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Reviewed, UniProtKB/Swiss-Prot Q2TBA3 (MALT1_MOUSE)

Last modified February 9, 2010. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog
    EC=3.4.22.-
Alternative name(s):
    Paracaspase
Gene names
Name: Malt1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length832 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity By similarity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion By similarity. UniProtKB Q9UDY8

Subunit structure

Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6 By similarity. UniProtKB Q9UDY8

Subcellular location

Cytoplasm › perinuclear region By similarity. Nucleus By similarity. Note: Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10 By similarity.

Sequence similarities

Belongs to the peptidase C14B family.

Contains 1 death domain.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

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Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
   DomainImmunoglobulin domain
Repeat
   Molecular functionHydrolase
Protease
   PTMDisulfide bond
Phosphoprotein
Gene Ontology (GO)
   Biological processB-1 B cell differentiation

Inferred from mutant phenotype. Source: MGI

T cell proliferation

Inferred from mutant phenotype. Source: MGI

T cell receptor signaling pathway

Traceable author statement. Source: UniProtKB

innate immune response

Inferred from expression pattern. Source: UniProtKB

modification-dependent protein catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of NF-kappaB transcription factor activity

Inferred from mutant phenotype. Source: MGI

positive regulation of T cell activation

Inferred from mutant phenotype. Source: MGI

regulation of T cell receptor signaling pathway

Inferred from mutant phenotype. Source: MGI

response to fungus

Inferred from mutant phenotype. Source: MGI

response to molecule of bacterial origin

Inferred from expression pattern. Source: UniProtKB

   Cellular componentcytosol

Inferred from direct assay. Source: UniProtKB

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.2 (identifier: Q2TBA3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.2 Ref.1 (identifier: Q2TBA3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     318-328: Missing.
Isoform 3 Ref.2 (identifier: Q2TBA3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-543: Missing.
Note: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 832832Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog
PRO_0000272961

Regions

Domain45 – 13288Death
Domain131 – 20777Ig-like C2-type 1
Domain218 – 31497Ig-like C2-type 2
Region356 – 570215Caspase-like
Motif377 – 3848Nuclear export signal By similarity UniProtKB Q9UDY8

Sites

Active site4231 By similarity
Active site4721 By similarity

Amino acid modifications

Modified residue1411Phosphoserine By similarity
Disulfide bond154 ↔ 196 By similarity
Disulfide bond257 ↔ 299 By similarity

Natural variations

Alternative sequence1 – 543543Missing in isoform 3. Ref.2
VSP_052278
Alternative sequence318 – 32811Missing in isoform 2. Ref.2 Ref.1
VSP_052279

Experimental info

Sequence conflict2651P → S in AAI10489. Ref.2
Sequence conflict5761P → H in AAI10488. Ref.2
Sequence conflict7931T → A in AAH46536. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 891D59585A360D68

FASTA83293,216
        10         20         30         40         50         60 
MSLWGQPLQA SPPLAVRQPP TASSGPSTSP PAGATLNRLP EPLLRRLSES LDRAPEGRGW 

        70         80         90        100        110        120 
RQLAELAGSR GRLRLSGLDL EQCSLKVLEP EGSPSLCLLK LMGEKGCTVT ELSDFLQALE 

       130        140        150        160        170        180 
HTEVLPLLNP PGLKITVNPE SKAVLAGQFV KLCCRATGHP FVQYQWFKMN KEIPYGNSSE 

       190        200        210        220        230        240 
LVFNTVHVKD AGFYVCRVNN SSTFEFSQWS QLDVCDVAEV TDSFQGSMDG ISESRLQICV 

       250        260        270        280        290        300 
EPRSQRLVPG SMLLLQCVAI GSPMPHYQWF KDESPLTHET KKHYTVPYVD IEHEGTYWCH 

       310        320        330        340        350        360 
VYNDRDSQDS KKAEVTIGRT DEAVECTEDE LNNLGHPDNK EQTGQPLAKD KVALLIGNMS 

       370        380        390        400        410        420 
YWEHPKLKAP LVDVYELTNL LRQLDFKVVS LLDLTEYEMC NAVDEFLLLL DKGVYGLLYY 

       430        440        450        460        470        480 
AGHGYENFGN SFMVPVDAPN PYRSENCLCV QNILKLMQEK ETGLNVFLLD MCRKRNDYDD 

       490        500        510        520        530        540 
TIPILDALKV TANIVFGYAT CQGAEAFEIQ HSGLANGIFM KFLKDRLLED KKITVLLDEV 

       550        560        570        580        590        600 
AEDMGKCHLT KGRQALEIRS SLSEKRALTD PVQGAPCSAE ALVRNLQWAK AHELPESMCL 

       610        620        630        640        650        660 
KFQCGVHIQL GFAAEFSNVM IIYTSIVHKP PEIIMCDAYV TDFPLDLDID PKHANKGTPE 

       670        680        690        700        710        720 
ETGSYLVSKD LPKHCLYTRL SSLQKLKEHL IFTVCLSYQY SGLEDTVEEK QEVNVGKPLI 

       730        740        750        760        770        780 
AKLDMHRGLG RKTCFQACRM PDEPYHSSTS TSAGAGHFHS SQDSFHDVYH SHLGNADSGM 

       790        800        810        820        830 
PPDRCHCSRT PHTFISNYPP HHYCQFGRSN VPVETTDEMP FSFSDRLMIS EN

« Hide

Isoform 2.

Checksum: F1B9027E3EC5B6E6
Show »

FASTA82192,025
Isoform 3.

Checksum: 78378D64D756224F
Show »

FASTA28932,428

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References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Hippocampus, Lung and Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Strain: Czech II.
Tissue: Mammary gland.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK041919 mRNA. Translation: BAC31096.1.
AK049821 mRNA. Translation: BAC33935.1.
AK085071 mRNA. Translation: BAC39355.1.
BC046536 mRNA. Translation: AAH46536.1.
BC110487 mRNA. Translation: AAI10488.1.
BC110488 mRNA. Translation: AAI10489.1.
IPIIPI00172934.
IPI00828263.
IPI00828716.
RefSeqNP_766421.1.
UniGeneMm.132613

3D structure databases

HSSPHSSP built from PDB template 2G7R based on UniProtKB Q9UDY8.
SMRQ2TBA3. Positions 21-140, 234-317, 351-565.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2TBA3.

Protein family/group databases

MEROPSC14.026.

PTM databases

PhosphoSiteQ2TBA3.

Proteomic databases

PRIDEQ2TBA3.

Genome annotation databases

EnsemblENSMUST00000049248; ENSMUSP00000048376; ENSMUSG00000032688; Mus musculus. [Genome view]
ENSMUST00000102868; ENSMUSP00000099932; ENSMUSG00000032688; Mus musculus. [Genome view]
GeneID240354.
KEGGmmu:240354.
UCSCuc008fez.1. mouse.
uc008ffa.1. mouse.
uc008ffb.1. mouse.

Organism-specific databases

CTD240354.
MGIMGI:2445027. Malt1.

Phylogenomic databases

HOGENOMHBG446517.
HOVERGENQ2TBA3.
InParanoidQ2TBA3.
OMAGTYWCHV.

Gene expression databases

ArrayExpressQ2TBA3.
BgeeQ2TBA3.
GenevestigatorQ2TBA3.

Family and domain databases

InterProIPR011029. DEATH-like.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR011600. Pept_C14_cat.
IPR001309. Pept_C14_ICE_p20.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 2 hits.
PfamPF00656. Peptidase_C14. 1 hit.
[Graphical view]
SMARTSM00408. IGc2. 2 hits.
[Graphical view]
PROSITEPS50208. CASPASE_P20. 1 hit.
PS50017. DEATH_DOMAIN. False negative.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameMALT1_MOUSE
AccessionPrimary (citable) accession number: Q2TBA3
Secondary accession number(s): Q2TBA2 expand/collapse secondary AC list , Q811E3, Q8BFT0, Q8C7N9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: February 9, 2010
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents