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Q2TBF2

- WSCD2_HUMAN

UniProt

Q2TBF2 - WSCD2_HUMAN

Protein

WSC domain-containing protein 2

Gene

WSCD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WSC domain-containing protein 2
    Gene namesi
    Name:WSCD2
    Synonyms:KIAA0789
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:29117. WSCD2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162409276.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 565565WSC domain-containing protein 2PRO_0000305065Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ2TBF2.
    PRIDEiQ2TBF2.

    PTM databases

    PhosphoSiteiQ2TBF2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ2TBF2.
    BgeeiQ2TBF2.
    CleanExiHS_WSCD2.
    GenevestigatoriQ2TBF2.

    Organism-specific databases

    HPAiHPA013346.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000331933.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2TBF2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 4123HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini127 – 21993WSC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini230 – 32495WSC 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the WSCD family.Curated
    Contains 2 WSC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG288908.
    HOGENOMiHOG000060082.
    HOVERGENiHBG102242.
    InParanoidiQ2TBF2.
    OMAiYKKMTIF.
    OrthoDBiEOG7QZG95.
    PhylomeDBiQ2TBF2.
    TreeFamiTF324060.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR002889. WSC_carb-bd.
    IPR013994. WSC_carb-bd_subgr.
    [Graphical view]
    PfamiPF01822. WSC. 2 hits.
    [Graphical view]
    SMARTiSM00321. WSC. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51212. WSC. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q2TBF2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKLWFKFQR YFRRKPVRFF TFLALYLTAG SLVFLHSGFV GQPAVSGNQA    50
    NPAAAGGPAE GAELSFLGDM HLGRGFRDTG EASSIARRYG PWFKGKDGNE 100
    RAKLGDYGGA WSRALKGRVV REKEEERAKY IGCYLDDTQS RALRGVSFFD 150
    YKKMTIFRCQ DNCAERGYLY GGLEFGAECY CGHKIQATNV SEAECDMECK 200
    GERGSVCGGA NRLSVYRLQL AQESARRYGS AVFRGCFRRP DNLSLALPVT 250
    AAMLNMSVDK CVDFCTEKEY PLAALAGTAC HCGFPTTRFP LHDREDEQLC 300
    AQKCSAEEFE SCGTPSYFIV YQTQVQDNRC MDRRFLPGKS KQLIALASFP 350
    GAGNTWARHL IELATGFYTG SYYFDGSLYN KGFKGERDHW RSGRTICIKT 400
    HESGQKEIEA FDAAILLIRN PYKALMAEFN RKYGGHIGFA AHAHWKGKEW 450
    PEFVRNYAPW WATHTLDWLK FGKKVLVVHF EDLKQDLFVQ LGRMVSLLGV 500
    AVREDRLLCV ESQKDGNFKR SGLRKLEYDP YTADMQKTIS AYIKMVDAAL 550
    KGRNLTGVPD DYYPR 565
    Length:565
    Mass (Da):63,817
    Last modified:October 2, 2007 - v2
    Checksum:iC47F8EBE88734709
    GO
    Isoform 2 (identifier: Q2TBF2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         448-448: K → KGAVPGSLQILFRSICTASVG

    Note: No experimental confirmation available.

    Show »
    Length:585
    Mass (Da):65,775
    Checksum:i69099C7E01D5816F
    GO

    Sequence cautioni

    The sequence AAH37969.2 differs from that shown. Reason: Contaminating sequence. The N-terminus may be contaminated with vector sequence.
    The sequence BAA34509.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti325 – 3251V → D in BAG57182. (PubMed:14702039)Curated
    Sequence conflicti367 – 3671F → S in BAG57182. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti266 – 2661T → I.1 Publication
    Corresponds to variant rs3764002 [ dbSNP | Ensembl ].
    VAR_035161

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei448 – 4481K → KGAVPGSLQILFRSICTASV G in isoform 2. 1 PublicationVSP_028211

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018332 mRNA. Translation: BAA34509.2. Different initiation.
    AK293764 mRNA. Translation: BAG57182.1.
    CH471054 Genomic DNA. Translation: EAW97809.1.
    BC037969 mRNA. Translation: AAH37969.2. Sequence problems.
    BC110330 mRNA. Translation: AAI10331.1.
    BC136687 mRNA. Translation: AAI36688.1.
    BC136688 mRNA. Translation: AAI36689.1.
    CCDSiCCDS41828.1. [Q2TBF2-1]
    RefSeqiNP_055468.2. NM_014653.2. [Q2TBF2-1]
    XP_006719765.1. XM_006719702.1. [Q2TBF2-1]
    UniGeneiHs.143591.

    Genome annotation databases

    EnsembliENST00000332082; ENSP00000331933; ENSG00000075035. [Q2TBF2-1]
    ENST00000547525; ENSP00000448047; ENSG00000075035. [Q2TBF2-1]
    ENST00000549903; ENSP00000447272; ENSG00000075035. [Q2TBF2-2]
    GeneIDi9671.
    KEGGihsa:9671.
    UCSCiuc001tms.3. human. [Q2TBF2-1]
    uc001tmu.3. human. [Q2TBF2-2]

    Polymorphism databases

    DMDMi158706498.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018332 mRNA. Translation: BAA34509.2 . Different initiation.
    AK293764 mRNA. Translation: BAG57182.1 .
    CH471054 Genomic DNA. Translation: EAW97809.1 .
    BC037969 mRNA. Translation: AAH37969.2 . Sequence problems.
    BC110330 mRNA. Translation: AAI10331.1 .
    BC136687 mRNA. Translation: AAI36688.1 .
    BC136688 mRNA. Translation: AAI36689.1 .
    CCDSi CCDS41828.1. [Q2TBF2-1 ]
    RefSeqi NP_055468.2. NM_014653.2. [Q2TBF2-1 ]
    XP_006719765.1. XM_006719702.1. [Q2TBF2-1 ]
    UniGenei Hs.143591.

    3D structure databases

    ProteinModelPortali Q2TBF2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000331933.

    PTM databases

    PhosphoSitei Q2TBF2.

    Polymorphism databases

    DMDMi 158706498.

    Proteomic databases

    PaxDbi Q2TBF2.
    PRIDEi Q2TBF2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332082 ; ENSP00000331933 ; ENSG00000075035 . [Q2TBF2-1 ]
    ENST00000547525 ; ENSP00000448047 ; ENSG00000075035 . [Q2TBF2-1 ]
    ENST00000549903 ; ENSP00000447272 ; ENSG00000075035 . [Q2TBF2-2 ]
    GeneIDi 9671.
    KEGGi hsa:9671.
    UCSCi uc001tms.3. human. [Q2TBF2-1 ]
    uc001tmu.3. human. [Q2TBF2-2 ]

    Organism-specific databases

    CTDi 9671.
    GeneCardsi GC12P108523.
    H-InvDB HIX0010963.
    HGNCi HGNC:29117. WSCD2.
    HPAi HPA013346.
    neXtProti NX_Q2TBF2.
    PharmGKBi PA162409276.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288908.
    HOGENOMi HOG000060082.
    HOVERGENi HBG102242.
    InParanoidi Q2TBF2.
    OMAi YKKMTIF.
    OrthoDBi EOG7QZG95.
    PhylomeDBi Q2TBF2.
    TreeFami TF324060.

    Miscellaneous databases

    GenomeRNAii 9671.
    NextBioi 35471299.
    PROi Q2TBF2.

    Gene expression databases

    ArrayExpressi Q2TBF2.
    Bgeei Q2TBF2.
    CleanExi HS_WSCD2.
    Genevestigatori Q2TBF2.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR002889. WSC_carb-bd.
    IPR013994. WSC_carb-bd_subgr.
    [Graphical view ]
    Pfami PF01822. WSC. 2 hits.
    [Graphical view ]
    SMARTi SM00321. WSC. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51212. WSC. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 261-565 (ISOFORM 2), VARIANT ILE-266.
      Tissue: Brain, Testis and Urinary bladder.

    Entry informationi

    Entry nameiWSCD2_HUMAN
    AccessioniPrimary (citable) accession number: Q2TBF2
    Secondary accession number(s): B2RN48
    , B4DES1, Q8IY35, Q9Y4B7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3