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Q2T9Y5

- Q2T9Y5_BOVIN

UniProt

Q2T9Y5 - Q2T9Y5_BOVIN

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Protein

DNA ligase

Gene

LIG3

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: RefGenome
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation Source: RefGenome
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-KW
  5. lagging strand elongation Source: RefGenome
  6. nucleotide-excision repair Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:LIG3Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: RefGenome
  2. nucleus Source: RefGenome
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ2T9Y5.

Structurei

3D structure databases

ProteinModelPortaliQ2T9Y5.
SMRiQ2T9Y5. Positions 87-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000007653.
HOVERGENiHBG005515.
KOiK10776.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS00347. PARP_ZN_FINGER_1. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2T9Y5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLAFKILFP PTLRVLRKKE LCLFREHRRP DIRHFGRWSE TVFCGYHLLQ
60 70 80 90 100
RRKPVPSFQE SNLKLRATCL VYLPGSHVGL CSGPCEMAEQ RFCVDYAKRG
110 120 130 140 150
TAGCKKCKEK IVKGVCRIGK VVPNPFSESG GDMKEWYHIK CMFEKQERAP
160 170 180 190 200
ATTKKIEDLT ELEGWEELEE NEKEQISQHI ADLSSKATST PKKKAVVQAK
210 220 230 240 250
LTATGQVASP VKGASFVTNS NPRKFSGFSA KPNNSGEAHS SPTPKTPKTS
260 270 280 290 300
MSSSKCDPKH KDCLLREFRK LCAMVAENPS YNTKTQIIQD FLQKGSAGDG
310 320 330 340 350
FHGDVYLTVK LLLPGVIKSV YNLNDKQIVK LFSRIFNCNS DDMTRDLEQG
360 370 380 390 400
DVSETIRVFF EQSKSFPPAA KSLLTIQEVD EFLLRLSKLT KEDEQQQALQ
410 420 430 440 450
DIASRCTAND LKCIIRLIKH DLKMNSGAKH VLDALDPNAY EAFKASRNLQ
460 470 480 490 500
DVVERVLRNE QEVEKEPGQR RALSVQASLM TPVQPMLAEA CKSIEYAMKK
510 520 530 540 550
CPNGMFSEIK YDGERVQVHK KGDHFSYFSR SLKPVLPHKV AHFKDFIPRA
560 570 580 590 600
FPGGHSMILD SEVLLVDNRT GKPLPFGTLG VHKKAAFQDA NVCQFVFDCI
610 620 630 640 650
YFNDVSLMDR PLCERRKLLH DNMVEIPNRI MFSEMKQVTK ASDLVDMINR
660 670 680 690 700
VIQEGLEGLV LKDVKGTYEP GKRHWLKVKK DYLNEGAMAD TADLVVLGAF
710 720 730 740 750
YGQGSKGGMM SIFLMGCYDP SSQKWCTVTK CAGGHDDATL ARLQTELDMV
760 770 780 790 800
KISKDPSKIP NWLKINKIYY PDFIVPDPKK AAVWEITGAE FSKSEAHTAD
810 820 830 840 850
GISIRFPRCT RIRDDKDWKS ATTLPQLKEL YQLSKERAAF AITAGDEGSS
860 870 880 890 900
ATGGSSGENE GTSGPAVPHK APRASPKQPP TSAKKAGGKP GGCTSRGGNL
910 920 930 940
PAAEPSPVRA GVKRKAPDVT PCQAKRRPAS KRRGRRAVPT GRR
Length:943
Mass (Da):105,101
Last modified:January 24, 2006 - v1
Checksum:i05873FA748DA489F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC111207 mRNA. Translation: AAI11208.1.
RefSeqiNP_001033196.1. NM_001038107.2.
UniGeneiBt.25483.

Genome annotation databases

GeneIDi514719.
KEGGibta:514719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC111207 mRNA. Translation: AAI11208.1 .
RefSeqi NP_001033196.1. NM_001038107.2.
UniGenei Bt.25483.

3D structure databases

ProteinModelPortali Q2T9Y5.
SMRi Q2T9Y5. Positions 87-202.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q2T9Y5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 514719.
KEGGi bta:514719.

Organism-specific databases

CTDi 3980.

Phylogenomic databases

HOGENOMi HOG000007653.
HOVERGENi HBG005515.
KOi K10776.

Miscellaneous databases

NextBioi 20871477.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS00347. PARP_ZN_FINGER_1. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Crossbred x AngusImported.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ2T9Y5_BOVIN
AccessioniPrimary (citable) accession number: Q2T9Y5
Entry historyi
Integrated into UniProtKB/TrEMBL: January 24, 2006
Last sequence update: January 24, 2006
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)