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Q2TBF2

- WSCD2_HUMAN

UniProt

Q2TBF2 - WSCD2_HUMAN

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Protein

WSC domain-containing protein 2

Gene

WSCD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
WSC domain-containing protein 2
Gene namesi
Name:WSCD2
Synonyms:KIAA0789
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:29117. WSCD2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565WSC domain-containing protein 2PRO_0000305065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2TBF2.
PRIDEiQ2TBF2.

PTM databases

PhosphoSiteiQ2TBF2.

Expressioni

Gene expression databases

BgeeiQ2TBF2.
CleanExiHS_WSCD2.
ExpressionAtlasiQ2TBF2. baseline and differential.
GenevestigatoriQ2TBF2.

Organism-specific databases

HPAiHPA013346.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331933.

Structurei

3D structure databases

ProteinModelPortaliQ2TBF2.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 4123HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini127 – 21993WSC 1PROSITE-ProRule annotationAdd
BLAST
Domaini230 – 32495WSC 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the WSCD family.Curated
Contains 2 WSC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288908.
GeneTreeiENSGT00390000012250.
HOGENOMiHOG000060082.
HOVERGENiHBG102242.
InParanoidiQ2TBF2.
OMAiYKKMTIF.
OrthoDBiEOG7QZG95.
PhylomeDBiQ2TBF2.
TreeFamiTF324060.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002889. WSC_carb-bd.
IPR013994. WSC_carb-bd_subgr.
[Graphical view]
PfamiPF01822. WSC. 2 hits.
[Graphical view]
SMARTiSM00321. WSC. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51212. WSC. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2TBF2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKLWFKFQR YFRRKPVRFF TFLALYLTAG SLVFLHSGFV GQPAVSGNQA
60 70 80 90 100
NPAAAGGPAE GAELSFLGDM HLGRGFRDTG EASSIARRYG PWFKGKDGNE
110 120 130 140 150
RAKLGDYGGA WSRALKGRVV REKEEERAKY IGCYLDDTQS RALRGVSFFD
160 170 180 190 200
YKKMTIFRCQ DNCAERGYLY GGLEFGAECY CGHKIQATNV SEAECDMECK
210 220 230 240 250
GERGSVCGGA NRLSVYRLQL AQESARRYGS AVFRGCFRRP DNLSLALPVT
260 270 280 290 300
AAMLNMSVDK CVDFCTEKEY PLAALAGTAC HCGFPTTRFP LHDREDEQLC
310 320 330 340 350
AQKCSAEEFE SCGTPSYFIV YQTQVQDNRC MDRRFLPGKS KQLIALASFP
360 370 380 390 400
GAGNTWARHL IELATGFYTG SYYFDGSLYN KGFKGERDHW RSGRTICIKT
410 420 430 440 450
HESGQKEIEA FDAAILLIRN PYKALMAEFN RKYGGHIGFA AHAHWKGKEW
460 470 480 490 500
PEFVRNYAPW WATHTLDWLK FGKKVLVVHF EDLKQDLFVQ LGRMVSLLGV
510 520 530 540 550
AVREDRLLCV ESQKDGNFKR SGLRKLEYDP YTADMQKTIS AYIKMVDAAL
560
KGRNLTGVPD DYYPR
Length:565
Mass (Da):63,817
Last modified:October 2, 2007 - v2
Checksum:iC47F8EBE88734709
GO
Isoform 2 (identifier: Q2TBF2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     448-448: K → KGAVPGSLQILFRSICTASVG

Note: No experimental confirmation available.

Show »
Length:585
Mass (Da):65,775
Checksum:i69099C7E01D5816F
GO

Sequence cautioni

The sequence AAH37969.2 differs from that shown. Reason: Contaminating sequence. The N-terminus may be contaminated with vector sequence.
The sequence BAA34509.2 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti325 – 3251V → D in BAG57182. (PubMed:14702039)Curated
Sequence conflicti367 – 3671F → S in BAG57182. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti266 – 2661T → I.1 Publication
Corresponds to variant rs3764002 [ dbSNP | Ensembl ].
VAR_035161

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei448 – 4481K → KGAVPGSLQILFRSICTASV G in isoform 2. 1 PublicationVSP_028211

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018332 mRNA. Translation: BAA34509.2. Different initiation.
AK293764 mRNA. Translation: BAG57182.1.
CH471054 Genomic DNA. Translation: EAW97809.1.
BC037969 mRNA. Translation: AAH37969.2. Sequence problems.
BC110330 mRNA. Translation: AAI10331.1.
BC136687 mRNA. Translation: AAI36688.1.
BC136688 mRNA. Translation: AAI36689.1.
CCDSiCCDS41828.1. [Q2TBF2-1]
RefSeqiNP_055468.2. NM_014653.2. [Q2TBF2-1]
XP_006719765.1. XM_006719702.1. [Q2TBF2-1]
UniGeneiHs.143591.

Genome annotation databases

EnsembliENST00000332082; ENSP00000331933; ENSG00000075035. [Q2TBF2-1]
ENST00000547525; ENSP00000448047; ENSG00000075035. [Q2TBF2-1]
ENST00000549903; ENSP00000447272; ENSG00000075035. [Q2TBF2-2]
GeneIDi9671.
KEGGihsa:9671.
UCSCiuc001tms.3. human. [Q2TBF2-1]
uc001tmu.3. human. [Q2TBF2-2]

Polymorphism databases

DMDMi158706498.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018332 mRNA. Translation: BAA34509.2 . Different initiation.
AK293764 mRNA. Translation: BAG57182.1 .
CH471054 Genomic DNA. Translation: EAW97809.1 .
BC037969 mRNA. Translation: AAH37969.2 . Sequence problems.
BC110330 mRNA. Translation: AAI10331.1 .
BC136687 mRNA. Translation: AAI36688.1 .
BC136688 mRNA. Translation: AAI36689.1 .
CCDSi CCDS41828.1. [Q2TBF2-1 ]
RefSeqi NP_055468.2. NM_014653.2. [Q2TBF2-1 ]
XP_006719765.1. XM_006719702.1. [Q2TBF2-1 ]
UniGenei Hs.143591.

3D structure databases

ProteinModelPortali Q2TBF2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000331933.

PTM databases

PhosphoSitei Q2TBF2.

Polymorphism databases

DMDMi 158706498.

Proteomic databases

PaxDbi Q2TBF2.
PRIDEi Q2TBF2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332082 ; ENSP00000331933 ; ENSG00000075035 . [Q2TBF2-1 ]
ENST00000547525 ; ENSP00000448047 ; ENSG00000075035 . [Q2TBF2-1 ]
ENST00000549903 ; ENSP00000447272 ; ENSG00000075035 . [Q2TBF2-2 ]
GeneIDi 9671.
KEGGi hsa:9671.
UCSCi uc001tms.3. human. [Q2TBF2-1 ]
uc001tmu.3. human. [Q2TBF2-2 ]

Organism-specific databases

CTDi 9671.
GeneCardsi GC12P108523.
H-InvDB HIX0010963.
HGNCi HGNC:29117. WSCD2.
HPAi HPA013346.
neXtProti NX_Q2TBF2.
PharmGKBi PA162409276.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288908.
GeneTreei ENSGT00390000012250.
HOGENOMi HOG000060082.
HOVERGENi HBG102242.
InParanoidi Q2TBF2.
OMAi YKKMTIF.
OrthoDBi EOG7QZG95.
PhylomeDBi Q2TBF2.
TreeFami TF324060.

Miscellaneous databases

GenomeRNAii 9671.
NextBioi 35471299.
PROi Q2TBF2.

Gene expression databases

Bgeei Q2TBF2.
CleanExi HS_WSCD2.
ExpressionAtlasi Q2TBF2. baseline and differential.
Genevestigatori Q2TBF2.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR002889. WSC_carb-bd.
IPR013994. WSC_carb-bd_subgr.
[Graphical view ]
Pfami PF01822. WSC. 2 hits.
[Graphical view ]
SMARTi SM00321. WSC. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS51212. WSC. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 261-565 (ISOFORM 2), VARIANT ILE-266.
    Tissue: Brain, Testis and Urinary bladder.

Entry informationi

Entry nameiWSCD2_HUMAN
AccessioniPrimary (citable) accession number: Q2TBF2
Secondary accession number(s): B2RN48
, B4DES1, Q8IY35, Q9Y4B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3