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Protein

BAG family molecular chaperone regulator 5

Gene

BAG5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiR-BTA-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 5
Short name:
BAG-5
Alternative name(s):
Bcl-2-associated athanogene 5
Gene namesi
Name:BAG5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447BAG family molecular chaperone regulator 5PRO_0000282860Add
BLAST

Proteomic databases

PaxDbiQ2TA08.
PRIDEiQ2TA08.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017361.

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023084.

Structurei

3D structure databases

ProteinModelPortaliQ2TA08.
SMRiQ2TA08. Positions 1-89, 276-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 8678BAG 1PROSITE-ProRule annotationAdd
BLAST
Domaini95 – 16773BAG 2PROSITE-ProRule annotationAdd
BLAST
Domaini182 – 26079BAG 3PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 35076BAG 4PROSITE-ProRule annotationAdd
BLAST
Domaini365 – 44278BAG 5PROSITE-ProRule annotationAdd
BLAST

Domaini

The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.By similarity

Sequence similaritiesi

Contains 5 BAG domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4361. Eukaryota.
ENOG4111WNH. LUCA.
GeneTreeiENSGT00530000063256.
HOGENOMiHOG000070447.
HOVERGENiHBG004810.
InParanoidiQ2TA08.
KOiK09559.
OMAiANHPHRI.
OrthoDBiEOG091G08LY.
TreeFamiTF102014.

Family and domain databases

Gene3Di1.20.58.120. 4 hits.
InterProiIPR003103. BAG_domain.
[Graphical view]
PfamiPF02179. BAG. 4 hits.
[Graphical view]
SMARTiSM00264. BAG. 4 hits.
[Graphical view]
SUPFAMiSSF63491. SSF63491. 4 hits.
PROSITEiPS51035. BAG. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2TA08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMGNQHPSI SRLQEIQKEV KSIEQQVLGF SGLSDDKNYK KLERILTKQL
60 70 80 90 100
FEIDSVDTEG KGDIQQARKR AAQETERLLK ELEQNANHPH RLEIQNIFQE
110 120 130 140 150
AQALVKEKVV PFYNGGNCVT DEFEEGIQDV ILRLTHVKTG GKVSLRKARY
160 170 180 190 200
HTLTKICAVQ EIIENCMKKQ PSLPLSEDAH PSVAKINSVM CEVNKTRGTL
210 220 230 240 250
IALLMGVNNK ETCRHLSCVL SGLMADLDAL DVCGHTEIRN YRKEVVEDIN
260 270 280 290 300
QLLRYLDLEE EADTTHAFDL GQNHSILKIE KVLKRMREIK TELLQAQNPP
310 320 330 340 350
ELYLSAKTEL QGLIGQLDEV SLEKNPCIRE ARRRAVIEVQ TLITYIDLKE
360 370 380 390 400
ALEKRKLLAC EEHPSHKAVW DVLGNLSEIQ GEVLSFDGNR TDKNYIRLEE
410 420 430 440
LLTKQLLALD AVDPQGEEKC KAARKQAVKL AQNILSYLDL KSDEWEY
Length:447
Mass (Da):50,954
Last modified:January 24, 2006 - v1
Checksum:iE9811887ACDF9C48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB211978 mRNA. Translation: BAE94654.1.
BC111177 mRNA. Translation: AAI11178.1.
RefSeqiNP_001035634.1. NM_001040544.2.
XP_005222261.1. XM_005222204.3.
XP_010815554.1. XM_010817252.2.
UniGeneiBt.88460.

Genome annotation databases

EnsembliENSBTAT00000023084; ENSBTAP00000023084; ENSBTAG00000017361.
GeneIDi522854.
KEGGibta:522854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB211978 mRNA. Translation: BAE94654.1.
BC111177 mRNA. Translation: AAI11178.1.
RefSeqiNP_001035634.1. NM_001040544.2.
XP_005222261.1. XM_005222204.3.
XP_010815554.1. XM_010817252.2.
UniGeneiBt.88460.

3D structure databases

ProteinModelPortaliQ2TA08.
SMRiQ2TA08. Positions 1-89, 276-351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023084.

Proteomic databases

PaxDbiQ2TA08.
PRIDEiQ2TA08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000023084; ENSBTAP00000023084; ENSBTAG00000017361.
GeneIDi522854.
KEGGibta:522854.

Organism-specific databases

CTDi9529.

Phylogenomic databases

eggNOGiKOG4361. Eukaryota.
ENOG4111WNH. LUCA.
GeneTreeiENSGT00530000063256.
HOGENOMiHOG000070447.
HOVERGENiHBG004810.
InParanoidiQ2TA08.
KOiK09559.
OMAiANHPHRI.
OrthoDBiEOG091G08LY.
TreeFamiTF102014.

Enzyme and pathway databases

ReactomeiR-BTA-3371453. Regulation of HSF1-mediated heat shock response.

Gene expression databases

BgeeiENSBTAG00000017361.

Family and domain databases

Gene3Di1.20.58.120. 4 hits.
InterProiIPR003103. BAG_domain.
[Graphical view]
PfamiPF02179. BAG. 4 hits.
[Graphical view]
SMARTiSM00264. BAG. 4 hits.
[Graphical view]
SUPFAMiSSF63491. SSF63491. 4 hits.
PROSITEiPS51035. BAG. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAG5_BOVIN
AccessioniPrimary (citable) accession number: Q2TA08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 24, 2006
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.