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Q2TAA8

- TXIP1_HUMAN

UniProt

Q2TAA8 - TXIP1_HUMAN

Protein

Translin-associated factor X-interacting protein 1

Gene

TSNAXIP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Possible role in spermatogenesis.By similarity

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translin-associated factor X-interacting protein 1
    Short name:
    Trax-interacting protein 1
    Gene namesi
    Name:TSNAXIP1Imported
    Synonyms:TXI1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:18586. TSNAXIP1.

    Subcellular locationi

    Cytoplasmperinuclear region By similarity

    GO - Cellular componenti

    1. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134961990.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 658658Translin-associated factor X-interacting protein 1PRO_0000323608Add
    BLAST

    Proteomic databases

    MaxQBiQ2TAA8.
    PaxDbiQ2TAA8.
    PRIDEiQ2TAA8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ2TAA8.
    BgeeiQ2TAA8.
    CleanExiHS_TSNAXIP1.
    GenevestigatoriQ2TAA8.

    Organism-specific databases

    HPAiHPA040962.

    Interactioni

    Subunit structurei

    Interacts with TSNAX.By similarity

    Protein-protein interaction databases

    BioGridi120925. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2TAA8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili144 – 18441Sequence AnalysisAdd
    BLAST
    Coiled coili230 – 29566Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG67646.
    HOGENOMiHOG000290178.
    HOVERGENiHBG076872.
    InParanoidiQ2TAA8.
    PhylomeDBiQ2TAA8.
    TreeFamiTF329002.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q2TAA8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGGHLSPWPT YTSGQTILQN RKPCSDDYRK RVGSCQQHPF RTAKPQYLEE    50
    LENYLRKELL LLDLGTDSTQ ELRLQPYREI FEFFIEDFKT YKPLLSSIKN 100
    AYEGMLAHQR EKIRALEPLK AKLVTVNEDC NERILAMRAE EKYEISLLKK 150
    EKMNLLKLID KKNEEKISLQ SEVTKLRKNL AEEYLHYLSE RDACKILIAD 200
    LNELRYQRED MSLAQSPGIW GEDPVKLTLA LKMTRQDLTR TQMELNNMKA 250
    NFGDVVPRRD FEMQEKTNKD LQEQLDTLRA SYEEVRKEHE ILMQLHMSTL 300
    KERDQFFSEL QEIQRTSTPR PDWTKCKDVV AGGPERWQML AEGKNSDQLV 350
    DVLLEEIGSG LLREKDFFPG LGYGEAIPAF LRFDGLVENK KPSKKDVVNL 400
    LKDAWKERLA EEQKETFPDF FFNFLEHRFG PSDAMAWAYT IFENIKIFHS 450
    NEVMSQFYAV LMGKRSENVY VTQKETVAQL LKEMTNADSQ NEGLLTMEQF 500
    NTVLKSTFPL KTEEQIQELM EAGGWHPSSS NADLLNYRSL FMEDEEGQSE 550
    PFVQKLWEQY MDEKDEYLQQ LKQELGIELH EEVTLPKLRG GLMTIDPSLD 600
    KQTVNTYMSQ AFQLPESEMP EEGDEKEEAV VEILQTALER LQVIDIRRVG 650
    PREPEPAS 658

    Note: No experimental confirmation available.Curated

    Length:658
    Mass (Da):76,773
    Last modified:January 24, 2006 - v1
    Checksum:i6CC03A9AB772AD01
    GO
    Isoform 21 Publication (identifier: Q2TAA8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-292: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:366
    Mass (Da):42,299
    Checksum:i2F190A1F2E90DF19
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 292292Missing in isoform 2. 2 PublicationsVSP_052710Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132730 mRNA. Translation: AAF66441.1.
    CH471092 Genomic DNA. Translation: EAW83169.1.
    CH471092 Genomic DNA. Translation: EAW83174.1.
    BC111018 mRNA. Translation: AAI11019.1.
    CCDSiCCDS10846.2. [Q2TAA8-1]
    RefSeqiNP_001275920.1. NM_001288991.1.
    NP_001275921.1. NM_001288992.1. [Q2TAA8-2]
    NP_001275922.1. NM_001288993.1. [Q2TAA8-2]
    NP_001275923.1. NM_001288994.1. [Q2TAA8-2]
    NP_060900.2. NM_018430.3. [Q2TAA8-1]
    UniGeneiHs.632212.

    Genome annotation databases

    EnsembliENST00000388833; ENSP00000373485; ENSG00000102904. [Q2TAA8-1]
    GeneIDi55815.
    KEGGihsa:55815.
    UCSCiuc002euf.4. human. [Q2TAA8-2]
    uc002euh.4. human. [Q2TAA8-1]

    Polymorphism databases

    DMDMi121946829.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132730 mRNA. Translation: AAF66441.1 .
    CH471092 Genomic DNA. Translation: EAW83169.1 .
    CH471092 Genomic DNA. Translation: EAW83174.1 .
    BC111018 mRNA. Translation: AAI11019.1 .
    CCDSi CCDS10846.2. [Q2TAA8-1 ]
    RefSeqi NP_001275920.1. NM_001288991.1.
    NP_001275921.1. NM_001288992.1. [Q2TAA8-2 ]
    NP_001275922.1. NM_001288993.1. [Q2TAA8-2 ]
    NP_001275923.1. NM_001288994.1. [Q2TAA8-2 ]
    NP_060900.2. NM_018430.3. [Q2TAA8-1 ]
    UniGenei Hs.632212.

    3D structure databases

    ProteinModelPortali Q2TAA8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120925. 2 interactions.

    Polymorphism databases

    DMDMi 121946829.

    Proteomic databases

    MaxQBi Q2TAA8.
    PaxDbi Q2TAA8.
    PRIDEi Q2TAA8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000388833 ; ENSP00000373485 ; ENSG00000102904 . [Q2TAA8-1 ]
    GeneIDi 55815.
    KEGGi hsa:55815.
    UCSCi uc002euf.4. human. [Q2TAA8-2 ]
    uc002euh.4. human. [Q2TAA8-1 ]

    Organism-specific databases

    CTDi 55815.
    GeneCardsi GC16P067840.
    HGNCi HGNC:18586. TSNAXIP1.
    HPAi HPA040962.
    MIMi 607720. gene.
    neXtProti NX_Q2TAA8.
    PharmGKBi PA134961990.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG67646.
    HOGENOMi HOG000290178.
    HOVERGENi HBG076872.
    InParanoidi Q2TAA8.
    PhylomeDBi Q2TAA8.
    TreeFami TF329002.

    Miscellaneous databases

    ChiTaRSi TSNAXIP1. human.
    GenomeRNAii 55815.
    NextBioi 60994.
    PROi Q2TAA8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q2TAA8.
    Bgeei Q2TAA8.
    CleanExi HS_TSNAXIP1.
    Genevestigatori Q2TAA8.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Luo W.Q., Chen J.H., Huang X.W., Zhou Y., Zhou H.J., Hu S.N., Yuan J.G.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: BrainImported.

    Entry informationi

    Entry nameiTXIP1_HUMAN
    AccessioniPrimary (citable) accession number: Q2TAA8
    Secondary accession number(s): Q9P105
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3