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Protein

CWF19-like protein 2

Gene

CWF19L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
CWF19-like protein 2
Gene namesi
Name:CWF19L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26508. CWF19L2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi143884.
OpenTargetsiENSG00000152404.
PharmGKBiPA134914164.

Polymorphism and mutation databases

BioMutaiCWF19L2.
DMDMi300669615.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003156481 – 894CWF19-like protein 2Add BLAST894

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineCombined sources1
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei360PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei479PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Cross-linki604Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ2TBE0.
MaxQBiQ2TBE0.
PaxDbiQ2TBE0.
PeptideAtlasiQ2TBE0.
PRIDEiQ2TBE0.

PTM databases

iPTMnetiQ2TBE0.
PhosphoSitePlusiQ2TBE0.

Expressioni

Gene expression databases

BgeeiENSG00000152404.
CleanExiHS_CWF19L2.
ExpressionAtlasiQ2TBE0. baseline and differential.
GenevisibleiQ2TBE0. HS.

Organism-specific databases

HPAiHPA038166.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi126821. 58 interactors.
IntActiQ2TBE0. 31 interactors.
STRINGi9606.ENSP00000282251.

Structurei

3D structure databases

ProteinModelPortaliQ2TBE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 107Sequence analysisAdd BLAST95
Coiled coili166 – 281Sequence analysisAdd BLAST116
Coiled coili502 – 530Sequence analysisAdd BLAST29
Coiled coili644 – 675Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi77 – 104Lys-richAdd BLAST28
Compositional biasi108 – 115Poly-Ser8

Sequence similaritiesi

Belongs to the CWF19 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2477. Eukaryota.
ENOG410YGTC. LUCA.
GeneTreeiENSGT00530000063414.
HOGENOMiHOG000098306.
HOVERGENiHBG057501.
InParanoidiQ2TBE0.
OMAiEWVEAVP.
OrthoDBiEOG091G085U.
PhylomeDBiQ2TBE0.
TreeFamiTF351271.

Family and domain databases

Gene3Di3.30.428.10. 1 hit.
InterProiView protein in InterPro
IPR006768. Cwf19-like_C_dom-1.
IPR006767. Cwf19-like_C_dom-2.
IPR011146. HIT-like.
PfamiView protein in Pfam
PF04677. CwfJ_C_1. 1 hit.
PF04676. CwfJ_C_2. 1 hit.
SUPFAMiSSF54197. SSF54197. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2TBE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSMAAASG RFESAKSIEE RKEQTRNARA EVLRQAKANF EKEERRKELK
60 70 80 90 100
RLRGEDTWML PDVNERIEQF SQEHSVKKKK KKDKHSKKAK KEKKKKSKKQ
110 120 130 140 150
KYEKNNESSD SSSSSEDEWV EAVPSQTPDK EKAWKVKDEK SGKDDTQIIK
160 170 180 190 200
RDEWMTVDFM SVKTVSSSSL KAEKETMRKI EQEKNQALEQ SKLMERELNP
210 220 230 240 250
YWKDGGTGLP PEDCSVSSIT KVSVVEDGGL SWLRKSYLRM KEQAEKQSRN
260 270 280 290 300
FEDIVAERYG SMEIFQSKLE DAEKAASTKE DYRRERWRKP TYSDKAQNCQ
310 320 330 340 350
ESRESDLVKY GNSSRDRYAT TDTAKNSNNE KFIGDEKDKR PGSLETCRRE
360 370 380 390 400
SNPRQNQEFS FGNLRAKFLR PSDDEELSFH SKGRKFEPLS SSSALVAQGS
410 420 430 440 450
LCSGFRKPTK NSEERLTSWS RSDGRGDKKH SNQKPSETST DEHQHVPEDP
460 470 480 490 500
REKSQDEVLR DDPPKKEHLR DTKSTFAGSP ERESIHILSV DEKNKLGAKI
510 520 530 540 550
IKAEMMGNME LAEQLKVQLE KANKFKETIT QIPKKSGVEN EDQQEVILVR
560 570 580 590 600
TDQSGRVWPV NTPGKSLESQ GGRRKRQMVS THEERERVRY FHDDDNLSLN
610 620 630 640 650
DLVKNEKMGT AENQNKLFMR MASKFMGKTD GDYYTLDDMF VSKAAERERL
660 670 680 690 700
GEEEENQRKK AIAEHRSLAA QMEKCLYCFD SSQFPKHLIV AIGVKVYLCL
710 720 730 740 750
PNVRSLTEGH CLIVPLQHHR AATLLDEDIW EEIQMFRKSL VKMFEDKGLD
760 770 780 790 800
CIFLETNMSM KKQYHMVYEC IPLPKEVGDM APIYFKKAIM ESDEEWSMNK
810 820 830 840 850
KLIDLSSKDI RKSVPRGLPY FSVDFGLHGG FAHVIEDQHK FPHYFGKEII
860 870 880 890
GGMLDIEPRL WRKGIRESFE DQRKKALQFA QWWKPYDFTK SKNY
Length:894
Mass (Da):103,787
Last modified:July 13, 2010 - v4
Checksum:iE40E8289255C57CF
GO
Isoform 2 (identifier: Q2TBE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     735-742: MFRKSLVK → IKSRTVIQ
     743-894: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:742
Mass (Da):85,672
Checksum:iA3D32E757EC93559
GO
Isoform 3 (identifier: Q2TBE0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     625-672: FMGKTDGDYY...AEHRSLAAQM → QLRENVLVKR...LNFPSILLLQ
     673-894: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:672
Mass (Da):77,599
Checksum:iC1B684294BDAE2B9
GO

Sequence cautioni

The sequence AAI10440 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI10441 differs from that shown. Reason: Frameshift at position 754.Curated
The sequence AAI10441 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI10442 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI10443 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI18670 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB71307 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF85690 differs from that shown.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti584E → K in AAI10443 (PubMed:15489334).Curated1
Sequence conflicti626M → G in AAH56241 (PubMed:15489334).Curated1
Sequence conflicti819P → L in BAF85690 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038268210P → T. Corresponds to variant dbSNP:rs608634Ensembl.1
Natural variantiVAR_038269443H → Y1 PublicationCorresponds to variant dbSNP:rs659040Ensembl.1
Natural variantiVAR_038270445H → Q. Corresponds to variant dbSNP:rs35968518Ensembl.1
Natural variantiVAR_038271537G → R. Corresponds to variant dbSNP:rs17106909Ensembl.1
Natural variantiVAR_038272894Y → C1 PublicationCorresponds to variant dbSNP:rs3758911Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030590625 – 672FMGKT…LAAQM → QLRENVLVKRKRTKGKKLLL SIGVLLHKWKNVCIVLTALN FPSILLLQ in isoform 3. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_030591673 – 894Missing in isoform 3. 1 PublicationAdd BLAST222
Alternative sequenceiVSP_030592735 – 742MFRKSLVK → IKSRTVIQ in isoform 2. 1 Publication8
Alternative sequenceiVSP_030593743 – 894Missing in isoform 2. 1 PublicationAdd BLAST152

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000766 Genomic DNA. No translation available.
AP001823 Genomic DNA. No translation available.
AK056905 mRNA. Translation: BAB71307.1. Different initiation.
AK293001 mRNA. Translation: BAF85690.1. Sequence problems.
BC056241 mRNA. Translation: AAH56241.1.
BC110439 mRNA. Translation: AAI10440.1. Different initiation.
BC110440 mRNA. Translation: AAI10441.1. Sequence problems.
BC110441 mRNA. Translation: AAI10442.1. Different initiation.
BC110442 mRNA. Translation: AAI10443.2. Different initiation.
BC118669 mRNA. Translation: AAI18670.1. Different initiation.
CCDSiCCDS8336.2. [Q2TBE0-1]
RefSeqiNP_689647.2. NM_152434.2. [Q2TBE0-1]
UniGeneiHs.212140.

Genome annotation databases

EnsembliENST00000282251; ENSP00000282251; ENSG00000152404. [Q2TBE0-1]
GeneIDi143884.
KEGGihsa:143884.
UCSCiuc010rvp.3. human. [Q2TBE0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiC19L2_HUMAN
AccessioniPrimary (citable) accession number: Q2TBE0
Secondary accession number(s): A4FU66
, A4FU67, A4FU68, A8KAD6, Q6PHW1, Q96MI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 13, 2010
Last modified: August 30, 2017
This is version 101 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families