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Q2TAL6

- VWC2_HUMAN

UniProt

Q2TAL6 - VWC2_HUMAN

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Protein

Brorin

Gene
VWC2, UNQ739/PRO1434
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

BMP antagonist which may play a role in neural development. Promotes cell adhesion By similarity.

GO - Biological processi

  1. negative regulation of BMP signaling pathway Source: HGNC
  2. positive regulation of cell-substrate adhesion Source: Ensembl
  3. positive regulation of neuron differentiation Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Brorin
Alternative name(s):
Brain-specific chordin-like protein
von Willebrand factor C domain-containing protein 2
Gene namesi
Name:VWC2
ORF Names:UNQ739/PRO1434
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:30200. VWC2.

Subcellular locationi

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: Ensembl
  2. basement membrane Source: UniProtKB-SubCell
  3. cell junction Source: UniProtKB-KW
  4. extracellular space Source: HGNC
  5. interstitial matrix Source: Ensembl
  6. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Cell junction, Extracellular matrix, Secreted, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147357154.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 325298BrorinPRO_0000307159Add
BLAST

Proteomic databases

PaxDbiQ2TAL6.
PRIDEiQ2TAL6.

Expressioni

Gene expression databases

BgeeiQ2TAL6.
CleanExiHS_VWC2.
GenevestigatoriQ2TAL6.

Organism-specific databases

HPAiHPA055243.

Interactioni

Subunit structurei

Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000341819.

Structurei

3D structure databases

ProteinModelPortaliQ2TAL6.
SMRiQ2TAL6. Positions 153-212, 214-276.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 21260VWFC 1Add
BLAST
Domaini216 – 27459VWFC 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi114 – 1163Mediates cell adhesion By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi120 – 1278Poly-Ala

Sequence similaritiesi

Contains 2 VWFC domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG83498.
HOGENOMiHOG000036086.
HOVERGENiHBG094842.
InParanoidiQ2TAL6.
OMAiSKQKQAW.
OrthoDBiEOG73Z2TT.
PhylomeDBiQ2TAL6.
TreeFamiTF329913.

Family and domain databases

InterProiIPR001007. VWF_C.
[Graphical view]
PfamiPF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 2 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TAL6-1 [UniParc]FASTAAdd to Basket

« Hide

MPSSTAMAVG ALSSSLLVTC CLMVALCSPS IPLEKLAQAP EQPGQEKREH    50
ASRDGPGRVN ELGRPARDEG GSGRDWKSKS GRGLAGREPW SKLKQAWVSQ 100
GGGAKAGDLQ VRPRGDTPQA EALAAAAQDA IGPELAPTPE PPEEYVYPDY 150
RGKGCVDESG FVYAIGEKFA PGPSACPCLC TEEGPLCAQP ECPRLHPRCI 200
HVDTSQCCPQ CKERKNYCEF RGKTYQTLEE FVVSPCERCR CEANGEVLCT 250
VSACPQTECV DPVYEPDQCC PICKNGPNCF AETAVIPAGR EVKTDECTIC 300
HCTYEEGTWR IERQAMCTRH ECRQM 325
Length:325
Mass (Da):35,282
Last modified:January 24, 2006 - v1
Checksum:iA38B673AB376B64D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201A → G.
Corresponds to variant rs769604 [ dbSNP | Ensembl ].
VAR_035371

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521S → T in BAF51551. 1 Publication
Sequence conflicti52 – 521S → T in AAQ88759. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB292671 mRNA. Translation: BAF51551.1.
AY358393 mRNA. Translation: AAQ88759.1.
CH471128 Genomic DNA. Translation: EAW60985.1.
CH236955 Genomic DNA. Translation: EAL23904.1.
BC110857 mRNA. Translation: AAI10858.1.
CCDSiCCDS5508.1.
RefSeqiNP_940972.2. NM_198570.3.
UniGeneiHs.629302.

Genome annotation databases

EnsembliENST00000340652; ENSP00000341819; ENSG00000188730.
GeneIDi375567.
KEGGihsa:375567.
UCSCiuc003tot.1. human.

Polymorphism databases

DMDMi121941771.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB292671 mRNA. Translation: BAF51551.1 .
AY358393 mRNA. Translation: AAQ88759.1 .
CH471128 Genomic DNA. Translation: EAW60985.1 .
CH236955 Genomic DNA. Translation: EAL23904.1 .
BC110857 mRNA. Translation: AAI10858.1 .
CCDSi CCDS5508.1.
RefSeqi NP_940972.2. NM_198570.3.
UniGenei Hs.629302.

3D structure databases

ProteinModelPortali Q2TAL6.
SMRi Q2TAL6. Positions 153-212, 214-276.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000341819.

Polymorphism databases

DMDMi 121941771.

Proteomic databases

PaxDbi Q2TAL6.
PRIDEi Q2TAL6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340652 ; ENSP00000341819 ; ENSG00000188730 .
GeneIDi 375567.
KEGGi hsa:375567.
UCSCi uc003tot.1. human.

Organism-specific databases

CTDi 375567.
GeneCardsi GC07P049783.
H-InvDB HIX0033600.
HGNCi HGNC:30200. VWC2.
HPAi HPA055243.
MIMi 611108. gene.
neXtProti NX_Q2TAL6.
PharmGKBi PA147357154.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG83498.
HOGENOMi HOG000036086.
HOVERGENi HBG094842.
InParanoidi Q2TAL6.
OMAi SKQKQAW.
OrthoDBi EOG73Z2TT.
PhylomeDBi Q2TAL6.
TreeFami TF329913.

Miscellaneous databases

GenomeRNAii 375567.
NextBioi 100529.
PROi Q2TAL6.
SOURCEi Search...

Gene expression databases

Bgeei Q2TAL6.
CleanExi HS_VWC2.
Genevestigatori Q2TAL6.

Family and domain databases

InterProi IPR001007. VWF_C.
[Graphical view ]
Pfami PF00093. VWC. 1 hit.
[Graphical view ]
SMARTi SM00214. VWC. 2 hits.
[Graphical view ]
PROSITEi PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells."
    Koike N., Kassai Y., Kouta Y., Miwa H., Konishi M., Itoh N.
    J. Biol. Chem. 282:15843-15850(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiVWC2_HUMAN
AccessioniPrimary (citable) accession number: Q2TAL6
Secondary accession number(s): Q6UXE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 24, 2006
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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