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Q2TAL6

- VWC2_HUMAN

UniProt

Q2TAL6 - VWC2_HUMAN

Protein

Brorin

Gene

VWC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    BMP antagonist which may play a role in neural development. Promotes cell adhesion By similarity.By similarity

    GO - Biological processi

    1. negative regulation of BMP signaling pathway Source: HGNC
    2. positive regulation of cell-substrate adhesion Source: Ensembl
    3. positive regulation of neuron differentiation Source: HGNC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brorin
    Alternative name(s):
    Brain-specific chordin-like protein
    von Willebrand factor C domain-containing protein 2
    Gene namesi
    Name:VWC2
    ORF Names:UNQ739/PRO1434
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:30200. VWC2.

    Subcellular locationi

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: Ensembl
    2. basement membrane Source: UniProtKB-SubCell
    3. cell junction Source: UniProtKB-KW
    4. extracellular space Source: HGNC
    5. interstitial matrix Source: Ensembl
    6. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Basement membrane, Cell junction, Extracellular matrix, Secreted, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA147357154.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 325298BrorinPRO_0000307159Add
    BLAST

    Proteomic databases

    PaxDbiQ2TAL6.
    PRIDEiQ2TAL6.

    Expressioni

    Gene expression databases

    BgeeiQ2TAL6.
    CleanExiHS_VWC2.
    GenevestigatoriQ2TAL6.

    Organism-specific databases

    HPAiHPA055243.

    Interactioni

    Subunit structurei

    Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000341819.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2TAL6.
    SMRiQ2TAL6. Positions 153-212, 214-276.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini153 – 21260VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini216 – 27459VWFC 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi114 – 1163Mediates cell adhesionBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi120 – 1278Poly-Ala

    Sequence similaritiesi

    Contains 2 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG83498.
    HOGENOMiHOG000036086.
    HOVERGENiHBG094842.
    InParanoidiQ2TAL6.
    OMAiSKQKQAW.
    OrthoDBiEOG73Z2TT.
    PhylomeDBiQ2TAL6.
    TreeFamiTF329913.

    Family and domain databases

    InterProiIPR001007. VWF_C.
    [Graphical view]
    PfamiPF00093. VWC. 1 hit.
    [Graphical view]
    SMARTiSM00214. VWC. 2 hits.
    [Graphical view]
    PROSITEiPS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2TAL6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSSTAMAVG ALSSSLLVTC CLMVALCSPS IPLEKLAQAP EQPGQEKREH    50
    ASRDGPGRVN ELGRPARDEG GSGRDWKSKS GRGLAGREPW SKLKQAWVSQ 100
    GGGAKAGDLQ VRPRGDTPQA EALAAAAQDA IGPELAPTPE PPEEYVYPDY 150
    RGKGCVDESG FVYAIGEKFA PGPSACPCLC TEEGPLCAQP ECPRLHPRCI 200
    HVDTSQCCPQ CKERKNYCEF RGKTYQTLEE FVVSPCERCR CEANGEVLCT 250
    VSACPQTECV DPVYEPDQCC PICKNGPNCF AETAVIPAGR EVKTDECTIC 300
    HCTYEEGTWR IERQAMCTRH ECRQM 325
    Length:325
    Mass (Da):35,282
    Last modified:January 24, 2006 - v1
    Checksum:iA38B673AB376B64D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521S → T in BAF51551. (PubMed:17400546)Curated
    Sequence conflicti52 – 521S → T in AAQ88759. (PubMed:12975309)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti120 – 1201A → G.
    Corresponds to variant rs769604 [ dbSNP | Ensembl ].
    VAR_035371

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB292671 mRNA. Translation: BAF51551.1.
    AY358393 mRNA. Translation: AAQ88759.1.
    CH471128 Genomic DNA. Translation: EAW60985.1.
    CH236955 Genomic DNA. Translation: EAL23904.1.
    BC110857 mRNA. Translation: AAI10858.1.
    CCDSiCCDS5508.1.
    RefSeqiNP_940972.2. NM_198570.3.
    UniGeneiHs.629302.

    Genome annotation databases

    EnsembliENST00000340652; ENSP00000341819; ENSG00000188730.
    GeneIDi375567.
    KEGGihsa:375567.
    UCSCiuc003tot.1. human.

    Polymorphism databases

    DMDMi121941771.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB292671 mRNA. Translation: BAF51551.1 .
    AY358393 mRNA. Translation: AAQ88759.1 .
    CH471128 Genomic DNA. Translation: EAW60985.1 .
    CH236955 Genomic DNA. Translation: EAL23904.1 .
    BC110857 mRNA. Translation: AAI10858.1 .
    CCDSi CCDS5508.1.
    RefSeqi NP_940972.2. NM_198570.3.
    UniGenei Hs.629302.

    3D structure databases

    ProteinModelPortali Q2TAL6.
    SMRi Q2TAL6. Positions 153-212, 214-276.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000341819.

    Polymorphism databases

    DMDMi 121941771.

    Proteomic databases

    PaxDbi Q2TAL6.
    PRIDEi Q2TAL6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340652 ; ENSP00000341819 ; ENSG00000188730 .
    GeneIDi 375567.
    KEGGi hsa:375567.
    UCSCi uc003tot.1. human.

    Organism-specific databases

    CTDi 375567.
    GeneCardsi GC07P049783.
    H-InvDB HIX0033600.
    HGNCi HGNC:30200. VWC2.
    HPAi HPA055243.
    MIMi 611108. gene.
    neXtProti NX_Q2TAL6.
    PharmGKBi PA147357154.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83498.
    HOGENOMi HOG000036086.
    HOVERGENi HBG094842.
    InParanoidi Q2TAL6.
    OMAi SKQKQAW.
    OrthoDBi EOG73Z2TT.
    PhylomeDBi Q2TAL6.
    TreeFami TF329913.

    Miscellaneous databases

    GenomeRNAii 375567.
    NextBioi 100529.
    PROi Q2TAL6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q2TAL6.
    CleanExi HS_VWC2.
    Genevestigatori Q2TAL6.

    Family and domain databases

    InterProi IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00093. VWC. 1 hit.
    [Graphical view ]
    SMARTi SM00214. VWC. 2 hits.
    [Graphical view ]
    PROSITEi PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells."
      Koike N., Kassai Y., Kouta Y., Miwa H., Konishi M., Itoh N.
      J. Biol. Chem. 282:15843-15850(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiVWC2_HUMAN
    AccessioniPrimary (citable) accession number: Q2TAL6
    Secondary accession number(s): Q6UXE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3