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Protein

Translin-associated factor X-interacting protein 1

Gene

TSNAXIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Possible role in spermatogenesis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translin-associated factor X-interacting protein 1
Short name:
Trax-interacting protein 1
Gene namesi
Name:TSNAXIP1Imported
Synonyms:TXI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:18586. TSNAXIP1.

Subcellular locationi

  • Cytoplasmperinuclear region By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961990.

Polymorphism and mutation databases

DMDMi121946829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 658658Translin-associated factor X-interacting protein 1PRO_0000323608Add
BLAST

Proteomic databases

MaxQBiQ2TAA8.
PaxDbiQ2TAA8.
PRIDEiQ2TAA8.

Expressioni

Gene expression databases

BgeeiQ2TAA8.
CleanExiHS_TSNAXIP1.
ExpressionAtlasiQ2TAA8. baseline and differential.
GenevestigatoriQ2TAA8.

Organism-specific databases

HPAiHPA040962.

Interactioni

Subunit structurei

Interacts with TSNAX.By similarity

Protein-protein interaction databases

BioGridi120925. 2 interactions.
IntActiQ2TAA8. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ2TAA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili144 – 18441Sequence AnalysisAdd
BLAST
Coiled coili230 – 29566Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG67646.
GeneTreeiENSGT00390000018598.
HOGENOMiHOG000290178.
HOVERGENiHBG076872.
InParanoidiQ2TAA8.
PhylomeDBiQ2TAA8.
TreeFamiTF329002.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q2TAA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGHLSPWPT YTSGQTILQN RKPCSDDYRK RVGSCQQHPF RTAKPQYLEE
60 70 80 90 100
LENYLRKELL LLDLGTDSTQ ELRLQPYREI FEFFIEDFKT YKPLLSSIKN
110 120 130 140 150
AYEGMLAHQR EKIRALEPLK AKLVTVNEDC NERILAMRAE EKYEISLLKK
160 170 180 190 200
EKMNLLKLID KKNEEKISLQ SEVTKLRKNL AEEYLHYLSE RDACKILIAD
210 220 230 240 250
LNELRYQRED MSLAQSPGIW GEDPVKLTLA LKMTRQDLTR TQMELNNMKA
260 270 280 290 300
NFGDVVPRRD FEMQEKTNKD LQEQLDTLRA SYEEVRKEHE ILMQLHMSTL
310 320 330 340 350
KERDQFFSEL QEIQRTSTPR PDWTKCKDVV AGGPERWQML AEGKNSDQLV
360 370 380 390 400
DVLLEEIGSG LLREKDFFPG LGYGEAIPAF LRFDGLVENK KPSKKDVVNL
410 420 430 440 450
LKDAWKERLA EEQKETFPDF FFNFLEHRFG PSDAMAWAYT IFENIKIFHS
460 470 480 490 500
NEVMSQFYAV LMGKRSENVY VTQKETVAQL LKEMTNADSQ NEGLLTMEQF
510 520 530 540 550
NTVLKSTFPL KTEEQIQELM EAGGWHPSSS NADLLNYRSL FMEDEEGQSE
560 570 580 590 600
PFVQKLWEQY MDEKDEYLQQ LKQELGIELH EEVTLPKLRG GLMTIDPSLD
610 620 630 640 650
KQTVNTYMSQ AFQLPESEMP EEGDEKEEAV VEILQTALER LQVIDIRRVG

PREPEPAS

Note: No experimental confirmation available.Curated

Length:658
Mass (Da):76,773
Last modified:January 24, 2006 - v1
Checksum:i6CC03A9AB772AD01
GO
Isoform 21 Publication (identifier: Q2TAA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-292: Missing.

Note: No experimental confirmation available.

Show »
Length:366
Mass (Da):42,299
Checksum:i2F190A1F2E90DF19
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 292292Missing in isoform 2. 2 PublicationsVSP_052710Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132730 mRNA. Translation: AAF66441.1.
CH471092 Genomic DNA. Translation: EAW83169.1.
CH471092 Genomic DNA. Translation: EAW83174.1.
BC111018 mRNA. Translation: AAI11019.1.
CCDSiCCDS10846.2. [Q2TAA8-1]
RefSeqiNP_001275920.1. NM_001288991.1.
NP_001275921.1. NM_001288992.1. [Q2TAA8-2]
NP_001275922.1. NM_001288993.1. [Q2TAA8-2]
NP_001275923.1. NM_001288994.1. [Q2TAA8-2]
NP_060900.2. NM_018430.3. [Q2TAA8-1]
UniGeneiHs.632212.

Genome annotation databases

EnsembliENST00000388833; ENSP00000373485; ENSG00000102904. [Q2TAA8-1]
GeneIDi55815.
KEGGihsa:55815.
UCSCiuc002euf.4. human. [Q2TAA8-2]
uc002euh.4. human. [Q2TAA8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132730 mRNA. Translation: AAF66441.1.
CH471092 Genomic DNA. Translation: EAW83169.1.
CH471092 Genomic DNA. Translation: EAW83174.1.
BC111018 mRNA. Translation: AAI11019.1.
CCDSiCCDS10846.2. [Q2TAA8-1]
RefSeqiNP_001275920.1. NM_001288991.1.
NP_001275921.1. NM_001288992.1. [Q2TAA8-2]
NP_001275922.1. NM_001288993.1. [Q2TAA8-2]
NP_001275923.1. NM_001288994.1. [Q2TAA8-2]
NP_060900.2. NM_018430.3. [Q2TAA8-1]
UniGeneiHs.632212.

3D structure databases

ProteinModelPortaliQ2TAA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120925. 2 interactions.
IntActiQ2TAA8. 1 interaction.

Polymorphism and mutation databases

DMDMi121946829.

Proteomic databases

MaxQBiQ2TAA8.
PaxDbiQ2TAA8.
PRIDEiQ2TAA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388833; ENSP00000373485; ENSG00000102904. [Q2TAA8-1]
GeneIDi55815.
KEGGihsa:55815.
UCSCiuc002euf.4. human. [Q2TAA8-2]
uc002euh.4. human. [Q2TAA8-1]

Organism-specific databases

CTDi55815.
GeneCardsiGC16P067840.
HGNCiHGNC:18586. TSNAXIP1.
HPAiHPA040962.
MIMi607720. gene.
neXtProtiNX_Q2TAA8.
PharmGKBiPA134961990.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG67646.
GeneTreeiENSGT00390000018598.
HOGENOMiHOG000290178.
HOVERGENiHBG076872.
InParanoidiQ2TAA8.
PhylomeDBiQ2TAA8.
TreeFamiTF329002.

Miscellaneous databases

ChiTaRSiTSNAXIP1. human.
GenomeRNAii55815.
NextBioi60994.
PROiQ2TAA8.
SOURCEiSearch...

Gene expression databases

BgeeiQ2TAA8.
CleanExiHS_TSNAXIP1.
ExpressionAtlasiQ2TAA8. baseline and differential.
GenevestigatoriQ2TAA8.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Luo W.Q., Chen J.H., Huang X.W., Zhou Y., Zhou H.J., Hu S.N., Yuan J.G.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: BrainImported.

Entry informationi

Entry nameiTXIP1_HUMAN
AccessioniPrimary (citable) accession number: Q2TAA8
Secondary accession number(s): Q9P105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 24, 2006
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.