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Protein

UPF0583 protein C15orf59

Gene

C15orf59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32634-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0583 protein C15orf59
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:33753. C15orf59.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205363.
PharmGKBiPA162378260.

Polymorphism and mutation databases

BioMutaiC15orf59.
DMDMi121941727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003370451 – 293UPF0583 protein C15orf59Add BLAST293

Proteomic databases

PaxDbiQ2T9L4.
PeptideAtlasiQ2T9L4.
PRIDEiQ2T9L4.

PTM databases

iPTMnetiQ2T9L4.
PhosphoSitePlusiQ2T9L4.

Expressioni

Gene expression databases

BgeeiENSG00000205363.
CleanExiHS_C15orf59.
ExpressionAtlasiQ2T9L4. baseline and differential.
GenevisibleiQ2T9L4. HS.

Organism-specific databases

HPAiHPA041563.

Interactioni

Protein-protein interaction databases

BioGridi132568. 1 interactor.
IntActiQ2T9L4. 4 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ2T9L4.
SMRiQ2T9L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili30 – 63Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi207 – 214Poly-Glu8

Sequence similaritiesi

Belongs to the UPF0583 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGKB. Eukaryota.
ENOG4111MNH. LUCA.
GeneTreeiENSGT00730000111309.
HOGENOMiHOG000072696.
HOVERGENiHBG107739.
InParanoidiQ2T9L4.
OMAiMNIRGTP.
OrthoDBiEOG091G0FR0.
PhylomeDBiQ2T9L4.
TreeFamiTF332382.

Family and domain databases

InterProiIPR027997. DUF4589.
[Graphical view]
PfamiPF15252. DUF4589. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2T9L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIRGAPDLG QPSDDPSSGG ERERIRQRMK MVIGQLEGIL RELKEVAKEL
60 70 80 90 100
REVVSQIDKL TSDFDFELEP DDWTTATVSS TSSSDKAGMG GPFDLGHLDF
110 120 130 140 150
MTADILSDSW EFCSFLDVST PSDSVDGPES TRPGAGPDYR LMNGGTPIPN
160 170 180 190 200
GPRVETPDSS SEEAFGAGPT VKSQLPQRTP GTRERVRFSD KVLYHALCCD
210 220 230 240 250
DEEGDGEQEV EEEEVGLPPE PAHTEAHAGP HKPSPAPYKS RRSPLTSRHS
260 270 280 290
GSTLAPEQTR RVTRNSSTQT VSDKSTQTVL PYTATRQKAR GKN
Length:293
Mass (Da):31,928
Last modified:January 24, 2006 - v1
Checksum:iDC3E535979396B67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111368 mRNA. Translation: AAI11369.1.
CCDSiCCDS32289.1.
RefSeqiNP_001034703.1. NM_001039614.2.
XP_005254426.1. XM_005254369.4.
UniGeneiHs.213493.
Hs.40794.

Genome annotation databases

EnsembliENST00000379822; ENSP00000369150; ENSG00000205363.
ENST00000569673; ENSP00000457205; ENSG00000205363.
GeneIDi388135.
KEGGihsa:388135.
UCSCiuc002avy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC111368 mRNA. Translation: AAI11369.1.
CCDSiCCDS32289.1.
RefSeqiNP_001034703.1. NM_001039614.2.
XP_005254426.1. XM_005254369.4.
UniGeneiHs.213493.
Hs.40794.

3D structure databases

ProteinModelPortaliQ2T9L4.
SMRiQ2T9L4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132568. 1 interactor.
IntActiQ2T9L4. 4 interactors.

PTM databases

iPTMnetiQ2T9L4.
PhosphoSitePlusiQ2T9L4.

Polymorphism and mutation databases

BioMutaiC15orf59.
DMDMi121941727.

Proteomic databases

PaxDbiQ2T9L4.
PeptideAtlasiQ2T9L4.
PRIDEiQ2T9L4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379822; ENSP00000369150; ENSG00000205363.
ENST00000569673; ENSP00000457205; ENSG00000205363.
GeneIDi388135.
KEGGihsa:388135.
UCSCiuc002avy.4. human.

Organism-specific databases

CTDi388135.
GeneCardsiC15orf59.
HGNCiHGNC:33753. C15orf59.
HPAiHPA041563.
neXtProtiNX_Q2T9L4.
OpenTargetsiENSG00000205363.
PharmGKBiPA162378260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGKB. Eukaryota.
ENOG4111MNH. LUCA.
GeneTreeiENSGT00730000111309.
HOGENOMiHOG000072696.
HOVERGENiHBG107739.
InParanoidiQ2T9L4.
OMAiMNIRGTP.
OrthoDBiEOG091G0FR0.
PhylomeDBiQ2T9L4.
TreeFamiTF332382.

Enzyme and pathway databases

BioCyciZFISH:G66-32634-MONOMER.

Miscellaneous databases

GenomeRNAii388135.
PROiQ2T9L4.

Gene expression databases

BgeeiENSG00000205363.
CleanExiHS_C15orf59.
ExpressionAtlasiQ2T9L4. baseline and differential.
GenevisibleiQ2T9L4. HS.

Family and domain databases

InterProiIPR027997. DUF4589.
[Graphical view]
PfamiPF15252. DUF4589. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCO059_HUMAN
AccessioniPrimary (citable) accession number: Q2T9L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 24, 2006
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.