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Q2TAA8

- TXIP1_HUMAN

UniProt

Q2TAA8 - TXIP1_HUMAN

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Protein

Translin-associated factor X-interacting protein 1

Gene

TSNAXIP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Possible role in spermatogenesis.By similarity

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translin-associated factor X-interacting protein 1
Short name:
Trax-interacting protein 1
Gene namesi
Name:TSNAXIP1Imported
Synonyms:TXI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:18586. TSNAXIP1.

Subcellular locationi

Cytoplasmperinuclear region By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 658658Translin-associated factor X-interacting protein 1PRO_0000323608Add
BLAST

Proteomic databases

MaxQBiQ2TAA8.
PaxDbiQ2TAA8.
PRIDEiQ2TAA8.

Expressioni

Gene expression databases

BgeeiQ2TAA8.
CleanExiHS_TSNAXIP1.
ExpressionAtlasiQ2TAA8. baseline and differential.
GenevestigatoriQ2TAA8.

Organism-specific databases

HPAiHPA040962.

Interactioni

Subunit structurei

Interacts with TSNAX.By similarity

Protein-protein interaction databases

BioGridi120925. 2 interactions.
IntActiQ2TAA8. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ2TAA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili144 – 18441Sequence AnalysisAdd
BLAST
Coiled coili230 – 29566Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG67646.
GeneTreeiENSGT00390000018598.
HOGENOMiHOG000290178.
HOVERGENiHBG076872.
InParanoidiQ2TAA8.
PhylomeDBiQ2TAA8.
TreeFamiTF329002.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q2TAA8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGHLSPWPT YTSGQTILQN RKPCSDDYRK RVGSCQQHPF RTAKPQYLEE
60 70 80 90 100
LENYLRKELL LLDLGTDSTQ ELRLQPYREI FEFFIEDFKT YKPLLSSIKN
110 120 130 140 150
AYEGMLAHQR EKIRALEPLK AKLVTVNEDC NERILAMRAE EKYEISLLKK
160 170 180 190 200
EKMNLLKLID KKNEEKISLQ SEVTKLRKNL AEEYLHYLSE RDACKILIAD
210 220 230 240 250
LNELRYQRED MSLAQSPGIW GEDPVKLTLA LKMTRQDLTR TQMELNNMKA
260 270 280 290 300
NFGDVVPRRD FEMQEKTNKD LQEQLDTLRA SYEEVRKEHE ILMQLHMSTL
310 320 330 340 350
KERDQFFSEL QEIQRTSTPR PDWTKCKDVV AGGPERWQML AEGKNSDQLV
360 370 380 390 400
DVLLEEIGSG LLREKDFFPG LGYGEAIPAF LRFDGLVENK KPSKKDVVNL
410 420 430 440 450
LKDAWKERLA EEQKETFPDF FFNFLEHRFG PSDAMAWAYT IFENIKIFHS
460 470 480 490 500
NEVMSQFYAV LMGKRSENVY VTQKETVAQL LKEMTNADSQ NEGLLTMEQF
510 520 530 540 550
NTVLKSTFPL KTEEQIQELM EAGGWHPSSS NADLLNYRSL FMEDEEGQSE
560 570 580 590 600
PFVQKLWEQY MDEKDEYLQQ LKQELGIELH EEVTLPKLRG GLMTIDPSLD
610 620 630 640 650
KQTVNTYMSQ AFQLPESEMP EEGDEKEEAV VEILQTALER LQVIDIRRVG

PREPEPAS

Note: No experimental confirmation available.Curated

Length:658
Mass (Da):76,773
Last modified:January 24, 2006 - v1
Checksum:i6CC03A9AB772AD01
GO
Isoform 21 Publication (identifier: Q2TAA8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-292: Missing.

Note: No experimental confirmation available.

Show »
Length:366
Mass (Da):42,299
Checksum:i2F190A1F2E90DF19
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 292292Missing in isoform 2. 2 PublicationsVSP_052710Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132730 mRNA. Translation: AAF66441.1.
CH471092 Genomic DNA. Translation: EAW83169.1.
CH471092 Genomic DNA. Translation: EAW83174.1.
BC111018 mRNA. Translation: AAI11019.1.
CCDSiCCDS10846.2. [Q2TAA8-1]
RefSeqiNP_001275920.1. NM_001288991.1.
NP_001275921.1. NM_001288992.1. [Q2TAA8-2]
NP_001275922.1. NM_001288993.1. [Q2TAA8-2]
NP_001275923.1. NM_001288994.1. [Q2TAA8-2]
NP_060900.2. NM_018430.3. [Q2TAA8-1]
UniGeneiHs.632212.

Genome annotation databases

EnsembliENST00000388833; ENSP00000373485; ENSG00000102904. [Q2TAA8-1]
GeneIDi55815.
KEGGihsa:55815.
UCSCiuc002euf.4. human. [Q2TAA8-2]
uc002euh.4. human. [Q2TAA8-1]

Polymorphism databases

DMDMi121946829.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132730 mRNA. Translation: AAF66441.1 .
CH471092 Genomic DNA. Translation: EAW83169.1 .
CH471092 Genomic DNA. Translation: EAW83174.1 .
BC111018 mRNA. Translation: AAI11019.1 .
CCDSi CCDS10846.2. [Q2TAA8-1 ]
RefSeqi NP_001275920.1. NM_001288991.1.
NP_001275921.1. NM_001288992.1. [Q2TAA8-2 ]
NP_001275922.1. NM_001288993.1. [Q2TAA8-2 ]
NP_001275923.1. NM_001288994.1. [Q2TAA8-2 ]
NP_060900.2. NM_018430.3. [Q2TAA8-1 ]
UniGenei Hs.632212.

3D structure databases

ProteinModelPortali Q2TAA8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120925. 2 interactions.
IntActi Q2TAA8. 1 interaction.

Polymorphism databases

DMDMi 121946829.

Proteomic databases

MaxQBi Q2TAA8.
PaxDbi Q2TAA8.
PRIDEi Q2TAA8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000388833 ; ENSP00000373485 ; ENSG00000102904 . [Q2TAA8-1 ]
GeneIDi 55815.
KEGGi hsa:55815.
UCSCi uc002euf.4. human. [Q2TAA8-2 ]
uc002euh.4. human. [Q2TAA8-1 ]

Organism-specific databases

CTDi 55815.
GeneCardsi GC16P067840.
HGNCi HGNC:18586. TSNAXIP1.
HPAi HPA040962.
MIMi 607720. gene.
neXtProti NX_Q2TAA8.
PharmGKBi PA134961990.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG67646.
GeneTreei ENSGT00390000018598.
HOGENOMi HOG000290178.
HOVERGENi HBG076872.
InParanoidi Q2TAA8.
PhylomeDBi Q2TAA8.
TreeFami TF329002.

Miscellaneous databases

ChiTaRSi TSNAXIP1. human.
GenomeRNAii 55815.
NextBioi 60994.
PROi Q2TAA8.
SOURCEi Search...

Gene expression databases

Bgeei Q2TAA8.
CleanExi HS_TSNAXIP1.
ExpressionAtlasi Q2TAA8. baseline and differential.
Genevestigatori Q2TAA8.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Luo W.Q., Chen J.H., Huang X.W., Zhou Y., Zhou H.J., Hu S.N., Yuan J.G.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: BrainImported.

Entry informationi

Entry nameiTXIP1_HUMAN
AccessioniPrimary (citable) accession number: Q2TAA8
Secondary accession number(s): Q9P105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 24, 2006
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3