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Protein

Chemotaxis response regulator protein-glutamate methylesterase 2

Gene

cheB2

Organism
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176UniRule annotation1
Active sitei202UniRule annotation1
Active sitei298UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 2UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB2UniRule annotation
Ordered Locus Names:BTH_II0161
OrganismiBurkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000001930 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642681 – 354Chemotaxis response regulator protein-glutamate methylesterase 2Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ2T8Y6.
SMRiQ2T8Y6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 120Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini164 – 354CheB-type methylesteraseUniRule annotationAdd BLAST191

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000151423.
KOiK03412.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2T8Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRVVVVDDS MSMRTLLERI INGCDGMTCV GAAEDASAAR EMIRALDPDV
60 70 80 90 100
VTLDVEMPGM DGLEFLRRMM LLKPTPTIMV SGRTTSGSDA ALRALELGAV
110 120 130 140 150
DVIAKPLLTR PADLADYARD IAELIRGAAA ARVKGGALAA ASSAGRERAC
160 170 180 190 200
AHRPRGAKKA GIAATRLSRV IAIGASTGGT EALRTVLQDM SGTPPPILIC
210 220 230 240 250
QHMPEGFTAS FAARLDAICG IRVKEAEQGE PLHYGCAYVA PGHSHLSLAA
260 270 280 290 300
TGRLYVCRLE ASPPVNRHRP SVDVLFDSVA RLAGKRALGA ILTGMGKDGA
310 320 330 340 350
AGLLRMRASG ARTFAQDEPS CVVFGMPKEA IAMGAVDEIL PLARMGARLS

EALQ
Length:354
Mass (Da):37,092
Last modified:December 12, 2006 - v2
Checksum:iC113B279BEF61B90
GO

Sequence cautioni

The sequence ABC35113 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000085 Genomic DNA. Translation: ABC35113.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiABC35113; ABC35113; BTH_II0161.
KEGGibte:BTH_II0161.

Similar proteinsi

Entry informationi

Entry nameiCHEB2_BURTA
AccessioniPrimary (citable) accession number: Q2T8Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: November 22, 2017
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome