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Q2T7N4

- GCH4_BURTA

UniProt

Q2T7N4 - GCH4_BURTA

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBTHA271848:GJMY-3959-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:BTH_II0615
OrganismiBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000001930: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269GTP cyclohydrolase FolE2PRO_0000289483Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi271848.BTH_II0615.

Structurei

3D structure databases

ProteinModelPortaliQ2T7N4.
SMRiQ2T7N4. Positions 21-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2T7N4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLMNPEFVM PDVQSTVDTR QMPIQRVGVR AVRHPLTVRT AEGETQATVG
60 70 80 90 100
TWNLDVHLPA DQKGTHMSRF VALLEESGGP LTADAFRAML ATMLEKLEAQ
110 120 130 140 150
AGRIEVSFPY FVNKTAPVSG VRSLLDYEVT LTGDVRDGLT RVFAKVLVPV
160 170 180 190 200
TSLCPCSKKI SQYGAHNQRS HVTIDAELAA DVPVEDLIRI AEEEASCELW
210 220 230 240 250
GLLKRPDEKF VTERAYENPK FVEDLVRDVA RRLDADERIV AYVLEAENFE
260
SIHNHSAYAL IERDKRRRA
Length:269
Mass (Da):30,188
Last modified:May 29, 2007 - v2
Checksum:i1BEEFDB5625B2024
GO

Sequence cautioni

The sequence ABC35595.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000085 Genomic DNA. Translation: ABC35595.1. Different initiation.
RefSeqiYP_438815.1. NC_007650.1.

Genome annotation databases

EnsemblBacteriaiABC35595; ABC35595; BTH_II0615.
GeneIDi3844888.
KEGGibte:BTH_II0615.
PATRICi19298738. VBIBurTha36512_0700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000085 Genomic DNA. Translation: ABC35595.1 . Different initiation.
RefSeqi YP_438815.1. NC_007650.1.

3D structure databases

ProteinModelPortali Q2T7N4.
SMRi Q2T7N4. Positions 21-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 271848.BTH_II0615.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC35595 ; ABC35595 ; BTH_II0615 .
GeneIDi 3844888.
KEGGi bte:BTH_II0615.
PATRICi 19298738. VBIBurTha36512_0700.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BTHA271848:GJMY-3959-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
    Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
    BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Entry informationi

Entry nameiGCH4_BURTA
AccessioniPrimary (citable) accession number: Q2T7N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 1, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3