Q2T3K4 (Q2T3K4_BURTA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase 2 HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE2 HAMAP MF_00222
Ordered Locus Names:	BTH_II2057

Organism

Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [Complete proteome] [HAMAP] EMBL ABC34595.1

Taxonomic identifier

271848 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	134 – 138	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	74	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	Q2T3K4 [UniParc]. Last modified January 24, 2006. Version 1. Checksum: 6A9C80FEA29F57B9	FASTA	284	30,020
	10 20 30 40 50 60 MSGRSFLIGL IGSGIGGSLS PAMHEEAGRR QGLNYVYRRI DLDALRLTAD ALPELLTAAE 70 80 90 100 110 120 RMGFDGLNIT HPCKQRVIEH LDELSPDAAA LGAVNTVRFL DGRRIGHNTD WSGFAKAFAR 130 140 150 160 170 180 GLPGASLERV VQLGAGGAGA AVAHAALTMG ATQLALFDVD PARARSLADQ LQARFPHTRL 190 200 210 220 230 240 SAGGPLAGAL ANANGLIHAT PTGMLKHPGL PLPAELLRSD LWVADIVYFP LETELIRAAC 250 260 270 280 ALGCRTLPGG GMAVYQAVDA FEIFTGRAPD AERMFEHFQA LVAR

References

[1]

"Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies." Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C., DeShazer D. BMC Genomics 6:174-174(2005) [PubMed: 16336651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: E264 / ATCC 700388 / DSM 13276 / CIP 106301.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000085 Genomic DNA. Translation: ABC34595.1.
RefSeq	YP_440245.1. NC_007650.1.
3D structure databases
ProteinModelPortal	Q2T3K4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2T3K4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3845348.
GenomeReviews	Gene locus BTH_II2057 in contig CP000085_GR.
KEGG	bte:BTH_II2057.
PATRIC	19301892. VBIBurTha36512_2268.
TIGR	BTH_II2057.
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	HEHEGDA.
ProtClustDB	PRK12549.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2T3K4_BURTA

Accession

Primary (citable) accession number: Q2T3K4

Entry history

Integrated into UniProtKB/TrEMBL:	January 24, 2006
Last sequence update:	January 24, 2006
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)