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Protein

Protein asteroid homolog 1

Gene

ASTE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in EGF receptor signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein asteroid homolog 1
Gene namesi
Name:ASTE1
ORF Names:HT001
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25021. ASTE1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672577.

Polymorphism and mutation databases

BioMutaiASTE1.
DMDMi121941802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 679679Protein asteroid homolog 1PRO_0000310458Add
BLAST

Proteomic databases

EPDiQ2TB18.
MaxQBiQ2TB18.
PaxDbiQ2TB18.
PRIDEiQ2TB18.

Expressioni

Gene expression databases

BgeeiQ2TB18.
CleanExiHS_ASTE1.
ExpressionAtlasiQ2TB18. baseline and differential.
GenevisibleiQ2TB18. HS.

Organism-specific databases

HPAiHPA037010.
HPA037011.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
XRCC4Q134263EBI-2875586,EBI-717592

Protein-protein interaction databases

BioGridi118811. 18 interactions.
IntActiQ2TB18. 15 interactions.
STRINGi9606.ENSP00000264992.

Structurei

3D structure databases

ProteinModelPortaliQ2TB18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the asteroid family.Curated

Phylogenomic databases

eggNOGiENOG410IFPJ. Eukaryota.
ENOG4111F5P. LUCA.
GeneTreeiENSGT00390000010145.
HOGENOMiHOG000034110.
HOVERGENiHBG103560.
InParanoidiQ2TB18.
PhylomeDBiQ2TB18.
TreeFamiTF324582.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR026832. Asteroid.
IPR029060. PIN_domain-like.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PANTHERiPTHR15665. PTHR15665. 1 hit.
PfamiPF00752. XPG_N. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2TB18-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGIRGLMSFV EDHSNEFFTD LKLRDTKIVI DGYALFHRLC FSSNLDLRYG
60 70 80 90 100
GDYDSFADVV QKFFESLFAC NICPYVVLDG GCDISDKKLT TLKDRAREKI
110 120 130 140 150
QMAHSLSVGG SGYVCPLLIR EVFIQVLIKL RVCFVQCFSE ADRDIMTLAN
160 170 180 190 200
HWNCPVLSSD SDFCIFDLKT GFCPLNSFQW RNMNTIKGTQ NYIPAKCFSL
210 220 230 240 250
DAFCHHFSNM NKALLPLFAV LCGNDHVNLP IMETFLSKAR LPLGATSSKG
260 270 280 290 300
RRHHRILGLL NWLSHFANPT EALDNVLKYL PKKDRENVKE LLCCSMEEYQ
310 320 330 340 350
QSQVKLQDFF QCGTYVCPDA LNLGLPEWVL VALAKGQLSP FISDALVLRR
360 370 380 390 400
TILPTQVENM QQPNAHRISQ PIRQIIYGLL LNASPHLDKT SWNALPPQPL
410 420 430 440 450
AFSEVERINK NIRTSIIDAV ELAKDHSDLS RLTELSLRRR QMLLLETLKV
460 470 480 490 500
KQTILEPIPT SLKLPIAVSC YWLQHTETKA KLHHLQSLLL TMLVGPLIAI
510 520 530 540 550
INSPGKEELQ EDGAKMLYAE FQRVKAQTRL GTRLDLDTAH IFCQWQSCLQ
560 570 580 590 600
MGMYLNQLLS TPLPEPDLTR LYSGSLVHGL CQQLLASTSV ESLLSICPEA
610 620 630 640 650
KQLYEYLFNA TRSYAPAEIF LPKGRSNSKK KRQKKQNTSC SKNRGRTTAH
660 670
TKCWYEGNNR FGLLMVENLE EHSEASNIE
Length:679
Mass (Da):77,093
Last modified:January 24, 2006 - v1
Checksum:i488DE83A8CD8E82B
GO
Isoform 2 (identifier: Q2TB18-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-520: KEELQEDGAKMLYAE → NVDPVPRQAQCLAPR
     521-679: Missing.

Note: No experimental confirmation available.
Show »
Length:520
Mass (Da):58,874
Checksum:i7BCB73B4A4019808
GO

Sequence cautioni

The sequence AAF14876.1 differs from that shown. Reason: Frameshift at position 336. Curated
The sequence AAH30274.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI03710.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti303 – 3031Q → P in AAF14876 (PubMed:10931946).Curated
Sequence conflicti312 – 3143CGT → YGS in AAF14876 (PubMed:10931946).Curated
Sequence conflicti318 – 3181P → T in AAF14876 (PubMed:10931946).Curated
Sequence conflicti321 – 3222LN → SD in AAF14876 (PubMed:10931946).Curated
Sequence conflicti331 – 3311V → G in AAF14876 (PubMed:10931946).Curated
Sequence conflicti337 – 3393QLS → RVP in AAF14876 (PubMed:10931946).Curated
Sequence conflicti352 – 3543ILP → FLH in AAF14876 (PubMed:10931946).Curated
Sequence conflicti362 – 3621Q → R in AAF14876 (PubMed:10931946).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei506 – 52015KEELQ…MLYAE → NVDPVPRQAQCLAPR in isoform 2. 1 PublicationVSP_056699Add
BLAST
Alternative sequencei521 – 679159Missing in isoform 2. 1 PublicationVSP_056700Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027806 mRNA. Translation: BAB55383.1.
AK294156 mRNA. Translation: BAG57480.1.
AC055733 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79215.1.
BC030274 mRNA. Translation: AAH30274.2. Different initiation.
BC103709 mRNA. Translation: AAI03710.1. Different initiation.
BC110616 mRNA. Translation: AAI10617.1.
AF113539 mRNA. Translation: AAF14876.1. Frameshift.
CCDSiCCDS3068.1. [Q2TB18-1]
RefSeqiNP_001275879.1. NM_001288950.1.
NP_054784.2. NM_014065.3. [Q2TB18-1]
UniGeneiHs.100878.

Genome annotation databases

EnsembliENST00000264992; ENSP00000264992; ENSG00000034533. [Q2TB18-1]
ENST00000507978; ENSP00000421019; ENSG00000034533. [Q2TB18-2]
GeneIDi28990.
KEGGihsa:28990.
UCSCiuc003env.3. human. [Q2TB18-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027806 mRNA. Translation: BAB55383.1.
AK294156 mRNA. Translation: BAG57480.1.
AC055733 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79215.1.
BC030274 mRNA. Translation: AAH30274.2. Different initiation.
BC103709 mRNA. Translation: AAI03710.1. Different initiation.
BC110616 mRNA. Translation: AAI10617.1.
AF113539 mRNA. Translation: AAF14876.1. Frameshift.
CCDSiCCDS3068.1. [Q2TB18-1]
RefSeqiNP_001275879.1. NM_001288950.1.
NP_054784.2. NM_014065.3. [Q2TB18-1]
UniGeneiHs.100878.

3D structure databases

ProteinModelPortaliQ2TB18.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118811. 18 interactions.
IntActiQ2TB18. 15 interactions.
STRINGi9606.ENSP00000264992.

Polymorphism and mutation databases

BioMutaiASTE1.
DMDMi121941802.

Proteomic databases

EPDiQ2TB18.
MaxQBiQ2TB18.
PaxDbiQ2TB18.
PRIDEiQ2TB18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264992; ENSP00000264992; ENSG00000034533. [Q2TB18-1]
ENST00000507978; ENSP00000421019; ENSG00000034533. [Q2TB18-2]
GeneIDi28990.
KEGGihsa:28990.
UCSCiuc003env.3. human. [Q2TB18-1]

Organism-specific databases

CTDi28990.
GeneCardsiASTE1.
HGNCiHGNC:25021. ASTE1.
HPAiHPA037010.
HPA037011.
neXtProtiNX_Q2TB18.
PharmGKBiPA142672577.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFPJ. Eukaryota.
ENOG4111F5P. LUCA.
GeneTreeiENSGT00390000010145.
HOGENOMiHOG000034110.
HOVERGENiHBG103560.
InParanoidiQ2TB18.
PhylomeDBiQ2TB18.
TreeFamiTF324582.

Miscellaneous databases

GenomeRNAii28990.
NextBioi35471526.
PROiQ2TB18.

Gene expression databases

BgeeiQ2TB18.
CleanExiHS_ASTE1.
ExpressionAtlasiQ2TB18. baseline and differential.
GenevisibleiQ2TB18. HS.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR026832. Asteroid.
IPR029060. PIN_domain-like.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PANTHERiPTHR15665. PTHR15665. 1 hit.
PfamiPF00752. XPG_N. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-626 (ISOFORM 1).
    Tissue: Brain cortex and Placenta.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Skin.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 285-679 (ISOFORM 1).
    Tissue: Hypothalamus.

Entry informationi

Entry nameiASTE1_HUMAN
AccessioniPrimary (citable) accession number: Q2TB18
Secondary accession number(s): B4DFL9
, Q3MIB6, Q8N6G4, Q96JY1, Q9UHX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 24, 2006
Last modified: April 13, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.