Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isoamyl acetate-hydrolyzing esterase 1 homolog

Gene

IAH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable lipase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei24 – 241NucleophileBy similarity
Binding sitei56 – 561Substrate; via amide nitrogenBy similarity
Binding sitei89 – 891SubstrateBy similarity
Active sitei196 – 1961By similarity
Active sitei199 – 1991By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Isoamyl acetate-hydrolyzing esterase 1 homolog (EC:3.1.-.-)
Gene namesi
Name:IAH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:27696. IAH1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162391893.

Polymorphism and mutation databases

BioMutaiIAH1.
DMDMi121941741.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Isoamyl acetate-hydrolyzing esterase 1 homologPRO_0000315723Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631N6-succinyllysineBy similarity

Proteomic databases

EPDiQ2TAA2.
MaxQBiQ2TAA2.
PaxDbiQ2TAA2.
PRIDEiQ2TAA2.

2D gel databases

REPRODUCTION-2DPAGEIPI00419194.

PTM databases

iPTMnetiQ2TAA2.
PhosphoSiteiQ2TAA2.

Expressioni

Gene expression databases

BgeeiQ2TAA2.
CleanExiHS_IAH1.
ExpressionAtlasiQ2TAA2. baseline and differential.
GenevisibleiQ2TAA2. HS.

Organism-specific databases

HPAiHPA040523.
HPA053112.

Interactioni

Protein-protein interaction databases

BioGridi130027. 1 interaction.
STRINGi9606.ENSP00000417580.

Structurei

3D structure databases

ProteinModelPortaliQ2TAA2.
SMRiQ2TAA2. Positions 15-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3035. Eukaryota.
COG2755. LUCA.
GeneTreeiENSGT00390000008069.
HOGENOMiHOG000214294.
HOVERGENiHBG105140.
InParanoidiQ2TAA2.
OMAiWEKECII.
PhylomeDBiQ2TAA2.
TreeFamiTF328918.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13472. Lipase_GDSL_2. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2TAA2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALCEAAGCG SALLWPRLLL FGDSITQFSF QQGGWGASLA DRLVRKCDVL
60 70 80 90 100
NRGFSGYNTR WAKIILPRLI RKGNSLDIPV AVTIFFGAND SALKDENPKQ
110 120 130 140 150
HIPLEEYAAN LKSMVQYLKS VDIPENRVIL ITPTPLCETA WEEQCIIQGC
160 170 180 190 200
KLNRLNSVVG EYANACLQVA QDCGTDVLDL WTLMQDSQDF SSYLSDGLHL
210 220 230 240
SPKGNEFLFS HLWPLIEKKV SSLPLLLPYW RDVAEAKPEL SLLGDGDH
Length:248
Mass (Da):27,599
Last modified:January 24, 2006 - v1
Checksum:iB21C1C0EC9F69778
GO
Isoform 2 (identifier: Q2TAA2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):15,191
Checksum:iE833B4C239579D88
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 113113Missing in isoform 2. 1 PublicationVSP_056571Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291984 mRNA. Translation: BAF84673.1.
AK297648 mRNA. Translation: BAG60015.1.
AC080162 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00983.1.
CH471053 Genomic DNA. Translation: EAX00984.1.
CH471053 Genomic DNA. Translation: EAX00985.1.
CH471053 Genomic DNA. Translation: EAX00988.1.
BC111025 mRNA. Translation: AAI11026.1.
CCDSiCCDS42651.1. [Q2TAA2-1]
RefSeqiNP_001034702.1. NM_001039613.2. [Q2TAA2-1]
UniGeneiHs.667226.
Hs.744980.

Genome annotation databases

EnsembliENST00000470914; ENSP00000419224; ENSG00000134330. [Q2TAA2-2]
ENST00000482918; ENSP00000419110; ENSG00000134330. [Q2TAA2-2]
ENST00000497473; ENSP00000417580; ENSG00000134330. [Q2TAA2-1]
GeneIDi285148.
KEGGihsa:285148.
UCSCiuc002qzr.4. human. [Q2TAA2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291984 mRNA. Translation: BAF84673.1.
AK297648 mRNA. Translation: BAG60015.1.
AC080162 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00983.1.
CH471053 Genomic DNA. Translation: EAX00984.1.
CH471053 Genomic DNA. Translation: EAX00985.1.
CH471053 Genomic DNA. Translation: EAX00988.1.
BC111025 mRNA. Translation: AAI11026.1.
CCDSiCCDS42651.1. [Q2TAA2-1]
RefSeqiNP_001034702.1. NM_001039613.2. [Q2TAA2-1]
UniGeneiHs.667226.
Hs.744980.

3D structure databases

ProteinModelPortaliQ2TAA2.
SMRiQ2TAA2. Positions 15-235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130027. 1 interaction.
STRINGi9606.ENSP00000417580.

PTM databases

iPTMnetiQ2TAA2.
PhosphoSiteiQ2TAA2.

Polymorphism and mutation databases

BioMutaiIAH1.
DMDMi121941741.

2D gel databases

REPRODUCTION-2DPAGEIPI00419194.

Proteomic databases

EPDiQ2TAA2.
MaxQBiQ2TAA2.
PaxDbiQ2TAA2.
PRIDEiQ2TAA2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000470914; ENSP00000419224; ENSG00000134330. [Q2TAA2-2]
ENST00000482918; ENSP00000419110; ENSG00000134330. [Q2TAA2-2]
ENST00000497473; ENSP00000417580; ENSG00000134330. [Q2TAA2-1]
GeneIDi285148.
KEGGihsa:285148.
UCSCiuc002qzr.4. human. [Q2TAA2-1]

Organism-specific databases

CTDi285148.
GeneCardsiIAH1.
H-InvDBHIX0001810.
HGNCiHGNC:27696. IAH1.
HPAiHPA040523.
HPA053112.
neXtProtiNX_Q2TAA2.
PharmGKBiPA162391893.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3035. Eukaryota.
COG2755. LUCA.
GeneTreeiENSGT00390000008069.
HOGENOMiHOG000214294.
HOVERGENiHBG105140.
InParanoidiQ2TAA2.
OMAiWEKECII.
PhylomeDBiQ2TAA2.
TreeFamiTF328918.

Miscellaneous databases

ChiTaRSiIAH1. human.
GenomeRNAii285148.
NextBioi35473433.
PROiQ2TAA2.

Gene expression databases

BgeeiQ2TAA2.
CleanExiHS_IAH1.
ExpressionAtlasiQ2TAA2. baseline and differential.
GenevisibleiQ2TAA2. HS.

Family and domain databases

Gene3Di3.40.50.1110. 1 hit.
InterProiIPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13472. Lipase_GDSL_2. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Small intestine.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiIAH1_HUMAN
AccessioniPrimary (citable) accession number: Q2TAA2
Secondary accession number(s): B4DMV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.