Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q2TBF2 (WSCD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WSC domain-containing protein 2
Gene names
Name:WSCD2
Synonyms:KIAA0789
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length565 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the WSCD family.

Contains 2 WSC domains.

Sequence caution

The sequence AAH37969.2 differs from that shown. Reason: Contaminating sequence. The N-terminus may be contaminated with vector sequence.

The sequence BAA34509.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q2TBF2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q2TBF2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     448-448: K → KGAVPGSLQILFRSICTASVG
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 565565WSC domain-containing protein 2
PRO_0000305065

Regions

Transmembrane19 – 4123Helical; Potential
Domain127 – 21993WSC 1
Domain230 – 32495WSC 2

Amino acid modifications

Glycosylation1891N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence4481K → KGAVPGSLQILFRSICTASV G in isoform 2.
VSP_028211
Natural variant2661T → I. Ref.5
Corresponds to variant rs3764002 [ dbSNP | Ensembl ].
VAR_035161

Experimental info

Sequence conflict3251V → D in BAG57182. Ref.3
Sequence conflict3671F → S in BAG57182. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 2, 2007. Version 2.
Checksum: C47F8EBE88734709

FASTA56563,817
        10         20         30         40         50         60 
MAKLWFKFQR YFRRKPVRFF TFLALYLTAG SLVFLHSGFV GQPAVSGNQA NPAAAGGPAE 

        70         80         90        100        110        120 
GAELSFLGDM HLGRGFRDTG EASSIARRYG PWFKGKDGNE RAKLGDYGGA WSRALKGRVV 

       130        140        150        160        170        180 
REKEEERAKY IGCYLDDTQS RALRGVSFFD YKKMTIFRCQ DNCAERGYLY GGLEFGAECY 

       190        200        210        220        230        240 
CGHKIQATNV SEAECDMECK GERGSVCGGA NRLSVYRLQL AQESARRYGS AVFRGCFRRP 

       250        260        270        280        290        300 
DNLSLALPVT AAMLNMSVDK CVDFCTEKEY PLAALAGTAC HCGFPTTRFP LHDREDEQLC 

       310        320        330        340        350        360 
AQKCSAEEFE SCGTPSYFIV YQTQVQDNRC MDRRFLPGKS KQLIALASFP GAGNTWARHL 

       370        380        390        400        410        420 
IELATGFYTG SYYFDGSLYN KGFKGERDHW RSGRTICIKT HESGQKEIEA FDAAILLIRN 

       430        440        450        460        470        480 
PYKALMAEFN RKYGGHIGFA AHAHWKGKEW PEFVRNYAPW WATHTLDWLK FGKKVLVVHF 

       490        500        510        520        530        540 
EDLKQDLFVQ LGRMVSLLGV AVREDRLLCV ESQKDGNFKR SGLRKLEYDP YTADMQKTIS 

       550        560 
AYIKMVDAAL KGRNLTGVPD DYYPR 

« Hide

Isoform 2 [UniParc].

Checksum: 69099C7E01D5816F
Show »

FASTA58565,775

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 261-565 (ISOFORM 2), VARIANT ILE-266.
Tissue: Brain, Testis and Urinary bladder.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB018332 mRNA. Translation: BAA34509.2. Different initiation.
AK293764 mRNA. Translation: BAG57182.1.
CH471054 Genomic DNA. Translation: EAW97809.1.
BC037969 mRNA. Translation: AAH37969.2. Sequence problems.
BC110330 mRNA. Translation: AAI10331.1.
BC136687 mRNA. Translation: AAI36688.1.
BC136688 mRNA. Translation: AAI36689.1.
CCDSCCDS41828.1. [Q2TBF2-1]
RefSeqNP_055468.2. NM_014653.2. [Q2TBF2-1]
XP_006719765.1. XM_006719702.1. [Q2TBF2-1]
UniGeneHs.143591.

3D structure databases

ProteinModelPortalQ2TBF2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000331933.

PTM databases

PhosphoSiteQ2TBF2.

Polymorphism databases

DMDM158706498.

Proteomic databases

PaxDbQ2TBF2.
PRIDEQ2TBF2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261400; ENSP00000261400; ENSG00000075035. [Q2TBF2-2]
ENST00000332082; ENSP00000331933; ENSG00000075035. [Q2TBF2-1]
ENST00000547525; ENSP00000448047; ENSG00000075035. [Q2TBF2-1]
ENST00000549903; ENSP00000447272; ENSG00000075035. [Q2TBF2-2]
GeneID9671.
KEGGhsa:9671.
UCSCuc001tms.3. human. [Q2TBF2-1]
uc001tmu.3. human. [Q2TBF2-2]

Organism-specific databases

CTD9671.
GeneCardsGC12P108523.
H-InvDBHIX0010963.
HGNCHGNC:29117. WSCD2.
HPAHPA013346.
neXtProtNX_Q2TBF2.
PharmGKBPA162409276.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288908.
HOGENOMHOG000060082.
HOVERGENHBG102242.
InParanoidQ2TBF2.
OMAYKKMTIF.
OrthoDBEOG7QZG95.
PhylomeDBQ2TBF2.
TreeFamTF324060.

Gene expression databases

ArrayExpressQ2TBF2.
BgeeQ2TBF2.
CleanExHS_WSCD2.
GenevestigatorQ2TBF2.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR002889. WSC_carb-bd.
IPR013994. WSC_carb-bd_subgr.
[Graphical view]
PfamPF01822. WSC. 2 hits.
[Graphical view]
SMARTSM00321. WSC. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS51212. WSC. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9671.
NextBio36315.
PROQ2TBF2.

Entry information

Entry nameWSCD2_HUMAN
AccessionPrimary (citable) accession number: Q2TBF2
Secondary accession number(s): B2RN48 expand/collapse secondary AC list , B4DES1, Q8IY35, Q9Y4B7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM