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Q2TAZ0

- ATG2A_HUMAN

UniProt

Q2TAZ0 - ATG2A_HUMAN

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Protein

Autophagy-related protein 2 homolog A

Gene

ATG2A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.1 Publication

GO - Biological processi

  1. autophagic vacuole assembly Source: RefGenome
  2. cellular response to nitrogen starvation Source: RefGenome
  3. mitochondrion degradation Source: RefGenome
  4. nucleophagy Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 2 homolog A
Gene namesi
Name:ATG2A
Synonyms:KIAA0404
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:29028. ATG2A.

Subcellular locationi

GO - Cellular componenti

  1. extrinsic component of membrane Source: RefGenome
  2. lipid particle Source: UniProtKB-KW
  3. pre-autophagosomal structure Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19381938Autophagy-related protein 2 homolog APRO_0000315234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei892 – 8921PhosphoserineBy similarity
Modified residuei894 – 8941PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ2TAZ0.
PaxDbiQ2TAZ0.
PRIDEiQ2TAZ0.

PTM databases

PhosphoSiteiQ2TAZ0.

Expressioni

Gene expression databases

BgeeiQ2TAZ0.
CleanExiHS_ATG2A.
ExpressionAtlasiQ2TAZ0. baseline and differential.
GenevestigatoriQ2TAZ0.

Organism-specific databases

HPAiHPA038715.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951662EBI-2514077,EBI-712001
GABARAPL1Q9H0R83EBI-2514077,EBI-746969
GABARAPL2P605202EBI-2514077,EBI-720116
MAP1LC3BQ9GZQ82EBI-2514077,EBI-373144

Protein-protein interaction databases

BioGridi116748. 13 interactions.
IntActiQ2TAZ0. 16 interactions.
STRINGi9606.ENSP00000366475.

Structurei

3D structure databases

ProteinModelPortaliQ2TAZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG2 family.Curated

Phylogenomic databases

eggNOGiNOG304940.
GeneTreeiENSGT00620000087966.
HOVERGENiHBG079553.
InParanoidiQ2TAZ0.
KOiK17906.
OMAiNDLLMWE.
PhylomeDBiQ2TAZ0.
TreeFamiTF313482.

Family and domain databases

InterProiIPR026849. ATG2.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13A_N.
[Graphical view]
PANTHERiPTHR13190. PTHR13190. 1 hit.
PfamiPF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2TAZ0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRWLWPWSN CVKERVCRYL LHHYLGHFFQ EHLSLDQLSL DLYKGSVALR
60 70 80 90 100
DIHLEIWSVN EVLESMESPL ELVEGFVGSI EVAVPWAALL TDHCTVRVSG
110 120 130 140 150
LQLTLQPRRG PAPGAADSQS WASCMTTSLQ LAQECLRDGL PEPSEPPQPL
160 170 180 190 200
EGLEMFAQTI ETVLRRIKVT FLDTVVRVEH SPGDGERGVA VEVRVQRLEY
210 220 230 240 250
CDEAVRDPSQ APPVDVHQPP AFLHKLLQLA GVRLHYEELP AQEEPPEPPL
260 270 280 290 300
QIGSCSGYME LMVKLKQNEA FPGPKLEVAG QLGSLHLLLT PRQLQQLQEL
310 320 330 340 350
LSAVSLTDHE GLADKLNKSR PLGAEDLWLI EQDLNQQLQA GAVAEPLSPD
360 370 380 390 400
PLTNPLLNLD NTDLFFSMAG LTSSVASALS ELSLSDVDLA SSVRSDMASR
410 420 430 440 450
RLSAQAHPAG KMAPNPLLDT MRPDSLLKMT LGGVTLTLLQ TSAPSSGPPD
460 470 480 490 500
LATHFFTEFD ATKDGPFGSR DFHHLRPRFQ RACPCSHVRL TGTAVQLSWE
510 520 530 540 550
LRTGSRGRRT TSMEVHFGQL EVLECLWPRG TSEPEYTEIL TFPGTLGSQA
560 570 580 590 600
SARPCAHLRH TQILRRVPKS RPRRSVACHC HSELALDLAN FQADVELGAL
610 620 630 640 650
DRLAALLRLA TVPAEPPAGL LTEPLPAMEQ QTVFRLSAPR ATLRLRFPIA
660 670 680 690 700
DLRPEPDPWA GQAVRAEQLR LELSEPQFRS ELSSGPGPPV PTHLELTCSD
710 720 730 740 750
LHGIYEDGGK PPVPCLRVSK ALDPKSTGRK YFLPQVVVTV NPQSSSTQWE
760 770 780 790 800
VAPEKGEELE LSVESPCELR EPEPSPFSSK RTMYETEEMV IPGDPEEMRT
810 820 830 840 850
FQSRTLALSR CSLEVILPSV HIFLPSKEVY ESIYNRINND LLMWEPADLL
860 870 880 890 900
PTPDPAAQPS GFPGPSGFWH DSFKMCKSAF KLANCFDLTP DSDSDDEDAH
910 920 930 940 950
FFSVGASGGP QAAAPEAPSL HLQSTFSTLV TVLKGRITAL CETKDEGGKR
960 970 980 990 1000
LEAVHGELVL DMEHGTLFSV SQYCGQPGLG YFCLEAEKAT LYHRAAVDDY
1010 1020 1030 1040 1050
PLPSHLDLPS FAPPAQLAPT IYPSEEGVTE RGASGRKGQG RGPHMLSTAV
1060 1070 1080 1090 1100
RIHLDPHKNV KEFLVTLRLH KATLRHYMAL PEQSWHSQLL EFLDVLDDPV
1110 1120 1130 1140 1150
LGYLPPTVIT ILHTHLFSCS VDYRPLYLPV RVLITAETFT LSSNIIMDTS
1160 1170 1180 1190 1200
TFLLRFILDD SALYLSDKCE VETLDLRRDY VCVLDVDLLE LVIKTWKGST
1210 1220 1230 1240 1250
EGKLSQPLFE LRCSNNVVHV HSCADSCALL VNLLQYVMST GDLHPPPRPP
1260 1270 1280 1290 1300
SPTEIAGQKL SESPASLPSC PPVETALINQ RDLADALLDT ERSLRELAQP
1310 1320 1330 1340 1350
SGGHLPQASP ISVYLFPGER SGAPPPSPPV GGPAGSLGSC SEEKEDEREE
1360 1370 1380 1390 1400
EGDGDTLDSD EFCILDAPGL GIPPRDGEPV VTQLHPGPIV VRDGYFSRPI
1410 1420 1430 1440 1450
GSTDLLRAPA HFPVPSTRVV LREVSLVWHL YGGRDFGPHP GHRARTGLSG
1460 1470 1480 1490 1500
PRSSPSRCSG PNRPQNSWRT QGGSGRQHHV LMEIQLSKVS FQHEVYPAEP
1510 1520 1530 1540 1550
ATGPAAPSQE LEERPLSRQV FIVQELEVRD RLASSQINKF LYLHTSERMP
1560 1570 1580 1590 1600
RRAHSNMLTI KALHVAPTTN LGGPECCLRV SLMPLRLNVD QDALFFLKDF
1610 1620 1630 1640 1650
FTSLVAGINP VVPGETSAEA RPETRAQPSS PLEGQAEGVE TTGSQEAPGG
1660 1670 1680 1690 1700
GHSPSPPDQQ PIYFREFRFT SEVPIWLDYH GKHVTMDQVG TFAGLLIGLA
1710 1720 1730 1740 1750
QLNCSELKLK RLCCRHGLLG VDKVLGYALN EWLQDIRKNQ LPGLLGGVGP
1760 1770 1780 1790 1800
MHSVVQLFQG FRDLLWLPIE QYRKDGRLMR GLQRGAASFG SSTASAALEL
1810 1820 1830 1840 1850
SNRLVQAIQA TAETVYDILS PAAPVSRSLQ DKRSARRLRR GQQPADLREG
1860 1870 1880 1890 1900
VAKAYDTVRE GILDTAQTIC DVASRGHEQK GLTGAVGGVI RQLPPTVVKP
1910 1920 1930
LILATEATSS LLGGMRNQIV PDAHKDHALK WRSDSAQD
Length:1,938
Mass (Da):212,860
Last modified:May 18, 2010 - v3
Checksum:iB0072E075E305A33
GO
Isoform 2 (identifier: Q2TAZ0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1259-1259: K → KVQ

Note: No experimental confirmation available.

Show »
Length:1,940
Mass (Da):213,087
Checksum:i7236DF3A60D98208
GO
Isoform 3 (identifier: Q2TAZ0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1607: Missing.
     1608-1724: INPVVPGETS...RHGLLGVDKV → MAVAMVKLCE...SSARGCRLTE

Note: No experimental confirmation available.

Show »
Length:331
Mass (Da):35,255
Checksum:iA6DFB099A5053B97
GO
Isoform 4 (identifier: Q2TAZ0-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-121: SVNEVLESME...APGAADSQSW → VRSQARVQEV...AHLAAPPGSR
     122-1938: Missing.

Note: No experimental confirmation available.

Show »
Length:121
Mass (Da):13,576
Checksum:i40E9AF595AA38556
GO

Sequence cautioni

The sequence BAA23700.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1286 – 12861A → S in AAI10651. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti175 – 1751V → I.
Corresponds to variant rs12293826 [ dbSNP | Ensembl ].
VAR_038158
Natural varianti394 – 3941R → C.
Corresponds to variant rs35115827 [ dbSNP | Ensembl ].
VAR_061027
Natural varianti404 – 4041A → V.
Corresponds to variant rs60711419 [ dbSNP | Ensembl ].
VAR_061028
Natural varianti627 – 6271A → V.
Corresponds to variant rs2285347 [ dbSNP | Ensembl ].
VAR_038159
Natural varianti656 – 6561P → R.2 Publications
Corresponds to variant rs656195 [ dbSNP | Ensembl ].
VAR_061029
Natural varianti948 – 9481G → R.
Corresponds to variant rs11827140 [ dbSNP | Ensembl ].
VAR_038160

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 16071607Missing in isoform 3. 1 PublicationVSP_030510Add
BLAST
Alternative sequencei58 – 12164SVNEV…DSQSW → VRSQARVQEVCERGAGVNGV TAGAGGRLRGLHRGGRALGC SAHRPLHSARVRPPAHLAAP PGSR in isoform 4. 1 PublicationVSP_030511Add
BLAST
Alternative sequencei122 – 19381817Missing in isoform 4. 1 PublicationVSP_030512Add
BLAST
Alternative sequencei1259 – 12591K → KVQ in isoform 2. 1 PublicationVSP_030515
Alternative sequencei1608 – 1724117INPVV…GVDKV → MAVAMVKLCERAGLPLLAAP LLRSLLPRAPQPGPAQPRSV QGQRCPARHPPGNLVCERGA GVNGVTAGAGGRLRGLHRGG RALGCSAHRPLHSARVRPPA HLAAPPGSSARGCRLTE in isoform 3. 1 PublicationVSP_030516Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007864 mRNA. Translation: BAA23700.1. Different initiation.
AK126181 mRNA. Translation: BAC86477.1.
AP001187 Genomic DNA. No translation available.
BC008593 mRNA. Translation: AAH08593.1.
BC027481 mRNA. Translation: AAH27481.1.
BC053596 mRNA. Translation: AAH53596.1.
BC110650 mRNA. Translation: AAI10651.1.
BC113091 mRNA. Translation: AAI13092.1.
CCDSiCCDS31602.1. [Q2TAZ0-1]
PIRiT00051.
RefSeqiNP_055919.2. NM_015104.2. [Q2TAZ0-1]
UniGeneiHs.370671.

Genome annotation databases

EnsembliENST00000377264; ENSP00000366475; ENSG00000110046. [Q2TAZ0-1]
ENST00000421419; ENSP00000410522; ENSG00000110046. [Q2TAZ0-4]
GeneIDi23130.
KEGGihsa:23130.
UCSCiuc001obx.3. human. [Q2TAZ0-1]

Polymorphism databases

DMDMi296439433.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007864 mRNA. Translation: BAA23700.1 . Different initiation.
AK126181 mRNA. Translation: BAC86477.1 .
AP001187 Genomic DNA. No translation available.
BC008593 mRNA. Translation: AAH08593.1 .
BC027481 mRNA. Translation: AAH27481.1 .
BC053596 mRNA. Translation: AAH53596.1 .
BC110650 mRNA. Translation: AAI10651.1 .
BC113091 mRNA. Translation: AAI13092.1 .
CCDSi CCDS31602.1. [Q2TAZ0-1 ]
PIRi T00051.
RefSeqi NP_055919.2. NM_015104.2. [Q2TAZ0-1 ]
UniGenei Hs.370671.

3D structure databases

ProteinModelPortali Q2TAZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116748. 13 interactions.
IntActi Q2TAZ0. 16 interactions.
STRINGi 9606.ENSP00000366475.

PTM databases

PhosphoSitei Q2TAZ0.

Polymorphism databases

DMDMi 296439433.

Proteomic databases

MaxQBi Q2TAZ0.
PaxDbi Q2TAZ0.
PRIDEi Q2TAZ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377264 ; ENSP00000366475 ; ENSG00000110046 . [Q2TAZ0-1 ]
ENST00000421419 ; ENSP00000410522 ; ENSG00000110046 . [Q2TAZ0-4 ]
GeneIDi 23130.
KEGGi hsa:23130.
UCSCi uc001obx.3. human. [Q2TAZ0-1 ]

Organism-specific databases

CTDi 23130.
GeneCardsi GC11M064662.
H-InvDB HIX0009774.
HGNCi HGNC:29028. ATG2A.
HPAi HPA038715.
neXtProti NX_Q2TAZ0.
PharmGKBi PA162377101.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304940.
GeneTreei ENSGT00620000087966.
HOVERGENi HBG079553.
InParanoidi Q2TAZ0.
KOi K17906.
OMAi NDLLMWE.
PhylomeDBi Q2TAZ0.
TreeFami TF313482.

Miscellaneous databases

ChiTaRSi ATG2A. human.
GenomeRNAii 23130.
NextBioi 44375.
PROi Q2TAZ0.

Gene expression databases

Bgeei Q2TAZ0.
CleanExi HS_ATG2A.
ExpressionAtlasi Q2TAZ0. baseline and differential.
Genevestigatori Q2TAZ0.

Family and domain databases

InterProi IPR026849. ATG2.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13A_N.
[Graphical view ]
PANTHERi PTHR13190. PTHR13190. 1 hit.
Pfami PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
    Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-656.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1189-1938 (ISOFORM 2), VARIANT ARG-656.
    Tissue: Cervix, Hippocampus and Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Delta strain."
    Romanyuk D., Polak A., Maleszewska A., Sienko M., Grynberg M., Zoladek T.
    Acta Biochim. Pol. 58:365-374(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets."
    Velikkakath A.K., Nishimura T., Oita E., Ishihara N., Mizushima N.
    Mol. Biol. Cell 23:896-909(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiATG2A_HUMAN
AccessioniPrimary (citable) accession number: Q2TAZ0
Secondary accession number(s): O43154
, Q14DM2, Q6ZTV2, Q7Z6K8, Q8IVY5, Q8TAI8, Q96HH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3