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Protein

Brorin

Gene

VWC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).By similarity

GO - Biological processi

  1. negative regulation of BMP signaling pathway Source: HGNC
  2. positive regulation of cell-substrate adhesion Source: Ensembl
  3. positive regulation of neuron differentiation Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Brorin
Alternative name(s):
Brain-specific chordin-like protein
von Willebrand factor C domain-containing protein 2
Gene namesi
Name:VWC2
ORF Names:UNQ739/PRO1434
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:30200. VWC2.

Subcellular locationi

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: Ensembl
  2. basement membrane Source: UniProtKB-SubCell
  3. cell junction Source: UniProtKB-KW
  4. extracellular space Source: HGNC
  5. interstitial matrix Source: Ensembl
  6. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Cell junction, Extracellular matrix, Secreted, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147357154.

Polymorphism and mutation databases

BioMutaiVWC2.
DMDMi121941771.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 325298BrorinPRO_0000307159Add
BLAST

Proteomic databases

PaxDbiQ2TAL6.
PRIDEiQ2TAL6.

Expressioni

Gene expression databases

BgeeiQ2TAL6.
CleanExiHS_VWC2.
GenevestigatoriQ2TAL6.

Organism-specific databases

HPAiHPA055243.

Interactioni

Subunit structurei

Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000341819.

Structurei

3D structure databases

ProteinModelPortaliQ2TAL6.
SMRiQ2TAL6. Positions 154-192, 218-254, 265-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini153 – 21260VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini216 – 27459VWFC 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi114 – 1163Mediates cell adhesionBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi120 – 1278Poly-Ala

Sequence similaritiesi

Contains 2 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG83498.
GeneTreeiENSGT00720000108792.
HOGENOMiHOG000036086.
HOVERGENiHBG094842.
InParanoidiQ2TAL6.
OMAiSKQKQAW.
OrthoDBiEOG73Z2TT.
PhylomeDBiQ2TAL6.
TreeFamiTF329913.

Family and domain databases

InterProiIPR030111. Brorin.
IPR001007. VWF_C.
[Graphical view]
PANTHERiPTHR11339:SF258. PTHR11339:SF258. 1 hit.
PfamiPF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 2 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q2TAL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSTAMAVG ALSSSLLVTC CLMVALCSPS IPLEKLAQAP EQPGQEKREH
60 70 80 90 100
ASRDGPGRVN ELGRPARDEG GSGRDWKSKS GRGLAGREPW SKLKQAWVSQ
110 120 130 140 150
GGGAKAGDLQ VRPRGDTPQA EALAAAAQDA IGPELAPTPE PPEEYVYPDY
160 170 180 190 200
RGKGCVDESG FVYAIGEKFA PGPSACPCLC TEEGPLCAQP ECPRLHPRCI
210 220 230 240 250
HVDTSQCCPQ CKERKNYCEF RGKTYQTLEE FVVSPCERCR CEANGEVLCT
260 270 280 290 300
VSACPQTECV DPVYEPDQCC PICKNGPNCF AETAVIPAGR EVKTDECTIC
310 320
HCTYEEGTWR IERQAMCTRH ECRQM
Length:325
Mass (Da):35,282
Last modified:January 24, 2006 - v1
Checksum:iA38B673AB376B64D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521S → T in BAF51551 (PubMed:17400546).Curated
Sequence conflicti52 – 521S → T in AAQ88759 (PubMed:12975309).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201A → G.
Corresponds to variant rs769604 [ dbSNP | Ensembl ].
VAR_035371

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB292671 mRNA. Translation: BAF51551.1.
AY358393 mRNA. Translation: AAQ88759.1.
CH471128 Genomic DNA. Translation: EAW60985.1.
CH236955 Genomic DNA. Translation: EAL23904.1.
BC110857 mRNA. Translation: AAI10858.1.
CCDSiCCDS5508.1.
RefSeqiNP_940972.2. NM_198570.3.
UniGeneiHs.629302.

Genome annotation databases

EnsembliENST00000340652; ENSP00000341819; ENSG00000188730.
GeneIDi375567.
KEGGihsa:375567.
UCSCiuc003tot.1. human.

Polymorphism and mutation databases

BioMutaiVWC2.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB292671 mRNA. Translation: BAF51551.1.
AY358393 mRNA. Translation: AAQ88759.1.
CH471128 Genomic DNA. Translation: EAW60985.1.
CH236955 Genomic DNA. Translation: EAL23904.1.
BC110857 mRNA. Translation: AAI10858.1.
CCDSiCCDS5508.1.
RefSeqiNP_940972.2. NM_198570.3.
UniGeneiHs.629302.

3D structure databases

ProteinModelPortaliQ2TAL6.
SMRiQ2TAL6. Positions 154-192, 218-254, 265-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341819.

Polymorphism and mutation databases

BioMutaiVWC2.
DMDMi121941771.

Proteomic databases

PaxDbiQ2TAL6.
PRIDEiQ2TAL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340652; ENSP00000341819; ENSG00000188730.
GeneIDi375567.
KEGGihsa:375567.
UCSCiuc003tot.1. human.

Organism-specific databases

CTDi375567.
GeneCardsiGC07P049783.
H-InvDBHIX0033600.
HGNCiHGNC:30200. VWC2.
HPAiHPA055243.
MIMi611108. gene.
neXtProtiNX_Q2TAL6.
PharmGKBiPA147357154.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG83498.
GeneTreeiENSGT00720000108792.
HOGENOMiHOG000036086.
HOVERGENiHBG094842.
InParanoidiQ2TAL6.
OMAiSKQKQAW.
OrthoDBiEOG73Z2TT.
PhylomeDBiQ2TAL6.
TreeFamiTF329913.

Miscellaneous databases

GenomeRNAii375567.
NextBioi100529.
PROiQ2TAL6.
SOURCEiSearch...

Gene expression databases

BgeeiQ2TAL6.
CleanExiHS_VWC2.
GenevestigatoriQ2TAL6.

Family and domain databases

InterProiIPR030111. Brorin.
IPR001007. VWF_C.
[Graphical view]
PANTHERiPTHR11339:SF258. PTHR11339:SF258. 1 hit.
PfamiPF00093. VWC. 1 hit.
[Graphical view]
SMARTiSM00214. VWC. 2 hits.
[Graphical view]
PROSITEiPS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells."
    Koike N., Kassai Y., Kouta Y., Miwa H., Konishi M., Itoh N.
    J. Biol. Chem. 282:15843-15850(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiVWC2_HUMAN
AccessioniPrimary (citable) accession number: Q2TAL6
Secondary accession number(s): Q6UXE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: January 24, 2006
Last modified: April 29, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.