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Q2T9Y5

- Q2T9Y5_BOVIN

UniProt

Q2T9Y5 - Q2T9Y5_BOVIN

Protein

DNA ligase

Gene

LIG3

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: RefGenome
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. DNA ligation Source: RefGenome
    2. DNA ligation involved in DNA repair Source: InterPro
    3. DNA recombination Source: UniProtKB-KW
    4. lagging strand elongation Source: RefGenome
    5. nucleotide-excision repair Source: RefGenome

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    Name:LIG3Imported
    OrganismiBos taurus (Bovine)Imported
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

    Subcellular locationi

    GO - Cellular componenti

    1. chromosome Source: RefGenome
    2. nucleus Source: RefGenome

    PTM / Processingi

    Proteomic databases

    PRIDEiQ2T9Y5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2T9Y5.
    SMRiQ2T9Y5. Positions 87-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000007653.
    HOVERGENiHBG005515.
    KOiK10776.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1740.10. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    IPR001510. Znf_PARP.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF00645. zf-PARP. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    PS00347. PARP_ZN_FINGER_1. 1 hit.
    PS50064. PARP_ZN_FINGER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2T9Y5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLAFKILFP PTLRVLRKKE LCLFREHRRP DIRHFGRWSE TVFCGYHLLQ    50
    RRKPVPSFQE SNLKLRATCL VYLPGSHVGL CSGPCEMAEQ RFCVDYAKRG 100
    TAGCKKCKEK IVKGVCRIGK VVPNPFSESG GDMKEWYHIK CMFEKQERAP 150
    ATTKKIEDLT ELEGWEELEE NEKEQISQHI ADLSSKATST PKKKAVVQAK 200
    LTATGQVASP VKGASFVTNS NPRKFSGFSA KPNNSGEAHS SPTPKTPKTS 250
    MSSSKCDPKH KDCLLREFRK LCAMVAENPS YNTKTQIIQD FLQKGSAGDG 300
    FHGDVYLTVK LLLPGVIKSV YNLNDKQIVK LFSRIFNCNS DDMTRDLEQG 350
    DVSETIRVFF EQSKSFPPAA KSLLTIQEVD EFLLRLSKLT KEDEQQQALQ 400
    DIASRCTAND LKCIIRLIKH DLKMNSGAKH VLDALDPNAY EAFKASRNLQ 450
    DVVERVLRNE QEVEKEPGQR RALSVQASLM TPVQPMLAEA CKSIEYAMKK 500
    CPNGMFSEIK YDGERVQVHK KGDHFSYFSR SLKPVLPHKV AHFKDFIPRA 550
    FPGGHSMILD SEVLLVDNRT GKPLPFGTLG VHKKAAFQDA NVCQFVFDCI 600
    YFNDVSLMDR PLCERRKLLH DNMVEIPNRI MFSEMKQVTK ASDLVDMINR 650
    VIQEGLEGLV LKDVKGTYEP GKRHWLKVKK DYLNEGAMAD TADLVVLGAF 700
    YGQGSKGGMM SIFLMGCYDP SSQKWCTVTK CAGGHDDATL ARLQTELDMV 750
    KISKDPSKIP NWLKINKIYY PDFIVPDPKK AAVWEITGAE FSKSEAHTAD 800
    GISIRFPRCT RIRDDKDWKS ATTLPQLKEL YQLSKERAAF AITAGDEGSS 850
    ATGGSSGENE GTSGPAVPHK APRASPKQPP TSAKKAGGKP GGCTSRGGNL 900
    PAAEPSPVRA GVKRKAPDVT PCQAKRRPAS KRRGRRAVPT GRR 943
    Length:943
    Mass (Da):105,101
    Last modified:January 24, 2006 - v1
    Checksum:i05873FA748DA489F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC111207 mRNA. Translation: AAI11208.1.
    RefSeqiNP_001033196.1. NM_001038107.2.
    UniGeneiBt.25483.

    Genome annotation databases

    GeneIDi514719.
    KEGGibta:514719.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC111207 mRNA. Translation: AAI11208.1 .
    RefSeqi NP_001033196.1. NM_001038107.2.
    UniGenei Bt.25483.

    3D structure databases

    ProteinModelPortali Q2T9Y5.
    SMRi Q2T9Y5. Positions 87-202.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q2T9Y5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 514719.
    KEGGi bta:514719.

    Organism-specific databases

    CTDi 3980.

    Phylogenomic databases

    HOGENOMi HOG000007653.
    HOVERGENi HBG005515.
    KOi K10776.

    Miscellaneous databases

    NextBioi 20871477.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1740.10. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    IPR001510. Znf_PARP.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    PF00645. zf-PARP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    PS00347. PARP_ZN_FINGER_1. 1 hit.
    PS50064. PARP_ZN_FINGER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Crossbred x AngusImported.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiQ2T9Y5_BOVIN
    AccessioniPrimary (citable) accession number: Q2T9Y5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)