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Protein

F-box/WD repeat-containing protein 9

Gene

FBXW9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 9
Alternative name(s):
F-box and WD-40 domain-containing protein 9
Gene namesi
Name:FBXW9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458F-box/WD repeat-containing protein 9PRO_0000249466Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei18 – 181PhosphoserineBy similarity
Modified residuei59 – 591PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ2T9T9.
PRIDEiQ2T9T9.

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027872.

Structurei

3D structure databases

ProteinModelPortaliQ2T9T9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 12348F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati171 – 21040WD 1Add
BLAST
Repeati224 – 26138WD 2Add
BLAST
Repeati264 – 30138WD 3Add
BLAST
Repeati305 – 34238WD 4Add
BLAST
Repeati344 – 38138WD 5Add
BLAST
Repeati387 – 42438WD 6Add
BLAST
Repeati427 – 45832WD 7Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQD3. Eukaryota.
ENOG4111G8F. LUCA.
HOGENOMiHOG000112556.
HOVERGENiHBG051598.
InParanoidiQ2T9T9.
KOiK10265.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2T9T9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPPGPRDD PHAWDDDSDP ELEPDTDAQA EAYVARLLSP PKLGLAPPRA
60 70 80 90 100
PPLPAPTVSF GSLEPRAASK GPTVAVPGLL SLPPELLLEI CAYLDARLVL
110 120 130 140 150
HVLPRVCHAL RDLVRDRVTW RLRAQRRVRA PYPVVEEEDF DWPTACIELE
160 170 180 190 200
QHLSRWADDG RRAEYFCLAD GHFASIDSVL LLQGGTLCLS GSRDRNVNLW
210 220 230 240 250
DLQQLGVEPS RVLVKTLGTQ KNSTHKGWVW SLAALDHRVC SGSWDSTVKL
260 270 280 290 300
WDMAADGQQF GEIKGKAAVL CLSYRPDILV TGTYDKKVTV YDPRVGPALL
310 320 330 340 350
KSRRLHSSAV LALLADDRHI ISGSEDHTLV VFDRRANSVL QRLQLDSYLL
360 370 380 390 400
CMSYQEPQLW AGDNQGLLHV FANRSGCFQL VRSFDVGHRS QITGIKHSLG
410 420 430 440 450
ALYTTSTDKT IRVHVPTDPP RTICTRSHHN VLNGICAEGN LVVAASGGLS

LEVWRLQA
Length:458
Mass (Da):50,654
Last modified:January 24, 2006 - v1
Checksum:i8BAB059AE827994D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111274 mRNA. Translation: AAI11275.1.
RefSeqiNP_001033240.1. NM_001038151.2.
UniGeneiBt.43176.

Genome annotation databases

GeneIDi532538.
KEGGibta:532538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111274 mRNA. Translation: AAI11275.1.
RefSeqiNP_001033240.1. NM_001038151.2.
UniGeneiBt.43176.

3D structure databases

ProteinModelPortaliQ2T9T9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027872.

Proteomic databases

PaxDbiQ2T9T9.
PRIDEiQ2T9T9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi532538.
KEGGibta:532538.

Organism-specific databases

CTDi84261.

Phylogenomic databases

eggNOGiENOG410IQD3. Eukaryota.
ENOG4111G8F. LUCA.
HOGENOMiHOG000112556.
HOVERGENiHBG051598.
InParanoidiQ2T9T9.
KOiK10265.

Miscellaneous databases

NextBioi20875721.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiFBXW9_BOVIN
AccessioniPrimary (citable) accession number: Q2T9T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: January 24, 2006
Last modified: November 11, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.