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Protein

Glycerol-3-phosphate phosphatase

Gene

PGP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity
Glycerol 1-phosphate + H2O = glycerol + phosphate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341NucleophileBy similarity
Metal bindingi34 – 341MagnesiumBy similarity
Active sitei36 – 361Proton donorBy similarity
Metal bindingi36 – 361Magnesium; via carbonyl oxygenBy similarity
Sitei204 – 2041Important for substrate specificityBy similarity
Metal bindingi260 – 2601MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate phosphataseCurated (EC:3.1.3.21By similarity)
Short name:
G3PPBy similarity
Alternative name(s):
Aspartate-based ubiquitous Mg(2+)-dependent phosphataseBy similarity (EC:3.1.3.48By similarity)
Short name:
AUMBy similarity
Phosphoglycolate phosphataseBy similarity
Short name:
PGPBy similarity
Gene namesi
Name:PGPBy similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Glycerol-3-phosphate phosphatasePRO_0000316887Add
BLAST

Proteomic databases

PaxDbiQ2T9S4.
PRIDEiQ2T9S4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009951.
ExpressionAtlasiQ2T9S4. baseline and differential.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013127.

Structurei

3D structure databases

ProteinModelPortaliQ2T9S4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2882. Eukaryota.
COG0647. LUCA.
GeneTreeiENSGT00510000047020.
HOGENOMiHOG000068104.
HOVERGENiHBG049429.
InParanoidiQ2T9S4.
KOiK19269.
OMAiEYLNGSH.
OrthoDBiEOG091G0I92.
TreeFamiTF314344.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
3.40.50.10410. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006357. HAD-SF_hydro_IIA.
IPR023215. NPhePase-like_dom.
IPR006349. PGP_euk.
[Graphical view]
PfamiPF13344. Hydrolase_6. 1 hit.
[Graphical view]
PIRSFiPIRSF000915. PGP-type_phosphatase. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01460. HAD-SF-IIA. 1 hit.
TIGR01452. PGP_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2T9S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAEAGGDD GRCVRLNAER AQALLADVDT LLFDCDGVLW RGETAVPGAP
60 70 80 90 100
ETLTALRARG KRLAFITNNS SKTREAYAEK LRCLGFGAPA GPDAGREVFG
110 120 130 140 150
TAYCTALYLR QRLTGPPAPK AYVLGSVALA AELEAVGVSC VGVGPEPLLG
160 170 180 190 200
DGPGAWLDAP LEPDVRAVVV GFDPHFSYMK LTKAVRYLQQ PDCLLVGTNM
210 220 230 240 250
DNRLPLENGR FIAGTGCLVR AVEMAAQRQA DIIGKPSRFI FDCVSQEYGI
260 270 280 290 300
HPERTVMVGD RLDTDILLGV TCGLKTILTL TGVSSLRDVK SNQESDCMAK
310 320
KKMVPDFYVD SIADLLPALQ G
Length:321
Mass (Da):34,320
Last modified:January 24, 2006 - v1
Checksum:i209E64F8BF5B9E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111291 mRNA. Translation: AAI11292.1.
RefSeqiNP_001033261.1. NM_001038172.2.
UniGeneiBt.32423.

Genome annotation databases

EnsembliENSBTAT00000013127; ENSBTAP00000013127; ENSBTAG00000009951.
GeneIDi538173.
KEGGibta:538173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111291 mRNA. Translation: AAI11292.1.
RefSeqiNP_001033261.1. NM_001038172.2.
UniGeneiBt.32423.

3D structure databases

ProteinModelPortaliQ2T9S4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013127.

Proteomic databases

PaxDbiQ2T9S4.
PRIDEiQ2T9S4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000013127; ENSBTAP00000013127; ENSBTAG00000009951.
GeneIDi538173.
KEGGibta:538173.

Organism-specific databases

CTDi283871.

Phylogenomic databases

eggNOGiKOG2882. Eukaryota.
COG0647. LUCA.
GeneTreeiENSGT00510000047020.
HOGENOMiHOG000068104.
HOVERGENiHBG049429.
InParanoidiQ2T9S4.
KOiK19269.
OMAiEYLNGSH.
OrthoDBiEOG091G0I92.
TreeFamiTF314344.

Gene expression databases

BgeeiENSBTAG00000009951.
ExpressionAtlasiQ2T9S4. baseline and differential.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
3.40.50.10410. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR006357. HAD-SF_hydro_IIA.
IPR023215. NPhePase-like_dom.
IPR006349. PGP_euk.
[Graphical view]
PfamiPF13344. Hydrolase_6. 1 hit.
[Graphical view]
PIRSFiPIRSF000915. PGP-type_phosphatase. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01460. HAD-SF-IIA. 1 hit.
TIGR01452. PGP_euk. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGP_BOVIN
AccessioniPrimary (citable) accession number: Q2T9S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 24, 2006
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.