Q2T7P9 (KHSE_BURTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	BTH_II0600

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Homoserine kinase HAMAP MF_00301		PRO_0000300790

Sequences

	Sequence		Length	Mass (Da)
	Q2T7P9 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 9644DE0A2AD7F63E	FASTA	331	36,702
	10 20 30 40 50 60 MAVFTAVSDA DLALWMRHYD LGDVVAFRGI PSGIENSNFF LTTTHGEYVL TIFENLTAGQ 70 80 90 100 110 120 LPFYIDLMSH LAKHGVPVPA PVARDDGTLF GELHGKPAAI VTKLEGAAEL APGIEHCVEV 130 140 150 160 170 180 GQMLARMHLA GRDYPQHQPN LRSLPWWRDA VPAIVPFITG EQRALLEGEL AHQAAFFASD 190 200 210 220 230 240 DYAALPEGPC HCDLFRDNAL FAHAAPDTGH SVRLGGFFDF YFAGCDKWLF DVAVTVNDWC 250 260 270 280 290 300 VDLSTGALDA GRADALLRAY QTVRPFTTGE RRHWGDMLRA GAYRFWVSRL YDFHLPRAAQ 310 320 330 MLKPHDPGHF ERILRERIAH AGALPETHAC N

References

[1]

"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies." Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D. BMC Genomics 6:174-174(2005) [PubMed: 16336651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000085 Genomic DNA. Translation: ABC34066.1.
RefSeq	YP_438800.1. NC_007650.1.
3D structure databases
ProteinModelPortal	Q2T7P9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2T7P9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3845891.
GenomeReviews	Gene locus BTH_II0600 in contig CP000085_GR.
KEGG	bte:BTH_II0600.
PATRIC	19298702. VBIBurTha36512_0682.
TIGR	BTH_II0600.
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	BTHA271848:BTH_II0600-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BURTA

Accession

Primary (citable) accession number: Q2T7P9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	January 24, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program