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Protein

WD40 repeat-containing protein SMU1

Gene

SMU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ2TAY7.

Names & Taxonomyi

Protein namesi
Recommended name:
WD40 repeat-containing protein SMU1
Alternative name(s):
Smu-1 suppressor of mec-8 and unc-52 protein homolog
Cleaved into the following chain:
Gene namesi
Name:SMU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:18247. SMU1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903890.

Polymorphism and mutation databases

BioMutaiSMU1.
DMDMi109939732.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513WD40 repeat-containing protein SMU1PRO_0000424520Add
BLAST
Initiator methionineiRemoved; alternateCombined sources1 Publication
Chaini2 – 513512WD40 repeat-containing protein SMU1, N-terminally processedPRO_0000237590Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei2 – 21N-acetylserine; in WD40 repeat-containing protein SMU1, N-terminally processedCombined sources1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ2TAY7.
MaxQBiQ2TAY7.
PaxDbiQ2TAY7.
PeptideAtlasiQ2TAY7.
PRIDEiQ2TAY7.

PTM databases

iPTMnetiQ2TAY7.
PhosphoSiteiQ2TAY7.

Expressioni

Gene expression databases

BgeeiQ2TAY7.
CleanExiHS_SMU1.
ExpressionAtlasiQ2TAY7. baseline and differential.
GenevisibleiQ2TAY7. HS.

Organism-specific databases

HPAiHPA019228.
HPA019708.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IKQ131232EBI-298027,EBI-713456
MRFAP1L1Q96HT84EBI-298027,EBI-748896

Protein-protein interaction databases

BioGridi120528. 51 interactions.
IntActiQ2TAY7. 19 interactions.
MINTiMINT-256588.
STRINGi9606.ENSP00000380336.

Structurei

3D structure databases

ProteinModelPortaliQ2TAY7.
SMRiQ2TAY7. Positions 1-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 3833LisHPROSITE-ProRule annotationAdd
BLAST
Domaini40 – 9253CTLHPROSITE-ProRule annotationAdd
BLAST
Repeati212 – 25342WD 1Add
BLAST
Repeati262 – 30342WD 2Add
BLAST
Repeati305 – 34642WD 3Add
BLAST
Repeati347 – 38640WD 4Add
BLAST
Repeati388 – 42639WD 5Add
BLAST
Repeati482 – 51332WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat SMU1 family.Curated
Contains 1 CTLH domain.PROSITE-ProRule annotation
Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0275. Eukaryota.
ENOG410XP39. LUCA.
GeneTreeiENSGT00840000129769.
HOGENOMiHOG000264846.
HOVERGENiHBG079573.
InParanoidiQ2TAY7.
KOiK13111.
OMAiCTMKLWK.
OrthoDBiEOG72VH5Q.
PhylomeDBiQ2TAY7.
TreeFamiTF313969.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR006595. CTLH_C.
IPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2TAY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSIEIESSDV IRLIMQYLKE NSLHRALATL QEETTVSLNT VDSIESFVAD
60 70 80 90 100
INSGHWDTVL QAIQSLKLPD KTLIDLYEQV VLELIELREL GAARSLLRQT
110 120 130 140 150
DPMIMLKQTQ PERYIHLENL LARSYFDPRE AYPDGSSKEK RRAAIAQALA
160 170 180 190 200
GEVSVVPPSR LMALLGQALK WQQHQGLLPP GMTIDLFRGK AAVKDVEEEK
210 220 230 240 250
FPTQLSRHIK FGQKSHVECA RFSPDGQYLV TGSVDGFIEV WNFTTGKIRK
260 270 280 290 300
DLKYQAQDNF MMMDDAVLCM CFSRDTEMLA TGAQDGKIKV WKIQSGQCLR
310 320 330 340 350
RFERAHSKGV TCLSFSKDSS QILSASFDQT IRIHGLKSGK TLKEFRGHSS
360 370 380 390 400
FVNEATFTQD GHYIISASSD GTVKIWNMKT TECSNTFKSL GSTAGTDITV
410 420 430 440 450
NSVILLPKNP EHFVVCNRSN TVVIMNMQGQ IVRSFSSGKR EGGDFVCCAL
460 470 480 490 500
SPRGEWIYCV GEDFVLYCFS TVTGKLERTL TVHEKDVIGI AHHPHQNLIA
510
TYSEDGLLKL WKP
Length:513
Mass (Da):57,544
Last modified:May 30, 2006 - v2
Checksum:iCB201E939DCCA188
GO
Isoform 2 (identifier: Q2TAY7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-161: Missing.

Note: No experimental confirmation available.
Show »
Length:352
Mass (Da):39,343
Checksum:iD8CBE40E0B77D66A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621A → V in AAI10655 (PubMed:15489334).Curated
Sequence conflicti424 – 4241I → V in AK022032 (PubMed:14702039).Curated
Sequence conflicti429 – 4291G → R in AK022032 (PubMed:14702039).Curated
Sequence conflicti498 – 4981L → P in BAA91822 (PubMed:14702039).Curated
Sequence conflicti506 – 5061G → A in AAI10655 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 161161Missing in isoform 2. 1 PublicationVSP_056394Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001667 mRNA. Translation: BAA91822.1.
AK022032 mRNA. No translation available.
AK304767 mRNA. Translation: BAG65522.1.
AL162590 Genomic DNA. Translation: CAI15554.1.
BC002876 mRNA. Translation: AAH02876.1.
BC110654 mRNA. Translation: AAI10655.1.
CCDSiCCDS6534.1. [Q2TAY7-1]
RefSeqiNP_060695.2. NM_018225.2. [Q2TAY7-1]
UniGeneiHs.655351.

Genome annotation databases

EnsembliENST00000397149; ENSP00000380336; ENSG00000122692. [Q2TAY7-1]
GeneIDi55234.
KEGGihsa:55234.
UCSCiuc003zsf.2. human. [Q2TAY7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001667 mRNA. Translation: BAA91822.1.
AK022032 mRNA. No translation available.
AK304767 mRNA. Translation: BAG65522.1.
AL162590 Genomic DNA. Translation: CAI15554.1.
BC002876 mRNA. Translation: AAH02876.1.
BC110654 mRNA. Translation: AAI10655.1.
CCDSiCCDS6534.1. [Q2TAY7-1]
RefSeqiNP_060695.2. NM_018225.2. [Q2TAY7-1]
UniGeneiHs.655351.

3D structure databases

ProteinModelPortaliQ2TAY7.
SMRiQ2TAY7. Positions 1-511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120528. 51 interactions.
IntActiQ2TAY7. 19 interactions.
MINTiMINT-256588.
STRINGi9606.ENSP00000380336.

PTM databases

iPTMnetiQ2TAY7.
PhosphoSiteiQ2TAY7.

Polymorphism and mutation databases

BioMutaiSMU1.
DMDMi109939732.

Proteomic databases

EPDiQ2TAY7.
MaxQBiQ2TAY7.
PaxDbiQ2TAY7.
PeptideAtlasiQ2TAY7.
PRIDEiQ2TAY7.

Protocols and materials databases

DNASUi55234.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397149; ENSP00000380336; ENSG00000122692. [Q2TAY7-1]
GeneIDi55234.
KEGGihsa:55234.
UCSCiuc003zsf.2. human. [Q2TAY7-1]

Organism-specific databases

CTDi55234.
GeneCardsiSMU1.
HGNCiHGNC:18247. SMU1.
HPAiHPA019228.
HPA019708.
neXtProtiNX_Q2TAY7.
PharmGKBiPA134903890.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0275. Eukaryota.
ENOG410XP39. LUCA.
GeneTreeiENSGT00840000129769.
HOGENOMiHOG000264846.
HOVERGENiHBG079573.
InParanoidiQ2TAY7.
KOiK13111.
OMAiCTMKLWK.
OrthoDBiEOG72VH5Q.
PhylomeDBiQ2TAY7.
TreeFamiTF313969.

Enzyme and pathway databases

SignaLinkiQ2TAY7.

Miscellaneous databases

ChiTaRSiSMU1. human.
GeneWikiiSMU1.
GenomeRNAii55234.
NextBioi35477565.
PROiQ2TAY7.

Gene expression databases

BgeeiQ2TAY7.
CleanExiHS_SMU1.
ExpressionAtlasiQ2TAY7. baseline and differential.
GenevisibleiQ2TAY7. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR006595. CTLH_C.
IPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Embryo and Uterus.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Skin.
  4. Bienvenut W.V., Zebisch A., Kolch W.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-12; 114-123; 275-287 AND 318-332, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Colon carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND SER-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSMU1_HUMAN
AccessioniPrimary (citable) accession number: Q2TAY7
Secondary accession number(s): B4E3L0
, Q9BU59, Q9HA96, Q9NVD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: May 11, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.