Reviewed,
UniProtKB/Swiss-Prot Q2TA32 (TYSY_BOVIN)
Last modified
September 1, 2009.
Version 33.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Thymidylate synthase Short name=TSase Short name=TS EC=2.1.1.45 | ||||
| Gene names |
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| Organism | Bos taurus (Bovine) | ||||
| Taxonomic identifier | 9913 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 354 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the thymidylate synthase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide biosynthesis |
| Molecular function | Methyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | dTMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | thymidylate synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver. |
| [2] | "Estimate of nucleotide diversity in dogs with a pool-and-sequence method." Brouillette J.A., Andrew J.R., Venta P.J. Mamm. Genome 11:1079-1086(2000) [PubMed: 11130975] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-255. |
Cross-references
Sequence databases | |
|---|---|
| BC111139 mRNA. Translation: AAI11140.1. AF203030, AF203029 Genomic DNA. Translation: AAF66224.1. | |
| IPI | IPI00708073. |
| RefSeq | NP_001032905.1. |
| UniGene | Bt.7738 |
3D structure databases | |
| SMR | Q2TA32. Positions 29-354. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q2TA32. |
Genome annotation databases | |
| Ensembl | ENSBTAT00000009214; ENSBTAP00000009214; ENSBTAG00000007003; Bos taurus. [Genome view] |
| GeneID | 507631. |
| KEGG | bta:507631. |
Organism-specific databases | |
| CTD | 507631. |
Phylogenomic databases | |
| HOVERGEN | Q2TA32. |
Enzyme and pathway databases | |
| BRENDA | 2.1.1.45. 251. |
Family and domain databases | |
| InterPro | IPR000398. Thymidylat_synth_C. [Graphical view] |
| Gene3D | G3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit. |
| PANTHER | PTHR11549:SF2. Thymidylat_synth_C. 1 hit. |
| Pfam | PF00303. Thymidylat_synt. 1 hit. [Graphical view] |
| PRINTS | PR00108. THYMDSNTHASE. |
| ProDom | PD001180. Thymidylat_synth. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR03284. thym_sym. 1 hit. |
| PROSITE | PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TYSY_BOVIN | ||||||||
| Accession | Primary (citable) accession number: Q2TA32 Secondary accession number(s): Q9N1D3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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