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Protein

Homoserine O-succinyltransferase

Gene

metXS

Organism
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.UniRule annotation1 Publication

Catalytic activityi

Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine.UniRule annotation1 Publication

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-succinyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-succinyltransferase (metX), Homoserine O-succinyltransferase (metXS)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-succinyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei151NucleophileUniRule annotation1
Binding sitei221SubstrateUniRule annotation1
Active sitei321UniRule annotation1
Sitei323Important for acyl-CoA specificityUniRule annotation1 Publication1
Active sitei354UniRule annotation1
Binding sitei355SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00051; UER00075.

Protein family/group databases

ESTHERiburma-metx. Homoserine_transacetylase.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-succinyltransferaseUniRule annotation (EC:2.3.1.46UniRule annotation1 Publication)
Short name:
HST1 PublicationUniRule annotation
Alternative name(s):
Homoserine transsuccinylaseUniRule annotation
Short name:
HTSUniRule annotation
Gene namesi
Name:metXS1 PublicationUniRule annotation
Ordered Locus Names:BTH_I0157
OrganismiBurkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000001930 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000218751 – 381Homoserine O-succinyltransferaseAdd BLAST381

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

SMRiQ2T284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 360AB hydrolase-1UniRule annotationAdd BLAST316

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MetX family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246301.
KOiK00641.
OMAiCQGTTGP.
OrthoDBiPOG091H08NY.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_00296. MetX_acyltransf. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoser/ser_AcTrfase.
IPR034387. Homoser_AcTrfase.
PfamiView protein in Pfam
PF00561. Abhydrolase_1. 1 hit.
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2T284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESIGVVAPH TMHFAEPLRL QSGSVLGNYQ LVVETYGELN AARSNAVLVC
60 70 80 90 100
HALNASHHVA GVYADDPRST GWWDNMVGPG KPLDTNRFFV IGVNNLGSCF
110 120 130 140 150
GSTGPMSIDP ATGTPYGARF PVVTVEDWVH AQARVADAFG IERFAAVMGG
160 170 180 190 200
SLGGMQALAW SLLYPERVAH CIDIASTPKL SAQNIAFNEV ARSAILSDPD
210 220 230 240 250
FHGGDYYAHG VKPRRGLRVA RMIGHITYLS DDDMAEKFGR ALRRADGALD
260 270 280 290 300
AYNFNFDVEF EVESYLRYQG DKFADYFDAN TYLLITRALD YFDPAKAFNG
310 320 330 340 350
NLSAALAHTK AKYLVASFTT DWRFAPARSR EIVKALLDNR RSVSYAEIDA
360 370 380
PHGHDAFLLD DARYHNLVRA YYERIAEEVG A
Length:381
Mass (Da):41,973
Last modified:January 24, 2006 - v1
Checksum:i2512B17358EA1450
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000086 Genomic DNA. Translation: ABC37574.1.
RefSeqiWP_009893578.1. NZ_CM000438.1.

Genome annotation databases

EnsemblBacteriaiABC37574; ABC37574; BTH_I0157.
KEGGibte:BTH_I0157.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMETXS_BURTA
AccessioniPrimary (citable) accession number: Q2T284
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: July 5, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families