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Q2TBA3

- MALT1_MOUSE

UniProt

Q2TBA3 - MALT1_MOUSE

Protein

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

Gene

Malt1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity By similarity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei423 – 4231Sequence Analysis
    Active sitei472 – 4721Sequence Analysis

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: InterPro
    2. kinase activator activity Source: Ensembl
    3. protease binding Source: BHF-UCL
    4. protein binding Source: MGI
    5. signal transducer activity Source: Ensembl
    6. ubiquitin-protein transferase activity Source: Ensembl

    GO - Biological processi

    1. activation of NF-kappaB-inducing kinase activity Source: Ensembl
    2. B-1 B cell differentiation Source: MGI
    3. B cell activation Source: MGI
    4. innate immune response Source: UniProtKB
    5. nuclear export Source: Ensembl
    6. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    7. positive regulation of interleukin-2 production Source: Ensembl
    8. positive regulation of NF-kappaB transcription factor activity Source: MGI
    9. positive regulation of T cell activation Source: MGI
    10. positive regulation of T cell cytokine production Source: Ensembl
    11. protein oligomerization Source: Ensembl
    12. regulation of apoptotic process Source: MGI
    13. regulation of T cell receptor signaling pathway Source: MGI
    14. response to fungus Source: MGI
    15. response to molecule of bacterial origin Source: UniProtKB
    16. T cell proliferation Source: MGI
    17. T cell receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_199121. Activation of NF-kappaB in B cells.
    REACT_205561. FCERI mediated NF-kB activation.
    REACT_225145. Downstream TCR signaling.

    Protein family/group databases

    MEROPSiC14.026.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog (EC:3.4.22.-)
    Alternative name(s):
    Paracaspase
    Gene namesi
    Name:Malt1Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:2445027. Malt1.

    Subcellular locationi

    Cytoplasmperinuclear region By similarity. Nucleus By similarity
    Note: Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10 By similarity.By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. nucleus Source: UniProtKB-SubCell
    3. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    4. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 832831Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homologPRO_0000272961Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei141 – 1411PhosphoserineBy similarity
    Disulfide bondi154 ↔ 196PROSITE-ProRule annotation
    Disulfide bondi257 ↔ 299PROSITE-ProRule annotation

    Keywords - PTMi

    Acetylation, Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiQ2TBA3.
    PaxDbiQ2TBA3.
    PRIDEiQ2TBA3.

    PTM databases

    PhosphoSiteiQ2TBA3.

    Expressioni

    Gene expression databases

    BgeeiQ2TBA3.
    GenevestigatoriQ2TBA3.

    Interactioni

    Subunit structurei

    Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi232195. 6 interactions.
    DIPiDIP-60308N.

    Structurei

    Secondary structure

    1
    832
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi351 – 3577
    Beta strandi362 – 3643
    Helixi369 – 38315
    Beta strandi387 – 3937
    Helixi396 – 40712
    Beta strandi415 – 42713
    Beta strandi430 – 4345
    Turni444 – 4463
    Beta strandi447 – 4493
    Helixi450 – 4589
    Turni459 – 4613
    Beta strandi463 – 4719
    Beta strandi494 – 5007
    Beta strandi507 – 5093
    Beta strandi512 – 5143
    Helixi518 – 5236
    Turni524 – 5285
    Helixi533 – 54513
    Turni548 – 5536
    Beta strandi557 – 5604
    Helixi579 – 58911
    Beta strandi598 – 6014
    Beta strandi607 – 61610
    Beta strandi619 – 62810
    Beta strandi633 – 6419
    Helixi645 – 6473
    Helixi651 – 6533
    Beta strandi654 – 6585
    Helixi659 – 6624
    Turni668 – 6703
    Beta strandi675 – 6806
    Helixi683 – 6853
    Beta strandi690 – 70011
    Beta strandi707 – 71711
    Helixi719 – 7235

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3V4LX-ray3.15A338-729[»]
    ProteinModelPortaliQ2TBA3.
    SMRiQ2TBA3. Positions 48-130, 134-729.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 13288DeathSequence AnalysisAdd
    BLAST
    Domaini131 – 20777Ig-like C2-type 1Sequence AnalysisAdd
    BLAST
    Domaini218 – 31497Ig-like C2-type 2Sequence AnalysisAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni356 – 570215Caspase-likeSequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi377 – 3848Nuclear export signalBy similarity

    Sequence similaritiesi

    Belongs to the peptidase C14B family.Curated
    Contains 1 death domain.Sequence Analysis
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Sequence Analysis

    Keywords - Domaini

    Immunoglobulin domain, Repeat

    Phylogenomic databases

    eggNOGiCOG4249.
    GeneTreeiENSGT00390000018044.
    HOGENOMiHOG000113471.
    HOVERGENiHBG052402.
    InParanoidiQ2TBA3.
    KOiK07369.
    OMAiMNKEIPN.
    OrthoDBiEOG7673BH.
    PhylomeDBiQ2TBA3.
    TreeFamiTF319744.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    2.60.40.10. 2 hits.
    3.40.50.1460. 1 hit.
    InterProiIPR029030. Caspase-like_dom.
    IPR011029. DEATH-like_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    [Graphical view]
    PfamiPF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    SMARTiSM00408. IGc2. 2 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50208. CASPASE_P20. 1 hit.
    PS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q2TBA3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLWGQPLQA SPPLAVRQPP TASSGPSTSP PAGATLNRLP EPLLRRLSES    50
    LDRAPEGRGW RQLAELAGSR GRLRLSGLDL EQCSLKVLEP EGSPSLCLLK 100
    LMGEKGCTVT ELSDFLQALE HTEVLPLLNP PGLKITVNPE SKAVLAGQFV 150
    KLCCRATGHP FVQYQWFKMN KEIPYGNSSE LVFNTVHVKD AGFYVCRVNN 200
    SSTFEFSQWS QLDVCDVAEV TDSFQGSMDG ISESRLQICV EPRSQRLVPG 250
    SMLLLQCVAI GSPMPHYQWF KDESPLTHET KKHYTVPYVD IEHEGTYWCH 300
    VYNDRDSQDS KKAEVTIGRT DEAVECTEDE LNNLGHPDNK EQTGQPLAKD 350
    KVALLIGNMS YWEHPKLKAP LVDVYELTNL LRQLDFKVVS LLDLTEYEMC 400
    NAVDEFLLLL DKGVYGLLYY AGHGYENFGN SFMVPVDAPN PYRSENCLCV 450
    QNILKLMQEK ETGLNVFLLD MCRKRNDYDD TIPILDALKV TANIVFGYAT 500
    CQGAEAFEIQ HSGLANGIFM KFLKDRLLED KKITVLLDEV AEDMGKCHLT 550
    KGRQALEIRS SLSEKRALTD PVQGAPCSAE ALVRNLQWAK AHELPESMCL 600
    KFQCGVHIQL GFAAEFSNVM IIYTSIVHKP PEIIMCDAYV TDFPLDLDID 650
    PKHANKGTPE ETGSYLVSKD LPKHCLYTRL SSLQKLKEHL IFTVCLSYQY 700
    SGLEDTVEEK QEVNVGKPLI AKLDMHRGLG RKTCFQACRM PDEPYHSSTS 750
    TSAGAGHFHS SQDSFHDVYH SHLGNADSGM PPDRCHCSRT PHTFISNYPP 800
    HHYCQFGRSN VPVETTDEMP FSFSDRLMIS EN 832
    Length:832
    Mass (Da):93,216
    Last modified:January 23, 2007 - v2
    Checksum:i891D59585A360D68
    GO
    Isoform 22 Publications (identifier: Q2TBA3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         318-328: Missing.

    Show »
    Length:821
    Mass (Da):92,025
    Checksum:iF1B9027E3EC5B6E6
    GO
    Isoform 31 Publication (identifier: Q2TBA3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-543: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:290
    Mass (Da):32,559
    Checksum:i031E49DB855C747A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti265 – 2651P → S in AAI10489. (PubMed:15489334)Curated
    Sequence conflicti576 – 5761P → H in AAI10488. (PubMed:15489334)Curated
    Sequence conflicti793 – 7931T → A in AAH46536. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2 – 543542Missing in isoform 3. 1 PublicationVSP_052278Add
    BLAST
    Alternative sequencei318 – 32811Missing in isoform 2. 2 PublicationsVSP_052279Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK041919 mRNA. Translation: BAC31096.1.
    AK049821 mRNA. Translation: BAC33935.1.
    AK085071 mRNA. Translation: BAC39355.1.
    BC046536 mRNA. Translation: AAH46536.1.
    BC110487 mRNA. Translation: AAI10488.1.
    BC110488 mRNA. Translation: AAI10489.1.
    CCDSiCCDS29306.1. [Q2TBA3-2]
    RefSeqiNP_766421.1. NM_172833.2. [Q2TBA3-2]
    XP_006526000.1. XM_006525937.1. [Q2TBA3-1]
    UniGeneiMm.132613.

    Genome annotation databases

    EnsembliENSMUST00000049248; ENSMUSP00000048376; ENSMUSG00000032688. [Q2TBA3-2]
    GeneIDi240354.
    KEGGimmu:240354.
    UCSCiuc008fez.1. mouse. [Q2TBA3-2]
    uc008ffa.1. mouse. [Q2TBA3-1]
    uc008ffb.1. mouse. [Q2TBA3-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK041919 mRNA. Translation: BAC31096.1 .
    AK049821 mRNA. Translation: BAC33935.1 .
    AK085071 mRNA. Translation: BAC39355.1 .
    BC046536 mRNA. Translation: AAH46536.1 .
    BC110487 mRNA. Translation: AAI10488.1 .
    BC110488 mRNA. Translation: AAI10489.1 .
    CCDSi CCDS29306.1. [Q2TBA3-2 ]
    RefSeqi NP_766421.1. NM_172833.2. [Q2TBA3-2 ]
    XP_006526000.1. XM_006525937.1. [Q2TBA3-1 ]
    UniGenei Mm.132613.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3V4L X-ray 3.15 A 338-729 [» ]
    ProteinModelPortali Q2TBA3.
    SMRi Q2TBA3. Positions 48-130, 134-729.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 232195. 6 interactions.
    DIPi DIP-60308N.

    Protein family/group databases

    MEROPSi C14.026.

    PTM databases

    PhosphoSitei Q2TBA3.

    Proteomic databases

    MaxQBi Q2TBA3.
    PaxDbi Q2TBA3.
    PRIDEi Q2TBA3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049248 ; ENSMUSP00000048376 ; ENSMUSG00000032688 . [Q2TBA3-2 ]
    GeneIDi 240354.
    KEGGi mmu:240354.
    UCSCi uc008fez.1. mouse. [Q2TBA3-2 ]
    uc008ffa.1. mouse. [Q2TBA3-1 ]
    uc008ffb.1. mouse. [Q2TBA3-3 ]

    Organism-specific databases

    CTDi 10892.
    MGIi MGI:2445027. Malt1.

    Phylogenomic databases

    eggNOGi COG4249.
    GeneTreei ENSGT00390000018044.
    HOGENOMi HOG000113471.
    HOVERGENi HBG052402.
    InParanoidi Q2TBA3.
    KOi K07369.
    OMAi MNKEIPN.
    OrthoDBi EOG7673BH.
    PhylomeDBi Q2TBA3.
    TreeFami TF319744.

    Enzyme and pathway databases

    Reactomei REACT_199121. Activation of NF-kappaB in B cells.
    REACT_205561. FCERI mediated NF-kB activation.
    REACT_225145. Downstream TCR signaling.

    Miscellaneous databases

    NextBioi 384566.
    PROi Q2TBA3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q2TBA3.
    Genevestigatori Q2TBA3.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    2.60.40.10. 2 hits.
    3.40.50.1460. 1 hit.
    InterProi IPR029030. Caspase-like_dom.
    IPR011029. DEATH-like_dom.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003598. Ig_sub2.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    [Graphical view ]
    Pfami PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    SMARTi SM00408. IGc2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50208. CASPASE_P20. 1 hit.
    PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6JImported.
      Tissue: HippocampusImported, LungImported and ThymusImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Strain: Czech IIImported.
      Tissue: Mammary glandImported.

    Entry informationi

    Entry nameiMALT1_MOUSE
    AccessioniPrimary (citable) accession number: Q2TBA3
    Secondary accession number(s): Q2TBA2
    , Q811E3, Q8BFT0, Q8C7N9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3