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Protein

Glutamine-rich protein 1

Gene

QRICH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31478-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine-rich protein 1
Gene namesi
Name:QRICH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24713. QRICH1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198218.
PharmGKBiPA142671106.

Polymorphism and mutation databases

BioMutaiQRICH1.
DMDMi121941773.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002698531 – 776Glutamine-rich protein 1Add BLAST776

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Modified residuei464PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ2TAL8.
MaxQBiQ2TAL8.
PaxDbiQ2TAL8.
PeptideAtlasiQ2TAL8.
PRIDEiQ2TAL8.

PTM databases

iPTMnetiQ2TAL8.
PhosphoSitePlusiQ2TAL8.

Expressioni

Gene expression databases

BgeeiENSG00000198218.
CleanExiHS_QRICH1.
ExpressionAtlasiQ2TAL8. baseline and differential.
GenevisibleiQ2TAL8. HS.

Organism-specific databases

HPAiHPA037677.
HPA037678.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRXO431865EBI-2798044,EBI-748171
FHL3Q136435EBI-2798044,EBI-741101
FLJ13057Q53SE73EBI-2798044,EBI-10172181
GMCL1Q96IK54EBI-2798044,EBI-2548508
HSFY2Q96LI63EBI-2798044,EBI-3957665
HSPB8Q9UJY15EBI-2798044,EBI-739074
MEOX1P502213EBI-2798044,EBI-2864512
NFIXQ149383EBI-2798044,EBI-8476987
NLKQ9UBE83EBI-2798044,EBI-366978
POGZQ7Z3K34EBI-2798044,EBI-1389308
PUF60Q9UHX13EBI-2798044,EBI-1053259
RBM17Q96I253EBI-2798044,EBI-740272
SEPHS1P499039EBI-2798044,EBI-714091
SIAH1Q8IUQ43EBI-2798044,EBI-747107
TRAF1Q130775EBI-2798044,EBI-359224

Protein-protein interaction databases

BioGridi120219. 41 interactors.
IntActiQ2TAL8. 31 interactors.
MINTiMINT-2873877.
STRINGi9606.ENSP00000350094.

Structurei

3D structure databases

ProteinModelPortaliQ2TAL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 64CARDAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 462Gln-richAdd BLAST378

Sequence similaritiesi

Contains 1 CARD domain.Curated

Phylogenomic databases

eggNOGiENOG410IE8I. Eukaryota.
ENOG410XQR6. LUCA.
GeneTreeiENSGT00550000074408.
HOGENOMiHOG000220895.
HOVERGENiHBG056512.
InParanoidiQ2TAL8.
OMAiQNITHIA.
OrthoDBiEOG091G00KQ.
PhylomeDBiQ2TAL8.
TreeFamiTF336988.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR021893. DUF3504.
[Graphical view]
PfamiPF12012. DUF3504. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TAL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNSLENTIS FEEYIRVKAR SVPQHRMKEF LDSLASKGPE ALQEFQQTAT
60 70 80 90 100
TTMVYQQGGN CIYTDSTEVA GSLLELACPV TTSVQPQTQQ EQQIQVQQPQ
110 120 130 140 150
QVQVQVQVQQ SPQQVSAQLS PQLTVHQPTE QPIQVQVQIQ GQAPQSAAPS
160 170 180 190 200
IQTPSLQSPS PSQLQAAQIQ VQHVQAAQQI QAAEIPEEHI PHQQIQAQLV
210 220 230 240 250
AGQSLAGGQQ IQIQTVGALS PPPSQQGSPR EGERRVGTAS VLQPVKKRKV
260 270 280 290 300
DMPITVSYAI SGQPVATVLA IPQGQQQSYV SLRPDLLTVD SAHLYSATGT
310 320 330 340 350
ITSPTGETWT IPVYSAQPRG DPQQQSITHI AIPQEAYNAV HVSGSPTALA
360 370 380 390 400
AVKLEDDKEK MVGTTSVVKN SHEEVVQTLA NSLFPAQFMN GNIHIPVAVQ
410 420 430 440 450
AVAGTYQNTA QTVHIWDPQQ QPQQQTPQEQ TPPPQQQQQQ LQVTCSAQTV
460 470 480 490 500
QVAEVEPQSQ PQPSPELLLP NSLKPEEGLE VWKNWAQTKN AELEKDAQNR
510 520 530 540 550
LAPIGRRQLL RFQEDLISSA VAELNYGLCL MTREARNGEG EPYDPDVLYY
560 570 580 590 600
IFLCIQKYLF ENGRVDDIFS DLYYVRFTEW LHEVLKDVQP RVTPLGYVLP
610 620 630 640 650
SHVTEEMLWE CKQLGAHSPS TLLTTLMFFN TKYFLLKTVD QHMKLAFSKV
660 670 680 690 700
LRQTKKNPSN PKDKSTSIRY LKALGIHQTG QKVTDDMYAE QTENPENPLR
710 720 730 740 750
CPIKLYDFYL FKCPQSVKGR NDTFYLTPEP VVAPNSPIWY SVQPISREQM
760 770
GQMLTRILVI REIQEAIAVA NASTMH
Length:776
Mass (Da):86,436
Last modified:January 24, 2006 - v1
Checksum:iD98CBAA9315B4D6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251D → E in BAB85047 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074313 mRNA. Translation: BAB85047.1.
BC000978 mRNA. Translation: AAH00978.2.
BC098375 mRNA. Translation: AAH98375.1.
BC110855 mRNA. Translation: AAI10856.1.
CCDSiCCDS2787.1.
RefSeqiNP_001307509.1. NM_001320580.1.
NP_001307510.1. NM_001320581.1.
NP_001307511.1. NM_001320582.1.
NP_001307512.1. NM_001320583.1.
NP_001307513.1. NM_001320584.1.
NP_001307514.1. NM_001320585.1.
NP_060200.2. NM_017730.3.
NP_942581.1. NM_198880.2.
XP_011532165.1. XM_011533863.1.
UniGeneiHs.297389.

Genome annotation databases

EnsembliENST00000357496; ENSP00000350094; ENSG00000198218.
ENST00000395443; ENSP00000378830; ENSG00000198218.
ENST00000424300; ENSP00000412890; ENSG00000198218.
GeneIDi54870.
KEGGihsa:54870.
UCSCiuc003cvu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074313 mRNA. Translation: BAB85047.1.
BC000978 mRNA. Translation: AAH00978.2.
BC098375 mRNA. Translation: AAH98375.1.
BC110855 mRNA. Translation: AAI10856.1.
CCDSiCCDS2787.1.
RefSeqiNP_001307509.1. NM_001320580.1.
NP_001307510.1. NM_001320581.1.
NP_001307511.1. NM_001320582.1.
NP_001307512.1. NM_001320583.1.
NP_001307513.1. NM_001320584.1.
NP_001307514.1. NM_001320585.1.
NP_060200.2. NM_017730.3.
NP_942581.1. NM_198880.2.
XP_011532165.1. XM_011533863.1.
UniGeneiHs.297389.

3D structure databases

ProteinModelPortaliQ2TAL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120219. 41 interactors.
IntActiQ2TAL8. 31 interactors.
MINTiMINT-2873877.
STRINGi9606.ENSP00000350094.

PTM databases

iPTMnetiQ2TAL8.
PhosphoSitePlusiQ2TAL8.

Polymorphism and mutation databases

BioMutaiQRICH1.
DMDMi121941773.

Proteomic databases

EPDiQ2TAL8.
MaxQBiQ2TAL8.
PaxDbiQ2TAL8.
PeptideAtlasiQ2TAL8.
PRIDEiQ2TAL8.

Protocols and materials databases

DNASUi54870.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357496; ENSP00000350094; ENSG00000198218.
ENST00000395443; ENSP00000378830; ENSG00000198218.
ENST00000424300; ENSP00000412890; ENSG00000198218.
GeneIDi54870.
KEGGihsa:54870.
UCSCiuc003cvu.4. human.

Organism-specific databases

CTDi54870.
GeneCardsiQRICH1.
HGNCiHGNC:24713. QRICH1.
HPAiHPA037677.
HPA037678.
neXtProtiNX_Q2TAL8.
OpenTargetsiENSG00000198218.
PharmGKBiPA142671106.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8I. Eukaryota.
ENOG410XQR6. LUCA.
GeneTreeiENSGT00550000074408.
HOGENOMiHOG000220895.
HOVERGENiHBG056512.
InParanoidiQ2TAL8.
OMAiQNITHIA.
OrthoDBiEOG091G00KQ.
PhylomeDBiQ2TAL8.
TreeFamiTF336988.

Enzyme and pathway databases

BioCyciZFISH:G66-31478-MONOMER.

Miscellaneous databases

ChiTaRSiQRICH1. human.
GeneWikiiQRICH1.
GenomeRNAii54870.
PROiQ2TAL8.

Gene expression databases

BgeeiENSG00000198218.
CleanExiHS_QRICH1.
ExpressionAtlasiQ2TAL8. baseline and differential.
GenevisibleiQ2TAL8. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR021893. DUF3504.
[Graphical view]
PfamiPF12012. DUF3504. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQRIC1_HUMAN
AccessioniPrimary (citable) accession number: Q2TAL8
Secondary accession number(s): Q4G0F7, Q7L621, Q8TEA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 24, 2006
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.