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Q2TAZ0

- ATG2A_HUMAN

UniProt

Q2TAZ0 - ATG2A_HUMAN

Protein

Autophagy-related protein 2 homolog A

Gene

ATG2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. autophagic vacuole assembly Source: RefGenome
    2. cellular response to nitrogen starvation Source: RefGenome
    3. mitochondrion degradation Source: RefGenome
    4. nucleophagy Source: RefGenome

    Keywords - Biological processi

    Autophagy

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy-related protein 2 homolog A
    Gene namesi
    Name:ATG2A
    Synonyms:KIAA0404
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:29028. ATG2A.

    Subcellular locationi

    GO - Cellular componenti

    1. extrinsic component of membrane Source: RefGenome
    2. lipid particle Source: UniProtKB-SubCell
    3. pre-autophagosomal structure Source: RefGenome
    4. pre-autophagosomal structure membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lipid droplet, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162377101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19381938Autophagy-related protein 2 homolog APRO_0000315234Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei892 – 8921PhosphoserineBy similarity
    Modified residuei894 – 8941PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ2TAZ0.
    PaxDbiQ2TAZ0.
    PRIDEiQ2TAZ0.

    PTM databases

    PhosphoSiteiQ2TAZ0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ2TAZ0.
    BgeeiQ2TAZ0.
    CleanExiHS_ATG2A.
    GenevestigatoriQ2TAZ0.

    Organism-specific databases

    HPAiHPA038715.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GABARAPO951662EBI-2514077,EBI-712001
    GABARAPL1Q9H0R83EBI-2514077,EBI-746969
    GABARAPL2P605202EBI-2514077,EBI-720116
    MAP1LC3BQ9GZQ82EBI-2514077,EBI-373144

    Protein-protein interaction databases

    BioGridi116748. 13 interactions.
    IntActiQ2TAZ0. 16 interactions.
    STRINGi9606.ENSP00000366475.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2TAZ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATG2 family.Curated

    Phylogenomic databases

    eggNOGiNOG304940.
    HOVERGENiHBG079553.
    InParanoidiQ2TAZ0.
    KOiK17906.
    OMAiNDLLMWE.
    PhylomeDBiQ2TAZ0.
    TreeFamiTF313482.

    Family and domain databases

    InterProiIPR026849. ATG2.
    IPR015412. Autophagy-rel_C.
    IPR026854. VPS13A_N.
    [Graphical view]
    PANTHERiPTHR13190. PTHR13190. 1 hit.
    PfamiPF09333. ATG_C. 1 hit.
    PF12624. Chorein_N. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q2TAZ0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRWLWPWSN CVKERVCRYL LHHYLGHFFQ EHLSLDQLSL DLYKGSVALR     50
    DIHLEIWSVN EVLESMESPL ELVEGFVGSI EVAVPWAALL TDHCTVRVSG 100
    LQLTLQPRRG PAPGAADSQS WASCMTTSLQ LAQECLRDGL PEPSEPPQPL 150
    EGLEMFAQTI ETVLRRIKVT FLDTVVRVEH SPGDGERGVA VEVRVQRLEY 200
    CDEAVRDPSQ APPVDVHQPP AFLHKLLQLA GVRLHYEELP AQEEPPEPPL 250
    QIGSCSGYME LMVKLKQNEA FPGPKLEVAG QLGSLHLLLT PRQLQQLQEL 300
    LSAVSLTDHE GLADKLNKSR PLGAEDLWLI EQDLNQQLQA GAVAEPLSPD 350
    PLTNPLLNLD NTDLFFSMAG LTSSVASALS ELSLSDVDLA SSVRSDMASR 400
    RLSAQAHPAG KMAPNPLLDT MRPDSLLKMT LGGVTLTLLQ TSAPSSGPPD 450
    LATHFFTEFD ATKDGPFGSR DFHHLRPRFQ RACPCSHVRL TGTAVQLSWE 500
    LRTGSRGRRT TSMEVHFGQL EVLECLWPRG TSEPEYTEIL TFPGTLGSQA 550
    SARPCAHLRH TQILRRVPKS RPRRSVACHC HSELALDLAN FQADVELGAL 600
    DRLAALLRLA TVPAEPPAGL LTEPLPAMEQ QTVFRLSAPR ATLRLRFPIA 650
    DLRPEPDPWA GQAVRAEQLR LELSEPQFRS ELSSGPGPPV PTHLELTCSD 700
    LHGIYEDGGK PPVPCLRVSK ALDPKSTGRK YFLPQVVVTV NPQSSSTQWE 750
    VAPEKGEELE LSVESPCELR EPEPSPFSSK RTMYETEEMV IPGDPEEMRT 800
    FQSRTLALSR CSLEVILPSV HIFLPSKEVY ESIYNRINND LLMWEPADLL 850
    PTPDPAAQPS GFPGPSGFWH DSFKMCKSAF KLANCFDLTP DSDSDDEDAH 900
    FFSVGASGGP QAAAPEAPSL HLQSTFSTLV TVLKGRITAL CETKDEGGKR 950
    LEAVHGELVL DMEHGTLFSV SQYCGQPGLG YFCLEAEKAT LYHRAAVDDY 1000
    PLPSHLDLPS FAPPAQLAPT IYPSEEGVTE RGASGRKGQG RGPHMLSTAV 1050
    RIHLDPHKNV KEFLVTLRLH KATLRHYMAL PEQSWHSQLL EFLDVLDDPV 1100
    LGYLPPTVIT ILHTHLFSCS VDYRPLYLPV RVLITAETFT LSSNIIMDTS 1150
    TFLLRFILDD SALYLSDKCE VETLDLRRDY VCVLDVDLLE LVIKTWKGST 1200
    EGKLSQPLFE LRCSNNVVHV HSCADSCALL VNLLQYVMST GDLHPPPRPP 1250
    SPTEIAGQKL SESPASLPSC PPVETALINQ RDLADALLDT ERSLRELAQP 1300
    SGGHLPQASP ISVYLFPGER SGAPPPSPPV GGPAGSLGSC SEEKEDEREE 1350
    EGDGDTLDSD EFCILDAPGL GIPPRDGEPV VTQLHPGPIV VRDGYFSRPI 1400
    GSTDLLRAPA HFPVPSTRVV LREVSLVWHL YGGRDFGPHP GHRARTGLSG 1450
    PRSSPSRCSG PNRPQNSWRT QGGSGRQHHV LMEIQLSKVS FQHEVYPAEP 1500
    ATGPAAPSQE LEERPLSRQV FIVQELEVRD RLASSQINKF LYLHTSERMP 1550
    RRAHSNMLTI KALHVAPTTN LGGPECCLRV SLMPLRLNVD QDALFFLKDF 1600
    FTSLVAGINP VVPGETSAEA RPETRAQPSS PLEGQAEGVE TTGSQEAPGG 1650
    GHSPSPPDQQ PIYFREFRFT SEVPIWLDYH GKHVTMDQVG TFAGLLIGLA 1700
    QLNCSELKLK RLCCRHGLLG VDKVLGYALN EWLQDIRKNQ LPGLLGGVGP 1750
    MHSVVQLFQG FRDLLWLPIE QYRKDGRLMR GLQRGAASFG SSTASAALEL 1800
    SNRLVQAIQA TAETVYDILS PAAPVSRSLQ DKRSARRLRR GQQPADLREG 1850
    VAKAYDTVRE GILDTAQTIC DVASRGHEQK GLTGAVGGVI RQLPPTVVKP 1900
    LILATEATSS LLGGMRNQIV PDAHKDHALK WRSDSAQD 1938
    Length:1,938
    Mass (Da):212,860
    Last modified:May 18, 2010 - v3
    Checksum:iB0072E075E305A33
    GO
    Isoform 2 (identifier: Q2TAZ0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1259-1259: K → KVQ

    Note: No experimental confirmation available.

    Show »
    Length:1,940
    Mass (Da):213,087
    Checksum:i7236DF3A60D98208
    GO
    Isoform 3 (identifier: Q2TAZ0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1607: Missing.
         1608-1724: INPVVPGETS...RHGLLGVDKV → MAVAMVKLCE...SSARGCRLTE

    Note: No experimental confirmation available.

    Show »
    Length:331
    Mass (Da):35,255
    Checksum:iA6DFB099A5053B97
    GO
    Isoform 4 (identifier: Q2TAZ0-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         58-121: SVNEVLESME...APGAADSQSW → VRSQARVQEV...AHLAAPPGSR
         122-1938: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:121
    Mass (Da):13,576
    Checksum:i40E9AF595AA38556
    GO

    Sequence cautioni

    The sequence BAA23700.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1286 – 12861A → S in AAI10651. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti175 – 1751V → I.
    Corresponds to variant rs12293826 [ dbSNP | Ensembl ].
    VAR_038158
    Natural varianti394 – 3941R → C.
    Corresponds to variant rs35115827 [ dbSNP | Ensembl ].
    VAR_061027
    Natural varianti404 – 4041A → V.
    Corresponds to variant rs60711419 [ dbSNP | Ensembl ].
    VAR_061028
    Natural varianti627 – 6271A → V.
    Corresponds to variant rs2285347 [ dbSNP | Ensembl ].
    VAR_038159
    Natural varianti656 – 6561P → R.2 Publications
    Corresponds to variant rs656195 [ dbSNP | Ensembl ].
    VAR_061029
    Natural varianti948 – 9481G → R.
    Corresponds to variant rs11827140 [ dbSNP | Ensembl ].
    VAR_038160

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 16071607Missing in isoform 3. 1 PublicationVSP_030510Add
    BLAST
    Alternative sequencei58 – 12164SVNEV…DSQSW → VRSQARVQEVCERGAGVNGV TAGAGGRLRGLHRGGRALGC SAHRPLHSARVRPPAHLAAP PGSR in isoform 4. 1 PublicationVSP_030511Add
    BLAST
    Alternative sequencei122 – 19381817Missing in isoform 4. 1 PublicationVSP_030512Add
    BLAST
    Alternative sequencei1259 – 12591K → KVQ in isoform 2. 1 PublicationVSP_030515
    Alternative sequencei1608 – 1724117INPVV…GVDKV → MAVAMVKLCERAGLPLLAAP LLRSLLPRAPQPGPAQPRSV QGQRCPARHPPGNLVCERGA GVNGVTAGAGGRLRGLHRGG RALGCSAHRPLHSARVRPPA HLAAPPGSSARGCRLTE in isoform 3. 1 PublicationVSP_030516Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB007864 mRNA. Translation: BAA23700.1. Different initiation.
    AK126181 mRNA. Translation: BAC86477.1.
    AP001187 Genomic DNA. No translation available.
    BC008593 mRNA. Translation: AAH08593.1.
    BC027481 mRNA. Translation: AAH27481.1.
    BC053596 mRNA. Translation: AAH53596.1.
    BC110650 mRNA. Translation: AAI10651.1.
    BC113091 mRNA. Translation: AAI13092.1.
    CCDSiCCDS31602.1. [Q2TAZ0-1]
    PIRiT00051.
    RefSeqiNP_055919.2. NM_015104.2. [Q2TAZ0-1]
    UniGeneiHs.370671.

    Genome annotation databases

    EnsembliENST00000377264; ENSP00000366475; ENSG00000110046. [Q2TAZ0-1]
    ENST00000421419; ENSP00000410522; ENSG00000110046. [Q2TAZ0-3]
    GeneIDi23130.
    KEGGihsa:23130.
    UCSCiuc001obx.3. human. [Q2TAZ0-1]

    Polymorphism databases

    DMDMi296439433.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB007864 mRNA. Translation: BAA23700.1 . Different initiation.
    AK126181 mRNA. Translation: BAC86477.1 .
    AP001187 Genomic DNA. No translation available.
    BC008593 mRNA. Translation: AAH08593.1 .
    BC027481 mRNA. Translation: AAH27481.1 .
    BC053596 mRNA. Translation: AAH53596.1 .
    BC110650 mRNA. Translation: AAI10651.1 .
    BC113091 mRNA. Translation: AAI13092.1 .
    CCDSi CCDS31602.1. [Q2TAZ0-1 ]
    PIRi T00051.
    RefSeqi NP_055919.2. NM_015104.2. [Q2TAZ0-1 ]
    UniGenei Hs.370671.

    3D structure databases

    ProteinModelPortali Q2TAZ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116748. 13 interactions.
    IntActi Q2TAZ0. 16 interactions.
    STRINGi 9606.ENSP00000366475.

    PTM databases

    PhosphoSitei Q2TAZ0.

    Polymorphism databases

    DMDMi 296439433.

    Proteomic databases

    MaxQBi Q2TAZ0.
    PaxDbi Q2TAZ0.
    PRIDEi Q2TAZ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377264 ; ENSP00000366475 ; ENSG00000110046 . [Q2TAZ0-1 ]
    ENST00000421419 ; ENSP00000410522 ; ENSG00000110046 . [Q2TAZ0-3 ]
    GeneIDi 23130.
    KEGGi hsa:23130.
    UCSCi uc001obx.3. human. [Q2TAZ0-1 ]

    Organism-specific databases

    CTDi 23130.
    GeneCardsi GC11M064662.
    H-InvDB HIX0009774.
    HGNCi HGNC:29028. ATG2A.
    HPAi HPA038715.
    neXtProti NX_Q2TAZ0.
    PharmGKBi PA162377101.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304940.
    HOVERGENi HBG079553.
    InParanoidi Q2TAZ0.
    KOi K17906.
    OMAi NDLLMWE.
    PhylomeDBi Q2TAZ0.
    TreeFami TF313482.

    Miscellaneous databases

    ChiTaRSi ATG2A. human.
    GenomeRNAii 23130.
    NextBioi 44375.
    PROi Q2TAZ0.

    Gene expression databases

    ArrayExpressi Q2TAZ0.
    Bgeei Q2TAZ0.
    CleanExi HS_ATG2A.
    Genevestigatori Q2TAZ0.

    Family and domain databases

    InterProi IPR026849. ATG2.
    IPR015412. Autophagy-rel_C.
    IPR026854. VPS13A_N.
    [Graphical view ]
    PANTHERi PTHR13190. PTHR13190. 1 hit.
    Pfami PF09333. ATG_C. 1 hit.
    PF12624. Chorein_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
      Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-656.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Thymus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1189-1938 (ISOFORM 2), VARIANT ARG-656.
      Tissue: Cervix, Hippocampus and Skin.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Delta strain."
      Romanyuk D., Polak A., Maleszewska A., Sienko M., Grynberg M., Zoladek T.
      Acta Biochim. Pol. 58:365-374(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. "Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets."
      Velikkakath A.K., Nishimura T., Oita E., Ishihara N., Mizushima N.
      Mol. Biol. Cell 23:896-909(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiATG2A_HUMAN
    AccessioniPrimary (citable) accession number: Q2TAZ0
    Secondary accession number(s): O43154
    , Q14DM2, Q6ZTV2, Q7Z6K8, Q8IVY5, Q8TAI8, Q96HH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 73 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3