Reviewed, UniProtKB/Swiss-Prot Q2TAM9 (TUSC1_HUMAN)

Names and origin

Protein names

Recommended name:
    Tumor suppressor candidate gene 1 protein
Alternative name(s):
    TSG-9
      Short name=TSG9

Gene names

Name:

TUSC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity

Widely expressed at low level. Expressed at higher level in testis, weakly expressed in muscle, colon, lung and spleen. Not detected in 3 non small cell lung carcinoma (NSCLC) cell lines with homozygous deletion of the 9p region, while it is down-regulated in 3 other tumor cell lines.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Tumor suppressor candidate gene 1 protein		PRO_0000312284
Regions
	Coiled coil	70 – 114	45	Potential
	Coiled coil	152 – 177	26	Potential
	Compositional bias	6 – 53	48	Gly-rich
Amino acid modifications
	Modified residue	142	1	Phosphoserine
	Modified residue	150	1	Phosphoserine
Natural variations
	Natural variant	120	1	D → N: dbSNP rs34498078.		VAR_037471

Sequences

	Sequence		Length	Mass (Da)
	Q2TAM9-1 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: FF9E9F38225BC987	FASTA	209	23,106
	10 20 30 40 50 60 MWRMRGGATR RGSCCGGDGA ADGRGPGRSG RARGGGSPSG GGGGVGWRGR ADGARQQLEE 70 80 90 100 110 120 RFADLAASHL EAIRARDEWD RQNARLRQEN ARLRLENRRL KRENRSLFRQ ALRLPGEGGD 130 140 150 160 170 180 GTPAEARRVP EEASTNRRAR DSGREDEPGS PRALRARLEK LEAMYRRALL QLHLEQRGPR 190 200 PSGDKEEQPL QEPDSGLRSR DSEPSGPWL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer." Shan Z., Parker T., Wiest J.S. Oncogene 23:6612-6620(2004) [PubMed: 15208665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ASN-120.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-120. Tissue: Brain, Colon and Skin.
[3]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142 AND SER-150, MASS SPECTROMETRY. Tissue: Epithelium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY168647 mRNA. Translation: AAO38227.2. BC017510 mRNA. Translation: AAH17510.1. BC028316 mRNA. Translation: AAH28316.1. BC046919 mRNA. Translation: AAH46919.1. BC110824 mRNA. Translation: AAI10825.1. Different initiation.
RefSeq	NP_001004125.1.
UniGene	Hs.26268 Hs.606014
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000198680. Homo sapiens. [Contig view]
GeneID	286319.
KEGG	hsa:286319.
Organism-specific databases
HGNC	HGNC:31010. TUSC1.
MIM	610529. gene.
PharmGKB	PA134889281.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q2TAM9.
HOVERGEN	Q2TAM9.
Gene expression databases
ArrayExpress	Q2TAM9.
CleanEx	HS_TUSC1.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	96146.
SOURCE	Search...

Entry information

Entry name

TUSC1_HUMAN

Accession

Primary (citable) accession number: Q2TAM9
Secondary accession number(s): A0PJ78 , Q67GI3, Q86SS1, Q8TAH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	November 4, 2008
This is version 15 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)