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Q2TAZ0 (ATG2A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Autophagy-related protein 2 homolog A
Gene names
Name:ATG2A
Synonyms:KIAA0404
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1938 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. Ref.7

Subcellular location

Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet Ref.6 Ref.7.

Sequence similarities

Belongs to the ATG2 family.

Sequence caution

The sequence BAA23700.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processAutophagy
   Cellular componentLipid droplet
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processautophagy

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentlipid particle

Inferred from electronic annotation. Source: UniProtKB-SubCell

pre-autophagosomal structure membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 20562859. Source: IntAct

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q2TAZ0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q2TAZ0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1259-1259: K → KVQ
Note: No experimental confirmation available.
Isoform 3 (identifier: Q2TAZ0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1607: Missing.
     1608-1724: INPVVPGETS...RHGLLGVDKV → MAVAMVKLCE...SSARGCRLTE
Note: No experimental confirmation available.
Isoform 4 (identifier: Q2TAZ0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     58-121: SVNEVLESME...APGAADSQSW → VRSQARVQEV...AHLAAPPGSR
     122-1938: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19381938Autophagy-related protein 2 homolog A
PRO_0000315234

Amino acid modifications

Modified residue8921Phosphoserine By similarity
Modified residue8941Phosphoserine By similarity

Natural variations

Alternative sequence1 – 16071607Missing in isoform 3.
VSP_030510
Alternative sequence58 – 12164SVNEV…DSQSW → VRSQARVQEVCERGAGVNGV TAGAGGRLRGLHRGGRALGC SAHRPLHSARVRPPAHLAAP PGSR in isoform 4.
VSP_030511
Alternative sequence122 – 19381817Missing in isoform 4.
VSP_030512
Alternative sequence12591K → KVQ in isoform 2.
VSP_030515
Alternative sequence1608 – 1724117INPVV…GVDKV → MAVAMVKLCERAGLPLLAAP LLRSLLPRAPQPGPAQPRSV QGQRCPARHPPGNLVCERGA GVNGVTAGAGGRLRGLHRGG RALGCSAHRPLHSARVRPPA HLAAPPGSSARGCRLTE in isoform 3.
VSP_030516
Natural variant1751V → I.
Corresponds to variant rs12293826 [ dbSNP | Ensembl ].
VAR_038158
Natural variant3941R → C.
Corresponds to variant rs35115827 [ dbSNP | Ensembl ].
VAR_061027
Natural variant4041A → V.
Corresponds to variant rs60711419 [ dbSNP | Ensembl ].
VAR_061028
Natural variant6271A → V.
Corresponds to variant rs2285347 [ dbSNP | Ensembl ].
VAR_038159
Natural variant6561P → R. Ref.1 Ref.4
Corresponds to variant rs656195 [ dbSNP | Ensembl ].
VAR_061029
Natural variant9481G → R.
Corresponds to variant rs11827140 [ dbSNP | Ensembl ].
VAR_038160

Experimental info

Sequence conflict12861A → S in AAI10651. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: B0072E075E305A33

FASTA1,938212,860
        10         20         30         40         50         60 
MSRWLWPWSN CVKERVCRYL LHHYLGHFFQ EHLSLDQLSL DLYKGSVALR DIHLEIWSVN 

        70         80         90        100        110        120 
EVLESMESPL ELVEGFVGSI EVAVPWAALL TDHCTVRVSG LQLTLQPRRG PAPGAADSQS 

       130        140        150        160        170        180 
WASCMTTSLQ LAQECLRDGL PEPSEPPQPL EGLEMFAQTI ETVLRRIKVT FLDTVVRVEH 

       190        200        210        220        230        240 
SPGDGERGVA VEVRVQRLEY CDEAVRDPSQ APPVDVHQPP AFLHKLLQLA GVRLHYEELP 

       250        260        270        280        290        300 
AQEEPPEPPL QIGSCSGYME LMVKLKQNEA FPGPKLEVAG QLGSLHLLLT PRQLQQLQEL 

       310        320        330        340        350        360 
LSAVSLTDHE GLADKLNKSR PLGAEDLWLI EQDLNQQLQA GAVAEPLSPD PLTNPLLNLD 

       370        380        390        400        410        420 
NTDLFFSMAG LTSSVASALS ELSLSDVDLA SSVRSDMASR RLSAQAHPAG KMAPNPLLDT 

       430        440        450        460        470        480 
MRPDSLLKMT LGGVTLTLLQ TSAPSSGPPD LATHFFTEFD ATKDGPFGSR DFHHLRPRFQ 

       490        500        510        520        530        540 
RACPCSHVRL TGTAVQLSWE LRTGSRGRRT TSMEVHFGQL EVLECLWPRG TSEPEYTEIL 

       550        560        570        580        590        600 
TFPGTLGSQA SARPCAHLRH TQILRRVPKS RPRRSVACHC HSELALDLAN FQADVELGAL 

       610        620        630        640        650        660 
DRLAALLRLA TVPAEPPAGL LTEPLPAMEQ QTVFRLSAPR ATLRLRFPIA DLRPEPDPWA 

       670        680        690        700        710        720 
GQAVRAEQLR LELSEPQFRS ELSSGPGPPV PTHLELTCSD LHGIYEDGGK PPVPCLRVSK 

       730        740        750        760        770        780 
ALDPKSTGRK YFLPQVVVTV NPQSSSTQWE VAPEKGEELE LSVESPCELR EPEPSPFSSK 

       790        800        810        820        830        840 
RTMYETEEMV IPGDPEEMRT FQSRTLALSR CSLEVILPSV HIFLPSKEVY ESIYNRINND 

       850        860        870        880        890        900 
LLMWEPADLL PTPDPAAQPS GFPGPSGFWH DSFKMCKSAF KLANCFDLTP DSDSDDEDAH 

       910        920        930        940        950        960 
FFSVGASGGP QAAAPEAPSL HLQSTFSTLV TVLKGRITAL CETKDEGGKR LEAVHGELVL 

       970        980        990       1000       1010       1020 
DMEHGTLFSV SQYCGQPGLG YFCLEAEKAT LYHRAAVDDY PLPSHLDLPS FAPPAQLAPT 

      1030       1040       1050       1060       1070       1080 
IYPSEEGVTE RGASGRKGQG RGPHMLSTAV RIHLDPHKNV KEFLVTLRLH KATLRHYMAL 

      1090       1100       1110       1120       1130       1140 
PEQSWHSQLL EFLDVLDDPV LGYLPPTVIT ILHTHLFSCS VDYRPLYLPV RVLITAETFT 

      1150       1160       1170       1180       1190       1200 
LSSNIIMDTS TFLLRFILDD SALYLSDKCE VETLDLRRDY VCVLDVDLLE LVIKTWKGST 

      1210       1220       1230       1240       1250       1260 
EGKLSQPLFE LRCSNNVVHV HSCADSCALL VNLLQYVMST GDLHPPPRPP SPTEIAGQKL 

      1270       1280       1290       1300       1310       1320 
SESPASLPSC PPVETALINQ RDLADALLDT ERSLRELAQP SGGHLPQASP ISVYLFPGER 

      1330       1340       1350       1360       1370       1380 
SGAPPPSPPV GGPAGSLGSC SEEKEDEREE EGDGDTLDSD EFCILDAPGL GIPPRDGEPV 

      1390       1400       1410       1420       1430       1440 
VTQLHPGPIV VRDGYFSRPI GSTDLLRAPA HFPVPSTRVV LREVSLVWHL YGGRDFGPHP 

      1450       1460       1470       1480       1490       1500 
GHRARTGLSG PRSSPSRCSG PNRPQNSWRT QGGSGRQHHV LMEIQLSKVS FQHEVYPAEP 

      1510       1520       1530       1540       1550       1560 
ATGPAAPSQE LEERPLSRQV FIVQELEVRD RLASSQINKF LYLHTSERMP RRAHSNMLTI 

      1570       1580       1590       1600       1610       1620 
KALHVAPTTN LGGPECCLRV SLMPLRLNVD QDALFFLKDF FTSLVAGINP VVPGETSAEA 

      1630       1640       1650       1660       1670       1680 
RPETRAQPSS PLEGQAEGVE TTGSQEAPGG GHSPSPPDQQ PIYFREFRFT SEVPIWLDYH 

      1690       1700       1710       1720       1730       1740 
GKHVTMDQVG TFAGLLIGLA QLNCSELKLK RLCCRHGLLG VDKVLGYALN EWLQDIRKNQ 

      1750       1760       1770       1780       1790       1800 
LPGLLGGVGP MHSVVQLFQG FRDLLWLPIE QYRKDGRLMR GLQRGAASFG SSTASAALEL 

      1810       1820       1830       1840       1850       1860 
SNRLVQAIQA TAETVYDILS PAAPVSRSLQ DKRSARRLRR GQQPADLREG VAKAYDTVRE 

      1870       1880       1890       1900       1910       1920 
GILDTAQTIC DVASRGHEQK GLTGAVGGVI RQLPPTVVKP LILATEATSS LLGGMRNQIV 

      1930 
PDAHKDHALK WRSDSAQD 

« Hide

Isoform 2 [UniParc].

Checksum: 7236DF3A60D98208
Show »

FASTA1,940213,087
Isoform 3 [UniParc].

Checksum: A6DFB099A5053B97
Show »

FASTA33135,255
Isoform 4 [UniParc].

Checksum: 40E9AF595AA38556
Show »

FASTA12113,576

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
Ishikawa K., Nagase T., Nakajima D., Seki N., Ohira M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-656.
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Thymus.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1189-1938 (ISOFORM 2), VARIANT ARG-656.
Tissue: Cervix, Hippocampus and Skin.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Human hAtg2A protein expressed in yeast is recruited to preautophagosomal structure but does not complement autophagy defects of atg2Delta strain."
Romanyuk D., Polak A., Maleszewska A., Sienko M., Grynberg M., Zoladek T.
Acta Biochim. Pol. 58:365-374(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[7]"Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets."
Velikkakath A.K., Nishimura T., Oita E., Ishihara N., Mizushima N.
Mol. Biol. Cell 23:896-909(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB007864 mRNA. Translation: BAA23700.1. Different initiation.
AK126181 mRNA. Translation: BAC86477.1.
AP001187 Genomic DNA. No translation available.
BC008593 mRNA. Translation: AAH08593.1.
BC027481 mRNA. Translation: AAH27481.1.
BC053596 mRNA. Translation: AAH53596.1.
BC110650 mRNA. Translation: AAI10651.1.
BC113091 mRNA. Translation: AAI13092.1.
CCDSCCDS31602.1. [Q2TAZ0-1]
PIRT00051.
RefSeqNP_055919.2. NM_015104.2. [Q2TAZ0-1]
UniGeneHs.370671.

3D structure databases

ProteinModelPortalQ2TAZ0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116748. 13 interactions.
IntActQ2TAZ0. 16 interactions.
STRING9606.ENSP00000366475.

PTM databases

PhosphoSiteQ2TAZ0.

Polymorphism databases

DMDM296439433.

Proteomic databases

MaxQBQ2TAZ0.
PaxDbQ2TAZ0.
PRIDEQ2TAZ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377264; ENSP00000366475; ENSG00000110046. [Q2TAZ0-1]
ENST00000421419; ENSP00000410522; ENSG00000110046. [Q2TAZ0-3]
GeneID23130.
KEGGhsa:23130.
UCSCuc001obx.3. human. [Q2TAZ0-1]

Organism-specific databases

CTD23130.
GeneCardsGC11M064662.
H-InvDBHIX0009774.
HGNCHGNC:29028. ATG2A.
HPAHPA038715.
neXtProtNX_Q2TAZ0.
PharmGKBPA162377101.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG304940.
HOVERGENHBG079553.
InParanoidQ2TAZ0.
KOK17906.
OMANDLLMWE.
PhylomeDBQ2TAZ0.
TreeFamTF313482.

Gene expression databases

ArrayExpressQ2TAZ0.
BgeeQ2TAZ0.
CleanExHS_ATG2A.
GenevestigatorQ2TAZ0.

Family and domain databases

InterProIPR026849. ATG2.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13A_N.
[Graphical view]
PANTHERPTHR13190. PTHR13190. 1 hit.
PfamPF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATG2A. human.
GenomeRNAi23130.
NextBio44375.
PROQ2TAZ0.

Entry information

Entry nameATG2A_HUMAN
AccessionPrimary (citable) accession number: Q2TAZ0
Secondary accession number(s): O43154 expand/collapse secondary AC list , Q14DM2, Q6ZTV2, Q7Z6K8, Q8IVY5, Q8TAI8, Q96HH7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 71 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM