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Protein

General transcription factor IIH subunit 5

Gene

GTF2H5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-BTA-112382 Formation of RNA Pol II elongation complex
R-BTA-5696395 Formation of Incision Complex in GG-NER
R-BTA-5696400 Dual Incision in GG-NER
R-BTA-674695 RNA Polymerase II Pre-transcription Events
R-BTA-6781823 Formation of TC-NER Pre-Incision Complex
R-BTA-6782135 Dual incision in TC-NER
R-BTA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-BTA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-BTA-72086 mRNA Capping
R-BTA-73762 RNA Polymerase I Transcription Initiation
R-BTA-73772 RNA Polymerase I Promoter Escape
R-BTA-73776 RNA Polymerase II Promoter Escape
R-BTA-73777 RNA Polymerase I Chain Elongation
R-BTA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-BTA-73863 RNA Polymerase I Transcription Termination
R-BTA-75953 RNA Polymerase II Transcription Initiation
R-BTA-75955 RNA Polymerase II Transcription Elongation
R-BTA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-BTA-77075 RNA Pol II CTD phosphorylation and interaction with CE

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 5
Alternative name(s):
General transcription factor IIH polypeptide 5
Gene namesi
Name:GTF2H5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 9

Organism-specific databases

VGNCiVGNC:29698 GTF2H5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003284221 – 71General transcription factor IIH subunit 5Add BLAST71

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2T9Z5
PRIDEiQ2T9Z5

Expressioni

Gene expression databases

BgeeiENSBTAG00000008543

Interactioni

Subunit structurei

Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011263

Structurei

3D structure databases

ProteinModelPortaliQ2T9Z5
SMRiQ2T9Z5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB5 family.Curated

Phylogenomic databases

eggNOGiKOG3451 Eukaryota
ENOG41121VZ LUCA
GeneTreeiENSGT00390000004028
HOVERGENiHBG055393
InParanoidiQ2T9Z5
KOiK10845
OMAiIMENMNP
OrthoDBiEOG091G1339
TreeFamiTF319487

Family and domain databases

Gene3Di3.30.70.1220, 1 hit
InterProiView protein in InterPro
IPR035935 TFB5-like_sf
IPR009400 TFIIH_TTDA/Tfb5
PANTHERiPTHR28580 PTHR28580, 1 hit
PfamiView protein in Pfam
PF06331 Tfb5, 1 hit
SMARTiView protein in SMART
SM01395 Tbf5, 1 hit
SUPFAMiSSF142897 SSF142897, 1 hit

Sequencei

Sequence statusi: Complete.

Q2T9Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNVLKGVLI ECDPAMKQFL LYLDESNALG KKFIIQDIDD THVFVIAELV
60 70
NVLQERVGEL MDQNAFSLTQ K
Length:71
Mass (Da):8,053
Last modified:January 24, 2006 - v1
Checksum:iDBEB4D3C9BFA2C54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111195 mRNA Translation: AAI11196.1
RefSeqiNP_001035627.1, NM_001040537.2
UniGeneiBt.21230

Genome annotation databases

EnsembliENSBTAT00000011263; ENSBTAP00000011263; ENSBTAG00000008543
GeneIDi518046
KEGGibta:518046

Similar proteinsi

Entry informationi

Entry nameiTF2H5_BOVIN
AccessioniPrimary (citable) accession number: Q2T9Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 24, 2006
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health