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Protein

General transcription factor IIH subunit 5

Gene

GTF2H5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-BTA-112382. Formation of RNA Pol II elongation complex.
R-BTA-5696395. Formation of Incision Complex in GG-NER.
R-BTA-5696400. Dual Incision in GG-NER.
R-BTA-674695. RNA Polymerase II Pre-transcription Events.
R-BTA-6781823. Formation of TC-NER Pre-Incision Complex.
R-BTA-6782135. Dual incision in TC-NER.
R-BTA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-BTA-72086. mRNA Capping.
R-BTA-73762. RNA Polymerase I Transcription Initiation.
R-BTA-73772. RNA Polymerase I Promoter Escape.
R-BTA-73776. RNA Polymerase II Promoter Escape.
R-BTA-73777. RNA Polymerase I Chain Elongation.
R-BTA-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-BTA-73863. RNA Polymerase I Transcription Termination.
R-BTA-75953. RNA Polymerase II Transcription Initiation.
R-BTA-75955. RNA Polymerase II Transcription Elongation.
R-BTA-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-BTA-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 5
Alternative name(s):
General transcription factor IIH polypeptide 5
Gene namesi
Name:GTF2H5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7171General transcription factor IIH subunit 5PRO_0000328422Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2T9Z5.

Interactioni

Subunit structurei

Subunit of the TFIIH basal transcription factor complex that contains ERCC2, ERCC3, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, MNAT1, CDK7 and CCNH.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011263.

Structurei

3D structure databases

ProteinModelPortaliQ2T9Z5.
SMRiQ2T9Z5. Positions 1-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB5 family.Curated

Phylogenomic databases

eggNOGiKOG3451. Eukaryota.
ENOG41121VZ. LUCA.
GeneTreeiENSGT00390000004028.
HOVERGENiHBG055393.
InParanoidiQ2T9Z5.
KOiK10845.
OMAiDETHVFI.
OrthoDBiEOG7BGHPM.
TreeFamiTF319487.

Family and domain databases

Gene3Di3.30.70.1220. 1 hit.
InterProiIPR009400. TFIIH_TTDA/Tfb5.
[Graphical view]
PfamiPF06331. Tfb5. 1 hit.
[Graphical view]
SMARTiSM01395. Tbf5. 1 hit.
[Graphical view]
SUPFAMiSSF142897. SSF142897. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2T9Z5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNVLKGVLI ECDPAMKQFL LYLDESNALG KKFIIQDIDD THVFVIAELV
60 70
NVLQERVGEL MDQNAFSLTQ K
Length:71
Mass (Da):8,053
Last modified:January 24, 2006 - v1
Checksum:iDBEB4D3C9BFA2C54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111195 mRNA. Translation: AAI11196.1.
RefSeqiNP_001035627.1. NM_001040537.2.
UniGeneiBt.21230.

Genome annotation databases

EnsembliENSBTAT00000011263; ENSBTAP00000011263; ENSBTAG00000008543.
GeneIDi518046.
KEGGibta:518046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111195 mRNA. Translation: AAI11196.1.
RefSeqiNP_001035627.1. NM_001040537.2.
UniGeneiBt.21230.

3D structure databases

ProteinModelPortaliQ2T9Z5.
SMRiQ2T9Z5. Positions 1-71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011263.

Proteomic databases

PaxDbiQ2T9Z5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011263; ENSBTAP00000011263; ENSBTAG00000008543.
GeneIDi518046.
KEGGibta:518046.

Organism-specific databases

CTDi404672.

Phylogenomic databases

eggNOGiKOG3451. Eukaryota.
ENOG41121VZ. LUCA.
GeneTreeiENSGT00390000004028.
HOVERGENiHBG055393.
InParanoidiQ2T9Z5.
KOiK10845.
OMAiDETHVFI.
OrthoDBiEOG7BGHPM.
TreeFamiTF319487.

Enzyme and pathway databases

ReactomeiR-BTA-112382. Formation of RNA Pol II elongation complex.
R-BTA-5696395. Formation of Incision Complex in GG-NER.
R-BTA-5696400. Dual Incision in GG-NER.
R-BTA-674695. RNA Polymerase II Pre-transcription Events.
R-BTA-6781823. Formation of TC-NER Pre-Incision Complex.
R-BTA-6782135. Dual incision in TC-NER.
R-BTA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-BTA-72086. mRNA Capping.
R-BTA-73762. RNA Polymerase I Transcription Initiation.
R-BTA-73772. RNA Polymerase I Promoter Escape.
R-BTA-73776. RNA Polymerase II Promoter Escape.
R-BTA-73777. RNA Polymerase I Chain Elongation.
R-BTA-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-BTA-73863. RNA Polymerase I Transcription Termination.
R-BTA-75953. RNA Polymerase II Transcription Initiation.
R-BTA-75955. RNA Polymerase II Transcription Elongation.
R-BTA-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-BTA-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Miscellaneous databases

NextBioi20872570.

Family and domain databases

Gene3Di3.30.70.1220. 1 hit.
InterProiIPR009400. TFIIH_TTDA/Tfb5.
[Graphical view]
PfamiPF06331. Tfb5. 1 hit.
[Graphical view]
SMARTiSM01395. Tbf5. 1 hit.
[Graphical view]
SUPFAMiSSF142897. SSF142897. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiTF2H5_BOVIN
AccessioniPrimary (citable) accession number: Q2T9Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 24, 2006
Last modified: May 11, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.