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Protein

Glycerol kinase

Gene

glpK

Organism
Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (glpK), Glycerol kinase (glpK)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13SubstrateUniRule annotation1
Binding sitei17ATPUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei309ATP; via carbonyl oxygenUniRule annotation1
Binding sitei313ATP; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 15ATPUniRule annotation3
Nucleotide bindingi410 – 414ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycerol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:BTH_I0599
OrganismiBurkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)
Taxonomic identifieri271848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000001930 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000207131 – 500Glycerol kinaseAdd BLAST500

Proteomic databases

PRIDEiQ2T0Z3

Structurei

3D structure databases

ProteinModelPortaliQ2T0Z3
SMRiQ2T0Z3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 84Substrate bindingUniRule annotation2
Regioni244 – 245Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000222134
KOiK00864
OMAiWQDTRTQ
OrthoDBiPOG091H02FA

Family and domain databases

HAMAPiMF_00186 Glycerol_kin, 1 hit
InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2T0Z3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDQYILALD QGTTSSRAML FDRQGNIVSI AQKEFEQIYP RPGWVEHDPQ
60 70 80 90 100
EIWSTQAGVA AEAVTRVGLN GTSIAAIGIT NQRETTIVWD RETGHPIYNA
110 120 130 140 150
IVWQDRRTAD FCDQLKAQGL SEKVRAKTGL PIDSYFSATK IRWILDNVEG
160 170 180 190 200
AREKARQGKL AFGTVDSWLV WNFTKHELHV TDVTNASRTM LFNIHTLDWD
210 220 230 240 250
DELLDALEIP RSMLPQVRAS SEIYGPTKTT VFASKIPLAG IAGDQQAALF
260 270 280 290 300
GQMCTSSGMV KNTYGTGCFL MMNTGETPIE SQNNLVTTIA WQVDGKVNYA
310 320 330 340 350
LEGSIFIAGA VVQWLRDGLG IIKSASEIEA LAAGVPHTDG VYLVPAFAGL
360 370 380 390 400
GAPHWNARAR GSLFGVTRGT TSAHLARAAL DSIAYQSLDV LKAMEADSGI
410 420 430 440 450
RIGELRVDGG ASANNLLMQF QADLLGVDAV RPRVTETTAL GAAYLAGLAI
460 470 480 490 500
GYWKNVDELH SQWQLERRFA PSMQREQVSS CLCGWQRAVR AAKAWADDTQ
Length:500
Mass (Da):54,710
Last modified:January 24, 2006 - v1
Checksum:iE1E14456E8E4F2F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000086 Genomic DNA Translation: ABC37809.1

Genome annotation databases

EnsemblBacteriaiABC37809; ABC37809; BTH_I0599
KEGGibte:BTH_I0599

Similar proteinsi

Entry informationi

Entry nameiGLPK_BURTA
AccessioniPrimary (citable) accession number: Q2T0Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 24, 2006
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health