Reviewed, UniProtKB/Swiss-Prot Q2TA32 (TYSY_BOVIN)

Names and origin

Protein names

Recommended name:
    Thymidylate synthase
      Short name=TSase
      Short name=TS
    EC=2.1.1.45

Gene names

Name:	TYMS
Synonyms:	TS

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Pathway	Pyrimidine metabolism; dTTP biosynthesis.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the thymidylate synthase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	dTMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	thymidylate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 354	353	Thymidylate synthase		PRO_0000317541
Sites
	Active site	198	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2TA32-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 2350409479AF4C40	FASTA	354	39,785
	10 20 30 40 50 60 MPAAGSEPSR PPSPPGVQEQ SAEPRPPPPP HGELQYLGQI EHILRCGFRR DDRTGTGTLS 70 80 90 100 110 120 VFGMQARYNL RDEFPLLTTK RVFWKGVLEE LLWFIKGSTN AKELSSKGVK IWDANGSRDF 130 140 150 160 170 180 LDGLGFSDRA EGDLGPVYGF QWRHFGAEYK DMDSEYSGQG VDQLQKVIDT IKTNPNDRRI 190 200 210 220 230 240 ILCAWNPKDL PLMALPPCHA LCQFYVVNGE LSCQLYQRSG DMGLGVPFNI ASYALLTYMI 250 260 270 280 290 300 AHITDLKPGD FVHTLGDAHI YLNHIEPLKT QALMELRGQS SRSLDGDGQA GTSRWAPVAT 310 320 330 340 350 DTERDRCCEL QREPRPFPKL KILRKVETID DFQAEDFQIE GYNPNPTIKM EMAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.
[2]	"Estimate of nucleotide diversity in dogs with a pool-and-sequence method." Brouillette J.A., Andrew J.R., Venta P.J. Mamm. Genome 11:1079-1086(2000) [PubMed: 11130975] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-255.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC111139 mRNA. Translation: AAI11140.1. AF203030, AF203029 Genomic DNA. Translation: AAF66224.1.
IPI	IPI00708073.
RefSeq	NP_001032905.1.
UniGene	Bt.7738
3D structure databases
SMR	Q2TA32. Positions 29-354.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2TA32.
Genome annotation databases
Ensembl	ENSBTAT00000009214; ENSBTAP00000009214; ENSBTAG00000007003; Bos taurus. [Genome view]
GeneID	507631.
KEGG	bta:507631.
Organism-specific databases
CTD	507631.
Phylogenomic databases
HOVERGEN	Q2TA32.
Enzyme and pathway databases
BRENDA	2.1.1.45. 251.
Family and domain databases
InterPro	IPR000398. Thymidylat_synth_C. [Graphical view]
Gene3D	G3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
PANTHER	PTHR11549:SF2. Thymidylat_synth_C. 1 hit.
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
ProDom	PD001180. Thymidylat_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_BOVIN

Accession

Primary (citable) accession number: Q2TA32
Secondary accession number(s): Q9N1D3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	January 24, 2006
Last modified:	September 1, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)