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Q2TA03 (UB2J2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 J2

EC=6.3.2.19
Gene names
Name:UBE2J2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type IV membrane protein By similarity.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Ubiquitin-conjugating enzyme E2 J2
PRO_0000245041

Regions

Topological domain1 – 226226Cytoplasmic Potential
Transmembrane227 – 24721Helical; Anchor for type IV membrane protein; Potential
Topological domain248 – 25912Lumenal Potential

Sites

Active site941Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2TA03 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: AFF8D77BD15BF8A4

FASTA25928,848
        10         20         30         40         50         60 
MSSNSVKRAP TTATQRLKQD YLRIKKDPVP YICAEPLPSN ILEWHYVVRG PEMTPYEGGY 

        70         80         90        100        110        120 
YHGKLIFPRE FPFKPPSIYM ITPNGRFKCN TRLCLSITDF HPDTWNPAWS VSTILTGLLS 

       130        140        150        160        170        180 
FMVEKGPTLG SIETSDFTKR QLAAQSLVFN LKDKVFCELF PEVVEEIKQK QKAQDELSSR 

       190        200        210        220        230        240 
PQALPLPDVV PDGETHHGQH GLPLLNGHAP GAGPHLAGLQ QANRHHGLLG GALANLFVIV 

       250 
GFAAFAYTVK YVLRSIAQE 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC111185 mRNA. Translation: AAI11186.1.
RefSeqNP_001033132.1. NM_001038043.1.
UniGeneBt.32465.

3D structure databases

ProteinModelPortalQ2TA03.
SMRQ2TA03. Positions 11-171.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000021109.

Proteomic databases

PRIDEQ2TA03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000021109; ENSBTAP00000021109; ENSBTAG00000015882.
GeneID506103.
KEGGbta:506103.

Organism-specific databases

CTD118424.

Phylogenomic databases

eggNOGCOG5078.
GeneTreeENSGT00530000063379.
HOGENOMHOG000170330.
HOVERGENHBG058434.
InParanoidQ2TA03.
KOK04554.
OMATSDYTKR.
OrthoDBEOG780RNH.
TreeFamTF101123.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20867450.

Entry information

Entry nameUB2J2_BOVIN
AccessionPrimary (citable) accession number: Q2TA03
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: January 24, 2006
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways