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Protein

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

Gene

Malt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity (By similarity). MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei423Sequence analysis1
Active sitei472Sequence analysis1

GO - Molecular functioni

GO - Biological processi

  • activation of NF-kappaB-inducing kinase activity Source: MGI
  • B-1 B cell differentiation Source: MGI
  • B cell activation Source: MGI
  • Fc-epsilon receptor signaling pathway Source: Reactome
  • innate immune response Source: UniProtKB
  • nuclear export Source: MGI
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • positive regulation of interleukin-2 production Source: MGI
  • positive regulation of NF-kappaB transcription factor activity Source: MGI
  • positive regulation of T cell activation Source: MGI
  • positive regulation of T cell cytokine production Source: MGI
  • protein oligomerization Source: MGI
  • proteolysis Source: MGI
  • regulation of apoptotic process Source: MGI
  • regulation of T cell receptor signaling pathway Source: MGI
  • response to fungus Source: MGI
  • response to molecule of bacterial origin Source: UniProtKB
  • T cell proliferation Source: MGI
  • T cell receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-202424. Downstream TCR signaling.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-5660668. CLEC7A/inflammasome pathway.

Protein family/group databases

MEROPSiC14.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog (EC:3.4.22.-)
Alternative name(s):
Paracaspase
Gene namesi
Name:Malt1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2445027. Malt1.

Subcellular locationi

  • Cytoplasmperinuclear region By similarity
  • Nucleus By similarity

  • Note: Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10 (By similarity).By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: UniProtKB
  • nucleolus Source: MGI
  • nucleus Source: MGI
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002729612 – 832Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homologAdd BLAST831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei141PhosphoserineBy similarity1
Disulfide bondi154 ↔ 196PROSITE-ProRule annotation
Disulfide bondi257 ↔ 299PROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ2TBA3.
PaxDbiQ2TBA3.
PeptideAtlasiQ2TBA3.
PRIDEiQ2TBA3.

PTM databases

iPTMnetiQ2TBA3.
PhosphoSitePlusiQ2TBA3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032688.
GenevisibleiQ2TBA3. MM.

Interactioni

Subunit structurei

Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6 (By similarity).By similarity

GO - Molecular functioni

  • protease binding Source: BHF-UCL
  • protein self-association Source: MGI

Protein-protein interaction databases

BioGridi232195. 6 interactors.
DIPiDIP-60308N.
STRINGi10090.ENSMUSP00000048376.

Structurei

Secondary structure

1832
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi351 – 357Combined sources7
Beta strandi362 – 364Combined sources3
Helixi369 – 383Combined sources15
Beta strandi387 – 393Combined sources7
Helixi396 – 407Combined sources12
Beta strandi415 – 427Combined sources13
Beta strandi430 – 434Combined sources5
Turni444 – 446Combined sources3
Beta strandi447 – 449Combined sources3
Helixi450 – 458Combined sources9
Turni459 – 461Combined sources3
Beta strandi463 – 471Combined sources9
Beta strandi494 – 500Combined sources7
Beta strandi507 – 509Combined sources3
Beta strandi512 – 514Combined sources3
Helixi518 – 523Combined sources6
Turni524 – 528Combined sources5
Helixi533 – 545Combined sources13
Turni548 – 553Combined sources6
Beta strandi557 – 560Combined sources4
Helixi579 – 589Combined sources11
Beta strandi598 – 601Combined sources4
Beta strandi607 – 616Combined sources10
Beta strandi619 – 628Combined sources10
Beta strandi633 – 641Combined sources9
Helixi645 – 647Combined sources3
Helixi651 – 653Combined sources3
Beta strandi654 – 658Combined sources5
Helixi659 – 662Combined sources4
Turni668 – 670Combined sources3
Beta strandi675 – 680Combined sources6
Helixi683 – 685Combined sources3
Beta strandi690 – 700Combined sources11
Beta strandi707 – 717Combined sources11
Helixi719 – 723Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V4LX-ray3.15A338-729[»]
ProteinModelPortaliQ2TBA3.
SMRiQ2TBA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 132DeathSequence analysisAdd BLAST88
Domaini131 – 207Ig-like C2-type 1Sequence analysisAdd BLAST77
Domaini218 – 314Ig-like C2-type 2Sequence analysisAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni356 – 570Caspase-likeSequence analysisAdd BLAST215

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi377 – 384Nuclear export signalBy similarity8

Sequence similaritiesi

Belongs to the peptidase C14B family.Curated
Contains 1 death domain.Sequence analysis
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Sequence analysis

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IG3U. Eukaryota.
COG4249. LUCA.
GeneTreeiENSGT00390000018044.
HOGENOMiHOG000113471.
HOVERGENiHBG052402.
InParanoidiQ2TBA3.
KOiK07369.
OMAiHPDNKEQ.
OrthoDBiEOG091G01PI.
PhylomeDBiQ2TBA3.
TreeFamiTF319744.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033540. MALT1.
IPR001309. Pept_C14_p20.
[Graphical view]
PANTHERiPTHR22576:SF29. PTHR22576:SF29. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48726. SSF48726. 2 hits.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q2TBA3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLWGQPLQA SPPLAVRQPP TASSGPSTSP PAGATLNRLP EPLLRRLSES
60 70 80 90 100
LDRAPEGRGW RQLAELAGSR GRLRLSGLDL EQCSLKVLEP EGSPSLCLLK
110 120 130 140 150
LMGEKGCTVT ELSDFLQALE HTEVLPLLNP PGLKITVNPE SKAVLAGQFV
160 170 180 190 200
KLCCRATGHP FVQYQWFKMN KEIPYGNSSE LVFNTVHVKD AGFYVCRVNN
210 220 230 240 250
SSTFEFSQWS QLDVCDVAEV TDSFQGSMDG ISESRLQICV EPRSQRLVPG
260 270 280 290 300
SMLLLQCVAI GSPMPHYQWF KDESPLTHET KKHYTVPYVD IEHEGTYWCH
310 320 330 340 350
VYNDRDSQDS KKAEVTIGRT DEAVECTEDE LNNLGHPDNK EQTGQPLAKD
360 370 380 390 400
KVALLIGNMS YWEHPKLKAP LVDVYELTNL LRQLDFKVVS LLDLTEYEMC
410 420 430 440 450
NAVDEFLLLL DKGVYGLLYY AGHGYENFGN SFMVPVDAPN PYRSENCLCV
460 470 480 490 500
QNILKLMQEK ETGLNVFLLD MCRKRNDYDD TIPILDALKV TANIVFGYAT
510 520 530 540 550
CQGAEAFEIQ HSGLANGIFM KFLKDRLLED KKITVLLDEV AEDMGKCHLT
560 570 580 590 600
KGRQALEIRS SLSEKRALTD PVQGAPCSAE ALVRNLQWAK AHELPESMCL
610 620 630 640 650
KFQCGVHIQL GFAAEFSNVM IIYTSIVHKP PEIIMCDAYV TDFPLDLDID
660 670 680 690 700
PKHANKGTPE ETGSYLVSKD LPKHCLYTRL SSLQKLKEHL IFTVCLSYQY
710 720 730 740 750
SGLEDTVEEK QEVNVGKPLI AKLDMHRGLG RKTCFQACRM PDEPYHSSTS
760 770 780 790 800
TSAGAGHFHS SQDSFHDVYH SHLGNADSGM PPDRCHCSRT PHTFISNYPP
810 820 830
HHYCQFGRSN VPVETTDEMP FSFSDRLMIS EN
Length:832
Mass (Da):93,216
Last modified:January 23, 2007 - v2
Checksum:i891D59585A360D68
GO
Isoform 22 Publications (identifier: Q2TBA3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-328: Missing.

Show »
Length:821
Mass (Da):92,025
Checksum:iF1B9027E3EC5B6E6
GO
Isoform 31 Publication (identifier: Q2TBA3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-543: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:289
Mass (Da):32,428
Checksum:i78378D64D756224F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265P → S in AAI10489 (PubMed:15489334).Curated1
Sequence conflicti576P → H in AAI10488 (PubMed:15489334).Curated1
Sequence conflicti793T → A in AAH46536 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0522781 – 543Missing in isoform 3. 1 PublicationAdd BLAST543
Alternative sequenceiVSP_052279318 – 328Missing in isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041919 mRNA. Translation: BAC31096.1.
AK049821 mRNA. Translation: BAC33935.1.
AK085071 mRNA. Translation: BAC39355.1.
BC046536 mRNA. Translation: AAH46536.1.
BC110487 mRNA. Translation: AAI10488.1.
BC110488 mRNA. Translation: AAI10489.1.
CCDSiCCDS29306.1. [Q2TBA3-2]
RefSeqiNP_766421.1. NM_172833.2. [Q2TBA3-2]
XP_006526000.1. XM_006525937.2. [Q2TBA3-1]
UniGeneiMm.132613.

Genome annotation databases

EnsembliENSMUST00000049248; ENSMUSP00000048376; ENSMUSG00000032688. [Q2TBA3-2]
GeneIDi240354.
KEGGimmu:240354.
UCSCiuc008fez.1. mouse. [Q2TBA3-2]
uc008ffa.1. mouse. [Q2TBA3-1]
uc008ffb.1. mouse. [Q2TBA3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041919 mRNA. Translation: BAC31096.1.
AK049821 mRNA. Translation: BAC33935.1.
AK085071 mRNA. Translation: BAC39355.1.
BC046536 mRNA. Translation: AAH46536.1.
BC110487 mRNA. Translation: AAI10488.1.
BC110488 mRNA. Translation: AAI10489.1.
CCDSiCCDS29306.1. [Q2TBA3-2]
RefSeqiNP_766421.1. NM_172833.2. [Q2TBA3-2]
XP_006526000.1. XM_006525937.2. [Q2TBA3-1]
UniGeneiMm.132613.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V4LX-ray3.15A338-729[»]
ProteinModelPortaliQ2TBA3.
SMRiQ2TBA3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232195. 6 interactors.
DIPiDIP-60308N.
STRINGi10090.ENSMUSP00000048376.

Protein family/group databases

MEROPSiC14.026.

PTM databases

iPTMnetiQ2TBA3.
PhosphoSitePlusiQ2TBA3.

Proteomic databases

MaxQBiQ2TBA3.
PaxDbiQ2TBA3.
PeptideAtlasiQ2TBA3.
PRIDEiQ2TBA3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049248; ENSMUSP00000048376; ENSMUSG00000032688. [Q2TBA3-2]
GeneIDi240354.
KEGGimmu:240354.
UCSCiuc008fez.1. mouse. [Q2TBA3-2]
uc008ffa.1. mouse. [Q2TBA3-1]
uc008ffb.1. mouse. [Q2TBA3-3]

Organism-specific databases

CTDi10892.
MGIiMGI:2445027. Malt1.

Phylogenomic databases

eggNOGiENOG410IG3U. Eukaryota.
COG4249. LUCA.
GeneTreeiENSGT00390000018044.
HOGENOMiHOG000113471.
HOVERGENiHBG052402.
InParanoidiQ2TBA3.
KOiK07369.
OMAiHPDNKEQ.
OrthoDBiEOG091G01PI.
PhylomeDBiQ2TBA3.
TreeFamiTF319744.

Enzyme and pathway databases

ReactomeiR-MMU-1169091. Activation of NF-kappaB in B cells.
R-MMU-202424. Downstream TCR signaling.
R-MMU-2871837. FCERI mediated NF-kB activation.
R-MMU-5607764. CLEC7A (Dectin-1) signaling.
R-MMU-5660668. CLEC7A/inflammasome pathway.

Miscellaneous databases

PROiQ2TBA3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032688.
GenevisibleiQ2TBA3. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033540. MALT1.
IPR001309. Pept_C14_p20.
[Graphical view]
PANTHERiPTHR22576:SF29. PTHR22576:SF29. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF48726. SSF48726. 2 hits.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMALT1_MOUSE
AccessioniPrimary (citable) accession number: Q2TBA3
Secondary accession number(s): Q2TBA2
, Q811E3, Q8BFT0, Q8C7N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.