Reviewed, UniProtKB/Swiss-Prot Q2TBL6 (TALDO_BOVIN)

Names and origin

Protein names

Recommended name:
    Transaldolase
    EC=2.2.1.2

Gene names

Name:

TALDO1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway By similarity.
Catalytic activity	Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the transaldolase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pentose shunt
Cellular component	Cytoplasm
Molecular function	Transferase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transaldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Transaldolase		PRO_0000246173
Sites
	Active site	142	1	By similarity
Amino acid modifications
	Modified residue	4	1	Phosphoserine By similarity
	Modified residue	219	1	N6-acetyllysine By similarity
	Modified residue	237	1	Phosphoserine By similarity
	Modified residue	269	1	N6-acetyllysine By similarity
	Modified residue	286	1	N6-acetyllysine By similarity
	Modified residue	321	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2TBL6-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 5CE56272B7706242	FASTA	337	37,685
	10 20 30 40 50 60 MSGSPVKRQR MENALDQLKQ FTTVVADTGD FHAIDEYKPQ DATTNPSLIL AAAQMPTYQE 70 80 90 100 110 120 LVEEAIAYGR KLGGSQEEQI TNAIDKLFVL FGAEILKKIP GRVSTEVDAR LSFDKDAMVA 130 140 150 160 170 180 RARRLIELYK EAGISKERIL IKLSSTWEGI QAGKELEEHH GIRCNMTLLF SFAQAVACAE 190 200 210 220 230 240 AGVTLISPFV GRILDWHVAN TDKKSYETQE DPGVKSVTKI YNYYKKFGYK TIVMGASFRN 250 260 270 280 290 300 TGEIKALAGC DFLTISPQLL GELLKDHSKL TPVLSAKAAQ ASDLEKIQLD EKAFRWLHNE 310 320 330 DRMAVEKLSD GIRRFAADAV KLERMLRERM FSAENGK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC109965 mRNA. Translation: AAI09966.1.
IPI	IPI00711241.
RefSeq	NP_001030360.2.
UniGene	Bt.7283
3D structure databases
SMR	Q2TBL6. Positions 11-332.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2TBL6.
Genome annotation databases
Ensembl	ENSBTAT00000013650; ENSBTAP00000013650; ENSBTAG00000010336; Bos taurus. [Genome view]
GeneID	513453.
KEGG	bta:513453.
Organism-specific databases
CTD	513453.
Phylogenomic databases
HOVERGEN	Q2TBL6.
Enzyme and pathway databases
BRENDA	2.2.1.2. 251.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001585. Transaldolase. IPR004730. Transaldolase_AB. IPR018225. Transaldolase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10683. Transaldolase. 1 hit. PTHR10683:SF3. Transaldolase_AB. 1 hit.
Pfam	PF00923. Transaldolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00874. talAB. 1 hit.
PROSITE	PS01054. TRANSALDOLASE_1. 1 hit. PS00958. TRANSALDOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TALDO_BOVIN

Accession

Primary (citable) accession number: Q2TBL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	January 24, 2006
Last modified:	October 13, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)