Q2TAM9 (TUSC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor suppressor candidate gene 1 protein

Alternative name(s):
TSG-9
Short name=TSG9

Gene names

Name:

TUSC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Widely expressed at low level. Expressed at higher level in testis, weakly expressed in muscle, colon, lung and spleen. Not detected in 3 non small cell lung carcinoma (NSCLC) cell lines with homozygous deletion of the 9p region, while it is down-regulated in 3 other tumor cell lines. Ref.1
Caution	It is uncertain whether Met-1 or Met-4 is the initiator.
Sequence caution	The sequence AAO38227.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Tumor suppressor candidate gene 1 protein		PRO_0000312284
Regions
	Coiled coil	73 – 117	45	Potential
	Coiled coil	155 – 180	26	Potential
	Compositional bias	9 – 56	48	Gly-rich
Amino acid modifications
	Modified residue	145	1	Phosphoserine Ref.4
	Modified residue	153	1	Phosphoserine Ref.4
Natural variations
	Natural variant	123	1	N → D. Ref.3 Corresponds to variant rs34498078 [ dbSNP | Ensembl ].		VAR_037471

Sequences

	Sequence		Length	Mass (Da)
	Q2TAM9 [UniParc]. Last modified September 22, 2009. Version 3. Checksum: 8D7B0038B40AA9B4	FASTA	212	23,390
	10 20 30 40 50 60 MGPMWRMRGG ATRRGSCCGG DGAADGRGPG RSGRARGGGS PSGGGGGVGW RGRADGARQQ 70 80 90 100 110 120 LEERFADLAA SHLEAIRARD EWDRQNARLR QENARLRLEN RRLKRENRSL FRQALRLPGE 130 140 150 160 170 180 GGNGTPAEAR RVPEEASTNR RARDSGREDE PGSPRALRAR LEKLEAMYRR ALLQLHLEQR 190 200 210 GPRPSGDKEE QPLQEPDSGL RSRDSEPSGP WL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer." Shan Z., Parker T., Wiest J.S. Oncogene 23:6612-6620(2004) [PubMed: 15208665] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-123. Tissue: Brain, Colon and Skin.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145 AND SER-153, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY168647 mRNA. Translation: AAO38227.2. Different initiation. AL590322 Genomic DNA. No translation available. BC017510 mRNA. Translation: AAH17510.1. BC028316 mRNA. Translation: AAH28316.1. BC046919 mRNA. Translation: AAH46919.1. BC110824 mRNA. Translation: AAI10825.1.
IPI	IPI00465443.
RefSeq	NP_001004125.1. NM_001004125.2.
UniGene	Hs.26268. Hs.606014.
3D structure databases
ProteinModelPortal	Q2TAM9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2TAM9.
Polymorphism databases
DMDM	259016374.
Proteomic databases
PRIDE	Q2TAM9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358022; ENSP00000350716; ENSG00000198680.
GeneID	286319.
KEGG	hsa:286319.
UCSC	uc003zpx.1. human.
Organism-specific databases
CTD	286319.
GeneCards	GC09M025668.
H-InvDB	HIX0034807.
HGNC	HGNC:31010. TUSC1.
MIM	610529. gene.
neXtProt	NX_Q2TAM9.
PharmGKB	PA134889281.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16308.
GeneTree	ENSGT00390000013920.
HOGENOM	HBG126449.
HOVERGEN	HBG094925.
InParanoid	Q2TAM9.
OMA	GWRGRAG.
OrthoDB	EOG40P485.
Gene expression databases
ArrayExpress	Q2TAM9.
Bgee	Q2TAM9.
CleanEx	HS_TUSC1.
Genevestigator	Q2TAM9.
Family and domain databases
ProtoNet	Search...
Other
NextBio	96146.
SOURCE	Search...

Entry information

Entry name

TUSC1_HUMAN

Accession

Primary (citable) accession number: Q2TAM9
Secondary accession number(s): A0PJ78 , Q67GI3, Q86SS1, Q8TAH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	September 22, 2009
Last modified:	December 14, 2011
This is version 40 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.