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Protein

Glutamine-rich protein 1

Gene

QRICH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine-rich protein 1
Gene namesi
Name:QRICH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000198218.10
HGNCiHGNC:24713 QRICH1
MIMi617387 gene
neXtProtiNX_Q2TAL8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198218
PharmGKBiPA142671106

Polymorphism and mutation databases

BioMutaiQRICH1
DMDMi121941773

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002698531 – 776Glutamine-rich protein 1Add BLAST776

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei345PhosphoserineCombined sources1
Cross-linki353Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki358Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei464PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ2TAL8
MaxQBiQ2TAL8
PaxDbiQ2TAL8
PeptideAtlasiQ2TAL8
PRIDEiQ2TAL8
ProteomicsDBi61468

PTM databases

iPTMnetiQ2TAL8
PhosphoSitePlusiQ2TAL8

Expressioni

Gene expression databases

BgeeiENSG00000198218
CleanExiHS_QRICH1
ExpressionAtlasiQ2TAL8 baseline and differential
GenevisibleiQ2TAL8 HS

Organism-specific databases

HPAiHPA037677
HPA037678

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120219, 50 interactors
IntActiQ2TAL8, 49 interactors
MINTiQ2TAL8
STRINGi9606.ENSP00000350094

Structurei

3D structure databases

ProteinModelPortaliQ2TAL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 64CARDAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 462Gln-richAdd BLAST378

Phylogenomic databases

eggNOGiENOG410IE8I Eukaryota
ENOG410XQR6 LUCA
GeneTreeiENSGT00550000074408
HOGENOMiHOG000220895
HOVERGENiHBG056512
InParanoidiQ2TAL8
OMAiEHIQHQQ
OrthoDBiEOG091G00KQ
PhylomeDBiQ2TAL8
TreeFamiTF336988

Family and domain databases

InterProiView protein in InterPro
IPR021893 DUF3504
PfamiView protein in Pfam
PF12012 DUF3504, 1 hit

Sequencei

Sequence statusi: Complete.

Q2TAL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNSLENTIS FEEYIRVKAR SVPQHRMKEF LDSLASKGPE ALQEFQQTAT
60 70 80 90 100
TTMVYQQGGN CIYTDSTEVA GSLLELACPV TTSVQPQTQQ EQQIQVQQPQ
110 120 130 140 150
QVQVQVQVQQ SPQQVSAQLS PQLTVHQPTE QPIQVQVQIQ GQAPQSAAPS
160 170 180 190 200
IQTPSLQSPS PSQLQAAQIQ VQHVQAAQQI QAAEIPEEHI PHQQIQAQLV
210 220 230 240 250
AGQSLAGGQQ IQIQTVGALS PPPSQQGSPR EGERRVGTAS VLQPVKKRKV
260 270 280 290 300
DMPITVSYAI SGQPVATVLA IPQGQQQSYV SLRPDLLTVD SAHLYSATGT
310 320 330 340 350
ITSPTGETWT IPVYSAQPRG DPQQQSITHI AIPQEAYNAV HVSGSPTALA
360 370 380 390 400
AVKLEDDKEK MVGTTSVVKN SHEEVVQTLA NSLFPAQFMN GNIHIPVAVQ
410 420 430 440 450
AVAGTYQNTA QTVHIWDPQQ QPQQQTPQEQ TPPPQQQQQQ LQVTCSAQTV
460 470 480 490 500
QVAEVEPQSQ PQPSPELLLP NSLKPEEGLE VWKNWAQTKN AELEKDAQNR
510 520 530 540 550
LAPIGRRQLL RFQEDLISSA VAELNYGLCL MTREARNGEG EPYDPDVLYY
560 570 580 590 600
IFLCIQKYLF ENGRVDDIFS DLYYVRFTEW LHEVLKDVQP RVTPLGYVLP
610 620 630 640 650
SHVTEEMLWE CKQLGAHSPS TLLTTLMFFN TKYFLLKTVD QHMKLAFSKV
660 670 680 690 700
LRQTKKNPSN PKDKSTSIRY LKALGIHQTG QKVTDDMYAE QTENPENPLR
710 720 730 740 750
CPIKLYDFYL FKCPQSVKGR NDTFYLTPEP VVAPNSPIWY SVQPISREQM
760 770
GQMLTRILVI REIQEAIAVA NASTMH
Length:776
Mass (Da):86,436
Last modified:January 24, 2006 - v1
Checksum:iD98CBAA9315B4D6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251D → E in BAB85047 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074313 mRNA Translation: BAB85047.1
BC000978 mRNA Translation: AAH00978.2
BC098375 mRNA Translation: AAH98375.1
BC110855 mRNA Translation: AAI10856.1
CCDSiCCDS2787.1
RefSeqiNP_001307509.1, NM_001320580.1
NP_001307510.1, NM_001320581.1
NP_001307511.1, NM_001320582.1
NP_001307512.1, NM_001320583.1
NP_001307513.1, NM_001320584.1
NP_001307514.1, NM_001320585.1
NP_060200.2, NM_017730.3
NP_942581.1, NM_198880.2
XP_011532165.1, XM_011533863.1
UniGeneiHs.297389

Genome annotation databases

EnsembliENST00000357496; ENSP00000350094; ENSG00000198218
ENST00000395443; ENSP00000378830; ENSG00000198218
ENST00000424300; ENSP00000412890; ENSG00000198218
GeneIDi54870
KEGGihsa:54870
UCSCiuc003cvu.4 human

Similar proteinsi

Entry informationi

Entry nameiQRIC1_HUMAN
AccessioniPrimary (citable) accession number: Q2TAL8
Secondary accession number(s): Q4G0F7, Q7L621, Q8TEA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 24, 2006
Last modified: June 20, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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