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Protein

Heat shock protein 75 kDa, mitochondrial

Gene

TRAP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181ATPBy similarity
Binding sitei157 – 1571ATPBy similarity
Binding sitei170 – 1701ATPBy similarity
Binding sitei204 – 2041ATP; via amide nitrogenBy similarity
Binding sitei401 – 4011ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 75 kDa, mitochondrial
Short name:
HSP 75
Alternative name(s):
TNFR-associated protein 1
Tumor necrosis factor type 1 receptor-associated protein
Short name:
TRAP-1
Gene namesi
Name:TRAP1
Synonyms:HSP75
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5656MitochondrionBy similarityAdd
BLAST
Chaini57 – 703647Heat shock protein 75 kDa, mitochondrialPRO_0000245028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei169 – 1691PhosphoserineBy similarity
Modified residuei173 – 1731PhosphothreonineBy similarity
Modified residuei423 – 4231N6-acetyllysineBy similarity
Modified residuei430 – 4301N6-acetyllysineBy similarity
Modified residuei465 – 4651N6-acetyllysineBy similarity
Modified residuei493 – 4931PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2TBI4.
PRIDEiQ2TBI4.

Expressioni

Gene expression databases

ExpressionAtlasiQ2TBI4. baseline and differential.

Interactioni

Subunit structurei

Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1 (By similarity). Interacts with SRC (By similarity). Interacts with SDHA (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026786.

Structurei

3D structure databases

ProteinModelPortaliQ2TBI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
COG0326. LUCA.
GeneTreeiENSGT00840000129758.
HOGENOMiHOG000031987.
HOVERGENiHBG103147.
InParanoidiQ2TBI4.
KOiK09488.
OMAiMKPSMFD.
OrthoDBiEOG7C8GGM.
TreeFamiTF315234.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90.
InterProiIPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TBI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARELRMLLL WGRRLRAPAL AAACGGKPVL CPWRPPAQSW GPPRSLASSF
60 70 80 90 100
HVGRPFSSQA AEDQAEAGPL HSVISSLEAV QGSATKHEFQ AETKKLLDIV
110 120 130 140 150
ARSLYSEKEV FIRELISNAS DALEKLRHKL VSEGQALPDM EIHLQTDADR
160 170 180 190 200
GTITIQDTGV GMSREELVSN LGTIARSGSK AFLDALQNQA EAGSKIIGQF
210 220 230 240 250
GVGFYSAFMV ADRVEVYSRS VDAGSLGYRW LSDGSGVFEV AEASGVRTGT
260 270 280 290 300
KIIIHLKADS REFASEARVR DVVTKYSNFV SFPLYLNGRR MNTLQAIWMM
310 320 330 340 350
DPKDVGEGQH EEFYRYVAQA HDRPRYTLHY RTDAPLSIRS IFYVPDAKPS
360 370 380 390 400
MFDVSRELGS SVSLYSRKVL IQTKATNILP TWLRFVRGVV DSEDIPLNLS
410 420 430 440 450
RELLQESALI RKLQGVLQQR LIKFFTDQSK KDAEKYARFF EDYGLFVREG
460 470 480 490 500
IVTTAEQEVK EDIAKLLRYE SSALPAGQLT SLSDYASRMQ AGTRNIYYLC
510 520 530 540 550
APNRHLAEHS PYYEAMKRKN TEVLFCYEQF DELTLLHLRE FDKKKLISVE
560 570 580 590 600
TDIVVDHYKE EKFEDGAPAG DCLSEKETED LMAWMRNALG SRITDVKVTL
610 620 630 640 650
RLDTHPAMIT VLEMGAARHF LRMRQLAKTQ EERAQLLQPT LEINPRHVLI
660 670 680 690 700
KKLSQLRDSE PDLAQLLVDQ IYENAMITAG LIDDPRPMVG RLNQLLVKAL

ERH
Length:703
Mass (Da):79,381
Last modified:January 24, 2006 - v1
Checksum:iB40410E8C77A4C86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110148 mRNA. Translation: AAI10149.1.
RefSeqiNP_001033764.1. NM_001038675.2.
UniGeneiBt.58930.

Genome annotation databases

EnsembliENSBTAT00000026786; ENSBTAP00000026786; ENSBTAG00000020109.
GeneIDi514472.
KEGGibta:514472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110148 mRNA. Translation: AAI10149.1.
RefSeqiNP_001033764.1. NM_001038675.2.
UniGeneiBt.58930.

3D structure databases

ProteinModelPortaliQ2TBI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026786.

Proteomic databases

PaxDbiQ2TBI4.
PRIDEiQ2TBI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026786; ENSBTAP00000026786; ENSBTAG00000020109.
GeneIDi514472.
KEGGibta:514472.

Organism-specific databases

CTDi10131.

Phylogenomic databases

eggNOGiKOG0019. Eukaryota.
COG0326. LUCA.
GeneTreeiENSGT00840000129758.
HOGENOMiHOG000031987.
HOVERGENiHBG103147.
InParanoidiQ2TBI4.
KOiK09488.
OMAiMKPSMFD.
OrthoDBiEOG7C8GGM.
TreeFamiTF315234.

Miscellaneous databases

NextBioi20871354.
PROiQ2TBI4.

Gene expression databases

ExpressionAtlasiQ2TBI4. baseline and differential.

Family and domain databases

Gene3Di3.30.565.10. 1 hit.
HAMAPiMF_00505. HSP90.
InterProiIPR003594. HATPase_C.
IPR001404. Hsp90_fam.
IPR020575. Hsp90_N.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PANTHERiPTHR11528. PTHR11528. 1 hit.
PfamiPF00183. HSP90. 1 hit.
[Graphical view]
PIRSFiPIRSF002583. Hsp90. 1 hit.
PRINTSiPR00775. HEATSHOCK90.
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiTRAP1_BOVIN
AccessioniPrimary (citable) accession number: Q2TBI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 24, 2006
Last modified: May 11, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.