Q2TAL6 (VWC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brorin

Alternative name(s):
Brain-specific chordin-like protein
von Willebrand factor C domain-containing protein 2

Gene names

Name:	VWC2
ORF Names:	UNQ739/PRO1434

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	BMP antagonist which may play a role in neural development. Promotes cell adhesion By similarity.
Subunit structure	Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix › basement membrane By similarity. Cell junction › synapse By similarity.
Sequence similarities	Contains 2 VWFC domains.

Ontologies

Keywords
Cellular component	Basement membrane Cell junction Extracellular matrix Secreted Synapse
Coding sequence diversity	Polymorphism
Domain	Repeat Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of BMP signaling pathway Inferred from sequence or structural similarity Ref.1. Source: HGNC positive regulation of cell-substrate adhesion Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from sequence or structural similarity Ref.1. Source: HGNC
Cellular_component	basement membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cell junction Inferred from electronic annotation. Source: UniProtKB-KW extracellular space Inferred from sequence or structural similarity Ref.1. Source: HGNC interstitial matrix Inferred from electronic annotation. Source: Compara synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 325	298	Brorin		PRO_0000307159
Regions
	Domain	153 – 212	60	VWFC 1
	Domain	216 – 274	59	VWFC 2
	Motif	114 – 116	3	Mediates cell adhesion By similarity
	Compositional bias	120 – 127	8	Poly-Ala
Natural variations
	Natural variant	120	1	A → G. Corresponds to variant rs769604 [ dbSNP | Ensembl ].		VAR_035371
Experimental info
	Sequence conflict	52	1	S → T in BAF51551. Ref.1
	Sequence conflict	52	1	S → T in AAQ88759. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q2TAL6 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: A38B673AB376B64D	FASTA	325	35,282
	10 20 30 40 50 60 MPSSTAMAVG ALSSSLLVTC CLMVALCSPS IPLEKLAQAP EQPGQEKREH ASRDGPGRVN 70 80 90 100 110 120 ELGRPARDEG GSGRDWKSKS GRGLAGREPW SKLKQAWVSQ GGGAKAGDLQ VRPRGDTPQA 130 140 150 160 170 180 EALAAAAQDA IGPELAPTPE PPEEYVYPDY RGKGCVDESG FVYAIGEKFA PGPSACPCLC 190 200 210 220 230 240 TEEGPLCAQP ECPRLHPRCI HVDTSQCCPQ CKERKNYCEF RGKTYQTLEE FVVSPCERCR 250 260 270 280 290 300 CEANGEVLCT VSACPQTECV DPVYEPDQCC PICKNGPNCF AETAVIPAGR EVKTDECTIC 310 320 HCTYEEGTWR IERQAMCTRH ECRQM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells." Koike N., Kassai Y., Kouta Y., Miwa H., Konishi M., Itoh N. J. Biol. Chem. 282:15843-15850(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB292671 mRNA. Translation: BAF51551.1. AY358393 mRNA. Translation: AAQ88759.1. CH471128 Genomic DNA. Translation: EAW60985.1. CH236955 Genomic DNA. Translation: EAL23904.1. BC110857 mRNA. Translation: AAI10858.1.
IPI	IPI00394870.
RefSeq	NP_940972.2. NM_198570.3.
UniGene	Hs.629302.
3D structure databases
ProteinModelPortal	Q2TAL6.
SMR	Q2TAL6. Positions 153-212, 214-276.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000341819.
Polymorphism databases
DMDM	121941771.
Proteomic databases
PaxDb	Q2TAL6.
PRIDE	Q2TAL6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340652; ENSP00000341819; ENSG00000188730.
GeneID	375567.
KEGG	hsa:375567.
UCSC	uc003tot.1. human.
Organism-specific databases
CTD	375567.
GeneCards	GC07P049783.
H-InvDB	HIX0033600.
HGNC	HGNC:30200. VWC2.
MIM	611108. gene.
neXtProt	NX_Q2TAL6.
PharmGKB	PA147357154.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG83498.
HOGENOM	HOG000036086.
HOVERGEN	HBG094842.
InParanoid	Q2TAL6.
OMA	SKQKQAW.
OrthoDB	EOG41NTMM.
PhylomeDB	Q2TAL6.
Gene expression databases
Bgee	Q2TAL6.
CleanEx	HS_VWC2.
Genevestigator	Q2TAL6.
Family and domain databases
InterPro	IPR001007. VWF_C. [Graphical view]
Pfam	PF00093. VWC. 1 hit. [Graphical view]
SMART	SM00214. VWC. 2 hits. [Graphical view]
PROSITE	PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	375567.
NextBio	100529.
SOURCE	Search...

Entry information

Entry name

VWC2_HUMAN

Accession

Primary (citable) accession number: Q2TAL6
Secondary accession number(s): Q6UXE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	January 24, 2006
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.