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Q2TA10

- UB2D1_BOVIN

UniProt

Q2TA10 - UB2D1_BOVIN

Protein

Ubiquitin-conjugating enzyme E2 D1

Gene

UBE2D1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 By similarity.By similarity

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of protein ubiquitination Source: Ensembl
    2. protein K48-linked ubiquitination Source: UniProtKB
    3. ubiquitin-dependent protein catabolic process Source: Ensembl

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_202328. IKK complex recruitment mediated by RIP1.
    REACT_203215. Senescence-Associated Secretory Phenotype (SASP).
    REACT_203853. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
    REACT_204829. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
    REACT_205339. APC/C:Cdc20 mediated degradation of Securin.
    REACT_208116. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_209611. Phosphorylation of the APC/C.
    REACT_211837. Signaling by BMP.
    REACT_212887. Separation of Sister Chromatids.
    REACT_213075. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_218125. Inactivation of APC/C via direct inhibition of the APC/C complex.
    REACT_218686. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_220866. APC/C:Cdc20 mediated degradation of mitotic proteins.
    REACT_222387. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
    REACT_222622. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 D1 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein D1
    Ubiquitin-protein ligase D1
    Gene namesi
    Name:UBE2D1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 26

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 147147Ubiquitin-conjugating enzyme E2 D1PRO_0000245033Add
    BLAST

    Interactioni

    Subunit structurei

    Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with RNF11.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000051358.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2TA10.
    SMRiQ2TA10. Positions 1-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00740000115162.
    HOGENOMiHOG000233455.
    HOVERGENiHBG063308.
    InParanoidiQ2TA10.
    KOiK06689.
    OMAiNTHAREW.
    OrthoDBiEOG7PCJGX.
    TreeFamiTF101108.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2TA10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALKRIQKEL SDLQRDPPAH CSAGPVGDDL FHWQATIMGP PDSAYQGGVF    50
    FLTVHFPTDY PFKPPKIAFT TKIYHPNINS NGSICLDILR SQWSPALTVS 100
    KVLLSICSLL CDPNPDDPLV PDIAQIYKSD KEKYNRHARE WTQKYAM 147
    Length:147
    Mass (Da):16,602
    Last modified:January 24, 2006 - v1
    Checksum:i2E96FD0179EE119D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC111175 mRNA. Translation: AAI11176.1.
    RefSeqiNP_001033256.1. NM_001038167.1.
    UniGeneiBt.52062.

    Genome annotation databases

    EnsembliENSBTAT00000055368; ENSBTAP00000051358; ENSBTAG00000020796.
    GeneIDi535287.
    KEGGibta:535287.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC111175 mRNA. Translation: AAI11176.1 .
    RefSeqi NP_001033256.1. NM_001038167.1.
    UniGenei Bt.52062.

    3D structure databases

    ProteinModelPortali Q2TA10.
    SMRi Q2TA10. Positions 1-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000051358.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000055368 ; ENSBTAP00000051358 ; ENSBTAG00000020796 .
    GeneIDi 535287.
    KEGGi bta:535287.

    Organism-specific databases

    CTDi 7321.

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00740000115162.
    HOGENOMi HOG000233455.
    HOVERGENi HBG063308.
    InParanoidi Q2TA10.
    KOi K06689.
    OMAi NTHAREW.
    OrthoDBi EOG7PCJGX.
    TreeFami TF101108.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_202328. IKK complex recruitment mediated by RIP1.
    REACT_203215. Senescence-Associated Secretory Phenotype (SASP).
    REACT_203853. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
    REACT_204829. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
    REACT_205339. APC/C:Cdc20 mediated degradation of Securin.
    REACT_208116. Autodegradation of Cdh1 by Cdh1:APC/C.
    REACT_209611. Phosphorylation of the APC/C.
    REACT_211837. Signaling by BMP.
    REACT_212887. Separation of Sister Chromatids.
    REACT_213075. Regulation of APC/C activators between G1/S and early anaphase.
    REACT_218125. Inactivation of APC/C via direct inhibition of the APC/C complex.
    REACT_218686. APC/C:Cdc20 mediated degradation of Cyclin B.
    REACT_220866. APC/C:Cdc20 mediated degradation of mitotic proteins.
    REACT_222387. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
    REACT_222622. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.

    Miscellaneous databases

    NextBioi 20876683.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiUB2D1_BOVIN
    AccessioniPrimary (citable) accession number: Q2TA10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3