Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

BAG family molecular chaperone regulator 5

Gene

BAG5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 5
Short name:
BAG-5
Alternative name(s):
Bcl-2-associated athanogene 5
Gene namesi
Name:BAG5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Organism-specific databases

VGNCiVGNC:26409 BAG5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828601 – 447BAG family molecular chaperone regulator 5Add BLAST447

Proteomic databases

PaxDbiQ2TA08
PRIDEiQ2TA08

Expressioni

Gene expression databases

BgeeiENSBTAG00000017361

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PRKN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023084

Structurei

3D structure databases

ProteinModelPortaliQ2TA08
SMRiQ2TA08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 86BAG 1PROSITE-ProRule annotationAdd BLAST78
Domaini95 – 167BAG 2PROSITE-ProRule annotationAdd BLAST73
Domaini182 – 260BAG 3PROSITE-ProRule annotationAdd BLAST79
Domaini275 – 350BAG 4PROSITE-ProRule annotationAdd BLAST76
Domaini365 – 442BAG 5PROSITE-ProRule annotationAdd BLAST78

Domaini

The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4361 Eukaryota
ENOG4111WNH LUCA
GeneTreeiENSGT00530000063256
HOGENOMiHOG000070447
HOVERGENiHBG004810
InParanoidiQ2TA08
KOiK09559
OMAiRTEIRNY
OrthoDBiEOG091G08LY
TreeFamiTF102014

Family and domain databases

Gene3Di1.20.58.120, 5 hits
InterProiView protein in InterPro
IPR036533 BAG_dom_sf
IPR003103 BAG_domain
PfamiView protein in Pfam
PF02179 BAG, 4 hits
SMARTiView protein in SMART
SM00264 BAG, 4 hits
SUPFAMiSSF63491 SSF63491, 4 hits
PROSITEiView protein in PROSITE
PS51035 BAG, 4 hits

Sequencei

Sequence statusi: Complete.

Q2TA08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMGNQHPSI SRLQEIQKEV KSIEQQVLGF SGLSDDKNYK KLERILTKQL
60 70 80 90 100
FEIDSVDTEG KGDIQQARKR AAQETERLLK ELEQNANHPH RLEIQNIFQE
110 120 130 140 150
AQALVKEKVV PFYNGGNCVT DEFEEGIQDV ILRLTHVKTG GKVSLRKARY
160 170 180 190 200
HTLTKICAVQ EIIENCMKKQ PSLPLSEDAH PSVAKINSVM CEVNKTRGTL
210 220 230 240 250
IALLMGVNNK ETCRHLSCVL SGLMADLDAL DVCGHTEIRN YRKEVVEDIN
260 270 280 290 300
QLLRYLDLEE EADTTHAFDL GQNHSILKIE KVLKRMREIK TELLQAQNPP
310 320 330 340 350
ELYLSAKTEL QGLIGQLDEV SLEKNPCIRE ARRRAVIEVQ TLITYIDLKE
360 370 380 390 400
ALEKRKLLAC EEHPSHKAVW DVLGNLSEIQ GEVLSFDGNR TDKNYIRLEE
410 420 430 440
LLTKQLLALD AVDPQGEEKC KAARKQAVKL AQNILSYLDL KSDEWEY
Length:447
Mass (Da):50,954
Last modified:January 24, 2006 - v1
Checksum:iE9811887ACDF9C48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB211978 mRNA Translation: BAE94654.1
BC111177 mRNA Translation: AAI11178.1
RefSeqiNP_001035634.1, NM_001040544.2
XP_005222261.1, XM_005222204.3
XP_010815554.1, XM_010817252.2
UniGeneiBt.88460

Genome annotation databases

EnsembliENSBTAT00000023084; ENSBTAP00000023084; ENSBTAG00000017361
GeneIDi522854
KEGGibta:522854

Similar proteinsi

Entry informationi

Entry nameiBAG5_BOVIN
AccessioniPrimary (citable) accession number: Q2TA08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 24, 2006
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health