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Protein
Submitted name:

FK506 binding protein 5

Gene

FKBP5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
FK506 binding protein 5Imported
Gene namesi
Name:FKBP5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28162.

PTM / Processingi

Proteomic databases

PaxDbiQ2TA84.
PeptideAtlasiQ2TA84.
PRIDEiQ2TA84.

Expressioni

Gene expression databases

GenevisibleiQ2TA84. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000338160.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 138PPIase FKBP-typeInterPro annotationAdd BLAST89
Domaini165 – 251PPIase FKBP-typeInterPro annotationAdd BLAST87
Domaini317 – 384TPR_REGIONInterPro annotationAdd BLAST68

Keywords - Domaini

RepeatSAAS annotation, TPR repeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0543. Eukaryota.
COG0545. LUCA.
HOVERGENiHBG051624.

Family and domain databases

Gene3Di1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR023114. Elongated_TPR_rpt_dom.
IPR031210. FKBP5.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PTHR10516:SF26. PTHR10516:SF26. 2 hits.
PfamiPF00254. FKBP_C. 2 hits.
PF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TA84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTDEGAKNN EESPTATVAE QGEDITSKKD RGVLKIVKRV GNGEETPMIG
60 70 80 90 100
DKVYVHYKGK LSNGKKFDSS HDRNEPFVFS LGKGQVIKAW DIGVATMKKG
110 120 130 140 150
EICHLLCKPE YAYGSAGSLP KIPSNATLFF EIELLDLKGE DLFEDGGIIR
160 170 180 190 200
RTKRKGEGYS NPNEGATVEI HLEGRCGGRM FDCRDVAFTV GEGEDHDIPI
210 220 230 240 250
GIDKALEKMQ REEQCILYLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF
260 270 280 290 300
EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYMQAVIQ YGKIVSWLEM
310 320 330 340 350
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN
360 370 380 390 400
EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ ISMCQKKAKE
410 420 430 440 450
HNERDRRIYA NMFKKFAEQD AKEEANKAMG KKTSEGVTNE KGTDSQAMEE

EKPEGHV
Length:457
Mass (Da):51,178
Last modified:January 24, 2006 - v1
Checksum:i7189EB6B4E203875
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111050 mRNA. Translation: AAI11051.1.
RefSeqiNP_004108.1. NM_004117.3.
UniGeneiHs.407190.

Genome annotation databases

GeneIDi2289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111050 mRNA. Translation: AAI11051.1.
RefSeqiNP_004108.1. NM_004117.3.
UniGeneiHs.407190.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000338160.

Proteomic databases

PaxDbiQ2TA84.
PeptideAtlasiQ2TA84.
PRIDEiQ2TA84.

Protocols and materials databases

DNASUi2289.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2289.

Organism-specific databases

CTDi2289.
PharmGKBiPA28162.

Phylogenomic databases

eggNOGiKOG0543. Eukaryota.
COG0545. LUCA.
HOVERGENiHBG051624.

Miscellaneous databases

ChiTaRSiFKBP5. human.
GenomeRNAii2289.

Gene expression databases

GenevisibleiQ2TA84. HS.

Family and domain databases

Gene3Di1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR023114. Elongated_TPR_rpt_dom.
IPR031210. FKBP5.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PTHR10516:SF26. PTHR10516:SF26. 2 hits.
PfamiPF00254. FKBP_C. 2 hits.
PF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ2TA84_HUMAN
AccessioniPrimary (citable) accession number: Q2TA84
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.