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Q2TA32

- TYSY_BOVIN

UniProt

Q2TA32 - TYSY_BOVIN

Protein

Thymidylate synthase

Gene

TYMS

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.By similarity

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei198 – 1981By similarity

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. dTMP biosynthetic process Source: InterPro
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthase (EC:2.1.1.45)
    Short name:
    TS
    Short name:
    TSase
    Gene namesi
    Name:TYMS
    Synonyms:TS
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Mitochondrion By similarity. Mitochondrion matrix By similarity. Mitochondrion inner membrane By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. mitochondrial inner membrane Source: UniProtKB
    3. mitochondrial matrix Source: UniProtKB
    4. mitochondrion Source: UniProtKB
    5. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 354353Thymidylate synthasePRO_0000317541Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei117 – 1171PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ2TA32.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000009214.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2TA32.
    SMRiQ2TA32. Positions 31-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257899.
    HOVERGENiHBG001934.
    InParanoidiQ2TA32.
    KOiK00560.

    Family and domain databases

    Gene3Di3.30.572.10. 2 hits.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 2 hits.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 2 hits.
    TIGRFAMsiTIGR03284. thym_sym. 1 hit.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q2TA32-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAAGSEPSR PPSPPGVQEQ SAEPRPPPPP HGELQYLGQI EHILRCGFRR    50
    DDRTGTGTLS VFGMQARYNL RDEFPLLTTK RVFWKGVLEE LLWFIKGSTN 100
    AKELSSKGVK IWDANGSRDF LDGLGFSDRA EGDLGPVYGF QWRHFGAEYK 150
    DMDSEYSGQG VDQLQKVIDT IKTNPNDRRI ILCAWNPKDL PLMALPPCHA 200
    LCQFYVVNGE LSCQLYQRSG DMGLGVPFNI ASYALLTYMI AHITDLKPGD 250
    FVHTLGDAHI YLNHIEPLKT QALMELRGQS SRSLDGDGQA GTSRWAPVAT 300
    DTERDRCCEL QREPRPFPKL KILRKVETID DFQAEDFQIE GYNPNPTIKM 350
    EMAV 354
    Length:354
    Mass (Da):39,785
    Last modified:January 24, 2006 - v1
    Checksum:i2350409479AF4C40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC111139 mRNA. Translation: AAI11140.1.
    AH009263 Genomic DNA. Translation: AAF66224.1.
    RefSeqiNP_001032905.1. NM_001037816.1.
    UniGeneiBt.7738.

    Genome annotation databases

    GeneIDi507631.
    KEGGibta:507631.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC111139 mRNA. Translation: AAI11140.1 .
    AH009263 Genomic DNA. Translation: AAF66224.1 .
    RefSeqi NP_001032905.1. NM_001037816.1.
    UniGenei Bt.7738.

    3D structure databases

    ProteinModelPortali Q2TA32.
    SMRi Q2TA32. Positions 31-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000009214.

    Proteomic databases

    PRIDEi Q2TA32.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 507631.
    KEGGi bta:507631.

    Organism-specific databases

    CTDi 7298.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257899.
    HOVERGENi HBG001934.
    InParanoidi Q2TA32.
    KOi K00560.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .

    Miscellaneous databases

    NextBioi 20868149.

    Family and domain databases

    Gene3Di 3.30.572.10. 2 hits.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 2 hits.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 2 hits.
    TIGRFAMsi TIGR03284. thym_sym. 1 hit.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.
    2. "Estimate of nucleotide diversity in dogs with a pool-and-sequence method."
      Brouillette J.A., Andrew J.R., Venta P.J.
      Mamm. Genome 11:1079-1086(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-255.

    Entry informationi

    Entry nameiTYSY_BOVIN
    AccessioniPrimary (citable) accession number: Q2TA32
    Secondary accession number(s): Q9N1D3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3