609; ENSBTAG00000033333.
GeneID615171.
785111.
KEGGbta:615171.
bta:785111.

Organism-specific databases

CTD8558.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00740000114964.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidQ2TBL8.
KOK02449.
OMACLQSSYF.
OrthoDBEOG74BJS4.
TreeFamTF101026.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20899483.

Entry information

Entry nameCDK10_BOVIN
AccessionPrimary (citable) accession number: Q2TBL8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 24, 2006
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families