Q2TBF2 (WSCD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WSC domain-containing protein 2

Gene names

Name:	WSCD2
Synonyms:	KIAA0789

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	565 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the WSCD family. Contains 2 WSC domains.
Sequence caution	The sequence AAH37969.2 differs from that shown. Reason: Contaminating sequence. The N-terminus may be contaminated with vector sequence. The sequence BAA34509.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q2TBF2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q2TBF2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     448-448: K → KGAVPGSLQILFRSICTASVG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 565	565	WSC domain-containing protein 2		PRO_0000305065
Regions
	Transmembrane	19 – 41	23	Helical; Potential
	Domain	127 – 219	93	WSC 1
	Domain	230 – 324	95	WSC 2
Amino acid modifications
	Glycosylation	189	1	N-linked (GlcNAc...) Potential
	Glycosylation	242	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	448	1	K → KGAVPGSLQILFRSICTASV G in isoform 2.		VSP_028211
	Natural variant	266	1	T → I. Ref.4 Corresponds to variant rs3764002 [ dbSNP | Ensembl ].		VAR_035161

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 2, 2007. Version 2. Checksum: C47F8EBE88734709	FASTA	565	63,817
	10 20 30 40 50 60 MAKLWFKFQR YFRRKPVRFF TFLALYLTAG SLVFLHSGFV GQPAVSGNQA NPAAAGGPAE 70 80 90 100 110 120 GAELSFLGDM HLGRGFRDTG EASSIARRYG PWFKGKDGNE RAKLGDYGGA WSRALKGRVV 130 140 150 160 170 180 REKEEERAKY IGCYLDDTQS RALRGVSFFD YKKMTIFRCQ DNCAERGYLY GGLEFGAECY 190 200 210 220 230 240 CGHKIQATNV SEAECDMECK GERGSVCGGA NRLSVYRLQL AQESARRYGS AVFRGCFRRP 250 260 270 280 290 300 DNLSLALPVT AAMLNMSVDK CVDFCTEKEY PLAALAGTAC HCGFPTTRFP LHDREDEQLC 310 320 330 340 350 360 AQKCSAEEFE SCGTPSYFIV YQTQVQDNRC MDRRFLPGKS KQLIALASFP GAGNTWARHL 370 380 390 400 410 420 IELATGFYTG SYYFDGSLYN KGFKGERDHW RSGRTICIKT HESGQKEIEA FDAAILLIRN 430 440 450 460 470 480 PYKALMAEFN RKYGGHIGFA AHAHWKGKEW PEFVRNYAPW WATHTLDWLK FGKKVLVVHF 490 500 510 520 530 540 EDLKQDLFVQ LGRMVSLLGV AVREDRLLCV ESQKDGNFKR SGLRKLEYDP YTADMQKTIS 550 560 AYIKMVDAAL KGRNLTGVPD DYYPR
	Isoform 2 [UniParc]. Checksum: 69099C7E01D5816F	FASTA	585	65,775
	10 20 30 40 50 60 MAKLWFKFQR YFRRKPVRFF TFLALYLTAG SLVFLHSGFV GQPAVSGNQA NPAAAGGPAE 70 80 90 100 110 120 GAELSFLGDM HLGRGFRDTG EASSIARRYG PWFKGKDGNE RAKLGDYGGA WSRALKGRVV 130 140 150 160 170 180 REKEEERAKY IGCYLDDTQS RALRGVSFFD YKKMTIFRCQ DNCAERGYLY GGLEFGAECY 190 200 210 220 230 240 CGHKIQATNV SEAECDMECK GERGSVCGGA NRLSVYRLQL AQESARRYGS AVFRGCFRRP 250 260 270 280 290 300 DNLSLALPVT AAMLNMSVDK CVDFCTEKEY PLAALAGTAC HCGFPTTRFP LHDREDEQLC 310 320 330 340 350 360 AQKCSAEEFE SCGTPSYFIV YQTQVQDNRC MDRRFLPGKS KQLIALASFP GAGNTWARHL 370 380 390 400 410 420 IELATGFYTG SYYFDGSLYN KGFKGERDHW RSGRTICIKT HESGQKEIEA FDAAILLIRN 430 440 450 460 470 480 PYKALMAEFN RKYGGHIGFA AHAHWKGKGA VPGSLQILFR SICTASVGEW PEFVRNYAPW 490 500 510 520 530 540 WATHTLDWLK FGKKVLVVHF EDLKQDLFVQ LGRMVSLLGV AVREDRLLCV ESQKDGNFKR 550 560 570 580 SGLRKLEYDP YTADMQKTIS AYIKMVDAAL KGRNLTGVPD DYYPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 261-565 (ISOFORM 2), VARIANT ILE-266. Tissue: Brain, Testis and Urinary bladder.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB018332 mRNA. Translation: BAA34509.2. Different initiation. CH471054 Genomic DNA. Translation: EAW97809.1. BC037969 mRNA. Translation: AAH37969.2. Sequence problems. BC110330 mRNA. Translation: AAI10331.1. BC136687 mRNA. Translation: AAI36688.1. BC136688 mRNA. Translation: AAI36689.1.
IPI	IPI00005652. IPI00217627.
RefSeq	NP_055468.2. NM_014653.2.
UniGene	Hs.143591.
3D structure databases
ProteinModelPortal	Q2TBF2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000331933.
PTM databases
PhosphoSite	Q2TBF2.
Polymorphism databases
DMDM	158706498.
Proteomic databases
PaxDb	Q2TBF2.
PRIDE	Q2TBF2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261400; ENSP00000261400; ENSG00000075035. ENST00000332082; ENSP00000331933; ENSG00000075035. ENST00000547525; ENSP00000448047; ENSG00000075035. ENST00000549903; ENSP00000447272; ENSG00000075035.
GeneID	9671.
KEGG	hsa:9671.
UCSC	uc001tms.3. human. uc001tmu.3. human.
Organism-specific databases
CTD	9671.
GeneCards	GC12P108523.
H-InvDB	HIX0010963.
HGNC	HGNC:29117. WSCD2.
HPA	HPA013346.
neXtProt	NX_Q2TBF2.
PharmGKB	PA162409276.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG288908.
HOGENOM	HOG000060082.
HOVERGEN	HBG102242.
InParanoid	Q2TBF2.
OMA	KNYAPWW.
Gene expression databases
ArrayExpress	Q2TBF2.
Bgee	Q2TBF2.
CleanEx	HS_WSCD2.
Genevestigator	Q2TBF2.
Family and domain databases
InterPro	IPR002889. WSC_carb-bd. IPR013994. WSC_carb-bd_subgr. [Graphical view]
Pfam	PF01822. WSC. 2 hits. [Graphical view]
SMART	SM00321. WSC. 2 hits. [Graphical view]
PROSITE	PS51212. WSC. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9671.
NextBio	36315.

Entry information

Entry name

WSCD2_HUMAN

Accession

Primary (citable) accession number: Q2TBF2
Secondary accession number(s): B2RN48, Q8IY35, Q9Y4B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	April 3, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.