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Protein

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

Gene

Malt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity (By similarity). MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei423Sequence analysis1
Active sitei472Sequence analysis1

GO - Molecular functioni

GO - Biological processi

  • activation of NF-kappaB-inducing kinase activity Source: MGI
  • B-1 B cell differentiation Source: MGI
  • B cell activation Source: MGI
  • innate immune response Source: UniProtKB
  • nuclear export Source: MGI
  • positive regulation of interleukin-2 production Source: MGI
  • positive regulation of NF-kappaB transcription factor activity Source: MGI
  • positive regulation of T cell activation Source: MGI
  • positive regulation of T cell cytokine production Source: MGI
  • protein complex oligomerization Source: MGI
  • proteolysis Source: MGI
  • regulation of apoptotic process Source: MGI
  • regulation of T cell receptor signaling pathway Source: MGI
  • response to fungus Source: MGI
  • response to molecule of bacterial origin Source: UniProtKB
  • T cell proliferation Source: MGI
  • T cell receptor signaling pathway Source: MGI

Keywordsi

Molecular functionHydrolase, Protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-1169091 Activation of NF-kappaB in B cells
R-MMU-202424 Downstream TCR signaling
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-5660668 CLEC7A/inflammasome pathway

Protein family/group databases

MEROPSiC14.026

Names & Taxonomyi

Protein namesi
Recommended name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog (EC:3.4.22.-)
Alternative name(s):
Paracaspase
Gene namesi
Name:Malt1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2445027 Malt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002729612 – 832Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homologAdd BLAST831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei141PhosphoserineBy similarity1
Disulfide bondi154 ↔ 196PROSITE-ProRule annotation
Disulfide bondi257 ↔ 299PROSITE-ProRule annotation

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ2TBA3
PaxDbiQ2TBA3
PeptideAtlasiQ2TBA3
PRIDEiQ2TBA3

PTM databases

iPTMnetiQ2TBA3
PhosphoSitePlusiQ2TBA3

Expressioni

Gene expression databases

BgeeiENSMUSG00000032688
GenevisibleiQ2TBA3 MM

Interactioni

Subunit structurei

Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Forms a complex with CARD14 and BCL10; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex. Interacts with BCL10; as part of a CBM (CARD11-BCL10-MALT1) complex involved in NF-kappa-B activation.By similarity

GO - Molecular functioni

  • identical protein binding Source: MGI
  • protease binding Source: BHF-UCL
  • protein self-association Source: MGI

Protein-protein interaction databases

BioGridi232195, 6 interactors
DIPiDIP-60308N
IntActiQ2TBA3, 2 interactors
STRINGi10090.ENSMUSP00000048376

Structurei

Secondary structure

1832
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi351 – 357Combined sources7
Beta strandi362 – 364Combined sources3
Helixi369 – 383Combined sources15
Beta strandi387 – 393Combined sources7
Helixi396 – 407Combined sources12
Beta strandi415 – 427Combined sources13
Beta strandi430 – 434Combined sources5
Turni444 – 446Combined sources3
Beta strandi447 – 449Combined sources3
Helixi450 – 458Combined sources9
Turni459 – 461Combined sources3
Beta strandi463 – 471Combined sources9
Beta strandi494 – 500Combined sources7
Beta strandi507 – 509Combined sources3
Beta strandi512 – 514Combined sources3
Helixi518 – 523Combined sources6
Turni524 – 528Combined sources5
Helixi533 – 545Combined sources13
Turni548 – 553Combined sources6
Beta strandi557 – 560Combined sources4
Helixi579 – 589Combined sources11
Beta strandi598 – 601Combined sources4
Beta strandi607 – 616Combined sources10
Beta strandi619 – 628Combined sources10
Beta strandi633 – 641Combined sources9
Helixi645 – 647Combined sources3
Helixi651 – 653Combined sources3
Beta strandi654 – 658Combined sources5
Helixi659 – 662Combined sources4
Turni668 – 670Combined sources3
Beta strandi675 – 680Combined sources6
Helixi683 – 685Combined sources3
Beta strandi690 – 700Combined sources11
Beta strandi707 – 717Combined sources11
Helixi719 – 723Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V4LX-ray3.15A338-729[»]
ProteinModelPortaliQ2TBA3
SMRiQ2TBA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 132DeathSequence analysisAdd BLAST88
Domaini131 – 207Ig-like C2-type 1Sequence analysisAdd BLAST77
Domaini218 – 314Ig-like C2-type 2Sequence analysisAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni356 – 570Caspase-likeSequence analysisAdd BLAST215

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi377 – 384Nuclear export signalBy similarity8

Sequence similaritiesi

Belongs to the peptidase C14B family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IG3U Eukaryota
COG4249 LUCA
GeneTreeiENSGT00390000018044
HOGENOMiHOG000113471
HOVERGENiHBG052402
InParanoidiQ2TBA3
KOiK07369
OMAiSNVMIIY
OrthoDBiEOG091G01PI
PhylomeDBiQ2TBA3
TreeFamiTF319744

Family and domain databases

CDDicd08783 Death_MALT1, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR029030 Caspase-like_dom_sf
IPR011029 DEATH-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR033540 MALT1
IPR037940 MALT1_Death
IPR001309 Pept_C14_p20
PANTHERiPTHR22576:SF29 PTHR22576:SF29, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF47986 SSF47986, 1 hit
SSF48726 SSF48726, 2 hits
SSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS50208 CASPASE_P20, 1 hit
PS50835 IG_LIKE, 2 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q2TBA3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLWGQPLQA SPPLAVRQPP TASSGPSTSP PAGATLNRLP EPLLRRLSES
60 70 80 90 100
LDRAPEGRGW RQLAELAGSR GRLRLSGLDL EQCSLKVLEP EGSPSLCLLK
110 120 130 140 150
LMGEKGCTVT ELSDFLQALE HTEVLPLLNP PGLKITVNPE SKAVLAGQFV
160 170 180 190 200
KLCCRATGHP FVQYQWFKMN KEIPYGNSSE LVFNTVHVKD AGFYVCRVNN
210 220 230 240 250
SSTFEFSQWS QLDVCDVAEV TDSFQGSMDG ISESRLQICV EPRSQRLVPG
260 270 280 290 300
SMLLLQCVAI GSPMPHYQWF KDESPLTHET KKHYTVPYVD IEHEGTYWCH
310 320 330 340 350
VYNDRDSQDS KKAEVTIGRT DEAVECTEDE LNNLGHPDNK EQTGQPLAKD
360 370 380 390 400
KVALLIGNMS YWEHPKLKAP LVDVYELTNL LRQLDFKVVS LLDLTEYEMC
410 420 430 440 450
NAVDEFLLLL DKGVYGLLYY AGHGYENFGN SFMVPVDAPN PYRSENCLCV
460 470 480 490 500
QNILKLMQEK ETGLNVFLLD MCRKRNDYDD TIPILDALKV TANIVFGYAT
510 520 530 540 550
CQGAEAFEIQ HSGLANGIFM KFLKDRLLED KKITVLLDEV AEDMGKCHLT
560 570 580 590 600
KGRQALEIRS SLSEKRALTD PVQGAPCSAE ALVRNLQWAK AHELPESMCL
610 620 630 640 650
KFQCGVHIQL GFAAEFSNVM IIYTSIVHKP PEIIMCDAYV TDFPLDLDID
660 670 680 690 700
PKHANKGTPE ETGSYLVSKD LPKHCLYTRL SSLQKLKEHL IFTVCLSYQY
710 720 730 740 750
SGLEDTVEEK QEVNVGKPLI AKLDMHRGLG RKTCFQACRM PDEPYHSSTS
760 770 780 790 800
TSAGAGHFHS SQDSFHDVYH SHLGNADSGM PPDRCHCSRT PHTFISNYPP
810 820 830
HHYCQFGRSN VPVETTDEMP FSFSDRLMIS EN
Length:832
Mass (Da):93,216
Last modified:January 23, 2007 - v2
Checksum:i891D59585A360D68
GO
Isoform 22 Publications (identifier: Q2TBA3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-328: Missing.

Show »
Length:821
Mass (Da):92,025
Checksum:iF1B9027E3EC5B6E6
GO
Isoform 31 Publication (identifier: Q2TBA3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-543: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:289
Mass (Da):32,428
Checksum:i78378D64D756224F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265P → S in AAI10489 (PubMed:15489334).Curated1
Sequence conflicti576P → H in AAI10488 (PubMed:15489334).Curated1
Sequence conflicti793T → A in AAH46536 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0522781 – 543Missing in isoform 3. 1 PublicationAdd BLAST543
Alternative sequenceiVSP_052279318 – 328Missing in isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041919 mRNA Translation: BAC31096.1
AK049821 mRNA Translation: BAC33935.1
AK085071 mRNA Translation: BAC39355.1
BC046536 mRNA Translation: AAH46536.1
BC110487 mRNA Translation: AAI10488.1
BC110488 mRNA Translation: AAI10489.1
CCDSiCCDS29306.1 [Q2TBA3-2]
RefSeqiNP_766421.1, NM_172833.2 [Q2TBA3-2]
XP_006526000.1, XM_006525937.2 [Q2TBA3-1]
UniGeneiMm.132613

Genome annotation databases

EnsembliENSMUST00000049248; ENSMUSP00000048376; ENSMUSG00000032688 [Q2TBA3-2]
ENSMUST00000224056; ENSMUSP00000153585; ENSMUSG00000032688 [Q2TBA3-1]
GeneIDi240354
KEGGimmu:240354
UCSCiuc008fez.1 mouse [Q2TBA3-2]
uc008ffa.1 mouse [Q2TBA3-1]
uc008ffb.1 mouse [Q2TBA3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMALT1_MOUSE
AccessioniPrimary (citable) accession number: Q2TBA3
Secondary accession number(s): Q2TBA2
, Q811E3, Q8BFT0, Q8C7N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health