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Q2TA03

- UB2J2_BOVIN

UniProt

Q2TA03 - UB2J2_BOVIN

Protein

Ubiquitin-conjugating enzyme E2 J2

Gene

UBE2J2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei94 – 941Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB-UniPathway
    2. response to unfolded protein Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway, Unfolded protein response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 J2 (EC:6.3.2.19)
    Gene namesi
    Name:UBE2J2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 16

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259Ubiquitin-conjugating enzyme E2 J2PRO_0000245041Add
    BLAST

    Proteomic databases

    PRIDEiQ2TA03.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000021109.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2TA03.
    SMRiQ2TA03. Positions 11-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 226226CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini248 – 25912LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei227 – 24721Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00530000063379.
    HOGENOMiHOG000170330.
    HOVERGENiHBG058434.
    InParanoidiQ2TA03.
    KOiK04554.
    OMAiTSDYTKR.
    OrthoDBiEOG780RNH.
    TreeFamiTF101123.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2TA03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSNSVKRAP TTATQRLKQD YLRIKKDPVP YICAEPLPSN ILEWHYVVRG    50
    PEMTPYEGGY YHGKLIFPRE FPFKPPSIYM ITPNGRFKCN TRLCLSITDF 100
    HPDTWNPAWS VSTILTGLLS FMVEKGPTLG SIETSDFTKR QLAAQSLVFN 150
    LKDKVFCELF PEVVEEIKQK QKAQDELSSR PQALPLPDVV PDGETHHGQH 200
    GLPLLNGHAP GAGPHLAGLQ QANRHHGLLG GALANLFVIV GFAAFAYTVK 250
    YVLRSIAQE 259
    Length:259
    Mass (Da):28,848
    Last modified:January 24, 2006 - v1
    Checksum:iAFF8D77BD15BF8A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC111185 mRNA. Translation: AAI11186.1.
    RefSeqiNP_001033132.1. NM_001038043.1.
    UniGeneiBt.32465.

    Genome annotation databases

    EnsembliENSBTAT00000021109; ENSBTAP00000021109; ENSBTAG00000015882.
    GeneIDi506103.
    KEGGibta:506103.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC111185 mRNA. Translation: AAI11186.1 .
    RefSeqi NP_001033132.1. NM_001038043.1.
    UniGenei Bt.32465.

    3D structure databases

    ProteinModelPortali Q2TA03.
    SMRi Q2TA03. Positions 11-171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000021109.

    Proteomic databases

    PRIDEi Q2TA03.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000021109 ; ENSBTAP00000021109 ; ENSBTAG00000015882 .
    GeneIDi 506103.
    KEGGi bta:506103.

    Organism-specific databases

    CTDi 118424.

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00530000063379.
    HOGENOMi HOG000170330.
    HOVERGENi HBG058434.
    InParanoidi Q2TA03.
    KOi K04554.
    OMAi TSDYTKR.
    OrthoDBi EOG780RNH.
    TreeFami TF101123.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 20867450.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.

    Entry informationi

    Entry nameiUB2J2_BOVIN
    AccessioniPrimary (citable) accession number: Q2TA03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3