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Q2TAZ0

- ATG2A_HUMAN

UniProt

Q2TAZ0 - ATG2A_HUMAN

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Protein
Autophagy-related protein 2 homolog A
Gene
ATG2A, KIAA0404
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. autophagic vacuole assembly Source: RefGenome
  2. cellular response to nitrogen starvation Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 2 homolog A
Gene namesi
Name:ATG2A
Synonyms:KIAA0404
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:29028. ATG2A.

Subcellular locationi

Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet 2 Publications

GO - Cellular componenti

  1. extrinsic component of membrane Source: RefGenome
  2. lipid particle Source: UniProtKB-SubCell
  3. pre-autophagosomal structure Source: RefGenome
  4. pre-autophagosomal structure membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19381938Autophagy-related protein 2 homolog A
PRO_0000315234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei892 – 8921Phosphoserine By similarity
Modified residuei894 – 8941Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ2TAZ0.
PaxDbiQ2TAZ0.
PRIDEiQ2TAZ0.

PTM databases

PhosphoSiteiQ2TAZ0.

Expressioni

Gene expression databases

ArrayExpressiQ2TAZ0.
BgeeiQ2TAZ0.
CleanExiHS_ATG2A.
GenevestigatoriQ2TAZ0.

Organism-specific databases

HPAiHPA038715.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951662EBI-2514077,EBI-712001
GABARAPL1Q9H0R83EBI-2514077,EBI-746969
GABARAPL2P605202EBI-2514077,EBI-720116
MAP1LC3BQ9GZQ82EBI-2514077,EBI-373144

Protein-protein interaction databases

BioGridi116748. 13 interactions.
IntActiQ2TAZ0. 16 interactions.
STRINGi9606.ENSP00000366475.

Structurei

3D structure databases

ProteinModelPortaliQ2TAZ0.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG2 family.

Phylogenomic databases

eggNOGiNOG304940.
HOVERGENiHBG079553.
InParanoidiQ2TAZ0.
KOiK17906.
OMAiNDLLMWE.
PhylomeDBiQ2TAZ0.
TreeFamiTF313482.

Family and domain databases

InterProiIPR026849. ATG2.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13A_N.
[Graphical view]
PANTHERiPTHR13190. PTHR13190. 1 hit.
PfamiPF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q2TAZ0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSRWLWPWSN CVKERVCRYL LHHYLGHFFQ EHLSLDQLSL DLYKGSVALR     50
DIHLEIWSVN EVLESMESPL ELVEGFVGSI EVAVPWAALL TDHCTVRVSG 100
LQLTLQPRRG PAPGAADSQS WASCMTTSLQ LAQECLRDGL PEPSEPPQPL 150
EGLEMFAQTI ETVLRRIKVT FLDTVVRVEH SPGDGERGVA VEVRVQRLEY 200
CDEAVRDPSQ APPVDVHQPP AFLHKLLQLA GVRLHYEELP AQEEPPEPPL 250
QIGSCSGYME LMVKLKQNEA FPGPKLEVAG QLGSLHLLLT PRQLQQLQEL 300
LSAVSLTDHE GLADKLNKSR PLGAEDLWLI EQDLNQQLQA GAVAEPLSPD 350
PLTNPLLNLD NTDLFFSMAG LTSSVASALS ELSLSDVDLA SSVRSDMASR 400
RLSAQAHPAG KMAPNPLLDT MRPDSLLKMT LGGVTLTLLQ TSAPSSGPPD 450
LATHFFTEFD ATKDGPFGSR DFHHLRPRFQ RACPCSHVRL TGTAVQLSWE 500
LRTGSRGRRT TSMEVHFGQL EVLECLWPRG TSEPEYTEIL TFPGTLGSQA 550
SARPCAHLRH TQILRRVPKS RPRRSVACHC HSELALDLAN FQADVELGAL 600
DRLAALLRLA TVPAEPPAGL LTEPLPAMEQ QTVFRLSAPR ATLRLRFPIA 650
DLRPEPDPWA GQAVRAEQLR LELSEPQFRS ELSSGPGPPV PTHLELTCSD 700
LHGIYEDGGK PPVPCLRVSK ALDPKSTGRK YFLPQVVVTV NPQSSSTQWE 750
VAPEKGEELE LSVESPCELR EPEPSPFSSK RTMYETEEMV IPGDPEEMRT 800
FQSRTLALSR CSLEVILPSV HIFLPSKEVY ESIYNRINND LLMWEPADLL 850
PTPDPAAQPS GFPGPSGFWH DSFKMCKSAF KLANCFDLTP DSDSDDEDAH 900
FFSVGASGGP QAAAPEAPSL HLQSTFSTLV TVLKGRITAL CETKDEGGKR 950
LEAVHGELVL DMEHGTLFSV SQYCGQPGLG YFCLEAEKAT LYHRAAVDDY 1000
PLPSHLDLPS FAPPAQLAPT IYPSEEGVTE RGASGRKGQG RGPHMLSTAV 1050
RIHLDPHKNV KEFLVTLRLH KATLRHYMAL PEQSWHSQLL EFLDVLDDPV 1100
LGYLPPTVIT ILHTHLFSCS VDYRPLYLPV RVLITAETFT LSSNIIMDTS 1150
TFLLRFILDD SALYLSDKCE VETLDLRRDY VCVLDVDLLE LVIKTWKGST 1200
EGKLSQPLFE LRCSNNVVHV HSCADSCALL VNLLQYVMST GDLHPPPRPP 1250
SPTEIAGQKL SESPASLPSC PPVETALINQ RDLADALLDT ERSLRELAQP 1300
SGGHLPQASP ISVYLFPGER SGAPPPSPPV GGPAGSLGSC SEEKEDEREE 1350
EGDGDTLDSD EFCILDAPGL GIPPRDGEPV VTQLHPGPIV VRDGYFSRPI 1400
GSTDLLRAPA HFPVPSTRVV LREVSLVWHL YGGRDFGPHP GHRARTGLSG 1450
PRSSPSRCSG PNRPQNSWRT QGGSGRQHHV LMEIQLSKVS FQHEVYPAEP 1500
ATGPAAPSQE LEERPLSRQV FIVQELEVRD RLASSQINKF LYLHTSERMP 1550
RRAHSNMLTI KALHVAPTTN LGGPECCLRV SLMPLRLNVD QDALFFLKDF 1600
FTSLVAGINP VVPGETSAEA RPETRAQPSS PLEGQAEGVE TTGSQEAPGG 1650
GHSPSPPDQQ PIYFREFRFT SEVPIWLDYH GKHVTMDQVG TFAGLLIGLA 1700
QLNCSELKLK RLCCRHGLLG VDKVLGYALN EWLQDIRKNQ LPGLLGGVGP 1750
MHSVVQLFQG FRDLLWLPIE QYRKDGRLMR GLQRGAASFG SSTASAALEL 1800
SNRLVQAIQA TAETVYDILS PAAPVSRSLQ DKRSARRLRR GQQPADLREG 1850
VAKAYDTVRE GILDTAQTIC DVASRGHEQK GLTGAVGGVI RQLPPTVVKP 1900
LILATEATSS LLGGMRNQIV PDAHKDHALK WRSDSAQD 1938
Length:1,938
Mass (Da):212,860
Last modified:May 18, 2010 - v3
Checksum:iB0072E075E305A33
GO
Isoform 2 (identifier: Q2TAZ0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1259-1259: K → KVQ

Note: No experimental confirmation available.

Show »
Length:1,940
Mass (Da):213,087
Checksum:i7236DF3A60D98208
GO
Isoform 3 (identifier: Q2TAZ0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1607: Missing.
     1608-1724: INPVVPGETS...RHGLLGVDKV → MAVAMVKLCE...SSARGCRLTE

Note: No experimental confirmation available.

Show »
Length:331
Mass (Da):35,255
Checksum:iA6DFB099A5053B97
GO
Isoform 4 (identifier: Q2TAZ0-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-121: SVNEVLESME...APGAADSQSW → VRSQARVQEV...AHLAAPPGSR
     122-1938: Missing.

Note: No experimental confirmation available.

Show »
Length:121
Mass (Da):13,576
Checksum:i40E9AF595AA38556
GO

Sequence cautioni

The sequence BAA23700.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti175 – 1751V → I.
Corresponds to variant rs12293826 [ dbSNP | Ensembl ].
VAR_038158
Natural varianti394 – 3941R → C.
Corresponds to variant rs35115827 [ dbSNP | Ensembl ].
VAR_061027
Natural varianti404 – 4041A → V.
Corresponds to variant rs60711419 [ dbSNP | Ensembl ].
VAR_061028
Natural varianti627 – 6271A → V.
Corresponds to variant rs2285347 [ dbSNP | Ensembl ].
VAR_038159
Natural varianti656 – 6561P → R.2 Publications
Corresponds to variant rs656195 [ dbSNP | Ensembl ].
VAR_061029
Natural varianti948 – 9481G → R.
Corresponds to variant rs11827140 [ dbSNP | Ensembl ].
VAR_038160

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 16071607Missing in isoform 3.
VSP_030510Add
BLAST
Alternative sequencei58 – 12164SVNEV…DSQSW → VRSQARVQEVCERGAGVNGV TAGAGGRLRGLHRGGRALGC SAHRPLHSARVRPPAHLAAP PGSR in isoform 4.
VSP_030511Add
BLAST
Alternative sequencei122 – 19381817Missing in isoform 4.
VSP_030512Add
BLAST
Alternative sequencei1259 – 12591K → KVQ in isoform 2.
VSP_030515
Alternative sequencei1608 – 1724117INPVV…GVDKV → MAVAMVKLCERAGLPLLAAP LLRSLLPRAPQPGPAQPRSV QGQRCPARHPPGNLVCERGA GVNGVTAGAGGRLRGLHRGG RALGCSAHRPLHSARVRPPA HLAAPPGSSARGCRLTE in isoform 3.
VSP_030516Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1286 – 12861A → S in AAI10651. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007864 mRNA. Translation: BAA23700.1. Different initiation.
AK126181 mRNA. Translation: BAC86477.1.
AP001187 Genomic DNA. No translation available.
BC008593 mRNA. Translation: AAH08593.1.
BC027481 mRNA. Translation: AAH27481.1.
BC053596 mRNA. Translation: AAH53596.1.
BC110650 mRNA. Translation: AAI10651.1.
BC113091 mRNA. Translation: AAI13092.1.
CCDSiCCDS31602.1. [Q2TAZ0-1]
PIRiT00051.
RefSeqiNP_055919.2. NM_015104.2. [Q2TAZ0-1]
UniGeneiHs.370671.

Genome annotation databases

EnsembliENST00000377264; ENSP00000366475; ENSG00000110046. [Q2TAZ0-1]
ENST00000421419; ENSP00000410522; ENSG00000110046. [Q2TAZ0-3]
GeneIDi23130.
KEGGihsa:23130.
UCSCiuc001obx.3. human. [Q2TAZ0-1]

Polymorphism databases

DMDMi296439433.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007864 mRNA. Translation: BAA23700.1 . Different initiation.
AK126181 mRNA. Translation: BAC86477.1 .
AP001187 Genomic DNA. No translation available.
BC008593 mRNA. Translation: AAH08593.1 .
BC027481 mRNA. Translation: AAH27481.1 .
BC053596 mRNA. Translation: AAH53596.1 .
BC110650 mRNA. Translation: AAI10651.1 .
BC113091 mRNA. Translation: AAI13092.1 .
CCDSi CCDS31602.1. [Q2TAZ0-1 ]
PIRi T00051.
RefSeqi NP_055919.2. NM_015104.2. [Q2TAZ0-1 ]
UniGenei Hs.370671.

3D structure databases

ProteinModelPortali Q2TAZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116748. 13 interactions.
IntActi Q2TAZ0. 16 interactions.
STRINGi 9606.ENSP00000366475.

PTM databases

PhosphoSitei Q2TAZ0.

Polymorphism databases

DMDMi 296439433.

Proteomic databases

MaxQBi Q2TAZ0.
PaxDbi Q2TAZ0.
PRIDEi Q2TAZ0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377264 ; ENSP00000366475 ; ENSG00000110046 . [Q2TAZ0-1 ]
ENST00000421419 ; ENSP00000410522 ; ENSG00000110046 . [Q2TAZ0-3 ]
GeneIDi 23130.
KEGGi hsa:23130.
UCSCi uc001obx.3. human. [Q2TAZ0-1 ]

Organism-specific databases

CTDi 23130.
GeneCardsi GC11M064662.
H-InvDB HIX0009774.
HGNCi HGNC:29028. ATG2A.
HPAi HPA038715.
neXtProti NX_Q2TAZ0.
PharmGKBi PA162377101.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304940.
HOVERGENi HBG079553.
InParanoidi Q2TAZ0.
KOi K17906.
OMAi NDLLMWE.
PhylomeDBi Q2TAZ0.
TreeFami TF313482.

Miscellaneous databases

ChiTaRSi ATG2A. human.
GenomeRNAii 23130.
NextBioi 44375.
PROi Q2TAZ0.

Gene expression databases

ArrayExpressi Q2TAZ0.
Bgeei Q2TAZ0.
CleanExi HS_ATG2A.
Genevestigatori Q2TAZ0.

Family and domain databases

InterProi IPR026849. ATG2.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13A_N.
[Graphical view ]
PANTHERi PTHR13190. PTHR13190. 1 hit.
Pfami PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
    Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-656.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1189-1938 (ISOFORM 2), VARIANT ARG-656.
    Tissue: Cervix, Hippocampus and Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Delta strain."
    Romanyuk D., Polak A., Maleszewska A., Sienko M., Grynberg M., Zoladek T.
    Acta Biochim. Pol. 58:365-374(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets."
    Velikkakath A.K., Nishimura T., Oita E., Ishihara N., Mizushima N.
    Mol. Biol. Cell 23:896-909(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiATG2A_HUMAN
AccessioniPrimary (citable) accession number: Q2TAZ0
Secondary accession number(s): O43154
, Q14DM2, Q6ZTV2, Q7Z6K8, Q8IVY5, Q8TAI8, Q96HH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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