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Protein

WSC domain-containing protein 2

Gene

WSCD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
WSC domain-containing protein 2
Gene namesi
Name:WSCD2
Synonyms:KIAA0789
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29117. WSCD2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 41HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9671.
OpenTargetsiENSG00000075035.
PharmGKBiPA162409276.

Polymorphism and mutation databases

BioMutaiWSCD2.
DMDMi158706498.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050651 – 565WSC domain-containing protein 2Add BLAST565

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2TBF2.
PeptideAtlasiQ2TBF2.
PRIDEiQ2TBF2.

PTM databases

iPTMnetiQ2TBF2.
PhosphoSitePlusiQ2TBF2.

Expressioni

Gene expression databases

BgeeiENSG00000075035.
CleanExiHS_WSCD2.
ExpressionAtlasiQ2TBF2. baseline and differential.
GenevisibleiQ2TBF2. HS.

Organism-specific databases

HPAiHPA013346.
HPA048133.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331933.

Structurei

3D structure databases

ProteinModelPortaliQ2TBF2.
SMRiQ2TBF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 219WSC 1PROSITE-ProRule annotationAdd BLAST93
Domaini230 – 324WSC 2PROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Belongs to the WSCD family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4157. Eukaryota.
ENOG4111FP9. LUCA.
GeneTreeiENSGT00390000012250.
HOGENOMiHOG000060082.
HOVERGENiHBG102242.
InParanoidiQ2TBF2.
OMAiQDNCAER.
OrthoDBiEOG091G03QE.
PhylomeDBiQ2TBF2.
TreeFamiTF324060.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR002889. WSC_carb-bd.
PfamiView protein in Pfam
PF01822. WSC. 2 hits.
SMARTiView protein in SMART
SM00321. WSC. 2 hits.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51212. WSC. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2TBF2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKLWFKFQR YFRRKPVRFF TFLALYLTAG SLVFLHSGFV GQPAVSGNQA
60 70 80 90 100
NPAAAGGPAE GAELSFLGDM HLGRGFRDTG EASSIARRYG PWFKGKDGNE
110 120 130 140 150
RAKLGDYGGA WSRALKGRVV REKEEERAKY IGCYLDDTQS RALRGVSFFD
160 170 180 190 200
YKKMTIFRCQ DNCAERGYLY GGLEFGAECY CGHKIQATNV SEAECDMECK
210 220 230 240 250
GERGSVCGGA NRLSVYRLQL AQESARRYGS AVFRGCFRRP DNLSLALPVT
260 270 280 290 300
AAMLNMSVDK CVDFCTEKEY PLAALAGTAC HCGFPTTRFP LHDREDEQLC
310 320 330 340 350
AQKCSAEEFE SCGTPSYFIV YQTQVQDNRC MDRRFLPGKS KQLIALASFP
360 370 380 390 400
GAGNTWARHL IELATGFYTG SYYFDGSLYN KGFKGERDHW RSGRTICIKT
410 420 430 440 450
HESGQKEIEA FDAAILLIRN PYKALMAEFN RKYGGHIGFA AHAHWKGKEW
460 470 480 490 500
PEFVRNYAPW WATHTLDWLK FGKKVLVVHF EDLKQDLFVQ LGRMVSLLGV
510 520 530 540 550
AVREDRLLCV ESQKDGNFKR SGLRKLEYDP YTADMQKTIS AYIKMVDAAL
560
KGRNLTGVPD DYYPR
Length:565
Mass (Da):63,817
Last modified:October 2, 2007 - v2
Checksum:iC47F8EBE88734709
GO
Isoform 2 (identifier: Q2TBF2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     448-448: K → KGAVPGSLQILFRSICTASVG

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):65,775
Checksum:i69099C7E01D5816F
GO

Sequence cautioni

The sequence AAH37969 differs from that shown. Contaminating sequence. The N-terminus may be contaminated with vector sequence.Curated
The sequence BAA34509 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti325V → D in BAG57182 (PubMed:14702039).Curated1
Sequence conflicti367F → S in BAG57182 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035161266T → I1 PublicationCorresponds to variant dbSNP:rs3764002Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028211448K → KGAVPGSLQILFRSICTASV G in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018332 mRNA. Translation: BAA34509.2. Different initiation.
AK293764 mRNA. Translation: BAG57182.1.
CH471054 Genomic DNA. Translation: EAW97809.1.
BC037969 mRNA. Translation: AAH37969.2. Sequence problems.
BC110330 mRNA. Translation: AAI10331.1.
BC136687 mRNA. Translation: AAI36688.1.
BC136688 mRNA. Translation: AAI36689.1.
CCDSiCCDS41828.1. [Q2TBF2-1]
RefSeqiNP_001291376.1. NM_001304447.1. [Q2TBF2-1]
NP_055468.2. NM_014653.3. [Q2TBF2-1]
XP_016875732.1. XM_017020243.1. [Q2TBF2-1]
XP_016875733.1. XM_017020244.1. [Q2TBF2-1]
XP_016875734.1. XM_017020245.1. [Q2TBF2-1]
XP_016875735.1. XM_017020246.1. [Q2TBF2-1]
XP_016875736.1. XM_017020247.1. [Q2TBF2-1]
XP_016875737.1. XM_017020248.1. [Q2TBF2-1]
UniGeneiHs.143591.

Genome annotation databases

EnsembliENST00000332082; ENSP00000331933; ENSG00000075035. [Q2TBF2-1]
ENST00000547525; ENSP00000448047; ENSG00000075035. [Q2TBF2-1]
ENST00000549903; ENSP00000447272; ENSG00000075035. [Q2TBF2-2]
GeneIDi9671.
KEGGihsa:9671.
UCSCiuc001tms.4. human. [Q2TBF2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiWSCD2_HUMAN
AccessioniPrimary (citable) accession number: Q2TBF2
Secondary accession number(s): B2RN48
, B4DES1, Q8IY35, Q9Y4B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 7, 2017
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families