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Q2TA10

- UB2D1_BOVIN

UniProt

Q2TA10 - UB2D1_BOVIN

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Protein
Ubiquitin-conjugating enzyme E2 D1
Gene
UBE2D1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro
  3. ubiquitin-protein transferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. positive regulation of protein ubiquitination Source: Ensembl
  2. protein K48-linked ubiquitination Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_202328. IKK complex recruitment mediated by RIP1.
REACT_203215. Senescence-Associated Secretory Phenotype (SASP).
REACT_203853. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
REACT_204829. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
REACT_205339. APC/C:Cdc20 mediated degradation of Securin.
REACT_208116. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_209611. Phosphorylation of the APC/C.
REACT_211837. Signaling by BMP.
REACT_212887. Separation of Sister Chromatids.
REACT_213075. Regulation of APC/C activators between G1/S and early anaphase.
REACT_218125. Inactivation of APC/C via direct inhibition of the APC/C complex.
REACT_218686. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_220866. APC/C:Cdc20 mediated degradation of mitotic proteins.
REACT_222387. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
REACT_222622. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 D1 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein D1
Ubiquitin-protein ligase D1
Gene namesi
Name:UBE2D1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 26

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Ubiquitin-conjugating enzyme E2 D1
PRO_0000245033Add
BLAST

Interactioni

Subunit structurei

Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X By similarity. Interacts with RNF11 By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051358.

Structurei

3D structure databases

ProteinModelPortaliQ2TA10.
SMRiQ2TA10. Positions 1-147.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00740000115162.
HOGENOMiHOG000233455.
HOVERGENiHBG063308.
InParanoidiQ2TA10.
KOiK06689.
OMAiNTHAREW.
OrthoDBiEOG7PCJGX.
TreeFamiTF101108.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TA10-1 [UniParc]FASTAAdd to Basket

« Hide

MALKRIQKEL SDLQRDPPAH CSAGPVGDDL FHWQATIMGP PDSAYQGGVF    50
FLTVHFPTDY PFKPPKIAFT TKIYHPNINS NGSICLDILR SQWSPALTVS 100
KVLLSICSLL CDPNPDDPLV PDIAQIYKSD KEKYNRHARE WTQKYAM 147
Length:147
Mass (Da):16,602
Last modified:January 24, 2006 - v1
Checksum:i2E96FD0179EE119D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC111175 mRNA. Translation: AAI11176.1.
RefSeqiNP_001033256.1. NM_001038167.1.
UniGeneiBt.52062.

Genome annotation databases

EnsembliENSBTAT00000055368; ENSBTAP00000051358; ENSBTAG00000020796.
GeneIDi535287.
KEGGibta:535287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC111175 mRNA. Translation: AAI11176.1 .
RefSeqi NP_001033256.1. NM_001038167.1.
UniGenei Bt.52062.

3D structure databases

ProteinModelPortali Q2TA10.
SMRi Q2TA10. Positions 1-147.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000051358.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000055368 ; ENSBTAP00000051358 ; ENSBTAG00000020796 .
GeneIDi 535287.
KEGGi bta:535287.

Organism-specific databases

CTDi 7321.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00740000115162.
HOGENOMi HOG000233455.
HOVERGENi HBG063308.
InParanoidi Q2TA10.
KOi K06689.
OMAi NTHAREW.
OrthoDBi EOG7PCJGX.
TreeFami TF101108.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_202328. IKK complex recruitment mediated by RIP1.
REACT_203215. Senescence-Associated Secretory Phenotype (SASP).
REACT_203853. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
REACT_204829. Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
REACT_205339. APC/C:Cdc20 mediated degradation of Securin.
REACT_208116. Autodegradation of Cdh1 by Cdh1:APC/C.
REACT_209611. Phosphorylation of the APC/C.
REACT_211837. Signaling by BMP.
REACT_212887. Separation of Sister Chromatids.
REACT_213075. Regulation of APC/C activators between G1/S and early anaphase.
REACT_218125. Inactivation of APC/C via direct inhibition of the APC/C complex.
REACT_218686. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_220866. APC/C:Cdc20 mediated degradation of mitotic proteins.
REACT_222387. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
REACT_222622. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.

Miscellaneous databases

NextBioi 20876683.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiUB2D1_BOVIN
AccessioniPrimary (citable) accession number: Q2TA10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 24, 2006
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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