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Q2TBA3

- MALT1_MOUSE

UniProt

Q2TBA3 - MALT1_MOUSE

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Protein
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog
Gene
Malt1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity By similarity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei423 – 4231 By similarity
Active sitei472 – 4721 By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: InterPro
  2. kinase activator activity Source: Ensembl
  3. protease binding Source: BHF-UCL
  4. protein binding Source: MGI
  5. signal transducer activity Source: Ensembl
  6. ubiquitin-protein transferase activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. B cell activation Source: MGI
  2. B-1 B cell differentiation Source: MGI
  3. T cell proliferation Source: MGI
  4. T cell receptor signaling pathway Source: UniProtKB
  5. activation of NF-kappaB-inducing kinase activity Source: Ensembl
  6. innate immune response Source: UniProtKB
  7. nuclear export Source: Ensembl
  8. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  9. positive regulation of NF-kappaB transcription factor activity Source: MGI
  10. positive regulation of T cell activation Source: MGI
  11. positive regulation of T cell cytokine production Source: Ensembl
  12. positive regulation of interleukin-2 production Source: Ensembl
  13. protein oligomerization Source: Ensembl
  14. regulation of T cell receptor signaling pathway Source: MGI
  15. regulation of apoptotic process Source: MGI
  16. response to fungus Source: MGI
  17. response to molecule of bacterial origin Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_199121. Activation of NF-kappaB in B cells.
REACT_205561. FCERI mediated NF-kB activation.
REACT_225145. Downstream TCR signaling.

Protein family/group databases

MEROPSiC14.026.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog (EC:3.4.22.-)
Alternative name(s):
Paracaspase
Gene namesi
Name:Malt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:2445027. Malt1.

Subcellular locationi

Cytoplasmperinuclear region By similarity. Nucleus By similarity
Note: Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10 By similarity.

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. nucleus Source: UniProtKB-SubCell
  3. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  4. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 832831Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog
PRO_0000272961Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei141 – 1411Phosphoserine By similarity
Disulfide bondi154 ↔ 196 By similarity
Disulfide bondi257 ↔ 299 By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiQ2TBA3.
PaxDbiQ2TBA3.
PRIDEiQ2TBA3.

PTM databases

PhosphoSiteiQ2TBA3.

Expressioni

Gene expression databases

BgeeiQ2TBA3.
GenevestigatoriQ2TBA3.

Interactioni

Subunit structurei

Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6 By similarity.By similarity

Protein-protein interaction databases

BioGridi232195. 6 interactions.
DIPiDIP-60308N.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi351 – 3577
Beta strandi362 – 3643
Helixi369 – 38315
Beta strandi387 – 3937
Helixi396 – 40712
Beta strandi415 – 42713
Beta strandi430 – 4345
Turni444 – 4463
Beta strandi447 – 4493
Helixi450 – 4589
Turni459 – 4613
Beta strandi463 – 4719
Beta strandi494 – 5007
Beta strandi507 – 5093
Beta strandi512 – 5143
Helixi518 – 5236
Turni524 – 5285
Helixi533 – 54513
Turni548 – 5536
Beta strandi557 – 5604
Helixi579 – 58911
Beta strandi598 – 6014
Beta strandi607 – 61610
Beta strandi619 – 62810
Beta strandi633 – 6419
Helixi645 – 6473
Helixi651 – 6533
Beta strandi654 – 6585
Helixi659 – 6624
Turni668 – 6703
Beta strandi675 – 6806
Helixi683 – 6853
Beta strandi690 – 70011
Beta strandi707 – 71711
Helixi719 – 7235

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3V4LX-ray3.15A338-729[»]
ProteinModelPortaliQ2TBA3.
SMRiQ2TBA3. Positions 48-130, 134-729.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 13288Death
Add
BLAST
Domaini131 – 20777Ig-like C2-type 1
Add
BLAST
Domaini218 – 31497Ig-like C2-type 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni356 – 570215Caspase-like
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi377 – 3848Nuclear export signal By similarityBy similarity

Sequence similaritiesi

Belongs to the peptidase C14B family.
Contains 1 death domain.

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiCOG4249.
GeneTreeiENSGT00390000018044.
HOGENOMiHOG000113471.
HOVERGENiHBG052402.
InParanoidiQ2TBA3.
KOiK07369.
OMAiMNKEIPN.
OrthoDBiEOG7673BH.
PhylomeDBiQ2TBA3.
TreeFamiTF319744.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
[Graphical view]
PfamiPF00656. Peptidase_C14. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q2TBA3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLWGQPLQA SPPLAVRQPP TASSGPSTSP PAGATLNRLP EPLLRRLSES    50
LDRAPEGRGW RQLAELAGSR GRLRLSGLDL EQCSLKVLEP EGSPSLCLLK 100
LMGEKGCTVT ELSDFLQALE HTEVLPLLNP PGLKITVNPE SKAVLAGQFV 150
KLCCRATGHP FVQYQWFKMN KEIPYGNSSE LVFNTVHVKD AGFYVCRVNN 200
SSTFEFSQWS QLDVCDVAEV TDSFQGSMDG ISESRLQICV EPRSQRLVPG 250
SMLLLQCVAI GSPMPHYQWF KDESPLTHET KKHYTVPYVD IEHEGTYWCH 300
VYNDRDSQDS KKAEVTIGRT DEAVECTEDE LNNLGHPDNK EQTGQPLAKD 350
KVALLIGNMS YWEHPKLKAP LVDVYELTNL LRQLDFKVVS LLDLTEYEMC 400
NAVDEFLLLL DKGVYGLLYY AGHGYENFGN SFMVPVDAPN PYRSENCLCV 450
QNILKLMQEK ETGLNVFLLD MCRKRNDYDD TIPILDALKV TANIVFGYAT 500
CQGAEAFEIQ HSGLANGIFM KFLKDRLLED KKITVLLDEV AEDMGKCHLT 550
KGRQALEIRS SLSEKRALTD PVQGAPCSAE ALVRNLQWAK AHELPESMCL 600
KFQCGVHIQL GFAAEFSNVM IIYTSIVHKP PEIIMCDAYV TDFPLDLDID 650
PKHANKGTPE ETGSYLVSKD LPKHCLYTRL SSLQKLKEHL IFTVCLSYQY 700
SGLEDTVEEK QEVNVGKPLI AKLDMHRGLG RKTCFQACRM PDEPYHSSTS 750
TSAGAGHFHS SQDSFHDVYH SHLGNADSGM PPDRCHCSRT PHTFISNYPP 800
HHYCQFGRSN VPVETTDEMP FSFSDRLMIS EN 832
Length:832
Mass (Da):93,216
Last modified:January 23, 2007 - v2
Checksum:i891D59585A360D68
GO
Isoform 22 Publications (identifier: Q2TBA3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-328: Missing.

Show »
Length:821
Mass (Da):92,025
Checksum:iF1B9027E3EC5B6E6
GO
Isoform 31 Publication (identifier: Q2TBA3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-543: Missing.

Note: No experimental confirmation available.

Show »
Length:290
Mass (Da):32,559
Checksum:i031E49DB855C747A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 543542Missing in isoform 3.
VSP_052278Add
BLAST
Alternative sequencei318 – 32811Missing in isoform 2. 2 Publications
VSP_052279Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti265 – 2651P → S in AAI10489. 1 Publication
Sequence conflicti576 – 5761P → H in AAI10488. 1 Publication
Sequence conflicti793 – 7931T → A in AAH46536. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK041919 mRNA. Translation: BAC31096.1.
AK049821 mRNA. Translation: BAC33935.1.
AK085071 mRNA. Translation: BAC39355.1.
BC046536 mRNA. Translation: AAH46536.1.
BC110487 mRNA. Translation: AAI10488.1.
BC110488 mRNA. Translation: AAI10489.1.
CCDSiCCDS29306.1. [Q2TBA3-2]
RefSeqiNP_766421.1. NM_172833.2. [Q2TBA3-2]
XP_006526000.1. XM_006525937.1. [Q2TBA3-1]
UniGeneiMm.132613.

Genome annotation databases

EnsembliENSMUST00000049248; ENSMUSP00000048376; ENSMUSG00000032688. [Q2TBA3-2]
GeneIDi240354.
KEGGimmu:240354.
UCSCiuc008fez.1. mouse. [Q2TBA3-2]
uc008ffa.1. mouse. [Q2TBA3-1]
uc008ffb.1. mouse. [Q2TBA3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK041919 mRNA. Translation: BAC31096.1 .
AK049821 mRNA. Translation: BAC33935.1 .
AK085071 mRNA. Translation: BAC39355.1 .
BC046536 mRNA. Translation: AAH46536.1 .
BC110487 mRNA. Translation: AAI10488.1 .
BC110488 mRNA. Translation: AAI10489.1 .
CCDSi CCDS29306.1. [Q2TBA3-2 ]
RefSeqi NP_766421.1. NM_172833.2. [Q2TBA3-2 ]
XP_006526000.1. XM_006525937.1. [Q2TBA3-1 ]
UniGenei Mm.132613.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3V4L X-ray 3.15 A 338-729 [» ]
ProteinModelPortali Q2TBA3.
SMRi Q2TBA3. Positions 48-130, 134-729.
ModBasei Search...

Protein-protein interaction databases

BioGridi 232195. 6 interactions.
DIPi DIP-60308N.

Protein family/group databases

MEROPSi C14.026.

PTM databases

PhosphoSitei Q2TBA3.

Proteomic databases

MaxQBi Q2TBA3.
PaxDbi Q2TBA3.
PRIDEi Q2TBA3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049248 ; ENSMUSP00000048376 ; ENSMUSG00000032688 . [Q2TBA3-2 ]
GeneIDi 240354.
KEGGi mmu:240354.
UCSCi uc008fez.1. mouse. [Q2TBA3-2 ]
uc008ffa.1. mouse. [Q2TBA3-1 ]
uc008ffb.1. mouse. [Q2TBA3-3 ]

Organism-specific databases

CTDi 10892.
MGIi MGI:2445027. Malt1.

Phylogenomic databases

eggNOGi COG4249.
GeneTreei ENSGT00390000018044.
HOGENOMi HOG000113471.
HOVERGENi HBG052402.
InParanoidi Q2TBA3.
KOi K07369.
OMAi MNKEIPN.
OrthoDBi EOG7673BH.
PhylomeDBi Q2TBA3.
TreeFami TF319744.

Enzyme and pathway databases

Reactomei REACT_199121. Activation of NF-kappaB in B cells.
REACT_205561. FCERI mediated NF-kB activation.
REACT_225145. Downstream TCR signaling.

Miscellaneous databases

NextBioi 384566.
PROi Q2TBA3.
SOURCEi Search...

Gene expression databases

Bgeei Q2TBA3.
Genevestigatori Q2TBA3.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.60.40.10. 2 hits.
3.40.50.1460. 1 hit.
InterProi IPR029030. Caspase-like_dom.
IPR011029. DEATH-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
[Graphical view ]
Pfami PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
SMARTi SM00408. IGc2. 2 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50208. CASPASE_P20. 1 hit.
PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Hippocampus, Lung and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: Czech II.
    Tissue: Mammary gland.

Entry informationi

Entry nameiMALT1_MOUSE
AccessioniPrimary (citable) accession number: Q2TBA3
Secondary accession number(s): Q2TBA2
, Q811E3, Q8BFT0, Q8C7N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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