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Q2TAA8 (TXIP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translin-associated factor X-interacting protein 1

Short name=Trax-interacting protein 1
Gene names
Name:TSNAXIP1
Synonyms:TXI1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length658 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possible role in spermatogenesis By similarity. UniProtKB Q99P25

Subunit structure

Interacts with TSNAX By similarity. UniProtKB Q99P25

Subcellular location

Cytoplasmperinuclear region By similarity UniProtKB Q99P25.

Ontologies

Keywords
   Biological processDifferentiation
Spermatogenesis
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

multicellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

spermatogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.3 (identifier: Q2TAA8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 Ref.1 Ref.3 (identifier: Q2TAA8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-292: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 658658Translin-associated factor X-interacting protein 1
PRO_0000323608

Regions

Coiled coil144 – 18441 Potential
Coiled coil230 – 29566 Potential

Natural variations

Alternative sequence1 – 292292Missing in isoform 2. Ref.1 Ref.3
VSP_052710

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 6CC03A9AB772AD01

FASTA65876,773
        10         20         30         40         50         60 
MGGHLSPWPT YTSGQTILQN RKPCSDDYRK RVGSCQQHPF RTAKPQYLEE LENYLRKELL 

        70         80         90        100        110        120 
LLDLGTDSTQ ELRLQPYREI FEFFIEDFKT YKPLLSSIKN AYEGMLAHQR EKIRALEPLK 

       130        140        150        160        170        180 
AKLVTVNEDC NERILAMRAE EKYEISLLKK EKMNLLKLID KKNEEKISLQ SEVTKLRKNL 

       190        200        210        220        230        240 
AEEYLHYLSE RDACKILIAD LNELRYQRED MSLAQSPGIW GEDPVKLTLA LKMTRQDLTR 

       250        260        270        280        290        300 
TQMELNNMKA NFGDVVPRRD FEMQEKTNKD LQEQLDTLRA SYEEVRKEHE ILMQLHMSTL 

       310        320        330        340        350        360 
KERDQFFSEL QEIQRTSTPR PDWTKCKDVV AGGPERWQML AEGKNSDQLV DVLLEEIGSG 

       370        380        390        400        410        420 
LLREKDFFPG LGYGEAIPAF LRFDGLVENK KPSKKDVVNL LKDAWKERLA EEQKETFPDF 

       430        440        450        460        470        480 
FFNFLEHRFG PSDAMAWAYT IFENIKIFHS NEVMSQFYAV LMGKRSENVY VTQKETVAQL 

       490        500        510        520        530        540 
LKEMTNADSQ NEGLLTMEQF NTVLKSTFPL KTEEQIQELM EAGGWHPSSS NADLLNYRSL 

       550        560        570        580        590        600 
FMEDEEGQSE PFVQKLWEQY MDEKDEYLQQ LKQELGIELH EEVTLPKLRG GLMTIDPSLD 

       610        620        630        640        650 
KQTVNTYMSQ AFQLPESEMP EEGDEKEEAV VEILQTALER LQVIDIRRVG PREPEPAS 

« Hide

Isoform 2 [UniParc].

Checksum: 2F190A1F2E90DF19
Show »

FASTA36642,299

References

« Hide 'large scale' references
[1]Luo W.Q., Chen J.H., Huang X.W., Zhou Y., Zhou H.J., Hu S.N., Yuan J.G.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF132730 mRNA. Translation: AAF66441.1.
CH471092 Genomic DNA. Translation: EAW83169.1.
CH471092 Genomic DNA. Translation: EAW83174.1.
BC111018 mRNA. Translation: AAI11019.1.
CCDSCCDS10846.2. [Q2TAA8-1]
RefSeqNP_001275920.1. NM_001288991.1.
NP_001275921.1. NM_001288992.1. [Q2TAA8-2]
NP_001275922.1. NM_001288993.1. [Q2TAA8-2]
NP_001275923.1. NM_001288994.1. [Q2TAA8-2]
NP_060900.2. NM_018430.3. [Q2TAA8-1]
UniGeneHs.632212.

3D structure databases

ProteinModelPortalQ2TAA8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120925. 2 interactions.

Polymorphism databases

DMDM121946829.

Proteomic databases

MaxQBQ2TAA8.
PaxDbQ2TAA8.
PRIDEQ2TAA8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000388833; ENSP00000373485; ENSG00000102904. [Q2TAA8-1]
GeneID55815.
KEGGhsa:55815.
UCSCuc002euf.4. human. [Q2TAA8-2]
uc002euh.4. human. [Q2TAA8-1]

Organism-specific databases

CTD55815.
GeneCardsGC16P067840.
HGNCHGNC:18586. TSNAXIP1.
HPAHPA040962.
MIM607720. gene.
neXtProtNX_Q2TAA8.
PharmGKBPA134961990.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG67646.
HOGENOMHOG000290178.
HOVERGENHBG076872.
InParanoidQ2TAA8.
PhylomeDBQ2TAA8.
TreeFamTF329002.

Gene expression databases

ArrayExpressQ2TAA8.
BgeeQ2TAA8.
CleanExHS_TSNAXIP1.
GenevestigatorQ2TAA8.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSTSNAXIP1. human.
GenomeRNAi55815.
NextBio60994.
PROQ2TAA8.
SOURCESearch...

Entry information

Entry nameTXIP1_HUMAN
AccessionPrimary (citable) accession number: Q2TAA8
Secondary accession number(s): Q9P105
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 24, 2006
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM