ID   GLPK_BURTA              Reviewed;         500 AA.
AC   Q2T0Z3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Glycerol kinase;
DE            EC=2.7.1.30;
DE   AltName: Full=ATP:glycerol 3-phosphotransferase;
DE   AltName: Full=Glycerokinase;
DE            Short=GK;
GN   Name=glpK; OrderedLocusNames=BTH_I0599;
OS   Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 /
OS   CIP 106301).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=271848;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R.,
RA   Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D.,
RA   Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J.,
RA   Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D.,
RA   Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P.,
RA   Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F.,
RA   Roberts K., Hatch B., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key enzyme in the regulation of glycerol uptake and
CC       metabolism.
CC   -!- CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-
CC       phosphate.
CC   -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol
CC       kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC   -!- SIMILARITY: Belongs to the FGGY kinase family.
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DR   EMBL; CP000086; ABC37809.1; -; Genomic_DNA.
DR   RefSeq; YP_441156.1; -.
DR   GeneID; 3849032; -.
DR   GenomeReviews; CP000086_GR; BTH_I0599.
DR   KEGG; bte:BTH_I0599; -.
DR   TIGR; BTH_I0599; -.
DR   HOGENOM; Q2T0Z3; -.
DR   OMA; Q2T0Z3; IAQREFT.
DR   BioCyc; BTHA271848:BTH_I0599-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004370; F:glycerol kinase activity; IEA:HAMAP.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:HAMAP.
DR   HAMAP; MF_00186; -; 1.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018485; Carb_kinase_FGGY_C.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018484; Carb_kinase_FGGY_N.
DR   InterPro; IPR005999; Glycerol_kin.
DR   PANTHER; PTHR10196; FGGY_kin; 1.
DR   PANTHER; PTHR10196:SF9; Glycerol_kin; 1.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   TIGRFAMs; TIGR01311; glycerol_kin; 1.
DR   PROSITE; PS00933; FGGY_KINASES_1; 1.
DR   PROSITE; PS00445; FGGY_KINASES_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Glycerol metabolism; Kinase;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    500       Glycerol kinase.
FT                                /FTId=PRO_1000020713.
FT   NP_BIND     410    414       ATP (By similarity).
FT   BINDING      13     13       Substrate (By similarity).
FT   BINDING      17     17       ATP (By similarity).
FT   BINDING      83     83       Substrate (By similarity).
FT   BINDING     135    135       Substrate (By similarity).
FT   BINDING     244    244       Substrate (By similarity).
FT   BINDING     266    266       ATP (By similarity).
FT   BINDING     309    309       ATP; via carbonyl oxygen (By similarity).
SQ   SEQUENCE   500 AA;  54710 MW;  E1E14456E8E4F2F6 CRC64;
     MQDQYILALD QGTTSSRAML FDRQGNIVSI AQKEFEQIYP RPGWVEHDPQ EIWSTQAGVA
     AEAVTRVGLN GTSIAAIGIT NQRETTIVWD RETGHPIYNA IVWQDRRTAD FCDQLKAQGL
     SEKVRAKTGL PIDSYFSATK IRWILDNVEG AREKARQGKL AFGTVDSWLV WNFTKHELHV
     TDVTNASRTM LFNIHTLDWD DELLDALEIP RSMLPQVRAS SEIYGPTKTT VFASKIPLAG
     IAGDQQAALF GQMCTSSGMV KNTYGTGCFL MMNTGETPIE SQNNLVTTIA WQVDGKVNYA
     LEGSIFIAGA VVQWLRDGLG IIKSASEIEA LAAGVPHTDG VYLVPAFAGL GAPHWNARAR
     GSLFGVTRGT TSAHLARAAL DSIAYQSLDV LKAMEADSGI RIGELRVDGG ASANNLLMQF
     QADLLGVDAV RPRVTETTAL GAAYLAGLAI GYWKNVDELH SQWQLERRFA PSMQREQVSS
     CLCGWQRAVR AAKAWADDTQ
//