Reviewed, UniProtKB/Swiss-Prot Q2T9S8 (AATC2_BOVIN)

Names and origin

Protein names

Recommended name:
    Putative aspartate aminotransferase, cytoplasmic 2
    EC=2.6.1.1
Alternative name(s):
    Transaminase A-like protein 1
    Glutamate oxaloacetate transaminase 1-like protein 1

Gene names

Name:

GOT1L1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-aspartate:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Putative aspartate aminotransferase, cytoplasmic 2		PRO_0000332998
Amino acid modifications
	Modified residue	249	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2T9S8-1 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 0509D33422969661	FASTA	407	45,918
	10 20 30 40 50 60 MPTLSVFTDV PMAQKLEGSL LKTYKQDDNP NKMFLAYKVC MTSKGRPWVS SVVRKTRMQI 70 80 90 100 110 120 AQDPSLNYEY TPVMGMKSFV QASLNLLFGK NSQVIVENRA GGVQTVGDSG AFQLGAQFLK 130 140 150 160 170 180 SWCQSSQIVY IVSSQKEPHG LIFQDMGFTV YEHTFWDSAH LCLDPNMLLD VVKHAPHGCV 190 200 210 220 230 240 FVIGSMGNCQ LTPSQWTQLM TLMKSKEIFP FFDIPYQGLS TGDLEEDARF LHYFVSQGFE 250 260 270 280 290 300 FFCSQSLSKN FGIYDEGVGT LVVVTLDNQL LLRVLSQLMN FARALWLNPP TTGARIITSV 310 320 330 340 350 360 LCNPAMQGEW RQSLEGVVEN VMMTKEKVKE KLRLLGTPGS WDHITEQKGS HSYLGLNSQQ 370 380 390 400 VEYLISEKHI YIPKNGRINF TCINSYNIDY ITSSINEAVC FTKDSER

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC111285 mRNA. Translation: AAI11286.1.
IPI	IPI00691443.
RefSeq	NP_001033147.1.
UniGene	Bt.54244
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2T9S8.
Genome annotation databases
Ensembl	ENSBTAT00000021864; ENSBTAP00000021864; ENSBTAG00000016446; Bos taurus. [Genome view]
GeneID	507913.
KEGG	bta:507913.
Organism-specific databases
CTD	507913.
Phylogenomic databases
HOVERGEN	Q2T9S8.
OMA	INFTCIN.
Family and domain databases
InterPro	IPR004839. Aminotransferase_I/II. IPR000796. Asp_trans. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11879. Asp_trans. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00799. TRANSAMINASE.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AATC2_BOVIN

Accession

Primary (citable) accession number: Q2T9S8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	January 24, 2006
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)