Q2TAZ0 (ATG2A_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 60.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Autophagy-related protein 2 homolog A | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 1938 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Sequence similarities | Belongs to the ATG2 family. |
| Sequence caution | The sequence BAA23700.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | autophagy Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| GABARAP | O95166 | 2 | EBI-2514077,EBI-712001 | |
| GABARAPL1 | Q9H0R8 | 3 | EBI-2514077,EBI-746969 | |
| GABARAPL2 | P60520 | 2 | EBI-2514077,EBI-720116 | |
| MAP1LC3B | Q9GZQ8 | 2 | EBI-2514077,EBI-373144 |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q2TAZ0-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q2TAZ0-3) The sequence of this isoform differs from the canonical sequence as follows: 1259-1259: K → KVQ | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 3 (identifier: Q2TAZ0-4) The sequence of this isoform differs from the canonical sequence as follows: 1-1607: Missing. 1608-1724: INPVVPGETS...RHGLLGVDKV → MAVAMVKLCE...SSARGCRLTE | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 4 (identifier: Q2TAZ0-5) The sequence of this isoform differs from the canonical sequence as follows: 58-121: SVNEVLESME...APGAADSQSW → VRSQARVQEV...AHLAAPPGSR 122-1938: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1938 | 1938 | Autophagy-related protein 2 homolog A | PRO_0000315234 | |||||
Amino acid modifications | |||||||||
| Modified residue | 892 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 894 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 1607 | 1607 | Missing in isoform 3. | VSP_030510 | |||||
| Alternative sequence | 58 – 121 | 64 | SVNEV…DSQSW → VRSQARVQEVCERGAGVNGV TAGAGGRLRGLHRGGRALGC SAHRPLHSARVRPPAHLAAP PGSR in isoform 4. | VSP_030511 | |||||
| Alternative sequence | 122 – 1938 | 1817 | Missing in isoform 4. | VSP_030512 | |||||
| Alternative sequence | 1259 | 1 | K → KVQ in isoform 2. | VSP_030515 | |||||
| Alternative sequence | 1608 – 1724 | 117 | INPVV…GVDKV → MAVAMVKLCERAGLPLLAAP LLRSLLPRAPQPGPAQPRSV QGQRCPARHPPGNLVCERGA GVNGVTAGAGGRLRGLHRGG RALGCSAHRPLHSARVRPPA HLAAPPGSSARGCRLTE in isoform 3. | VSP_030516 | |||||
| Natural variant | 175 | 1 | V → I. Corresponds to variant rs12293826 [ dbSNP | Ensembl ]. | VAR_038158 | |||||
| Natural variant | 394 | 1 | R → C. Corresponds to variant rs35115827 [ dbSNP | Ensembl ]. | VAR_061027 | |||||
| Natural variant | 404 | 1 | A → V. Corresponds to variant rs60711419 [ dbSNP | Ensembl ]. | VAR_061028 | |||||
| Natural variant | 627 | 1 | A → V. Corresponds to variant rs2285347 [ dbSNP | Ensembl ]. | VAR_038159 | |||||
| Natural variant | 656 | 1 | P → R. Ref.1 Ref.4 Corresponds to variant rs656195 [ dbSNP | Ensembl ]. | VAR_061029 | |||||
| Natural variant | 948 | 1 | G → R. Corresponds to variant rs11827140 [ dbSNP | Ensembl ]. | VAR_038160 | |||||
Experimental info | |||||||||
| Sequence conflict | 1286 | 1 | A → S in AAI10651. Ref.4 | ||||||
Sequences
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References
| [1] | "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro." Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-656. Tissue: Brain. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Thymus. |
| [3] | "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y.Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1189-1938 (ISOFORM 2), VARIANT ARG-656. Tissue: Cervix, Hippocampus and Skin. |
| [5] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB007864 mRNA. Translation: BAA23700.1. Different initiation. AK126181 mRNA. Translation: BAC86477.1. AP001187 Genomic DNA. No translation available. BC008593 mRNA. Translation: AAH08593.1. BC027481 mRNA. Translation: AAH27481.1. BC053596 mRNA. Translation: AAH53596.1. BC110650 mRNA. Translation: AAI10651.1. BC113091 mRNA. Translation: AAI13092.1. |
| IPI | IPI00304926. IPI00445332. IPI00658084. IPI00878288. |
| PIR | T00051. |
| RefSeq | NP_055919.2. NM_015104.2. |
| UniGene | Hs.370671. |
3D structure databases | |
| ProteinModelPortal | Q2TAZ0. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q2TAZ0. 16 interactions. |
| STRING | 9606.ENSP00000366475. |
PTM databases | |
| PhosphoSite | Q2TAZ0. |
Polymorphism databases | |
| DMDM | 296439433. |
Proteomic databases | |
| PaxDb | Q2TAZ0. |
| PRIDE | Q2TAZ0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000377264; ENSP00000366475; ENSG00000110046. ENST00000421419; ENSP00000410522; ENSG00000110046. |
| GeneID | 23130. |
| KEGG | hsa:23130. |
| UCSC | uc001obx.3. human. |
Organism-specific databases | |
| CTD | 23130. |
| GeneCards | GC11M064662. |
| H-InvDB | HIX0009774. |
| HGNC | HGNC:29028. ATG2A. |
| HPA | HPA038715. |
| neXtProt | NX_Q2TAZ0. |
| PharmGKB | PA162377101. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG304940. |
| HOVERGEN | HBG079553. |
| InParanoid | Q2TAZ0. |
| OMA | TVLHTHL. |
| OrthoDB | EOG4C5CHH. |
Gene expression databases | |
| ArrayExpress | Q2TAZ0. |
| Bgee | Q2TAZ0. |
| CleanEx | HS_ATG2A. |
| Genevestigator | Q2TAZ0. |
Family and domain databases | |
| InterPro | IPR026849. ATG2. IPR015412. Autophagy-rel_C. IPR026854. VPS13A_N. [Graphical view] |
| PANTHER | PTHR13190. PTHR13190. 1 hit. |
| Pfam | PF09333. ATG_C. 1 hit. PF12624. Chorein_N. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| ChiTaRS | ATG2A. human. |
| GenomeRNAi | 23130. |
| NextBio | 44375. |
Entry information
| Entry name | ATG2A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q2TAZ0 Secondary accession number(s): O43154 Q96HH7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with
