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Protein

Zinc finger protein 800

Gene

ZNF800

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri69 – 91C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 253C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri287 – 310C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri357 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri486 – 508C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 542C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri618 – 640C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 800
Gene namesi
Name:ZNF800
ORF Names:PP902
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000048405.9
HGNCiHGNC:27267 ZNF800
neXtProtiNX_Q2TB10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000048405
PharmGKBiPA162410582

Polymorphism and mutation databases

BioMutaiZNF800
DMDMi121941799

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003044101 – 664Zinc finger protein 800Add BLAST664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki132Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki279Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei317PhosphoserineCombined sources1
Modified residuei319PhosphothreonineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Cross-linki392Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki409Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki409Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei422PhosphoserineBy similarity1
Modified residuei426PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei460PhosphoserineBy similarity1
Modified residuei462PhosphoserineBy similarity1
Cross-linki476Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki599Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ2TB10
MaxQBiQ2TB10
PaxDbiQ2TB10
PeptideAtlasiQ2TB10
PRIDEiQ2TB10

PTM databases

iPTMnetiQ2TB10
PhosphoSitePlusiQ2TB10

Expressioni

Gene expression databases

BgeeiENSG00000048405
CleanExiHS_ZNF800
ExpressionAtlasiQ2TB10 baseline and differential
GenevisibleiQ2TB10 HS

Organism-specific databases

HPAiHPA023090
HPA052194

Interactioni

Protein-protein interaction databases

BioGridi127973, 18 interactors
IntActiQ2TB10, 4 interactors
STRINGi9606.ENSP00000265827

Structurei

3D structure databases

ProteinModelPortaliQ2TB10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 15Poly-His4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri69 – 91C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 253C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri287 – 310C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri357 – 382C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri486 – 508C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 542C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri618 – 640C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00390000008140
HOGENOMiHOG000168334
HOVERGENiHBG106061
InParanoidiQ2TB10
OMAiRDKCCQT
OrthoDBiEOG091G07JP
PhylomeDBiQ2TB10
TreeFamiTF333197

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q2TB10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLRDKYCQT DHHHHGCCEP VYILEPGDPP LLQQPLQTSK SGIQQIIECF
60 70 80 90 100
RSGTKQLKHI LLKDVDTIFE CKLCRSLFRG LPNLITHKKF YCPPSLQMDD
110 120 130 140 150
NLPDVNDKQS QAINDLLEAI YPSVDKREYI IKLEPIETNQ NAVFQYISRT
160 170 180 190 200
DNPIEVTESS STPEQTEVQI QETSTEQSKT VPVTDTEVET VEPPPVEIVT
210 220 230 240 250
DEVAPTSDEQ PQESQADLET SDNSDFGHQL ICCLCRKEFN SRRGVRRHIR
260 270 280 290 300
KVHKKKMEEL KKYIETRKNP NQSSKGRSKN VLVPLSRSCP VCCKSFATKA
310 320 330 340 350
NVRRHFDEVH RGLRRDSITP DIATKPGQPL FLDSISPKKS FKTRKQKSSS
360 370 380 390 400
KAEYNLTACK CLLCKRKYSS QIMLKRHMQI VHKITLSGTN SKREKGPNNT
410 420 430 440 450
ANSSEIKVKV EPADSVESSP PSITHSPQNE LKGTNHSNEK KNTPAAQKNK
460 470 480 490 500
VKQDSESPKS TSPSAAGGQQ KTRKPKLSAG FDFKQLYCKL CKRQFTSKQN
510 520 530 540 550
LTKHIELHTD GNNIYVKFYK CPLCTYETRR KRDVIRHITV VHKKSSRYLG
560 570 580 590 600
KITASLEIRA IKKPIDFVLN KVAKRGPSRD EAKHSDSKHD GTSNSPSKKY
610 620 630 640 650
EVADVGIEVK VTKNFSLHRC NKCGKAFAKK TYLEHHKKTH KANASNSPEG
660
NKTKGRSTRS KALV
Length:664
Mass (Da):75,236
Last modified:January 24, 2006 - v1
Checksum:iF0F0DA1214AC6F2E
GO

Sequence cautioni

The sequence AAG17274 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAG17274 differs from that shown. Reason: Frameshift at position 335.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052904102L → V. Corresponds to variant dbSNP:rs17865569Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471070 Genomic DNA Translation: EAW83626.1
BC110623 mRNA Translation: AAI10624.1
BC110624 mRNA Translation: AAI10625.1
AF218032 mRNA Translation: AAG17274.1 Sequence problems.
CCDSiCCDS5795.1
RefSeqiNP_789784.2, NM_176814.4
XP_005250238.1, XM_005250181.3
UniGeneiHs.159006
Hs.667035

Genome annotation databases

EnsembliENST00000265827; ENSP00000265827; ENSG00000048405
ENST00000393312; ENSP00000376988; ENSG00000048405
ENST00000393313; ENSP00000376989; ENSG00000048405
GeneIDi168850
KEGGihsa:168850
UCSCiuc003vly.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN800_HUMAN
AccessioniPrimary (citable) accession number: Q2TB10
Secondary accession number(s): Q9HBN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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