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Q2T5T2 (THIM_BURTA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:BTH_II1271
OrganismBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP]
Taxonomic identifier271848 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383830

Sites

Binding site1261ATP By similarity
Binding site1721ATP By similarity
Binding site1991Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2T5T2 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 16B064049901C5D4

FASTA26025,923
        10         20         30         40         50         60 
MESINWNTRS VREELAAVKR AAPFVYGLTN YVAANLSANV LLAVGAAPAI GAAADWPARF 

        70         80         90        100        110        120 
GAGAGALWIN TAALMSSGAD TLRTAARAAS ETGTRWVLDP VATGAGAPEY DAIVQELLAF 

       130        140        150        160        170        180 
RPSVIRGNAS ELIALAGGTA AGKGVDTTAS SDSALAYIGD LARRSGAVVA VSGPIDYVTD 

       190        200        210        220        230        240 
GIDTLAIAGG DARLTRVTGA GCALGALIAA LLAQRGAALA AAAAAHAIYA IAAERAADAR 

       250        260 
GTGSFAVRFV DELSLLDPGE 

« Hide

References

[1]"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000085 Genomic DNA. Translation: ABC34848.1.
RefSeqYP_439467.1. NC_007650.1.

3D structure databases

ProteinModelPortalQ2T5T2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING271848.BTH_II1271.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABC34848; ABC34848; BTH_II1271.
GeneID3846252.
KEGGbte:BTH_II1271.
PATRIC19300157. VBIBurTha36512_1408.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAQTFTANV.

Enzyme and pathway databases

BioCycBTHA271848:GJMY-4614-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_BURTA
AccessionPrimary (citable) accession number: Q2T5T2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: January 24, 2006
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways