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Protein

WD40 repeat-containing protein SMU1

Gene

SMU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (PubMed:15878348). Required for normal accumulation of IK (PubMed:24945353).By similarityCurated2 Publications
(Microbial infection) Required, together with IK, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.1 Publication

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

SignaLinkiQ2TAY7.

Names & Taxonomyi

Protein namesi
Recommended name:
WD40 repeat-containing protein SMU1
Alternative name(s):
Smu-1 suppressor of mec-8 and unc-52 protein homolog
Cleaved into the following chain:
Gene namesi
Name:SMU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000122692.8.
HGNCiHGNC:18247. SMU1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55234.
OpenTargetsiENSG00000122692.
PharmGKBiPA134903890.

Polymorphism and mutation databases

BioMutaiSMU1.
DMDMi109939732.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004245201 – 513WD40 repeat-containing protein SMU1Add BLAST513
Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00002375902 – 513WD40 repeat-containing protein SMU1, N-terminally processedAdd BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylserine; in WD40 repeat-containing protein SMU1, N-terminally processedCombined sources1 Publication1
Cross-linki379Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ2TAY7.
MaxQBiQ2TAY7.
PaxDbiQ2TAY7.
PeptideAtlasiQ2TAY7.
PRIDEiQ2TAY7.

PTM databases

iPTMnetiQ2TAY7.
PhosphoSitePlusiQ2TAY7.

Expressioni

Gene expression databases

BgeeiENSG00000122692.
CleanExiHS_SMU1.
ExpressionAtlasiQ2TAY7. baseline and differential.
GenevisibleiQ2TAY7. HS.

Organism-specific databases

HPAiHPA019228.
HPA019708.

Interactioni

Subunit structurei

Interacts with IK (PubMed:22365833, PubMed:24945353). Probable component of the spliceosome B complex (PubMed:22365833).2 Publications
(Microbial infection) Identified in a complex with IK and influenza A virus RNA polymerase subunits PB1 and PB2; does not directly interact with the viral proteins by itself.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120528. 56 interactors.
CORUMiQ2TAY7.
IntActiQ2TAY7. 25 interactors.
MINTiMINT-256588.
STRINGi9606.ENSP00000380336.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5O9Zelectron microscopy4.50L1-513[»]
ProteinModelPortaliQ2TAY7.
SMRiQ2TAY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 38LisHPROSITE-ProRule annotationAdd BLAST33
Domaini40 – 92CTLHPROSITE-ProRule annotationAdd BLAST53
Repeati212 – 253WD 1Sequence analysisAdd BLAST42
Repeati262 – 303WD 2Sequence analysisAdd BLAST42
Repeati305 – 346WD 3Sequence analysisAdd BLAST42
Repeati347 – 386WD 4Sequence analysisAdd BLAST40
Repeati395 – 436WD 5Sequence analysisAdd BLAST42
Repeati440 – 479WD 6Sequence analysisAdd BLAST40
Repeati482 – 513WD 7Sequence analysisAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 315Required for interaction with IK and with influenza A virus RNA polymerase1 PublicationAdd BLAST315

Domaini

The WD repeats assemble into a seven-bladed WD propeller.By similarity

Sequence similaritiesi

Belongs to the WD repeat SMU1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0275. Eukaryota.
ENOG410XP39. LUCA.
GeneTreeiENSGT00890000139419.
HOGENOMiHOG000264846.
HOVERGENiHBG079573.
InParanoidiQ2TAY7.
KOiK13111.
OMAiHTSFVNE.
OrthoDBiEOG091G04XF.
PhylomeDBiQ2TAY7.
TreeFamiTF313969.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR006595. CTLH_C.
IPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF00400. WD40. 5 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2TAY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSIEIESSDV IRLIMQYLKE NSLHRALATL QEETTVSLNT VDSIESFVAD
60 70 80 90 100
INSGHWDTVL QAIQSLKLPD KTLIDLYEQV VLELIELREL GAARSLLRQT
110 120 130 140 150
DPMIMLKQTQ PERYIHLENL LARSYFDPRE AYPDGSSKEK RRAAIAQALA
160 170 180 190 200
GEVSVVPPSR LMALLGQALK WQQHQGLLPP GMTIDLFRGK AAVKDVEEEK
210 220 230 240 250
FPTQLSRHIK FGQKSHVECA RFSPDGQYLV TGSVDGFIEV WNFTTGKIRK
260 270 280 290 300
DLKYQAQDNF MMMDDAVLCM CFSRDTEMLA TGAQDGKIKV WKIQSGQCLR
310 320 330 340 350
RFERAHSKGV TCLSFSKDSS QILSASFDQT IRIHGLKSGK TLKEFRGHSS
360 370 380 390 400
FVNEATFTQD GHYIISASSD GTVKIWNMKT TECSNTFKSL GSTAGTDITV
410 420 430 440 450
NSVILLPKNP EHFVVCNRSN TVVIMNMQGQ IVRSFSSGKR EGGDFVCCAL
460 470 480 490 500
SPRGEWIYCV GEDFVLYCFS TVTGKLERTL TVHEKDVIGI AHHPHQNLIA
510
TYSEDGLLKL WKP
Length:513
Mass (Da):57,544
Last modified:May 30, 2006 - v2
Checksum:iCB201E939DCCA188
GO
Isoform 2 (identifier: Q2TAY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.

Note: No experimental confirmation available.
Show »
Length:352
Mass (Da):39,343
Checksum:iD8CBE40E0B77D66A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62A → V in AAI10655 (PubMed:15489334).Curated1
Sequence conflicti424I → V in AK022032 (PubMed:14702039).Curated1
Sequence conflicti429G → R in AK022032 (PubMed:14702039).Curated1
Sequence conflicti498L → P in BAA91822 (PubMed:14702039).Curated1
Sequence conflicti506G → A in AAI10655 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563941 – 161Missing in isoform 2. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001667 mRNA. Translation: BAA91822.1.
AK022032 mRNA. No translation available.
AK304767 mRNA. Translation: BAG65522.1.
AL162590 Genomic DNA. Translation: CAI15554.1.
BC002876 mRNA. Translation: AAH02876.1.
BC110654 mRNA. Translation: AAI10655.1.
CCDSiCCDS6534.1. [Q2TAY7-1]
RefSeqiNP_060695.2. NM_018225.2. [Q2TAY7-1]
UniGeneiHs.655351.

Genome annotation databases

EnsembliENST00000397149; ENSP00000380336; ENSG00000122692. [Q2TAY7-1]
GeneIDi55234.
KEGGihsa:55234.
UCSCiuc003zsf.2. human. [Q2TAY7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSMU1_HUMAN
AccessioniPrimary (citable) accession number: Q2TAY7
Secondary accession number(s): B4E3L0
, Q9BU59, Q9HA96, Q9NVD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: October 25, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families