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Protein

Glycerol-3-phosphate phosphatase

Gene

PGP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2-phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.By similarity
Glycerol 1-phosphate + H2O = glycerol + phosphate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34NucleophileBy similarity1
Metal bindingi34MagnesiumBy similarity1
Active sitei36Proton donorBy similarity1
Metal bindingi36Magnesium; via carbonyl oxygenBy similarity1
Sitei204Important for substrate specificityBy similarity1
Metal bindingi260MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCarbohydrate metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate phosphataseCurated (EC:3.1.3.21By similarity)
Short name:
G3PPBy similarity
Alternative name(s):
Aspartate-based ubiquitous Mg(2+)-dependent phosphataseBy similarity (EC:3.1.3.48By similarity)
Short name:
AUMBy similarity
Phosphoglycolate phosphataseBy similarity
Short name:
PGPBy similarity
Gene namesi
Name:PGPBy similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:32798 PGP

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168871 – 321Glycerol-3-phosphate phosphataseAdd BLAST321

Proteomic databases

PaxDbiQ2T9S4
PRIDEiQ2T9S4

Expressioni

Gene expression databases

BgeeiENSBTAG00000009951
ExpressionAtlasiQ2T9S4 baseline and differential

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013127

Structurei

3D structure databases

ProteinModelPortaliQ2T9S4
SMRiQ2T9S4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2882 Eukaryota
COG0647 LUCA
GeneTreeiENSGT00510000047020
HOGENOMiHOG000068104
HOVERGENiHBG049429
InParanoidiQ2T9S4
KOiK19269
OMAiVFGTAYC
OrthoDBiEOG091G0I92
TreeFamiTF314344

Family and domain databases

Gene3Di3.40.50.1000, 3 hits
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006357 HAD-SF_hydro_IIA
IPR023214 HAD_sf
IPR006349 PGP_euk
PfamiView protein in Pfam
PF13344 Hydrolase_6, 1 hit
PIRSFiPIRSF000915 PGP-type_phosphatase, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01460 HAD-SF-IIA, 1 hit
TIGR01452 PGP_euk, 1 hit

Sequencei

Sequence statusi: Complete.

Q2T9S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAEAGGDD GRCVRLNAER AQALLADVDT LLFDCDGVLW RGETAVPGAP
60 70 80 90 100
ETLTALRARG KRLAFITNNS SKTREAYAEK LRCLGFGAPA GPDAGREVFG
110 120 130 140 150
TAYCTALYLR QRLTGPPAPK AYVLGSVALA AELEAVGVSC VGVGPEPLLG
160 170 180 190 200
DGPGAWLDAP LEPDVRAVVV GFDPHFSYMK LTKAVRYLQQ PDCLLVGTNM
210 220 230 240 250
DNRLPLENGR FIAGTGCLVR AVEMAAQRQA DIIGKPSRFI FDCVSQEYGI
260 270 280 290 300
HPERTVMVGD RLDTDILLGV TCGLKTILTL TGVSSLRDVK SNQESDCMAK
310 320
KKMVPDFYVD SIADLLPALQ G
Length:321
Mass (Da):34,320
Last modified:January 24, 2006 - v1
Checksum:i209E64F8BF5B9E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111291 mRNA Translation: AAI11292.1
RefSeqiNP_001033261.1, NM_001038172.2
UniGeneiBt.32423

Genome annotation databases

EnsembliENSBTAT00000013127; ENSBTAP00000013127; ENSBTAG00000009951
GeneIDi538173
KEGGibta:538173

Similar proteinsi

Entry informationi

Entry nameiPGP_BOVIN
AccessioniPrimary (citable) accession number: Q2T9S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: January 24, 2006
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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