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Protein

Kinesin-like protein KIF19

Gene

KIF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 111ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33115-MONOMER.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF19
Gene namesi
Name:KIF19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:26735. KIF19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi124602.
OpenTargetsiENSG00000196169.
PharmGKBiPA143485523.

Polymorphism and mutation databases

BioMutaiKIF19.
DMDMi126215730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782451 – 998Kinesin-like protein KIF19Add BLAST998

Proteomic databases

EPDiQ2TAC6.
PaxDbiQ2TAC6.
PeptideAtlasiQ2TAC6.
PRIDEiQ2TAC6.

PTM databases

iPTMnetiQ2TAC6.
PhosphoSitePlusiQ2TAC6.

Expressioni

Gene expression databases

BgeeiENSG00000196169.
CleanExiHS_KIF19.
ExpressionAtlasiQ2TAC6. baseline and differential.

Organism-specific databases

HPAiHPA043638.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000374566.

Structurei

3D structure databases

ProteinModelPortaliQ2TAC6.
SMRiQ2TAC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 346Kinesin motorPROSITE-ProRule annotationAdd BLAST336

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili360 – 391Sequence analysisAdd BLAST32
Coiled coili424 – 452Sequence analysisAdd BLAST29
Coiled coili507 – 552Sequence analysisAdd BLAST46

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0242. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133670.
HOGENOMiHOG000033701.
HOVERGENiHBG081853.
InParanoidiQ2TAC6.
KOiK10401.
OMAiSRPKTHL.
OrthoDBiEOG091G06HZ.
PhylomeDBiQ2TAC6.
TreeFamiTF331721.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2TAC6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKDSGDSKDQ QLMVALRVRP ISVAELEEGA TLIAHKVDEQ MVVLMDPMED
60 70 80 90 100
PDDILRAHRS REKSYLFDVA FDFTATQEMV YQATTKSLIE GVISGYNATV
110 120 130 140 150
FAYGPTGCGK TYTMLGTDQE PGIYVQTLND LFRAIEETSN DMEYEVSMSY
160 170 180 190 200
LEIYNEMIRD LLNPSLGYLE LREDSKGVIQ VAGITEVSTI NAKEIMQLLM
210 220 230 240 250
KGNRQRTQEP TAANQTSSRS HAVLQVTVRQ RSRVKNILQE VRQGRLFMID
260 270 280 290 300
LAGSERASQT QNRGQRMKEG AHINRSLLAL GNCINALSDK GSNKYINYRD
310 320 330 340 350
SKLTRLLKDS LGGNSRTVMI AHISPASSAF EESRNTLTYA GRAKNIKTRV
360 370 380 390 400
KQNLLNVSYH IAQYTSIIAD LRGEIQRLKR KIDEQTGRGQ ARGRQDRGDI
410 420 430 440 450
RHIQAEVQLH SGQGEKAGMG QLREQLASAF QEQMDVRRRL LELENRAMEV
460 470 480 490 500
QIDTSRHLLT IAGWKHEKSR RALKWREEQR KECYAKDDSE KDSDTGDDQP
510 520 530 540 550
DILEPPEVAA ARESIAALVD EQKQLRKQKL ALEQRCRELR ARGRRLEETL
560 570 580 590 600
PRRIGSEEQR EVLSLLCRVH ELEVENTEMQ SHALLRDGAL RHRHEAVRRL
610 620 630 640 650
EQHRSLCDEI IQGQRQIIDD YNLAVPQRLE ELYEVYLREL EEGSLEQATI
660 670 680 690 700
MDQVASRALQ DSSLPKITPA GTSLTPDSDL ESVKTLSSDA QHLQNSALPP
710 720 730 740 750
LSTESEGHHV FKAGTGAWQA KSSSVPTPPP IQLGSLVTQE APAQDSLGSW
760 770 780 790 800
INSSPDSSEN LSEIPLSHKE RKEILTGTKC IWVKAARRRS RALGTEGRHL
810 820 830 840 850
LAPATERSSL SLHSLSEGDD ARPPGPLACK RPPSPTLQHA ASEDNLSSST
860 870 880 890 900
GEAPSRAVGH HGDGPRPWLR GQKKSLGKKR EESLEAKRRK RRSRSFEVTG
910 920 930 940 950
QGLSHPKTHL LGPHQAERIS DHRMPVCRHP APGIRHLGKV TLPLAKVKLP
960 970 980 990
PSQNTGPGDS SPLAVPPNPG GGSRRATRGP RLPHGTSTHG KDGCSRHN
Length:998
Mass (Da):111,332
Last modified:February 20, 2007 - v2
Checksum:i7E42AB992F038E53
GO
Isoform 2 (identifier: Q2TAC6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     530-548: LALEQRCRELRARGRRLEE → VSRVWGDKESGFRGQGEQV
     549-998: Missing.

Note: Due to intron retention.
Show »
Length:548
Mass (Da):61,975
Checksum:iE920E205F3A6796E
GO
Isoform 3 (identifier: Q2TAC6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-193: Missing.
     530-548: LALEQRCRELRARGRRLEE → VSRVWGDKESGFRGQGEQV
     549-998: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:506
Mass (Da):57,300
Checksum:i38D042C6A2DF3852
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030719471R → W.1 PublicationCorresponds to variant rs2382644dbSNPEnsembl.1
Natural variantiVAR_059371807R → H.Corresponds to variant rs2271535dbSNPEnsembl.1
Natural variantiVAR_049703937L → P.Corresponds to variant rs9891620dbSNPEnsembl.1
Natural variantiVAR_061283974R → Q.Corresponds to variant rs9675190dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023207152 – 193Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_023208530 – 548LALEQ…RRLEE → VSRVWGDKESGFRGQGEQV in isoform 2 and isoform 3. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_023209549 – 998Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST450

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094619 mRNA. Translation: BAC04386.1.
AC055863 Genomic DNA. No translation available.
AC103809 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89153.1.
BC093631 mRNA. Translation: AAH93631.1.
BC104852 mRNA. Translation: AAI04853.1.
BC110989 mRNA. Translation: AAI10990.1.
BC143327 mRNA. Translation: AAI43328.1.
CCDSiCCDS32718.2. [Q2TAC6-1]
RefSeqiNP_694941.2. NM_153209.3. [Q2TAC6-1]
UniGeneiHs.372773.

Genome annotation databases

EnsembliENST00000389916; ENSP00000374566; ENSG00000196169. [Q2TAC6-1]
GeneIDi124602.
KEGGihsa:124602.
UCSCiuc002jkm.4. human. [Q2TAC6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094619 mRNA. Translation: BAC04386.1.
AC055863 Genomic DNA. No translation available.
AC103809 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89153.1.
BC093631 mRNA. Translation: AAH93631.1.
BC104852 mRNA. Translation: AAI04853.1.
BC110989 mRNA. Translation: AAI10990.1.
BC143327 mRNA. Translation: AAI43328.1.
CCDSiCCDS32718.2. [Q2TAC6-1]
RefSeqiNP_694941.2. NM_153209.3. [Q2TAC6-1]
UniGeneiHs.372773.

3D structure databases

ProteinModelPortaliQ2TAC6.
SMRiQ2TAC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000374566.

PTM databases

iPTMnetiQ2TAC6.
PhosphoSitePlusiQ2TAC6.

Polymorphism and mutation databases

BioMutaiKIF19.
DMDMi126215730.

Proteomic databases

EPDiQ2TAC6.
PaxDbiQ2TAC6.
PeptideAtlasiQ2TAC6.
PRIDEiQ2TAC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389916; ENSP00000374566; ENSG00000196169. [Q2TAC6-1]
GeneIDi124602.
KEGGihsa:124602.
UCSCiuc002jkm.4. human. [Q2TAC6-1]

Organism-specific databases

CTDi124602.
DisGeNETi124602.
GeneCardsiKIF19.
HGNCiHGNC:26735. KIF19.
HPAiHPA043638.
neXtProtiNX_Q2TAC6.
OpenTargetsiENSG00000196169.
PharmGKBiPA143485523.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0242. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00860000133670.
HOGENOMiHOG000033701.
HOVERGENiHBG081853.
InParanoidiQ2TAC6.
KOiK10401.
OMAiSRPKTHL.
OrthoDBiEOG091G06HZ.
PhylomeDBiQ2TAC6.
TreeFamiTF331721.

Enzyme and pathway databases

BioCyciZFISH:G66-33115-MONOMER.
ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Miscellaneous databases

ChiTaRSiKIF19. human.
GenomeRNAii124602.
PROiQ2TAC6.

Gene expression databases

BgeeiENSG00000196169.
CleanExiHS_KIF19.
ExpressionAtlasiQ2TAC6. baseline and differential.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKIF19_HUMAN
AccessioniPrimary (citable) accession number: Q2TAC6
Secondary accession number(s): A6NLG2
, B7ZKR1, Q52M87, Q8N1X8, Q8TAB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.