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Q2TAA8

- TXIP1_HUMAN

UniProt

Q2TAA8 - TXIP1_HUMAN

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Protein
Translin-associated factor X-interacting protein 1
Gene
TSNAXIP1, TXI1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Possible role in spermatogenesis By similarity.By similarity

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translin-associated factor X-interacting protein 1
Short name:
Trax-interacting protein 1
Gene namesi
Synonyms:TXI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:18586. TSNAXIP1.

Subcellular locationi

Cytoplasmperinuclear region By similarity By similarity

GO - Cellular componenti

  1. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 658658Translin-associated factor X-interacting protein 1
PRO_0000323608Add
BLAST

Proteomic databases

MaxQBiQ2TAA8.
PaxDbiQ2TAA8.
PRIDEiQ2TAA8.

Expressioni

Gene expression databases

ArrayExpressiQ2TAA8.
BgeeiQ2TAA8.
CleanExiHS_TSNAXIP1.
GenevestigatoriQ2TAA8.

Organism-specific databases

HPAiHPA040962.

Interactioni

Subunit structurei

Interacts with TSNAX By similarity.By similarity

Protein-protein interaction databases

BioGridi120925. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ2TAA8.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili144 – 18441 Reviewed prediction
Add
BLAST
Coiled coili230 – 29566 Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG67646.
HOGENOMiHOG000290178.
HOVERGENiHBG076872.
InParanoidiQ2TAA8.
PhylomeDBiQ2TAA8.
TreeFamiTF329002.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q2TAA8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGGHLSPWPT YTSGQTILQN RKPCSDDYRK RVGSCQQHPF RTAKPQYLEE    50
LENYLRKELL LLDLGTDSTQ ELRLQPYREI FEFFIEDFKT YKPLLSSIKN 100
AYEGMLAHQR EKIRALEPLK AKLVTVNEDC NERILAMRAE EKYEISLLKK 150
EKMNLLKLID KKNEEKISLQ SEVTKLRKNL AEEYLHYLSE RDACKILIAD 200
LNELRYQRED MSLAQSPGIW GEDPVKLTLA LKMTRQDLTR TQMELNNMKA 250
NFGDVVPRRD FEMQEKTNKD LQEQLDTLRA SYEEVRKEHE ILMQLHMSTL 300
KERDQFFSEL QEIQRTSTPR PDWTKCKDVV AGGPERWQML AEGKNSDQLV 350
DVLLEEIGSG LLREKDFFPG LGYGEAIPAF LRFDGLVENK KPSKKDVVNL 400
LKDAWKERLA EEQKETFPDF FFNFLEHRFG PSDAMAWAYT IFENIKIFHS 450
NEVMSQFYAV LMGKRSENVY VTQKETVAQL LKEMTNADSQ NEGLLTMEQF 500
NTVLKSTFPL KTEEQIQELM EAGGWHPSSS NADLLNYRSL FMEDEEGQSE 550
PFVQKLWEQY MDEKDEYLQQ LKQELGIELH EEVTLPKLRG GLMTIDPSLD 600
KQTVNTYMSQ AFQLPESEMP EEGDEKEEAV VEILQTALER LQVIDIRRVG 650
PREPEPAS 658

Note: No experimental confirmation available.

Length:658
Mass (Da):76,773
Last modified:January 24, 2006 - v1
Checksum:i6CC03A9AB772AD01
GO
Isoform 22 Publications (identifier: Q2TAA8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-292: Missing.

Note: No experimental confirmation available.

Show »
Length:366
Mass (Da):42,299
Checksum:i2F190A1F2E90DF19
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 292292Missing in isoform 2. 2 Publications
VSP_052710Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132730 mRNA. Translation: AAF66441.1.
CH471092 Genomic DNA. Translation: EAW83169.1.
CH471092 Genomic DNA. Translation: EAW83174.1.
BC111018 mRNA. Translation: AAI11019.1.
CCDSiCCDS10846.2. [Q2TAA8-1]
RefSeqiNP_001275920.1. NM_001288991.1.
NP_001275921.1. NM_001288992.1. [Q2TAA8-2]
NP_001275922.1. NM_001288993.1. [Q2TAA8-2]
NP_001275923.1. NM_001288994.1. [Q2TAA8-2]
NP_060900.2. NM_018430.3. [Q2TAA8-1]
UniGeneiHs.632212.

Genome annotation databases

EnsembliENST00000388833; ENSP00000373485; ENSG00000102904. [Q2TAA8-1]
GeneIDi55815.
KEGGihsa:55815.
UCSCiuc002euf.4. human. [Q2TAA8-2]
uc002euh.4. human. [Q2TAA8-1]

Polymorphism databases

DMDMi121946829.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132730 mRNA. Translation: AAF66441.1 .
CH471092 Genomic DNA. Translation: EAW83169.1 .
CH471092 Genomic DNA. Translation: EAW83174.1 .
BC111018 mRNA. Translation: AAI11019.1 .
CCDSi CCDS10846.2. [Q2TAA8-1 ]
RefSeqi NP_001275920.1. NM_001288991.1.
NP_001275921.1. NM_001288992.1. [Q2TAA8-2 ]
NP_001275922.1. NM_001288993.1. [Q2TAA8-2 ]
NP_001275923.1. NM_001288994.1. [Q2TAA8-2 ]
NP_060900.2. NM_018430.3. [Q2TAA8-1 ]
UniGenei Hs.632212.

3D structure databases

ProteinModelPortali Q2TAA8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120925. 2 interactions.

Polymorphism databases

DMDMi 121946829.

Proteomic databases

MaxQBi Q2TAA8.
PaxDbi Q2TAA8.
PRIDEi Q2TAA8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000388833 ; ENSP00000373485 ; ENSG00000102904 . [Q2TAA8-1 ]
GeneIDi 55815.
KEGGi hsa:55815.
UCSCi uc002euf.4. human. [Q2TAA8-2 ]
uc002euh.4. human. [Q2TAA8-1 ]

Organism-specific databases

CTDi 55815.
GeneCardsi GC16P067840.
HGNCi HGNC:18586. TSNAXIP1.
HPAi HPA040962.
MIMi 607720. gene.
neXtProti NX_Q2TAA8.
PharmGKBi PA134961990.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG67646.
HOGENOMi HOG000290178.
HOVERGENi HBG076872.
InParanoidi Q2TAA8.
PhylomeDBi Q2TAA8.
TreeFami TF329002.

Miscellaneous databases

ChiTaRSi TSNAXIP1. human.
GenomeRNAii 55815.
NextBioi 60994.
PROi Q2TAA8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q2TAA8.
Bgeei Q2TAA8.
CleanExi HS_TSNAXIP1.
Genevestigatori Q2TAA8.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Luo W.Q., Chen J.H., Huang X.W., Zhou Y., Zhou H.J., Hu S.N., Yuan J.G.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiTXIP1_HUMAN
AccessioniPrimary (citable) accession number: Q2TAA8
Secondary accession number(s): Q9P105
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 24, 2006
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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