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Protein

T-complex protein 1 subunit delta

Gene

CCT4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit delta
Short name:
TCP-1-delta
Alternative name(s):
CCT-delta
Gene namesi
Name:CCT4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002362611 – 542T-complex protein 1 subunit deltaAdd BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Omega-N-methylarginineBy similarity1
Modified residuei24N6-acetyllysineBy similarity1
Modified residuei39PhosphoserineBy similarity1
Modified residuei187PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei291N6-acetyllysineBy similarity1
Modified residuei305N6-acetyllysineBy similarity1
Modified residuei322N6-acetyllysineBy similarity1
Modified residuei329N6-acetyllysineBy similarity1
Modified residuei447PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ2T9X2.
PeptideAtlasiQ2T9X2.
PRIDEiQ2T9X2.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8 (By similarity). Interacts with DNAAF4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ2T9X2.
DIPiDIP-58619N.
STRINGi9913.ENSBTAP00000042274.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IYGelectron microscopy-D25-542[»]
4B2TX-ray5.50D/d1-542[»]
ProteinModelPortaliQ2T9X2.
SMRiQ2T9X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0358. Eukaryota.
COG0459. LUCA.
HOGENOMiHOG000226735.
HOVERGENiHBG106507.
InParanoidiQ2T9X2.
KOiK09496.

Family and domain databases

CDDicd03338. TCP1_delta. 1 hit.
Gene3Di1.10.560.10. 2 hits.
InterProiView protein in InterPro
IPR012717. Chap_CCT_delta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
PANTHERiPTHR11353:SF146. PTHR11353:SF146. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02342. chap_CCT_delta. 1 hit.
PROSITEiView protein in PROSITE
PS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2T9X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPENVAPRTG PPAGAAGAAG GRGKSAYQDR DKPAQIRFSN ISAAKAVADA
60 70 80 90 100
IRTSLGPKGM DKMIQDGKGD VTITNDGATI LKQMQVLHPA ARMLVELSKA
110 120 130 140 150
QDIEAGDGTT SVVIIAGSLL DSCTKLLQKG IHPTIISESF QKALEKGIEI
160 170 180 190 200
LTDMSRPEEL SDRETLLNSA ATSLNSKVVS QYSSLLSPMS VDAVMKVIDP
210 220 230 240 250
ATATSVDLRD IKIVKKLGGT IDDCELVEGL VLTQKVANSG ITRVEKAKIG
260 270 280 290 300
LIQFCLSAPK TDMDNQIVVS DYVQMDRVLR EERAYILNLV KQIKKTGCNV
310 320 330 340 350
LLIQKSILRD ALSDLALHFL NKMKIMVVKD IEREDIEFIC KTIGTKPVAH
360 370 380 390 400
VDQFTADMLG SAELAEEVSL NGSGKLIKIT GCASPGKTVT IVVRGSNKLV
410 420 430 440 450
IEEAERSIHD ALCVIRCLVK KRALIAGGGA PEIELALRLT EYSRTLSGME
460 470 480 490 500
SYCIRAFADA MEVIPSTLAE NAGLNPISTV TELRNRHAQG EKTTGINVRK
510 520 530 540
GGISNILEEQ VVQPLLVSVS ALTLATETVR SILKIDDVVN TR
Length:542
Mass (Da):58,206
Last modified:January 23, 2007 - v3
Checksum:i00610BF36473BB97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111225 mRNA. Translation: AAI11226.1.
RefSeqiNP_001033283.1. NM_001038194.1.
UniGeneiBt.6427.

Genome annotation databases

GeneIDi613336.
KEGGibta:613336.

Similar proteinsi

Entry informationi

Entry nameiTCPD_BOVIN
AccessioniPrimary (citable) accession number: Q2T9X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 82 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families