Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2T4T8

- MDH2_BURTA

UniProt

Q2T4T8 - MDH2_BURTA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Malate dehydrogenase 2

Gene

mdh2

Organism
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931SubstrateUniRule annotation
Binding sitei99 – 991SubstrateUniRule annotation
Binding sitei106 – 1061NADUniRule annotation
Binding sitei113 – 1131NADUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Binding sitei163 – 1631SubstrateUniRule annotation
Active sitei188 – 1881Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 187NADUniRule annotation
Nucleotide bindingi130 – 1323NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBTHA271848:GJMY-4960-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase 2UniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdh2UniRule annotation
Ordered Locus Names:BTH_II1617
OrganismiBurkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000001930: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Malate dehydrogenase 2PRO_0000292370Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi271848.BTH_II1617.

Structurei

3D structure databases

ProteinModelPortaliQ2T4T8.
SMRiQ2T4T8. Positions 5-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiFPDYRHA.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2T4T8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTEAKRIAV SGAAGQIAYS LLFRIAQGDL LGEDQPVILQ LLDLPQAYGA
60 70 80 90 100
VQGVVMELQD CAFPLLKEIQ VATDPHAAFL NADYAFLVGS KPRTKGMERR
110 120 130 140 150
DLLAENAAIF RTQGRALNEA ASRDVKVLVV GNPANTNASI LRRFAPDLPD
160 170 180 190 200
DAISAMIRLD HNRAVSMLAQ RCNVDVDSIA DMVVWGNHSP TMFPDYRHAR
210 220 230 240 250
IGRRLVKDLI NDENWYRESF IPKVAQRGTA IIEARGASSA ASAANAAIDQ
260 270 280 290 300
MRDWIFGSDG RWVSMSVPSD GSYGIAPGLM FGVPVICDGG RYERVKDIGI
310 320
DAFARQRIDL SVRELQEEAD VVNRLFADR
Length:329
Mass (Da):36,101
Last modified:January 24, 2006 - v1
Checksum:i7771577BC065D687
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000085 Genomic DNA. Translation: ABC35074.1.
RefSeqiYP_439811.1. NC_007650.1.

Genome annotation databases

EnsemblBacteriaiABC35074; ABC35074; BTH_II1617.
GeneIDi3844557.
KEGGibte:BTH_II1617.
PATRICi19300910. VBIBurTha36512_1783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000085 Genomic DNA. Translation: ABC35074.1 .
RefSeqi YP_439811.1. NC_007650.1.

3D structure databases

ProteinModelPortali Q2T4T8.
SMRi Q2T4T8. Positions 5-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 271848.BTH_II1617.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABC35074 ; ABC35074 ; BTH_II1617 .
GeneIDi 3844557.
KEGGi bte:BTH_II1617.
PATRICi 19300910. VBIBurTha36512_1783.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi FPDYRHA.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci BTHA271848:GJMY-4960-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies."
    Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D.
    BMC Genomics 6:174-174(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Entry informationi

Entry nameiMDH2_BURTA
AccessioniPrimary (citable) accession number: Q2T4T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: January 24, 2006
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3