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Q2TA32 (TYSY_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate synthase

Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:TYMS
Synonyms:TS
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway By similarity. HAMAP-Rule MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00008

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Mitochondrion By similarity. Mitochondrion matrix By similarity. Mitochondrion inner membrane By similarity HAMAP-Rule MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 354353Thymidylate synthase HAMAP-Rule MF_00008
PRO_0000317541

Sites

Active site1981 By similarity

Amino acid modifications

Modified residue1171Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2TA32 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 2350409479AF4C40

FASTA35439,785
        10         20         30         40         50         60 
MPAAGSEPSR PPSPPGVQEQ SAEPRPPPPP HGELQYLGQI EHILRCGFRR DDRTGTGTLS 

        70         80         90        100        110        120 
VFGMQARYNL RDEFPLLTTK RVFWKGVLEE LLWFIKGSTN AKELSSKGVK IWDANGSRDF 

       130        140        150        160        170        180 
LDGLGFSDRA EGDLGPVYGF QWRHFGAEYK DMDSEYSGQG VDQLQKVIDT IKTNPNDRRI 

       190        200        210        220        230        240 
ILCAWNPKDL PLMALPPCHA LCQFYVVNGE LSCQLYQRSG DMGLGVPFNI ASYALLTYMI 

       250        260        270        280        290        300 
AHITDLKPGD FVHTLGDAHI YLNHIEPLKT QALMELRGQS SRSLDGDGQA GTSRWAPVAT 

       310        320        330        340        350 
DTERDRCCEL QREPRPFPKL KILRKVETID DFQAEDFQIE GYNPNPTIKM EMAV 

« Hide

References

« Hide 'large scale' references
[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.
[2]"Estimate of nucleotide diversity in dogs with a pool-and-sequence method."
Brouillette J.A., Andrew J.R., Venta P.J.
Mamm. Genome 11:1079-1086(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-255.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC111139 mRNA. Translation: AAI11140.1.
AH009263 Genomic DNA. Translation: AAF66224.1.
RefSeqNP_001032905.1. NM_001037816.1.
UniGeneBt.7738.

3D structure databases

ProteinModelPortalQ2TA32.
SMRQ2TA32. Positions 31-354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000009214.

Proteomic databases

PRIDEQ2TA32.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID507631.
KEGGbta:507631.

Organism-specific databases

CTD7298.

Phylogenomic databases

eggNOGCOG0207.
HOGENOMHOG000257899.
HOVERGENHBG001934.
InParanoidQ2TA32.
KOK00560.

Enzyme and pathway databases

UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 2 hits.
HAMAPMF_00008. Thymidy_synth_bact.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamPF00303. Thymidylat_synt. 2 hits.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. SSF55831. 2 hits.
TIGRFAMsTIGR03284. thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20868149.

Entry information

Entry nameTYSY_BOVIN
AccessionPrimary (citable) accession number: Q2TA32
Secondary accession number(s): Q9N1D3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 24, 2006
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways