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Protein

Acetaldehyde dehydrogenase

Gene

mhpF

Organism
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei130Acyl-thioester intermediateUniRule annotation1
Binding sitei272NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 18NADUniRule annotation4
Nucleotide bindingi162 – 170NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Name:mhpFUniRule annotation
Ordered Locus Names:BTH_II0569
OrganismiBurkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000001930 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876421 – 297Acetaldehyde dehydrogenaseAdd BLAST297

Structurei

3D structure databases

ProteinModelPortaliQ2T7T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000052149.
KOiK04073.
OMAiNIGSDLM.
OrthoDBiPOG091H09NP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2T7T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKSSRTRV AILGSGSIGL DLMFKVKASE HFDLKFVVGR HANSDGLKLA
60 70 80 90 100
RSCNVETSSD GLDFLKENED AYDLVFDATS AAAHKVNNGF FSGAGKFVID
110 120 130 140 150
LTPAKLGRLC VPCINLDDIG AEQNVNLITC GGQASLPLAY ALKQAVDEIE
160 170 180 190 200
YLEVVSAIAS RSAGIATREN IDEYMTTTEY ALAQFSGAKK TKAILNINPA
210 220 230 240 250
EPGVRMQTTL YAHARYRDFD RVRACVAEMV EKVREYVPGY RLVVEPIESQ
260 270 280 290
GRITISLTVR GRGDYLPEYA GNLDIINCAA LAVASHRHAT ARLGATQ
Length:297
Mass (Da):32,241
Last modified:January 24, 2006 - v1
Checksum:iF9C07F405011D23B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000085 Genomic DNA. Translation: ABC35657.1.
RefSeqiWP_009907290.1. NC_007650.1.

Genome annotation databases

EnsemblBacteriaiABC35657; ABC35657; BTH_II0569.
KEGGibte:BTH_II0569.
PATRICi19298640. VBIBurTha36512_0651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000085 Genomic DNA. Translation: ABC35657.1.
RefSeqiWP_009907290.1. NC_007650.1.

3D structure databases

ProteinModelPortaliQ2T7T0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABC35657; ABC35657; BTH_II0569.
KEGGibte:BTH_II0569.
PATRICi19298640. VBIBurTha36512_0651.

Phylogenomic databases

HOGENOMiHOG000052149.
KOiK04073.
OMAiNIGSDLM.
OrthoDBiPOG091H09NP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACDH_BURTA
AccessioniPrimary (citable) accession number: Q2T7T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: January 24, 2006
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.