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Protein

Isoamyl acetate-hydrolyzing esterase 1 homolog

Gene

IAH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable lipase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei24NucleophileBy similarity1
Binding sitei56Transition state stabilizerBy similarity1
Binding sitei89Transition state stabilizerBy similarity1
Active sitei196Proton donorBy similarity1
Active sitei199Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Isoamyl acetate-hydrolyzing esterase 1 homolog (EC:3.1.-.-)
Gene namesi
Name:IAH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000134330.18
HGNCiHGNC:27696 IAH1
neXtProtiNX_Q2TAA2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134330
PharmGKBiPA162391893

Polymorphism and mutation databases

BioMutaiIAH1
DMDMi121941741

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157231 – 248Isoamyl acetate-hydrolyzing esterase 1 homologAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63N6-succinyllysineBy similarity1

Proteomic databases

EPDiQ2TAA2
MaxQBiQ2TAA2
PaxDbiQ2TAA2
PeptideAtlasiQ2TAA2
PRIDEiQ2TAA2
ProteomicsDBi61453

2D gel databases

REPRODUCTION-2DPAGEiIPI00419194

PTM databases

iPTMnetiQ2TAA2
PhosphoSitePlusiQ2TAA2

Expressioni

Gene expression databases

BgeeiENSG00000134330
CleanExiHS_IAH1
ExpressionAtlasiQ2TAA2 baseline and differential
GenevisibleiQ2TAA2 HS

Organism-specific databases

HPAiHPA040523

Interactioni

Protein-protein interaction databases

BioGridi130027, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ2TAA2
SMRiQ2TAA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3035 Eukaryota
COG2755 LUCA
GeneTreeiENSGT00390000008069
HOGENOMiHOG000214294
HOVERGENiHBG105140
InParanoidiQ2TAA2
OMAiLWTLMQK
OrthoDBiEOG091G0I3Q
PhylomeDBiQ2TAA2
TreeFamiTF328918

Family and domain databases

Gene3Di3.40.50.1110, 1 hit
InterProiView protein in InterPro
IPR013830 SGNH_hydro
IPR036514 SGNH_hydro_sf
PfamiView protein in Pfam
PF13472 Lipase_GDSL_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2TAA2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALCEAAGCG SALLWPRLLL FGDSITQFSF QQGGWGASLA DRLVRKCDVL
60 70 80 90 100
NRGFSGYNTR WAKIILPRLI RKGNSLDIPV AVTIFFGAND SALKDENPKQ
110 120 130 140 150
HIPLEEYAAN LKSMVQYLKS VDIPENRVIL ITPTPLCETA WEEQCIIQGC
160 170 180 190 200
KLNRLNSVVG EYANACLQVA QDCGTDVLDL WTLMQDSQDF SSYLSDGLHL
210 220 230 240
SPKGNEFLFS HLWPLIEKKV SSLPLLLPYW RDVAEAKPEL SLLGDGDH
Length:248
Mass (Da):27,599
Last modified:January 24, 2006 - v1
Checksum:iB21C1C0EC9F69778
GO
Isoform 2 (identifier: Q2TAA2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):15,191
Checksum:iE833B4C239579D88
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565711 – 113Missing in isoform 2. 1 PublicationAdd BLAST113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291984 mRNA Translation: BAF84673.1
AK297648 mRNA Translation: BAG60015.1
AC080162 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00983.1
CH471053 Genomic DNA Translation: EAX00984.1
CH471053 Genomic DNA Translation: EAX00985.1
CH471053 Genomic DNA Translation: EAX00988.1
BC111025 mRNA Translation: AAI11026.1
CCDSiCCDS42651.1 [Q2TAA2-1]
CCDS82418.1 [Q2TAA2-2]
RefSeqiNP_001034702.1, NM_001039613.2 [Q2TAA2-1]
NP_001307787.1, NM_001320858.1
NP_001307788.1, NM_001320859.1 [Q2TAA2-2]
NP_001307789.1, NM_001320860.1 [Q2TAA2-2]
NP_001307792.1, NM_001320863.1 [Q2TAA2-2]
XP_016859367.1, XM_017003878.1 [Q2TAA2-2]
UniGeneiHs.667226
Hs.744980

Genome annotation databases

EnsembliENST00000470914; ENSP00000419224; ENSG00000134330 [Q2TAA2-2]
ENST00000482918; ENSP00000419110; ENSG00000134330 [Q2TAA2-2]
ENST00000497473; ENSP00000417580; ENSG00000134330 [Q2TAA2-1]
GeneIDi285148
KEGGihsa:285148
UCSCiuc002qzr.4 human [Q2TAA2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIAH1_HUMAN
AccessioniPrimary (citable) accession number: Q2TAA2
Secondary accession number(s): B4DMV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: June 20, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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