Reviewed, UniProtKB/Swiss-Prot Q2TAE3 (DYR1A_XENLA)

Names and origin

Protein names

Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 1A
    EC=2.7.12.1
Alternative name(s):
    Protein kinase minibrain homolog

Gene names

Name:

dyrk1a

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	750 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates By similarity. UniProtKB Q13627
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Nucleus speckle By similarity.
Induction	By insulin. Ref.2
Post-translational modification	Autophosphorylated on tyrosine residues By similarity. UniProtKB Q13627
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	peptidyl-tyrosine phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB protein amino acid autophosphorylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	nuclear speck Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from sequence or structural similarity. Source: UniProtKB protein tyrosine kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 750	750	Dual specificity tyrosine-phosphorylation-regulated kinase 1A		PRO_0000284707
Regions
	Domain	151 – 471	321	Protein kinase
	Nucleotide binding	157 – 165	9	ATP By similarity
	Motif	109 – 126	18	Bipartite nuclear localization signal Potential
	Compositional bias	482 – 516	35	Ser-rich
	Compositional bias	589 – 609	21	His-rich
	Compositional bias	596 – 606	11	Poly-His
	Compositional bias	622 – 658	37	Ser-rich
Sites
	Active site	279	1	Proton acceptor By similarity
	Binding site	180	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2TAE3-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 2A14AA063E7EBC0E	FASTA	750	84,157
	10 20 30 40 50 60 MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMSHSHQQ YSDRHQQNLN DQQASALPYN 70 80 90 100 110 120 DQTPQPLPNQ RRMPQTFRDP ATAPLRKLSV DLIKTYKHIN EVYYAKKKRR HQQGQGDDSS 130 140 150 160 170 180 HKKERKVYND GYDDDNYDYI VKNGEKWMDR YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK 190 200 210 220 230 240 IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL 250 260 270 280 290 300 LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT PELSIIHCDL KPENILLCNP KRSAIKIVDF 310 320 330 340 350 360 GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG CILVEMHTGE PLFSGANEVD 370 380 390 400 410 420 QMSKIVEVLG IPPAHILDQA PKARKFFEKM PEGTWNLKKT KDGKKEYKPP GTRKLHNILG 430 440 450 460 470 480 VENGGPGGRR AGESGHTVAD YLKFKDVILR MLDYDAKTRI QPYYALQHSF FKKTADEGTN 490 500 510 520 530 540 TSNSVSTSPA MEQSQSSGTT SSTSSSSGGS SGTSNSGRAR SDPTHQHRHS GGHFTTAVAM 550 560 570 580 590 600 DCETHSPQVR QQFPPGWTVP EAPTQVTIET HPVQETTFHV PPSQKNVPHH HGNGSHHHHH 610 620 630 640 650 660 HHHHHHGQHI LSNRTRTRIY NSPSTSSSTQ DSMDIGNSHH SMTSLSSSTT SSSTSSSSTG 670 680 690 700 710 720 NQGNQAYQNR PVAANTLDFG QNGTLDVNLT VYSNPRQETG ITGHPDYQYS ANTGPGHYVT 730 740 750 EGQLTMRQGI DREDSPMTGV CVQQSPVASS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
[2]	"Two dual specificity kinases are preferentially induced by wild-type rather than by oncogenic RAS-P21 in Xenopus oocytes." Qu Y., Adler V., Chu T., Platica O., Michl J., Pestka S., Izotova L., Boutjdir M., Pincus M.R. Front. Biosci. 11:2420-2427(2006) [PubMed: 16720323] [Abstract] Cited for: INDUCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC110968 mRNA. Translation: AAI10969.1.
RefSeq	NP_001156669.1.
UniGene	Xl.29801
3D structure databases
HSSP	HSSP built from PDB template 1Z57 based on UniProtKB P49759.
SMR	Q2TAE3. Positions 133-477.
ModBase	Search...
Genome annotation databases
GeneID	446302.
KEGG	xla:446302.
Organism-specific databases
CTD	446302.
Xenbase	XB-FEAT-1017104. dyrk1a.
Phylogenomic databases
HOVERGEN	Q2TAE3.
Enzyme and pathway databases
BRENDA	2.7.12.1. 648.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DYR1A_XENLA

Accession

Primary (citable) accession number: Q2TAE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	January 24, 2006
Last modified:	January 19, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project