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Protein

Tumor suppressor candidate gene 1 protein

Gene

TUSC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate gene 1 protein
Alternative name(s):
TSG-9
Short name:
TSG9
Gene namesi
Name:TUSC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:31010. TUSC1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134889281.

Polymorphism and mutation databases

BioMutaiTUSC1.
DMDMi259016374.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Tumor suppressor candidate gene 1 proteinPRO_0000312284Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei153 – 1531PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ2TAM9.
MaxQBiQ2TAM9.
PaxDbiQ2TAM9.
PRIDEiQ2TAM9.

PTM databases

iPTMnetiQ2TAM9.

Expressioni

Tissue specificityi

Widely expressed at low level. Expressed at higher level in testis, weakly expressed in muscle, colon, lung and spleen. Not detected in 3 non small cell lung carcinoma (NSCLC) cell lines with homozygous deletion of the 9p region, while it is down-regulated in 3 other tumor cell lines.1 Publication

Gene expression databases

BgeeiQ2TAM9.
CleanExiHS_TUSC1.
GenevisibleiQ2TAM9. HS.

Organism-specific databases

HPAiHPA051426.

Interactioni

Protein-protein interaction databases

BioGridi130351. 2 interactions.
STRINGi9606.ENSP00000350716.

Structurei

3D structure databases

ProteinModelPortaliQ2TAM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili73 – 11745Sequence analysisAdd
BLAST
Coiled coili155 – 18026Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 5648Gly-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IYF1. Eukaryota.
ENOG41117ET. LUCA.
GeneTreeiENSGT00390000013920.
HOGENOMiHOG000154715.
HOVERGENiHBG094925.
InParanoidiQ2TAM9.
OMAiIRARDEW.
OrthoDBiEOG715Q5Q.
PhylomeDBiQ2TAM9.
TreeFamiTF336220.

Sequencei

Sequence statusi: Complete.

Q2TAM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPMWRMRGG ATRRGSCCGG DGAADGRGPG RSGRARGGGS PSGGGGGVGW
60 70 80 90 100
RGRADGARQQ LEERFADLAA SHLEAIRARD EWDRQNARLR QENARLRLEN
110 120 130 140 150
RRLKRENRSL FRQALRLPGE GGNGTPAEAR RVPEEASTNR RARDSGREDE
160 170 180 190 200
PGSPRALRAR LEKLEAMYRR ALLQLHLEQR GPRPSGDKEE QPLQEPDSGL
210
RSRDSEPSGP WL
Length:212
Mass (Da):23,390
Last modified:September 22, 2009 - v3
Checksum:i8D7B0038B40AA9B4
GO

Sequence cautioni

The sequence AAO38227.2 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231N → D.Combined sources1 Publication
Corresponds to variant rs34498078 [ dbSNP | Ensembl ].
VAR_037471

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168647 mRNA. Translation: AAO38227.2. Different initiation.
AL590322 Genomic DNA. No translation available.
BC017510 mRNA. Translation: AAH17510.1.
BC028316 mRNA. Translation: AAH28316.1.
BC046919 mRNA. Translation: AAH46919.1.
BC110824 mRNA. Translation: AAI10825.1.
CCDSiCCDS34999.1.
RefSeqiNP_001004125.1. NM_001004125.2.
UniGeneiHs.26268.
Hs.606014.

Genome annotation databases

EnsembliENST00000358022; ENSP00000350716; ENSG00000198680.
GeneIDi286319.
KEGGihsa:286319.
UCSCiuc003zpx.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168647 mRNA. Translation: AAO38227.2. Different initiation.
AL590322 Genomic DNA. No translation available.
BC017510 mRNA. Translation: AAH17510.1.
BC028316 mRNA. Translation: AAH28316.1.
BC046919 mRNA. Translation: AAH46919.1.
BC110824 mRNA. Translation: AAI10825.1.
CCDSiCCDS34999.1.
RefSeqiNP_001004125.1. NM_001004125.2.
UniGeneiHs.26268.
Hs.606014.

3D structure databases

ProteinModelPortaliQ2TAM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130351. 2 interactions.
STRINGi9606.ENSP00000350716.

PTM databases

iPTMnetiQ2TAM9.

Polymorphism and mutation databases

BioMutaiTUSC1.
DMDMi259016374.

Proteomic databases

EPDiQ2TAM9.
MaxQBiQ2TAM9.
PaxDbiQ2TAM9.
PRIDEiQ2TAM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358022; ENSP00000350716; ENSG00000198680.
GeneIDi286319.
KEGGihsa:286319.
UCSCiuc003zpx.4. human.

Organism-specific databases

CTDi286319.
GeneCardsiTUSC1.
HGNCiHGNC:31010. TUSC1.
HPAiHPA051426.
MIMi610529. gene.
neXtProtiNX_Q2TAM9.
PharmGKBiPA134889281.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYF1. Eukaryota.
ENOG41117ET. LUCA.
GeneTreeiENSGT00390000013920.
HOGENOMiHOG000154715.
HOVERGENiHBG094925.
InParanoidiQ2TAM9.
OMAiIRARDEW.
OrthoDBiEOG715Q5Q.
PhylomeDBiQ2TAM9.
TreeFamiTF336220.

Miscellaneous databases

GenomeRNAii286319.
PROiQ2TAM9.
SOURCEiSearch...

Gene expression databases

BgeeiQ2TAM9.
CleanExiHS_TUSC1.
GenevisibleiQ2TAM9. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer."
    Shan Z., Parker T., Wiest J.S.
    Oncogene 23:6612-6620(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-123.
    Tissue: Brain, Colon and Skin.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTUSC1_HUMAN
AccessioniPrimary (citable) accession number: Q2TAM9
Secondary accession number(s): A0PJ78
, Q67GI3, Q86SS1, Q8TAH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 22, 2009
Last modified: June 8, 2016
This is version 66 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.