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Protein

Lipopolysaccharide-binding protein

Gene

LBP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity, Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide-binding protein
Short name:
LBP
Gene namesi
Name:LBP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Secreted By similarity
  • Cytoplasmic granule membrane By similarity

  • Note: Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Chaini26 – 481456Lipopolysaccharide-binding proteinPRO_0000239847Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi159 ↔ 198By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence analysis
Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence analysis
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence analysis
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ2TBI0.
PRIDEiQ2TBI0.

Interactioni

Subunit structurei

When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022428.

Structurei

3D structure databases

ProteinModelPortaliQ2TBI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
HOGENOMiHOG000231250.
HOVERGENiHBG002797.
InParanoidiQ2TBI0.
KOiK05399.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR030675. BPI/LBP.
IPR032942. BPI/LBP/Plunc.
IPR030180. LBP.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF66. PTHR10504:SF66. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002417. Lipid_binding_protein. 1 hit.
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TBI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTSTGTLPS LLLGTLLTFT SGALGANPGL VVRITDQGLE YVAQEELLAL
60 70 80 90 100
QSKLHKVTLP DFNGDVRIKH FGSVDYRFHS LNIQSCKLLG SALKLLPNQG
110 120 130 140 150
LHFSISDSFI QVTGDWKVRK RILRLDGSFD VKVKGITISV NLLLDSEPSG
160 170 180 190 200
RPKVAVSSCS SHIRDVEVHI SGDLGWLLNL FHNQIESRFR RVLESKICEI
210 220 230 240 250
IEDSVTSELQ PYLQTLPVTT EIDHLAGLDY SLMGAPQATA QMLDVMFKGE
260 270 280 290 300
IFSRDDRFPV AFLAPVMNLP EEHSRMVYFA ISDYAFNTAS LVYHKAGFLN
310 320 330 340 350
FTITDDVIPP DSSIRQNTKS FRAFVPRIAR LYPNTNLELQ GAVISAPCLN
360 370 380 390 400
FSPGNLSTAA QMEIEAFVLL PNSVKEPVFR LSVATNVSAM LTFNTSKITG
410 420 430 440 450
FLEPGKIQVE LKESKVGRFN VELLEALLNY YLLNNFYPKV NDKLAEGFPL
460 470 480
PLLRKIQLYD PILQIHKDFL FLGTNVRYLR V
Length:481
Mass (Da):53,698
Last modified:January 24, 2006 - v1
Checksum:iB6FD8C2C2D4FD014
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110172 mRNA. Translation: AAI10173.1.
RefSeqiNP_001033763.1. NM_001038674.2.
UniGeneiBt.24181.

Genome annotation databases

GeneIDi512242.
KEGGibta:512242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110172 mRNA. Translation: AAI10173.1.
RefSeqiNP_001033763.1. NM_001038674.2.
UniGeneiBt.24181.

3D structure databases

ProteinModelPortaliQ2TBI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022428.

Proteomic databases

PaxDbiQ2TBI0.
PRIDEiQ2TBI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi512242.
KEGGibta:512242.

Organism-specific databases

CTDi3929.

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
HOGENOMiHOG000231250.
HOVERGENiHBG002797.
InParanoidiQ2TBI0.
KOiK05399.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR030675. BPI/LBP.
IPR032942. BPI/LBP/Plunc.
IPR030180. LBP.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF66. PTHR10504:SF66. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002417. Lipid_binding_protein. 1 hit.
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiLBP_BOVIN
AccessioniPrimary (citable) accession number: Q2TBI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 24, 2006
Last modified: June 8, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.